4.8 Review

Autoimmunity against laminin 332

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Letter Dermatology

Anti-β4 integrin autoantibodies in patients with mucous membrane pemphigoid: A retrospective analysis from a tertiary centre in Italy

Roberto Maglie et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2023)

Article Dermatology

Gene expression profiling of laminin α3-blocked keratinocytes reveals an immune-independent mechanism of blistering

Lei Bao et al.

Summary: Blocking Laminin alpha 3 alters keratinocyte differentiation, potentially leading to blistering through complement-independent mechanisms.

EXPERIMENTAL DERMATOLOGY (2022)

Article Dermatology

Evaluation of Site- and Autoantigen-Specific Characteristics of Mucous Membrane Pemphigoid

Nina van Beek et al.

Summary: This study aimed to characterize the clinical, immunoserological, and immunopathological features of patients with MMP, finding that the most frequently targeted antigen was BP180. Ocular disease was inversely associated with oral and nasal involvement and was associated with an increased risk of malignant neoplasms. Anti-laminin 332 reactivity was associated with malignant neoplasms, while anti-BP180 NC16A immunoglobulin G seropositivity was associated with the absence of ocular lesions.

JAMA DERMATOLOGY (2022)

Article Immunology

Increased Fibrosis in a Mouse Model of Anti-Laminin 332 Mucous Membrane Pemphigoid Remains Unaltered by Inhibition of Aldehyde Dehydrogenase

Sabrina Patzelt et al.

Summary: Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by scarring lesions in the oral cavity and conjunctivae. In this study, increased collagen fibril density was observed in the skin and conjunctival lesions of MMP mice. However, a potential anti-fibrotic therapy using disulfiram did not improve ocular lesions in the experimental MMP model.

FRONTIERS IN IMMUNOLOGY (2022)

Review Immunology

Mucous membrane pemphigoid

Gefei Du et al.

Summary: Mucous membrane pemphigoid (MMP) is a heterogeneous disease characterized by mucosal lesions, predominantly in the oral cavity and conjunctivae, leading to visual impairment and potential association with malignancy. The pathophysiology of MMP is not entirely understood.

AUTOIMMUNITY REVIEWS (2022)

Article Dermatology

Clinical and Serological Characterization of Orf-Induced Immunobullous Disease

Kaan Yilmaz et al.

Summary: This study aimed to characterize the main autoantigen in orf-induced immunobullous disease and provide a detailed description of this clinical entity.

JAMA DERMATOLOGY (2022)

Article Dermatology

A Probing of the Issue of Detecting IgG, IgG4 and IgA Antibodies to Laminin 332 Epitopes in Mucous Membrane Pemphigoid: A Clinical-Laboratory Experience of a Single Central European University Dermatology Department

Justyna Gornowicz-Porowska et al.

Summary: This study examined IgG, IgG4, and IgA autoantibodies specific to alpha 3, beta 3, or gamma 2 subunits of Ln-322 in MMP patients using the BIOCHIP mosaic-based indirect immunofluorescence technique. The results showed occasional detection of antibodies to Ln-332 chains in Polish MMP sufferers, and evaluating IgG4 antibodies can reduce false-negative results.

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY (2022)

Article Dermatology

S2k Guideline for the diagnosis and treatment of mucous membrane pemphigoid

Silke C. Hofmann et al.

Summary: Mucous membrane pemphigoid is a pemphigoid disease that primarily affects mucous membranes. It has a wide range of clinical manifestations and is challenging to treat. This guideline aims to provide guidance for diagnosing and treating this disease, emphasizing the importance of interdisciplinary cooperation and prompt therapy.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2022)

Article Immunology

Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases

Saeedeh Ghorbanalipoor et al.

Summary: Chronic blistering at the skin and/or mucous membranes, accompanied by inflammation, is a clinical hallmark of pemphigoid diseases. The diseases are caused by autoantibodies targeting structural proteins of the epithelial basement membrane. Activation of myeloid cells following binding to immune complexes plays a major role in the pathogenesis of skin blistering and inflammation.

FRONTIERS IN IMMUNOLOGY (2022)

Review Biochemistry & Molecular Biology

Anti-Laminin 332-Type Mucous Membrane Pemphigoid

Luhuai Shi et al.

Summary: Anti-LM332-type mucous membrane pemphigoid is a rare autoimmune bullous disease that is difficult to diagnose and treat, and may be correlated with tumors.

BIOMOLECULES (2022)

Article Dermatology

Anti-laminin 332 antibody detection using biochip immunofluorescence microscopy in a real-life cohort of Italian patients with mucous membrane pemphigoid

Giulia Gasparini et al.

Summary: Biochip immunofluorescence microscopy is a suitable technique for detecting anti-laminin 332 antibodies in MMP patients, and the results are consistent with traditional immunoblotting.

EUROPEAN JOURNAL OF DERMATOLOGY (2022)

Article Dermatology

S2k Guideline for the diagnosis and treatment of mucous membrane pemphigoid

Silke C. Hofmann et al.

Summary: Mucous membrane pemphigoid is a pemphigoid disease that mainly affects mucous membranes, leading to severe complications such as respiratory distress and blindness.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2022)

Article Dermatology

Serologic characterization of anti-p200 pemphigoid: Epitope spreading as a common phenomenon

Pranav Puri et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

Article Dermatology

Incidence of pemphigoid diseases in Northern Germany in 2016-first data from the Schleswig-Holstein Registry of Autoimmune Bullous Diseases

N. van Beek et al.

Summary: The study prospectively analyzed the incidence of PD in a well-defined geographical area in Northern Germany, finding the highest incidence among PD patients for bullous pemphigoid. The incidence of bullous pemphigoid is significantly increased compared to previous reports, and regional differences were also observed. Further studies are needed to clarify these findings.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

Article Dermatology

Dapsone Suppresses Disease in Preclinical Murine Models of Pemphigoid Diseases

Sripriya Murthy et al.

Summary: Patients with epidermolysis bullosa acquisita and mucous membrane pemphigoid are often treated with dapsone, which has shown to reduce inflammation and inhibit the release of LTB4 and ROS from neutrophils. Therefore, dapsone may work by inhibiting these processes in these diseases.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Article Immunology

Comparison of Two Diagnostic Assays for Anti-Laminin 332 Mucous Membrane Pemphigoid

Stephanie Goletz et al.

Summary: This study compared two diagnostic tests for anti-laminin 332 MMP and found that both assays are easy to perform, highly sensitive, and specific, which will further facilitate the diagnosis of the disease.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Subunit-Specific Reactivity of Autoantibodies Against Laminin-332 Reveals Direct Inflammatory Mechanisms on Keratinocytes

Lei Bao et al.

Summary: Laminin-332 pemphigoid is a rare and severe autoimmune blistering disease characterized by inflammatory infiltrate and non-complement-fixing antibodies, leading to upregulation of numerous cytokines and chemokines in keratinocytes. IgG autoantibodies targeting laminin-332 directly result in a pro-inflammatory response in keratinocytes, shedding light on the pathogenesis of this disease.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

The Second Study of Clinical and Immunological Findings in Anti-laminin 332-Type Mucous Membrane Pemphigoid Examined at Kurume University-Diagnosis Criteria Suggested by Summary of 133 Cases

Hua Qian et al.

Summary: This study provides a more detailed characterization of the clinical and immunological features of 133 cases of anti-LM332-type MMP. The new diagnostic criteria without positive direct immunofluorescence reactivity were found to be useful for diagnosis. The presence of additional autoantibodies to non-LM332 autoantigens in one-third of the patients may contribute to the complexity of anti-LM332-type MMP.

FRONTIERS IN IMMUNOLOGY (2021)

Review Medicine, General & Internal

Bullous Autoimmune Dermatoses Clinical Features, Diagnostic Evaluation, and Treatment Options

Nina van Beek et al.

Summary: Bullous autoimmune dermatoses in Germany have a prevalence of approximately 40,000 cases nationwide and an annual incidence of around 20 cases per million people. Recent research has improved diagnosis and therapy, such as identifying target antigens in patients using serological test systems. Current research is focused on new treatment approaches and gaining a better understanding of the underlying pathophysiology.

DEUTSCHES ARZTEBLATT INTERNATIONAL (2021)

Article Dermatology

European guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology - Part I

H. Rashid et al.

Summary: This guideline provides a comprehensive overview of mucous membrane pemphigoid (MMP) including its definition, epidemiology, subtypes, immunopathological characteristics, disease assessment, and outcome scores. Patients with MMP may have involvement of multiple sites and various assessment tools are available to monitor disease activity and treatment effectiveness.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

Article Dermatology

European Guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology - Part II

E. Schmidt et al.

Summary: This article presents guidelines for the diagnosis and management of mucous membrane pemphigoid (MMP). Recommendations include immunological testing and serum analysis for diagnosis of MMP, as well as tailored treatment options based on disease severity.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

Review Pharmacology & Pharmacy

Is the Conjunctiva a Potential Target for Advanced Therapy Medicinal Products?

Yolanda Diebold et al.

Summary: The conjunctiva, as a complex ocular tissue, plays a crucial role in protecting the ocular surface, but faces challenges in treatment. Cell therapy and tissue engineering techniques show promise in providing better treatment options for conjunctival diseases.

PHARMACEUTICS (2021)

Article Dermatology

Validation of the BIOCHIP test for the diagnosis of bullous pemphigoid, pemphigus vulgaris and pemphigus foliaceus

A. Yang et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Article Dermatology

Multicenter prospective study on multivariant diagnostics of autoimmune bullous dermatoses using the BIOCHIP technology

Nina van Beek et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Review Medicine, Research & Experimental

Ocular cicatricial pemphigoid

Daniel Branisteanu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

Article Dentistry, Oral Surgery & Medicine

The identification of autoantigens in mucous membrane pemphigoid using immortalized oral mucosal keratinocytes

Mayumi Kamaguchi et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2019)

Article Dermatology

Epidermolysis bullosa acquisita

S. C. Hofmann et al.

HAUTARZT (2019)

Review Biochemistry & Molecular Biology

Unique Biological Activity and Potential Role of Monomeric Laminin-2 as a Novel Biomarker for Hepatocellular Carcinoma: A Review

Hiroshi Yasuda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Letter Dermatology

Post-orf epidermolysis bullosa acquisita

M. Daneshpazhooh et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

Article Dermatology

Case of epidermolysis bullosa acquisita with concomitant anti-laminin-332 antibodies

Emi Nishida et al.

JOURNAL OF DERMATOLOGY (2018)

Review Dermatology

International Bullous Diseases Group: consensus on diagnostic criteria for epidermolysis bullosa acquisita

C. Prost-Squarcioni et al.

BRITISH JOURNAL OF DERMATOLOGY (2018)

Article Genetics & Heredity

Molecular diagnosis of anti-laminin 332 (epiligrin) mucous membrane pemphigoid

Roxana Chiorean et al.

ORPHANET JOURNAL OF RARE DISEASES (2018)

Article Dermatology

Human orf complicated by epidermolysis bullosa acquisita

E. Zuelgaray et al.

BRITISH JOURNAL OF DERMATOLOGY (2018)

Letter Dermatology

Prevalence and Age Distribution of Pemphigus and Pemphigoid Diseases in Germany

Franziska Huebner et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)

Article Medicine, Research & Experimental

Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring

Sarah D. Ahadome et al.

JCI INSIGHT (2016)

Article Dermatology

Integrin β4 is a major target antigen in pure ocular mucous membrane pemphigoid

Xiaoguang Li et al.

EUROPEAN JOURNAL OF DERMATOLOGY (2016)

Article Dermatology

Remission of anti-epiligrin cicatricial pemphigoid after excision of cervical adenocarcinoma

Dah-Ching Ding et al.

JOURNAL OF CUTANEOUS PATHOLOGY (2014)

Review Dermatology

Inherited epidermolysis bullosa: Updated recommendations on diagnosis and classification

Jo-David Fine et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2014)

Article Dentistry, Oral Surgery & Medicine

Diagnosis of oral mucous membrane pemphigoid by means of combined serologic testing

Taihei Hayakawa et al.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY (2014)

Article Dermatology

Sensitive and specific assays for routine serological diagnosis of epidermolysis bullosa acquisita

Lars Komorowski et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2013)

Article Cell Biology

The laminin family

Monique Aumailley

CELL ADHESION & MIGRATION (2013)

Article Dermatology

Diagnostics of autoimmune bullous diseases in German dermatology departments

Nina van Beek et al.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2012)

Article Biochemistry & Molecular Biology

Cell Surface Proteoglycans Syndecan-1 and-4 Bind Overlapping but Distinct Sites in Laminin α3 LG45 Protein Domain

Sonia Carulli et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Editorial Material Dermatology

Mucous membrane pemphigoid. Guidelines for the diagnosis and treatment

C. Bedane et al.

ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE (2011)

Article Biochemistry & Molecular Biology

Type XVII collagen (BP180) can function as a cell-matrix adhesion molecule via binding to laminin 332

F. Van den Bergh et al.

MATRIX BIOLOGY (2011)

Article Dermatology

Circulating IgA and IgE autoantibodies in antilaminin-332 mucous membrane pemphigoid

K. Natsuga et al.

BRITISH JOURNAL OF DERMATOLOGY (2010)

Article Dermatology

Prospective analysis of the incidence of autoimmune bullous disorders in Lower Franconia, Germany

Franziska Bertram et al.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2009)

Review Biochemistry & Molecular Biology

Defining the role of laminin-332 in carcinoma

Cherise M. Guess et al.

MATRIX BIOLOGY (2009)

Article Dermatology

IgG anti-laminin-332 autoantibodies are present in a subset of patients with mucous membrane, but not buflous, pemphigoid

Zelmira Lazarova et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2008)

Review Oncology

Laminin 332 in squamous-cell carcinoma

M. Peter Marinkovich

NATURE REVIEWS CANCER (2007)

Review Biochemistry & Molecular Biology

A simplified laminin nomenclature

M Aumailley et al.

MATRIX BIOLOGY (2005)

Article Dermatology

Subepidermal blistering disease with autoantibodies to both the p200 autoantigen and the α3 chain of laminin 5

I Shimanovich et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2005)

Article Medicine, General & Internal

Anti-epiligrin cicatricial pemphigoid and relative risk for cancer

CA Egan et al.

LANCET (2001)

Article Immunology

In vitro organ culture model for mucous membrane pemphigoid

JE Colón et al.

CLINICAL IMMUNOLOGY (2001)