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Trained immunity: a cutting edge approach for designing novel vaccines against parasitic diseases?

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Review Immunology

The role of neutrophils in trained immunity

Lydia Kalafati et al.

Summary: The principle of trained immunity represents innate immune memory due to sustained, mainly epigenetic, changes triggered by endogenous or exogenous stimuli in bone marrow (BM) progenitors and their innate immune cell progeny. Neutrophils, as the most abundant innate immune cell population, play a crucial role in trained immunity. However, trained immunity may have detrimental outcomes in chronic inflammation.

IMMUNOLOGICAL REVIEWS (2023)

Review Immunology

How to train your myeloid cells: a way forward for helminth vaccines?

Rory Doolan et al.

Summary: Soil-transmitted helminths affect approximately 1.5 billion people worldwide, but no human vaccine is currently available. The current strategy for elimination relies on preventive chemotherapy. Traditional vaccine approaches focusing on peptide antigens have had limited success, and mucosal and cellular-based vaccines may be a better alternative in fighting against helminth infection.

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Editorial Material Veterinary Sciences

Editorial: Vaccines against parasitic infections in domestic animals

Luiz Daniel de Barros et al.

FRONTIERS IN VETERINARY SCIENCE (2023)

Article Allergy

Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma

Antonie Lechner et al.

Summary: This study reveals the existence of macrophage-trained immunity in allergic asthma, characterized by inflammatory transcriptional reprogramming and excessive mediator responses. Allergen-triggered inflammation drives a TNF-dependent innate memory, which may perpetuate and exacerbate chronic type 2 airway inflammation and thus represents a target for asthma therapy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Immunology

Harnessing Mycobacterium bovis BCG Trained Immunity to Control Human and Bovine Babesiosis

Reginaldo G. Bastos et al.

Summary: This article discusses the potential use of BCG TI as a strategy to control babesiosis infection more efficiently, supported by experimental evidence and the possibility of vaccine development.

VACCINES (2022)

Article Multidisciplinary Sciences

Trained ILC3 responses promote intestinal defense

Nicolas Serafini et al.

Summary: Group 3 innate lymphoid cells (ILC3s) in the intestine remain activated for months after exposure to Citrobacter rodentium, leading to enhanced immune response and defense capability. These trained ILC3s undergo metabolic changes and exhibit enhanced proliferative capacity and IL-22 production.

SCIENCE (2022)

Article Immunology

MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages

Allison M. Owen et al.

Summary: Immunocompromised populations are at high risk of life-threatening infections, and strategies to protect these patients are urgently needed. This study explores the use of trained immunity, which enhances the immune response to subsequent infections, as a promising approach. The researchers demonstrate that the MyD88-dependent signaling pathway plays a critical role in TLR-mediated trained immunity, providing valuable insights into the mechanisms underlying this process.

FRONTIERS IN IMMUNOLOGY (2022)

Review Immunology

Trained immunity in type 2 immune responses

Franziska Hartung et al.

Summary: Trained immunity, the immunological memory of innate immune cells, plays a crucial role in infection and inflammation. Recent studies have shown that memory responses associated with type 2 immunity involve not only adaptive immune cells, but also the innate immune system and epithelial cells.

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Central and local controls of monocytopoiesis influence the outcome of Leishmania infection

Chandan Raybarman et al.

Summary: Leishmaniases are tropical diseases caused by the protozoon Leishmania, primarily controlled by monocytes and macrophages. These cells exhibit functional plasticity and play a crucial role in immune responses. Cytokines regulate the differentiation of monocytes and macrophages, impacting the pathogenesis of leishmanial infection and potential therapeutic interventions.

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Review Biochemistry & Molecular Biology

Immunometabolic control of trained immunity

Niels P. Riksen et al.

Summary: Trained immunity refers to the long-term inflammatory phenotypes adopted by innate immune cells following brief encounters with exogenous or endogenous stimuli. This phenomenon can enhance host defense against infections but may also be maladaptive in chronic inflammatory disorders. Understanding the mechanisms driving trained immunity, including changes in intracellular metabolism and epigenetic reprogramming, is crucial for future therapeutic exploitation.

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Vivek P. Chavda et al.

Summary: DNA vaccines have the potential to provide protection against SARS-CoV-2 by transforming host cells into protein factories that trigger the immune system to produce antibodies. This vaccine platform offers advantages such as strong cellular immune response, high safety margin, and simple production process, making it a robust choice for large-scale production.

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Review Immunology

A review on the interactions between dendritic cells, filarial parasite and parasite-derived molecules in regulating the host immune responses

Nikhilesh Joardar et al.

Summary: Lymphatic filariasis (LF) is the second leading cause of parasitic disabilities affecting millions of people in India and other tropical countries, characterized by immunopathological consequences such as lymphangitis, lymphadenitis, and elephantiasis. Filarial parasites interact with DCs to lower CD4(+) T-cell responses, which play a crucial role in immune-mediated pathologies associated with LF. In the chronic stage, pro-inflammatory immune responses shift towards an anti-inflammatory subtype, promoting parasite survivability within the host.

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Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products

Claire Drurey et al.

Summary: Helminth parasites can manipulate the immune system by modulating intestinal epithelial cells; experiments have shown that excretory/secretory products from parasites can inhibit the effects of IL-4/13, suppress tuft and goblet cell expansion, and induce fetal epithelial growth.

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Review Immunology

Trained Immunity: Reprogramming Innate Immunity in Health and Disease

Siroon Bekkering et al.

Summary: Trained immunity is a newly recognized phenomenon where cells of the innate immune system exhibit memory characteristics and enhanced responses upon secondary challenge. It explains the heterologous effects of vaccines, but can also lead to maladaptive effects in chronic inflammatory conditions.

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Helminth Imprinting of Hematopoietic Stem Cells Sustains Anti-Inflammatory Trained Innate Immunity That Attenuates Autoimmune Disease

Kyle T. Cunningham et al.

Summary: These findings demonstrate that helminth products can modulate HSCs to promote development of anti-inflammatory myeloid cells that attenuate T cell-mediated autoimmune disease.

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Granulocytic myeloid-derived suppressor cells inhibit T follicular helper cells during experimental Schistosoma japonicum infection

Yumei Zhang et al.

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Dongyoon Kim et al.

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Myeloid-Derived Suppressor Cells: A Propitious Road to Clinic

Amit Grover et al.

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Depeng Yang et al.

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The role of IL-32 in Bacillus Calmette-Guerin (BCG)-induced trained immunity in infections caused by different Leishmania spp.

Muriel Vilela Teodoro Silva et al.

Summary: BCG-induced trained immunity enhances the killing ability of monocytes against different Leishmania spp. through increased production of reactive oxygen species. IL-32 plays a crucial role in the development of trained immunity, and BCG vaccination shows protective effects against Leishmania infections.

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Myeloid-Derived Suppressor Cells in Trypanosoma cruzi Infection

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Promising Technologies in the Field of Helminth Vaccines

Dilhan J. Perera et al.

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Natural and trained innate immunity against Mycobacterium tuberculosis

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An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products

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Maiko Sezaki et al.

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Simone J. C. F. M. Moorlag et al.

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Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

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Outcomes of controlled human malaria infection after BCG vaccination

Jona Walk et al.

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