Rare variants in complement system genes associate with endothelial damage after pediatric allogeneic hematopoietic stem cell transplantation

Correction Multidisciplinary Sciences

FinnGen provides genetic insights from a well-phenotyped isolated population (vol 613, pg.no: 508, 2023)

Mitja I. Kurki et al.

NATURE (2023)

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Correction Multidisciplinary Sciences

FinnGen provides genetic insights from a well-phenotyped isolated population (vol 613, pg 508, 2023)

Mitja I. Kurki et al.

NATURE (2023)

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Article Biophysics

Early vascular toxicity after pediatric allogeneic hematopoietic stem cell transplantation

Lilli Leimi et al.

Summary: Vascular complications in hematopoietic stem cell transplantation are common and associated with endothelial damage, leading to poor outcomes. Factors influencing the results of HSCT mainly include donor-related factors and endotheliopathy.

BONE MARROW TRANSPLANTATION (2022)

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Article Respiratory System

Defibrotide Therapy for SARS-CoV-2 ARDS

David Frame et al.

CHEST (2022)

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Article Biochemistry & Molecular Biology

A Role of Complement in the Pathogenic Sequelae of Mouse Neonatal Germinal Matrix Hemorrhage

Mohammed Alshareef et al.

Summary: This study developed a mouse model of GMH and investigated the role of complement in PHH development. The results showed that CR2Crry treatment could slow down the progression of PHH, reduce lesion size, and improve central neuronal density and behavioral outcomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

Narsoplimab, a Mannan-Binding Lectin-Associated Serine Protease-2 Inhibitor, for the Treatment of Adult Hematopoietic Stem-Cell Transplantation-Associated Thrombotic Microangiopathy

Samer K. Khaled et al.

Summary: This study evaluated the safety and efficacy of Narsoplimab in adults with HSCT-TMA, and the results showed significant improvements in laboratory TMA markers, clinical response, and overall survival.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Multidisciplinary Sciences

The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor

Francisco J. Fernandez et al.

Summary: This study reveals the structural basis of the interaction between human opsonin iC3b and the von Willebrand A inserted domain of the alpha chain of CR3, providing insights into complement activation and pathogen clearance by macrophages.

NATURE COMMUNICATIONS (2022)

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Review Medicine, Research & Experimental

The Role of Complement in HSCT-TMA: Basic Science to Clinical Practice

Seppo Meri et al.

Summary: Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a common complication following transplantation, and the complement system plays a crucial role in its pathogenesis. Various risk factors and diagnostic methods have been identified, but the condition is often overshadowed by other symptoms. Targeted complement therapies offer promise in improving patient outcomes.

ADVANCES IN THERAPY (2022)

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Article Multidisciplinary Sciences

Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia

Suvi P. M. Douglas et al.

Summary: Despite progress in ALL therapies, a significant subset of patients have poor prognosis. Research revealed that germline variants associated with predisposition to ALL are prevalent in patients, especially in adults. Acknowledging genetic factors is crucial for patient care and post-therapy follow-up.

SCIENTIFIC REPORTS (2022)

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Article Immunology

Comprehensive Update and Revision of Nomenclature on Complement C6 and C7 Variants

Mariam Massri et al.

Summary: Complement genes encompass a wide array of variants, leading to numerous protein isoforms. This report discusses the inconsistencies in the nomenclature of complement C6 and C7 variants and aims to establish a classification system that unifies existing and future variants. Factors such as inconsistent annotation methods and modifications in primers contribute to the discrepancies in nomenclature. The report highlights incorrectly classified variants and demonstrates the importance of a unified classification system.

JOURNAL OF IMMUNOLOGY (2022)

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Article Hematology

A pragmatic multi-institutional approach to understanding transplant-associated thrombotic microangiopathy after stem cell transplant

Christopher E. Dandoy et al.

Summary: Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe complication of hematopoietic stem cell transplantation (HSCT) with a higher incidence and worse outcomes, including increased infections, longer hospital stay, and higher ICU utilization in affected patients. Systematic screening for TA-TMA is needed to improve patient outcomes.

BLOOD ADVANCES (2021)

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Article Obstetrics & Gynecology

Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre-eclampsia: a genetic and functional study

A. Lokki et al.

Summary: This study investigated genetic variants in complement receptors CR3 and CR4 in relation to pre-eclampsia and found that changes in complement-facilitated phagocytosis are associated with the disease. Further research is needed to determine if aberrant activity of CR3 and CR4 leads to altered immune responses in individuals carrying these variants, and their role in pre-eclampsia pathogenesis.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2021)

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Review Biophysics

Transplant-associated thrombotic microangiopathy: theoretical considerations and a practical approach to an unrefined diagnosis

Joanna A. Young et al.

Summary: TA-TMA is a recognized complication of HSCT with high morbidity and mortality. Complement inhibition has been explored as a therapeutic option, with Eculizumab and narsoplimab showing effectiveness. Early recognition and treatment may lead to improved outcomes.

BONE MARROW TRANSPLANTATION (2021)

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Review Oncology

Pulmonary Complications in Children Following Hematopoietic Cell Transplantation: A Case Report and Review of the Diagnostic Approach

Lama Elbahlawan et al.

Summary: Pulmonary complications are common in children following hematopoietic cell transplantation, early diagnosis is crucial for management and prevention of progression, bronchoscopy and lung biopsy can assist in diagnosis and treatment.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Pulmonary Complications After Pediatric Stem Cell Transplant

Taylor Fitch et al.

Summary: The number of disorders benefiting from hematopoietic stem cell transplantation (HSCT) has increased, leading to a rise in HSCT procedures. Pulmonary complications, both infectious and non-infectious, are a significant concern after HSCT, with different diagnostic and treatment approaches required for each type of complication.

FRONTIERS IN ONCOLOGY (2021)

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Review Biophysics

Endothelial cell dysfunction: a key determinant for the outcome of allogeneic stem cell transplantation

Thomas Luft et al.

Summary: Allogeneic hematopoietic stem cell transplantation (alloSCT) provides hope for curing malignant and non-malignant diseases of the lympho-hematopoietic system, but non-relapse mortality remains a significant challenge. Endothelial dysfunction plays a role in many life-threatening complications post-alloSCT, emphasizing the importance of biomarkers for predicting these complications.

BONE MARROW TRANSPLANTATION (2021)

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Review Neurosciences

The role of complement in brain injury following intracerebral hemorrhage: A review

Katherine Holste et al.

Summary: Intracerebral hemorrhage (ICH) leads to activation of the complement cascade, resulting in brain edema/injury, but inhibition of specific components of the complement cascade can reduce edema and improve functional outcomes. Additionally, complement plays a significant role in neurologic recovery after ICH.

EXPERIMENTAL NEUROLOGY (2021)

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Article Urology & Nephrology

Complement activation and blockade in massive post-partum haemorrhage, thrombotic microangiopathy and acute kidney injury: a case report

G. Guzzo et al.

Summary: Thrombotic microangiopathy-induced acute kidney injury following massive post-partum hemorrhage is a rare but severe complication. Prompt anti-C5 therapy can rapidly restore kidney function. Complement activation may be a major pathophysiological factor in this complication.

BMC NEPHROLOGY (2021)

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Article Immunology

Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins

Youssif M. Ali et al.

Summary: Early and persistent complement activation is crucial in the pathogenesis of COVID-19, leading to a series of pathological events that trigger severe inflammatory responses to SARS-CoV-2. Research targeting MASP-2 suggests that the LP pathway of the complement system could offer a therapeutic window for treating severe COVID-19.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Health Care Sciences & Services

Thrombotic Microangiopathy: Multi-Institutional Review of Pediatric Patients Who Underwent HSCT

Archana Ramgopal et al.

Summary: Thrombotic microangiopathy (TMA) is a rare but serious complication of hematopoietic stem cell transplantation (HSCT) in children. This study aimed to estimate the incidence and analyze the risk factors of TMA in HSCT recipients, finding that HHV6 is not only a risk factor for TMA, but also associated with increased mortality in these patients.

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Proteins of the Lectin Pathway of complement activation at the site of injury in subarachnoid hemorrhage compared with peripheral blood

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Is COVID-19 associated thrombosis caused by overactivation of the complement cascade? A literature review

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Shiga toxin triggers endothelial and podocyte injury: the role of complement activation

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Whole-exome sequencing detects mutations in pediatric patients with atypical hemolytic uremic syndrome in Taiwan

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Allogeneic reactivity-mediated endothelial cell complications after HSCT: a plea for consensual definitions

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The genetic fingerprint of susceptibility for transplant-associated thrombotic microangiopathy

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Improvement of overall survival after allogeneic hematopoietic stem cell transplantation for children and adolescents: a three-decade experience of a single institution

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A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury

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Serum Neutrophil Extracellular Trap Levels Predict Thrombotic Microangiopathy after Allogeneic Stem Cell Transplantation

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Rare variants in complement system genes associate with endothelial damage after pediatric allogeneic hematopoietic stem cell transplantation

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