期刊
FRONTIERS IN IMMUNOLOGY
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2023.1232820
关键词
autoimmune diseases; autoimmunity; B cell; B cell metabolism; B cell differentiation and function
类别
Autoimmune diseases result from the immune system's failure to distinguish self-antigens from foreign ones. B lymphocytes play a crucial role in autoimmune disorders by producing autoantibodies and pro-inflammatory cytokines. Metabolic dysregulation in B cell function disrupts immune regulation and leads to autoimmune diseases. This review summarizes the latest research on metabolic reprogramming of B lymphocytes in autoimmune diseases, identifies key pathways and regulatory factors, and considers metabolic interventions as potential therapeutic strategies.
Autoimmune diseases are heterogeneous disorders believed to stem from the immune system's inability to distinguish between auto- and foreign- antigens. B lymphocytes serve a crucial role in humoral immunity as they generate antibodies and present antigens. Dysregulation of B cell function induce the onset of autoimmune disorders by generating autoantibodies and pro-inflammatory cytokines, resulting in an imbalance in immune regulation. New research in immunometabolism shows that cellular metabolism plays an essential role in controlling B lymphocytes immune reactions by providing the energy and substrates for B lymphocytes activation, differentiation, and function. However, dysregulated immunometabolism lead to autoimmune diseases by disrupting self-tolerance mechanisms. This review summarizes the latest research on metabolic reprogramming of B lymphocytes in autoimmune diseases, identifying crucial pathways and regulatory factors. Moreover, we consider the potential of metabolic interventions as a promising therapeutic strategy. Understanding the metabolic mechanisms of B cells brings us closer to developing novel therapies for autoimmune disorders.
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