Single-cell analysis of graft-infiltrating host cells identifies caspase-1 as a potential therapeutic target for heart transplant rejection

Article Cardiac & Cardiovascular Systems

The dynamic cellular landscape of grafts with acute rejection after heart transplantation

Deqiang Kong et al.

Summary: This study identified a novel subcluster of cardiac fibroblasts that may mediate acute cardiac rejection. Targeting CXCR3 could prolong allograft survival.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2023)

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Article Immunology

Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation

Francisco Fueyo-Gonzalez et al.

Summary: This study identifies a mechanistic connection between IFN beta and Treg cells, showing that IFN beta enhances graft survival by promoting Treg cell induction.

IMMUNITY (2022)

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Article Immunology

Single-Cell RNA Sequencing Identifies Intra-Graft Population Heterogeneity in Acute Heart Allograft Rejection in Mouse

Yunhua Tang et al.

Summary: In this study, single-cell RNA sequencing technology was used to analyze graft-infiltrating cells in a mouse heart transplant model. The results identified different cell types and states associated with acute rejection, including specific macrophage and endothelial cell populations. The upregulation of Ubiquitin D in rejection was also validated as a potential biomarker for rejection in the clinic.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Donor Macrophages Modulate Rejection After Heart Transplantation

Benjamin J. Kopecky et al.

Summary: This study investigates the role of donor immune cells in heart transplantation and identifies donor CCR2(+) macrophages as key mediators of allograft rejection. Deletion of MYD88 signaling in donor macrophages suppresses rejection and extends allograft survival. These findings highlight the potential for interventions targeting donor immune cells in heart transplantation.

CIRCULATION (2022)

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Article Medicine, Research & Experimental

Single-Cell RNA sequencing reveals immune cell dynamics and local intercellular communication in acute murine cardiac allograft rejection

Zhang Chen et al.

Summary: This study investigated the immune cell dynamics and local intercellular communication of acute cardiac allograft rejection using single-cell RNA sequencing. The results revealed the functional characteristics and differentiation trajectory of various alloreactive cell subpopulations, and suggested that the CXCR3 pathway may serve as a potential therapeutic target for transplant rejection.

THERANOSTICS (2022)

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Article Cardiac & Cardiovascular Systems

Single-cell transcriptomic identified HIF1A as a target for attenuating acute rejection after heart transplantation

Yuan Chang et al.

Summary: Acute rejection (AR) is a significant contributor to graft failure post-heart transplantation, and the regulation of immune metabolism, particularly the increased glucose metabolism of cardiac macrophages in AR patients, has become a new focus for immunosuppressive drug development. Through single-cell RNA sequencing, it was found that during AR, cardiac resident macrophages were replaced by monocytes and proinflammatory macrophages, which exhibited higher antigen presentation and inflammatory recruitment capabilities, as well as glycolysis. The increase in glycolysis in monocytes/macrophages was primarily regulated by HIF1A, and inhibition of HIF1A could reduce inflammatory cells infiltration in AR.

BASIC RESEARCH IN CARDIOLOGY (2021)

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Review Biochemistry & Molecular Biology

The NLRP3 Inflammasome: Relevance in Solid Organ Transplantation

Ryan M. Burke et al.

Summary: The NLRP3 protein plays a central role in the inflammasome, regulating the inflammatory response and releasing pro-inflammatory cytokines. Aberrant activation of NLRP3 is associated with autoimmune pathology and alloimmune injury in solid organ transplant.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

Inference and analysis of cell-cell communication using CellChat

Suoqin Jin et al.

Summary: By constructing an interaction database and developing the tool CellChat, the authors quantitatively inferred and analyzed cell-cell communication networks, revealing important signaling inputs and outputs between cells, and achieved classification of conserved and context-specific pathways.

NATURE COMMUNICATIONS (2021)

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Review Immunology

Untangling Local Pro-Inflammatory, Reparative, and Regulatory Damage-Associated Molecular-Patterns (DAMPs) Pathways to Improve Transplant Outcomes

Gaelen K. Dwyer et al.

Summary: Inflammatory responses following solid organ transplantation are vital for the immune system to react to foreign antigens, but excessive or insufficient DAMPs can lead to negative outcomes. While DAMPs play a role in initiating anti-inflammatory and reparative functions, both their abundance or deficiency can impact tissue repair or the establishment of homeostasis.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Innate allorecognition in transplantation

Khodor I. Abou-Daya et al.

Summary: Successful allogeneic transplantation relies on suppressing activation of the adaptive immune system. While current immunosuppressive therapy targets T and B cells to prevent rejection, recent research has highlighted the crucial role of the innate immune system in initiating the allo-immune response. Understanding innate allorecognition better could lead to improved treatment strategies and prolong allograft survival.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2021)

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Article Biochemistry & Molecular Biology

UCell: Robust and scalable single-cell gene signature scoring

Massimo Andreatta et al.

Summary: UCell is an R package designed for evaluating gene signatures in single-cell datasets. It offers robust signature scores based on the Mann-Whitney U statistic, requiring less computing time and memory compared to other methods. UCell can handle large datasets in minutes and can interact directly with Seurat objects.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis

Xiumeng Hua et al.

CIRCULATION (2020)

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Article Multidisciplinary Sciences

PIRs mediate innate myeloid cell memory to nonself MHC molecules

Hehua Dai et al.

SCIENCE (2020)

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Article Cardiac & Cardiovascular Systems

Evaluation for Heart Transplantation and LVAD Implantation JACC Council Perspectives

Maya Guglin et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Review Immunology

Innate Functions of Dendritic Cell Subsets in Cardiac Allograft Tolerance

Samantha Schroth et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

Innate Allorecognition and Memory in Transplantation

Daqiang Zhao et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

The innate immune response to allotransplants: mechanisms and therapeutic potentials

Jordi Ochando et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2019)

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Article Hematology

Chemokines as Therapeutic Targets in Cardiovascular Disease The Road Behind, The Road Ahead

Heidi Noels et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

Christopher S. McGinnis et al.

CELL SYSTEMS (2019)

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Article Clinical Neurology

Role of TLR4 (Toll-Like Receptor 4) in N1/N2 Neutrophil Programming After Stroke

Alicia Garcia-Culebras et al.

STROKE (2019)

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Article Cardiac & Cardiovascular Systems

Single-Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload-Driven Heart Failure Reveals Extent of Immune Activation

Elisa Martini et al.

CIRCULATION (2019)

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Article Immunology

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

Dvir Aran et al.

NATURE IMMUNOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Late graft failure in heart transplant recipients: incidence, risk factors and clinical outcomes

Angela Lopez-Sainzi et al.

EUROPEAN JOURNAL OF HEART FAILURE (2018)

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Review Cardiac & Cardiovascular Systems

The NLRP3 inflammasome in acute myocardial infarction

Stefano Toldo et al.

NATURE REVIEWS CARDIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function

Jonathon P. Audia et al.

BASIC RESEARCH IN CARDIOLOGY (2018)

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Review Biochemistry & Molecular Biology

The tolerogenic role of IFN-γ

Primoz Rozman et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2018)

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Article Multidisciplinary Sciences

Isolation and Identification of Extravascular Immune Cells of the Heart

Laura Aronoff et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2018)

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Article Immunology

High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice

Adeline Crinier et al.

IMMUNITY (2018)

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Article Cell Biology

Revealing the Critical Regulators of Cell Identity in the Mouse Cell Atlas

Shengbao Suo et al.

CELL REPORTS (2018)

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Article Surgery

Macrophage subpopulations and their impact on chronic allograft rejection versus graft acceptance in a mouse heart transplant model

Yue Zhao et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2018)

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Review Surgery

The Role of Neutrophils in Transplanted Organs

D. Scozzi et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2017)

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Article Biochemistry & Molecular Biology

Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a

Maximilian Riess et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

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Review Medicine, Research & Experimental

Alloimmune T cells in transplantation

Susan DeWolf et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Review Medicine, Research & Experimental

Inflammasomes and IL-1 biology in the pathogenesis of allograft dysfunction

S. Samuel Weigt et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Article Medicine, Research & Experimental

TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies

Matthew D. McGeough et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Article Cardiac & Cardiovascular Systems

Advances in the immunology of heart transplantation

Joren C. Madsen

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2017)

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Article Biochemical Research Methods

SCENIC: single-cell regulatory network inference and clustering

Sara Aibar et al.

NATURE METHODS (2017)

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Article Cell Biology

Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection

Joaquin Amores-Iniesta et al.

CELL REPORTS (2017)

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Review Immunology

The Role of Interferons in Inflammation and Inflammasome Activation

Natasa Kopitar-Jerala

FRONTIERS IN IMMUNOLOGY (2017)

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Review Immunology

Targeting the Monocyte-Macrophage Lineage in Solid Organ Transplantation

Thierry P. P. van den Bosch et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Medicine, Research & Experimental

ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell-dependent autoimmune encephalomyelitis

Ryder F. Whittaker Hawkins et al.

JCI INSIGHT (2017)

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Review Immunology

Monocyte differentiation and antigen-presenting functions

Claudia V. Jakubzick et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Article Immunology

The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation

David Langlais et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

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Article Immunology

Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells

Kevin V. Chow et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

Graft-infiltrating host dendritic cells play a key role in organ transplant rejection

Quan Zhuang et al.

NATURE COMMUNICATIONS (2016)

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Review Immunology

Inflammasomes: mechanism of assembly, regulation and signalling

Petr Broz et al.

NATURE REVIEWS IMMUNOLOGY (2016)

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Review Immunology

Early T Cell Activation: integrating Biochemical, Structural, and Biophysical Cues

Bernard Malissen et al.

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)

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Review Immunology

Regulation of inflammasome activation

Si Ming Man et al.

IMMUNOLOGICAL REVIEWS (2015)

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Article Biotechnology & Applied Microbiology

Spatial reconstruction of single-cell gene expression data

Rahul Satija et al.

NATURE BIOTECHNOLOGY (2015)

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Review Immunology

Control of adaptive immunity by the innate immune system

Akiko Iwasaki et al.

NATURE IMMUNOLOGY (2015)

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Article Cell Biology

Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria

Bruno Coelho Rocha et al.

CELL REPORTS (2015)

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Review Transplantation

Innate immune cells in transplantation

Jessica H. Spahn et al.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2014)

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Review Immunology

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

Peter J. Murray et al.

IMMUNITY (2014)

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Article Medicine, Research & Experimental

Non-self recognition by monocytes initiates allograft rejection

Martin H. Oberbarnscheidt et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

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Article Biotechnology & Applied Microbiology

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

Cole Trapnell et al.

NATURE BIOTECHNOLOGY (2014)

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Article Multidisciplinary Sciences

Murine Heterotopic Heart Transplant Technique

Robert J. Plenter et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2014)

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Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

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Article Immunology

Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

Martin Guilliams et al.

NATURE REVIEWS IMMUNOLOGY (2014)

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Article Immunology

Type I IFN Drives a Distinctive Dendritic Cell Maturation Phenotype That Allows Continued Class II MHC Synthesis and Antigen Processing

Daimon P. Simmons et al.

JOURNAL OF IMMUNOLOGY (2012)

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Article Multidisciplinary Sciences

A Family of IFN-γ-Inducible 65-kD GTPases Protects Against Bacterial Infection

Bae-Hoon Kim et al.

SCIENCE (2011)

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Article Cardiac & Cardiovascular Systems

Upregulation of the apoptosis-related inflammasome in cardiac allograft rejection

Tatsuichiro Seto et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2010)

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Article Immunology

NK Cell Patrolling and Elimination of Donor-Derived Dendritic Cells Favor Indirect Alloreactivity

Kym R. Garrod et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Oncology

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: N1 versus N2 TAN

Zvi G. Fridlender et al.

CANCER CELL (2009)

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Article Cardiac & Cardiovascular Systems

Molecular Imaging of Innate Immune Cell Function in Transplant Rejection

Thomas Christen et al.

CIRCULATION (2009)

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Review Immunology

The innate immune system in allograft rejection and tolerance

David F. LaRosa et al.

JOURNAL OF IMMUNOLOGY (2007)

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Article Immunology

Gpnmb is induced in macrophages by IFN-γ and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses

Vera M. Ripoll et al.

JOURNAL OF IMMUNOLOGY (2007)

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Article Cardiac & Cardiovascular Systems

Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation

Daniele Torella et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

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Review Immunology

Immune cell migration in inflammation: present and future therapeutic targets

AD Luster et al.

NATURE IMMUNOLOGY (2005)

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Review Immunology

Mechanisms of type-I- and type-II-interferon-mediated signalling

LC Platanias

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Article Multidisciplinary Sciences

IRF-7 is the master regulator of type-I interferon-dependent immune responses

K Honda et al.

NATURE (2005)

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Article Hematology

Interferon-gamma switches monocyte differentiation from dendritic cells to macrophages

Y Delneste et al.

BLOOD (2003)

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Single-cell analysis of graft-infiltrating host cells identifies caspase-1 as a potential therapeutic target for heart transplant rejection

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