相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Article
Oncology
Xiaosong Liu et al.
Summary: This study investigated the tumor microenvironment of cervical cancer patients at different stages using single-nucleus transcriptomic and proteomic analysis. The results revealed the suppression of immune response pathways and the enrichment of cell and tissue development pathways in advanced stage cervical cancer patients. Additionally, certain collagens were found to be significantly upregulated and may serve as diagnostic markers for cervical cancer progression. A novel transcript, AC244205.1, was also identified as upregulated in advanced stage cervical cancer patients, suggesting its potential mechanistic role in cervical cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Nora Jee-Young Park et al.
Summary: Cervical cancer is a significant global health issue, especially in developing countries. This study identified potential biomarkers for early detection of cervical lesions using transcriptomic analysis. These findings have important clinical implications for improving cervical cancer screening.
CANCER GENOMICS & PROTEOMICS
(2023)
Article
Cell Biology
Jiawen Kang et al.
Summary: Cervical cancer, with the highest morbidity and mortality among female reproductive tract tumors, lacks satisfactory treatments for patients with persistent, recurrent or metastatic disease. This study aimed to develop a prognostic model based on angiogenesis-related genes for cervical cancer and provide guidance for comprehensive treatment. The model successfully assessed prognosis, identified high-risk patients, and provided insights into immune-related treatment options.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Oncology
Misako Kusakabe et al.
Summary: Approximately 95% of cervical cancer are caused by human papillomavirus (HPV) infection. Understanding the cellular origin of most cervical cancers, the manner of progression to cervical cancer depending on the type of high risk HPV (HR-HPV), and the involvement of the human immune response are important for the management and treatment of HPV-associated cervical cancer.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Genetics & Heredity
Dongzhi Hu et al.
Summary: This study used tumor microenvironment gene signatures to define the characteristics of immune subtypes in Cervical squamous cell carcinoma (CESC) and constructed a new prognostic model. Three molecular subtypes were identified, with C3 showing better survival outcomes and C1 having worse prognosis time. Additionally, a five-gene signature was developed to predict overall survival for CESC patients.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Tao Zhang et al.
Summary: This study identified cervical cancer stem cells and revealed the functional changes in cervical stem cells during malignant transformation. The original non-malignant stem cell properties gradually diminished, while the tumor stem cell properties were enhanced. Additionally, stem-like cells in the cervical microenvironment were associated with neoplastic recurrence, and interferon responses were upregulated during lesion progression.
Letter
Oncology
Chunbo Li et al.
CANCER COMMUNICATIONS
(2023)
Article
Oncology
Chenyan Guo et al.
Summary: This study revealed the temporal and spatial distribution of cellular subsets during the development of cervical cancer, providing insights into the mechanism and potential therapeutic targets. The identification of critical node genes and immune remodeling further contributes to accurate diagnosis, precise treatment, and prognosis evaluation of patients with precancer and cervical cancer.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Mengyan Tu et al.
Summary: Currently, surgery, chemotherapy, and radiotherapy are the main treatments for gynecological malignancies, but they have limitations when dealing with complex female diseases. Immunotherapy, as an alternative, can significantly improve the prognosis of patients and has better antitumor activities. However, the development of immunotherapy is not fast enough to meet current clinical needs, and more research is needed.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Oncology
Karl Kashofer et al.
Summary: This study evaluated the prevalence of somatic gene mutations in different stages of cervical carcinogenesis, finding that activating oncogenic gene mutations, particularly in the PIK3CA gene, occur early in the development of cervical cancer. The mutational status is not prognostically relevant in micro-invasive cervical squamous cell carcinoma.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Irene Tveiteras ovestad et al.
Summary: RNA sequencing was used to compare the transcriptomic immune-profile of cervical lesions and normal tissue, leading to the identification of genes associated with proliferation and immune response. NCAM1 and CDKN2A are promising markers for identifying women at high risk of developing cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Xiaojun Zhu et al.
Summary: Based on the expression profiles of 50 genes, HPV+ cervical cancers can be classified into two subtypes with significant differences in molecular, phenotypic, and clinical features. This classification method captures the comprehensive heterogeneity of HPV+ cervical cancers and has potential clinical implications for diagnosis and treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Tynisha S. Rafael et al.
Summary: HPV infection and HPV-related tumorigenesis have immune evasion mechanisms. Immunotherapy can be a beneficial addition to current treatment strategies, improving patient survival rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Hao Wen et al.
Summary: This study revealed the unique genomic profile of Chinese patients with cervical cancer and identified prevalent actionable variants related to the PI3K and DDR pathways. DDR alteration exerted significant influence on the tumor microenvironment in cervical cancer, guiding clinical decisions for treatment. CDHR5 was the first identified hub gene negatively correlated with DDR or hypoxia in cervical cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Michael Vincent Sherer et al.
Summary: Immunotherapy represents a novel treatment option for patients with cervical cancer, with immune checkpoint inhibitors being the most studied treatment. Encouraging phase II studies have defined a new standard of care, while vaccines and engineered T cells may offer additional benefits and synergies with radiation therapy. Combination therapies with immunomodulatory agents show promise for improving treatment outcomes in cervical cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Genetics & Heredity
Xinghao Wang et al.
Summary: This study explores the effect of DNA damage repair-related genes on immune function in cervical cancer patients, and establishes a prognosis model based on these genes. The immune score and key genes related to immune cell infiltration are analyzed. The study finds that DNA damage repair-related genes can effectively predict the prognosis in cervical cancer.
FRONTIERS IN GENETICS
(2022)
Article
Biology
Yongli Yang et al.
Summary: This study utilized immune-related genes to identify immune subtypes in cervical cancer and analyzed the immune infiltration landscape. The results showed that the immune-related gene score was associated with prognosis and immune infiltration in cervical cancer, providing important guidance for tailoring immunotherapy strategies.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biology
Chunbo Li et al.
Summary: Single-cell RNA sequencing of cervical cancer has identified four different subtypes of the disease and provided insights into populations of cancer-associated fibroblasts and CD8+ T cell diversity. These findings have implications for precision prognostic and therapeutic stratification of cervical cancer.
COMMUNICATIONS BIOLOGY
(2022)
Article
Immunology
Jianwei Zhang et al.
Summary: This study provides a comprehensive overview of the infiltration patterns of microenvironment cells throughout cervical cancer progression, revealing changes in abundance and activation status of immune cells, which contributes to a better understanding of the mechanisms involved in cervical cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Lingzhang Meng et al.
Summary: This study identifies HPV infection as a factor for the prognosis of cervical squamous cell carcinoma (CSCC) patients and validates a set of unfavorable molecules in HPV-negative CSCC cells. It provides a basis for the development of a rational post-operative follow-up program and an appropriate treatment plan for patients with cervical cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Chunbo Li et al.
Summary: This study used single-cell RNA sequencing to describe the composition and functional status of immune cells and mesenchymal cells during cervical cancer progression. The results showed distinct cell subpopulations at different stages of cervical cancer, with high-grade intraepithelial neoplasia exhibiting a low, recently activated tumor microenvironment, tumor tissue displaying an immunosuppressive state, and metastatic lymph node showing an early activated phase of immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Lili Liu et al.
Summary: We have developed a six-gene survival prediction model associated with hypoxia and angiogenesis, which accurately predicts the survival of cervical cancer patients and provides potential therapeutic targets.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Xia Li et al.
Summary: This study provides insights into the immune cell infiltration patterns of cervical cancer (CC). Hot tumors with higher immune infiltration and longer survival time were identified. Keratin, type I cytoskeletal 23 (KRT23) may serve as a potential immunotherapeutic target. A model based on differentially expressed genes (DEGs) showed good predictive power for the prognosis of CC patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Liguang Fang et al.
Summary: This article summarizes the dynamic evolution of inflammation from acute to chronic in tumor development and its impact on T cells. Understanding the state of inflammation and T cells at different stages is crucial for clinical decision-making and improving the efficacy of tumor immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Guanghui Song et al.
Summary: This study identified two immune subtypes of HPV+ cervical cancers, which showed significant differences in immunity, tumor characteristics, gene mutations, and clinical outcomes. These findings provide new insights into the tumor biology and clinical implications of cervical cancer.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Oncology
Tamara R. Litwin et al.
Summary: The study found fewer CD3+, CD4+, and CD8+ cells in cervical lesions and more cells in cancers compared to normal epithelium, and high infiltration of regulatory T-cells in persistent and precancerous lesions, with improved prognosis when regulatory T-cell levels are lower.
BRITISH JOURNAL OF CANCER
(2021)
Review
Oncology
Jiajie Hou et al.
Summary: The immune system plays crucial roles in cancer development and treatment, with adaptive immunity capable of preventing or constraining cancer and innate immunity and inflammation often promoting tumorigenesis. While immunotherapies derived from preclinical studies have shown efficacy in treating cancer, treatments targeting cancer-associated inflammation still require successful implementation. Anti-inflammatory agents have the potential to delay cancer onset and enhance the efficacy of conventional and next-generation cancer therapies.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Oncology
Yiying Wang et al.
Summary: Deciphering the immune response and expression changes during cervical tumorigenesis revealed the initiation of lesion-intrinsic immunosuppression at precancerous stages and the increase in various immune cell types from normalcy to cancer development. Immune escape initiated from high-grade squamous intraepithelial lesions and culminated in squamous cell carcinoma, with escalated expression of immune checkpoints, largely encompassed by HSIL and SCC under the stress of both activated and suppressive immune responses.
Article
Oncology
Mari K. Halle et al.
Summary: By analyzing transcriptomic data, a gene signature predicting CIN3 regression was identified, aiding in selecting patients who may safely refrain from conization. A high regression signature score was associated with immune activation, favorable survival, and smaller tumors.
Article
Genetics & Heredity
Alix Warburton et al.
Summary: Oncogenic human papillomavirus (HPV) genomes are frequently integrated into host chromosomes in HPV-associated cancers, promoting high viral oncogene expression. Tumors often contain multiple HPV integration sites, but only one main site expresses viral RNA. Integration breakpoints are enriched at fragile sites and enhancer-rich regions.
NPJ GENOMIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Xintong Lyu et al.
Summary: This study analyzed the immune landscape of cervical cancer and proposed a novel immune classification, which was validated in two validation sets. The research identified active immune and exhausted subtypes of cervical cancer, as well as key modulators like EGFR and JUN in the tumor immune microenvironment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
R. S. Jayshree
Summary: HPV infection is common worldwide, but most cases resolve with the help of the body's immune response. In some patients, immune response can lead to lesion regression, but persistent infection and other factors can progress to cervical cancer. Immune responses play a crucial role in the development of CIN to CxCa, and estradiol has been identified as a factor in cervical carcinogenesis. Therapeutic repurposing of estrogen-related drugs may modulate immune function in cervical precancer/cancer.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cell Biology
Yanan Kang et al.
Summary: The study classified cervical cancers in the TCGA dataset using various algorithms and found that patients with higher expression of immune cells had longer overall survival time. A scoring system was established, where tumors with higher scores exhibited better survival outcomes and were more sensitive to immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Megha Budhwani et al.
Summary: High expression of immune response-related genes is associated with increased survival probability in cervical cancer patients, while high expression of inhibitory immune genes may decrease survival probability.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Oncology
Rosalba De Nola et al.
Summary: Uterine cervical cancer ranks fourth among gynecological tumors worldwide, and is associated with factors such as HPV infection, estrogen receptor activation, and immune cell activity. In terms of treatment, immunotherapy is effective in advanced cases, while anti-angiogenic strategies can improve patient survival.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Yimin Li et al.
Summary: The study established a classification system to identify immune subtypes of cervical squamous cell carcinoma (SCC), which helps screen candidates who may respond to immune checkpoint inhibitors (ICIs). Two subtypes with different immunophenotypes were identified, where one subtype showed increased immune cell abundance, enriched immune activation pathways, and higher somatic mutation burden, while the other exhibited GPCR pathway activity and lower sensitivity to ICIs. Additionally, an 83-gene classifier was constructed for cervical SCC classification.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Genetics & Heredity
Rachel Adihe Lokanga et al.
Summary: The human genome contains fragile chromosomal regions that demonstrate breaks, gaps, or constrictions under replication stress. Common fragile sites are induced by aphidicolin, while rare fragile sites are induced by folate stress. Different fragile sites have distinct molecular bases and can cause chromosomal abnormalities, some of which are associated with intellectual disabilities.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Fangfang Xu et al.
Summary: The study identified eight hub immune-related prognostic genes and constructed an immune gene-related prognostic model (IGRPM) with six factors to predict clinical outcomes of CC patients. The predictive capability of the model was further assessed and validated using the Gene Expression Omnibus validation set, showing promising results for predicting prognoses and responses to immunotherapy for CC patients.
FRONTIERS IN GENETICS
(2021)
Article
Biochemical Research Methods
Steven Xijin Ge et al.
Article
Public, Environmental & Occupational Health
Marc Arbyn et al.
LANCET GLOBAL HEALTH
(2020)
Article
Genetics & Heredity
Zitong Zhao et al.
FRONTIERS IN GENETICS
(2020)
Article
Oncology
Xiaofan Lu et al.
Review
Oncology
Chenhao Zhou et al.
FRONTIERS IN ONCOLOGY
(2019)
Editorial Material
Obstetrics & Gynecology
Neerja Bhatla et al.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2019)
Review
Biotechnology & Applied Microbiology
Jerome Galon et al.
NATURE REVIEWS DRUG DISCOVERY
(2019)
Article
Immunology
Vesteinn Thorsson et al.
Article
Immunology
Jason Roszik et al.
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Dvir Aran et al.
Article
Biotechnology & Applied Microbiology
Michael I. Love et al.
Article
Biochemical Research Methods
Francesco Ferrari et al.
Article
Biochemical Research Methods
Mark D. Robinson et al.
Article
Biochemical Research Methods
Weijun Luo et al.
BMC BIOINFORMATICS
(2009)
Article
Biochemical Research Methods
Peter Langfelder et al.
BMC BIOINFORMATICS
(2008)
Article
Multidisciplinary Sciences
J Grimwood et al.
