RIPK1 and RIPK3 inhibitors: potential weapons against inflammation to treat diabetic complications

Article Respiratory System

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD

Hannelore P. Van Eeckhoutte et al.

Summary: RIPK1 plays a key role in COPD pathogenesis by mediating cell death and inflammation. Inhibition of RIPK1 kinase activity can alleviate airway inflammation and cell death caused by COPD, making it a potential therapeutic approach.

EUROPEAN RESPIRATORY JOURNAL (2023)

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Article

High Glucose-Induced Kidney Injury via Activation of Necroptosis in Diabetic Kidney Disease

Man Guo et al.

Oxidative Medicine and Cellular Longevity (2023)

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Review Immunology

ADAR1 and ZBP1 in innate immunity, cell death, and disease

Rajendra Karki et al.

Summary: ADAR1 and ZBP1 are two mammalian proteins with Z alpha domains that bind to nucleic acids. They play crucial roles in regulating various biological processes. Recent studies have expanded our understanding of their functions, establishing their fundamental regulation of innate immune responses. This review discusses their roles in innate immune responses in development and disease.

TRENDS IN IMMUNOLOGY (2023)

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Article Gastroenterology & Hepatology

Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance

Irma Garcia-Martinez et al.

Summary: This study reveals that small extracellular vesicles (sEV) released by hepatocytes under NAFLD conditions induce liver inflammation and insulin resistance in hepatocytes through paracrine hepatocyte-macrophage-hepatocyte crosstalk. These sEV act as transporters of saturated fatty acids (SFAs) and potent inducers of liver inflammation. Liver inflammation mediated by sEV can be attenuated by inhibiting Toll-like receptor-4 (TLR4). Evidence of macrophage-hepatocyte interactome was also found in patients with NAFLD, highlighting the relevance of sEV in SFAs-mediated lipotoxicity in NAFLD.

JHEP REPORTS (2023)

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Review Immunology

Mitochondrial control of inflammation

Saverio Marchi et al.

Summary: This article discusses the molecular mechanisms by which mitochondrial dysfunction leads to inflammatory reactions, the cellular pathways that regulate them, and the pathological consequences of dysregulated inflammatory responses elicited by mitochondrial damage-associated molecular patterns (DAMPs).

NATURE REVIEWS IMMUNOLOGY (2023)

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Article Biochemistry & Molecular Biology

Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia

Xiaoming Li et al.

Summary: This study reveals the important role of caspase-8 auto-cleavage in regulating necroptosis and maintaining lymphocyte homeostasis.

CELL DEATH AND DIFFERENTIATION (2022)

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Article Immunology

Interferon-g primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

Daniel S. Simpson et al.

Summary: Cell death is crucial in pathogen infections. IFNg sensitizes macrophages to TLR-induced death by triggering macrophage-intrinsic death ligands and caspase-8 enzymatic activity. This process requires BAX and BAK, the mitochondrial apoptotic effectors.

IMMUNITY (2022)

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Article Chemistry, Medicinal

Effects of Gentiopicroside on activation of NLRP3 inflammasome in acute gouty arthritis mice induced by MSU

Menglin He et al.

Summary: The study demonstrated that Gentiopicroside could treat acute gouty arthritis based on its anti-inflammatory and analgesic properties, possibly attributed to the inhibition on NLRP3 inflammasome.

JOURNAL OF NATURAL MEDICINES (2022)

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Review Cell Biology

Construction and imaging of a neurovascular unit model

Taiwei Dong et al.

Summary: The neurovascular unit, which plays a crucial role in the health and disease of blood vessels and nerves in the central nervous system, has attracted significant research interest. This review summarizes the composition of neurovascular units, investigates the efficacy of different stem cells and cell culture methods in constructing neurovascular unit models, and assesses the progress of imaging methods used for observing neurovascular units and their role in studying various central nervous system diseases.

NEURAL REGENERATION RESEARCH (2022)

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Article Cell Biology

RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes mellitus by impairing autophagic flux of cardiac fibroblasts

Shigang Qiao et al.

Summary: Receptor-interacting protein kinase 1 and 3 play important roles in myocardial fibrosis and diabetic cardiomyopathy by activating the RIPK1/RIPK3 pathway and impairing the autophagic process.

CELL DEATH & DISEASE (2022)

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Article Medicine, Research & Experimental

Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing

Sandra Franz et al.

Summary: This study identifies S100A9 as a previously unrecognized vital component in obesity-associated disturbed macrophage differentiation and subsequent impaired regulation of inflammation and wound repair. The findings open new opportunities for therapeutic implications for inflammatory diseases and wound repair in obesity.

THERANOSTICS (2022)

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Review Immunology

Gut Microbiota: An Important Player in Type 2 Diabetes Mellitus

Zheng Zhou et al.

Summary: Type 2 diabetes mellitus, a common metabolic disease, is associated with gut microbiota dysbiosis. Remodeling the gut microbiota may be a potential strategy for treating T2DM and its complications.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Pharmacology & Pharmacy

Proanthocyanidins Protect Against Cadmium-Induced Diabetic Nephropathy Through p38 MAPK and Keap1/Nrf2 Signaling Pathways

Pin Gong et al.

Summary: This study found that proanthocyanidins from grape seed have protective effects against Cd-induced diabetic nephropathy, possibly through regulating oxidative-antioxidative status, metal-binding ability, and oxidative stress-related signaling pathways.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Calcium-activated nucleotides 1 (CANT1)-driven nuclear factor-k-gene binding (NF-kappa B) signaling pathway facilitates the lung cancer progression

Fangfang Gao et al.

Summary: High amplification of CANT1 in lung cancer promotes cell proliferation and viability, and researchers have elucidated the role of the CANT1-NF-kappa B signaling axis in lung cancer.

BIOENGINEERED (2022)

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Review Immunology

A Detailed Overview of Immune Escape, Antibody Escape, Partial Vaccine Escape of SARS-CoV-2 and Their Emerging Variants With Escape Mutations

Chiranjib Chakraborty et al.

Summary: This review provides an overview of the immune escape and vaccine escape ability of emerging variants of SARS-CoV-2, discussing their different immune escape strategies and mutations in various locations. It also illustrates the partial vaccine escape ability of emerging variants.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury

Arthur Lau et al.

Summary: This study reveals the role of DPEP1 as a major leukocyte adhesion receptor in the kidney and a potential therapeutic target for AKI.

SCIENCE ADVANCES (2022)

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Review Multidisciplinary Sciences

Role of necroptosis in traumatic brain and spinal cord injuries

Xinli Hu et al.

Summary: This review summarizes the role of necroptosis in central nervous system trauma and its therapeutic implications, providing important suggestions for researchers conducting in-depth research. The study focuses on the necroptosis signaling pathway, execution, temporal patterns of RIPKs in CNS trauma, association of miRNAs with necroptosis, and different types of CNS trauma cell death. It also highlights potential agents for curtailing necroptosis-related cell death in CNS trauma.

JOURNAL OF ADVANCED RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Posttranscriptional Regulation of Insulin Resistance: Implications for Metabolic Diseases

Ana Perez-Garcia et al.

Summary: Insulin resistance is a condition that impairs the biological response to insulin action in target tissues, leading to the development of various metabolic diseases such as diabetes, obesity, and cardiovascular disease. MicroRNAs and RNA-binding proteins play a crucial role in regulating key genes in the insulin signaling pathway, impacting human metabolic diseases at the molecular level.

BIOMOLECULES (2022)

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Article Chemistry, Multidisciplinary

Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease

Xue-qi Liu et al.

Summary: Wogonin has been shown to alleviate glomerulopathy and podocyte injury in diabetic kidney disease (DKD) by regulating the Bcl-2-mediated crosstalk between autophagy and apoptosis. The study also demonstrated the inhibitory effects of wogonin on cellular damage and apoptosis induced by high glucose, as well as its promotion of autophagy in podocytes.

ACTA PHARMACOLOGICA SINICA (2022)

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Review Biochemistry & Molecular Biology

PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field

Lam Nhat Nguyen et al.

Summary: Viral infections can activate programmed cell death (PCD) pathways, including pyroptosis, apoptosis, and necroptosis. The emerging concept of PANoptosis suggests extensive crosstalk between these PCD pathways. PANoptosis plays a significant role in regulating viral infection, but it can also have different effects on host defense and viral pathogenesis.

JOURNAL OF MOLECULAR BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders

Binapani Mahaling et al.

Summary: Damage-associated molecular patterns (DAMPs) are endogenous danger molecules associated with retinal diseases. They can activate the innate immune system and have roles in both protective and pathological inflammation. However, the role of DAMPs in retinal disorders is not well understood and further research is needed.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biotechnology & Applied Microbiology

Drugging the efferocytosis process: concepts and opportunities

Parul Mehrotra et al.

Summary: This article discusses the mechanisms and role of efferocytosis in diseases, as well as evaluates strategies and agents for therapeutic intervention. Efferocytosis is crucial for maintaining homeostasis by removing apoptotic cells and promoting resolution. Abnormalities in efferocytosis are associated with various inflammatory pathologies, making it an important target for interventions. The recent discoveries in molecular machinery involved in efferocytosis have opened up new avenues for therapeutic development.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Review Neurosciences

Microglia: Key Players in Retinal Ageing and Neurodegeneration

Li Guo et al.

Summary: Microglia, as resident immune cells in the central nervous system, play a crucial role in maintaining the normal function of the retina and brain. They can be activated to protect neurons and tissue integrity, but their functions and phagocytic capacity may decline with aging, leading to neuroinflammation and neurodegenerative diseases.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

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Article Multidisciplinary Sciences

Differential recognition of canonical NF-κB dimers by Importin α3

Tyler J. Florio et al.

Summary: The authors identify a bipartite Nuclear Localization Signal in the NF-kappa B p50/p65 heterodimer that is recognized with high affinity by importin alpha 3. This study reveals the specific structure and mechanism of this signal and highlights the important role of importin alpha 3 in NF-kappa B signaling.

NATURE COMMUNICATIONS (2022)

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Article Pharmacology & Pharmacy

Zhilong Huoxue Tongyu Capsules Ameliorate Early Brain Inflammatory Injury Induced by Intracerebral Hemorrhage via Inhibition of Canonical NFκβ Signalling Pathway

Maryam Mazhar et al.

Summary: This study investigates the protective effects of ZLHXTY capsules against intracerebral hemorrhage (ICH) by targeting the nuclear factor kappa beta (NFk beta) signaling pathway. The results show that ZLHXTY capsules alleviate inflammatory brain injury after ICH induction, as evidenced by neurological scoring and histopathological evaluation. The downregulation of pro-inflammatory factors and the modulation of NFk beta pathway are associated with its neuroprotective effects.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy

Jinjing Wei et al.

Summary: This article provides the most updated data on cell death in diabetic cardiomyopathy (DCM) and emphasizes the critical role of cell death in the pathophysiological process. It offers valuable insights and directions for future studies.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Biotechnology & Applied Microbiology

Calreticulin (CALR)-induced activation of NF-κB signaling pathway boosts lung cancer cell proliferation

Fangfang Gao et al.

Summary: Calreticulin (CALR) is aberrantly expressed in lung cancer, and its overexpression promotes proliferation of lung cancer cells, possibly through activation of the NF-kappa B signaling pathway.

BIOENGINEERED (2022)

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Article Multidisciplinary Sciences

m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB-mediated antiapoptotic pathway

Ting Zhang et al.

Summary: Colonic mucosal barrier dysfunction is a major cause of inflammatory bowel disease (IBD), and m(6)A modification plays a crucial role in maintaining the homeostatic self-renewal of colonic stem cells.

SCIENCE ADVANCES (2022)

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Review Endocrinology & Metabolism

Impact of COVID-19 Lockdown on the Metabolic Control Parameters in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis

Ifan Ali Wafa et al.

Summary: This study found that lockdowns during the COVID-19 pandemic did not worsen glycemic control in patients with diabetes. While patients with T1DM showed improvements in time-in-range and time-above-range, those with T2DM saw a significant worsening in fasting blood glucose. Lipid parameters, particularly triglyceride, deteriorated during lockdown.

DIABETES & METABOLISM JOURNAL (2022)

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Review Biochemistry & Molecular Biology

Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives

Mariyam Khalid et al.

Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.

BIOMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Serum Metabolomics Based on GC-MS Reveals the Antipyretic Mechanism of Ellagic Acid in a Rat Model

Fengfeng Xie et al.

Summary: This study used serum metabolomics to explore the mechanism of action of ellagic acid (EA) on yeast-induced fever in rats and found that EA can exert antipyretic and anti-inflammatory effects by inhibiting the IKB-α/NF-κB signaling pathway and five metabolic pathways.

METABOLITES (2022)

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Article Multidisciplinary Sciences

SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation

Lingjie Yan et al.

Summary: This study identifies SENP1 as a key endogenous inhibitor of RIPK1 in the pathogenesis of nonalcoholic steatohepatitis, providing a potential therapeutic target.

NATURE COMMUNICATIONS (2022)

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Article Medicine, Research & Experimental

GATA1 regulates the microRNA-328-3p/PIM1 axis via circular RNA ITGB1 to promote renal ischemia/reperfusion injury in HK-2 cells

Yang Gao et al.

Summary: This study identified the downregulation of miR-328-3p in IRI and demonstrated its protective effect by targeting PIM1 to enhance cell viability and reduce apoptosis in hypoxia/reperfusion. The study also identified circITGB1 as a target of miR-328-3p and showed that its suppression could inhibit the H/R-induced inflammatory response. Furthermore, the study found that GATA1 binds to the ITGB1 promoter, leading to the expression of circITGB1.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2022)

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Article Multidisciplinary Sciences

Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells

Yung-Hsuan Wu et al.

Summary: Inhibition of Caspase-8 leads to inflammasome assembly and production of IL-10 and IL-18 in Toll-like receptor (TLR)-primed myeloid cells. Autophagy and cathepsin-B play important roles in the activation of inflammasomes when apoptosis and necroptosis are blocked and Caspase-8 is inhibited.

SCIENCE ADVANCES (2022)

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Article Virology

Preparation of the RIPK3 Polyclonal Antibody and Its Application in Immunoassays of Nephropathogenic Infectious Bronchitis Virus-Infected Chickens

Guanming Tian et al.

Summary: This study investigated the role of receptor interacting protein kinase 3 (RIPK3) in nephropathogenic infectious bronchitis virus (NIBV) infection in chickens. The results showed that RIPK3 protein is abundantly expressed in the liver and kidney of chicks, and NIBV infection significantly upregulates the expression levels of RIPK3 in the trachea and kidney. Coimmunoprecipitation experiments demonstrated the activation of necroptosis in response to NIBV infection through the phosphorylation of downstream mixed-spectrum kinase structural domain-like protein (MLKL) by RIPK3.

VIRUSES-BASEL (2022)

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Article Cell Biology

Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling

Yanxiang Meng et al.

Summary: Necroptosis is a caspase-independent mode of programmed cell death that relies on the activation of RIPK3 and its interaction with a protein called MLKL. Recent research has shown that RIPK3 undergoes phosphorylation prior to necroptosis, and this phosphorylation promotes the stable interaction between RIPK3 and MLKL. This study identified specific phosphorylation sites on RIPK3, with pT224 and pS227 being crucial for the interaction with MLKL. Additionally, the phosphorylation of S164/T165 negatively regulates the kinase activity of RIPK3.

CELL DEATH & DISEASE (2022)

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Review Immunology

Natural medicines of targeted rheumatoid arthritis and its action mechanism

Xueling Liu et al.

Summary: Rheumatoid arthritis is an autoimmune disease affecting joints, and natural medicines have shown potential therapeutic effects on RA through mechanisms such as anti-inflammation, anti-oxidation, and immune regulation.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Clinical Neurology

Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment

Beida Ren et al.

Summary: This review provides an overview of the current research status and future development direction of cerebral small vessel disease (CSVD), highlighting the risk factors, biological markers, pathological mechanisms, and treatment options. The research difficulties are summarized to elucidate the future directions of CSVD.

FRONTIERS IN NEUROLOGY (2022)

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Review Cell Biology

Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease

Yetirajam Rajesh et al.

Summary: Alzheimer's disease is a neurodegenerative disorder characterized by the formation of plaques and abnormalities in certain proteins. Immune cells play a crucial role in the development of the disease, as they can cause cell death and release proinflammatory cytokines. However, chronic inflammation can worsen the condition. Therefore, balancing the immune response is important for effectively clearing the abnormal proteins without inducing inflammation.

CELLS (2022)

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Review Cell Biology

Role of necroptosis in airflow limitation in chronic obstructive pulmonary disease: focus on small-airway disease and emphysema

Chanjing Liu et al.

Summary: This article reviewed the correlations of small-airway disease and emphysema with airflow limitation in COPD, analyzed the effects of necroptosis on small-airway disease and emphysema, and explored the possible mechanisms of necroptosis causing airflow limitation in COPD.

CELL DEATH DISCOVERY (2022)

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Review Cardiac & Cardiovascular Systems

Evidence for the Benefits of Melatonin in Cardiovascular Disease

Mohammad Tobeiha et al.

Summary: The pineal gland produces melatonin, a hormone that plays critical roles in the circadian rhythm and sleep-wake cycle. Melatonin has antioxidant and neuroprotective properties, and has been shown to have significant functions in cardiovascular disease and possibly anti-aging effects. It can decrease primary hypertension and reduce cardiac pathology in rodents. It also acts as an antioxidant, preventing heart damage caused by drugs. Melatonin has shown cardioprotective activity in multiple animal and human studies. This article summarizes the established benefits of melatonin in the cardiovascular system and discusses its molecular mechanisms.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Chemistry, Medicinal

3-Bromo-4,5-dihydroxybenzaldehyde Isolated from Polysiphonia morrowii Suppresses TNF-α/IFN-γ-Stimulated Inflammation and Deterioration of Skin Barrier in HaCaT Keratinocytes

Arachchige Maheshika Kumari Jayasinghe et al.

Summary: This study evaluates the protective effect of 3-bromo-4,5-dihydroxybenzaldehyde (BDB) isolated from Polysiphonia morrowii on inflammation and skin barrier deterioration in TNF-alpha/IFN-gamma-stimulated HaCaT keratinocytes. The findings reveal that BDB decreases ROS production and inflammatory cytokine expression, while increasing cell viability and skin hydration protein production. This suggests that BDB has the ability to protect against inflammation and skin barrier deterioration.

MARINE DRUGS (2022)

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Article Pharmacology & Pharmacy

Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease

Xian Wang et al.

Summary: This study found elevated necroptosis in DKD patients and demonstrated that PF can regulate podocyte necroptosis by targeting TNFR1, providing a new potential target for treating DKD.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Signaling pathways of chronic kidney diseases, implications for therapeutics

Qian Yuan et al.

Summary: This article reviews the key signaling pathways involved in lipotoxicity, oxidative stress, inflammation, and myofibroblast activation in chronic kidney disease (CKD), and introduces targeted drugs based on the latest research. Understanding these signaling pathways and developing targeted therapies will advance basic and clinical research in CKD.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Allergy

RIPK1 downregulation enhances neutrophil extracellular traps in psoriasis

Xinyu Meng et al.

Summary: This study found that the expression level of RIPIK1 in neutrophils from psoriasis patients was decreased, which may enhance the generation of NETs. RIPIK1 could be identified as a novel therapeutic target for the treatment of psoriasis.

POSTEPY DERMATOLOGII I ALERGOLOGII (2022)

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Article Biochemistry & Molecular Biology

Evaluation of Oxidative Stress Biomarkers, Pro-Inflammatory Cytokines, and Histological Changes in Experimental Hypertension, Dyslipidemia, and Type 1 Diabetes Mellitus

Paul-Mihai Boarescu et al.

Summary: This study aimed to compare the oxidative stress biomarkers, pro-inflammatory cytokines, and histological changes induced by three cardiovascular risk factors. The results showed that hypertension, dyslipidemia, and type 1 diabetes mellitus all increased oxidative stress and inflammation, with type 1 diabetes mellitus having the most significant irreversible changes on the arterial wall.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Ophthalmology

Hyperglycemia Induces Meibomian Gland Dysfunction

Yuli Guo et al.

Summary: This study found that long-term diabetes may lead to Meibomian gland dysfunction (MGD), and AMPK may be a potential therapeutic target for MGD induced by diabetes.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death

Matthias Kist et al.

Summary: Mutating the ubiquitination site K376 of RIPK1 in mice activates cell death, leading to embryonic lethality, while mutation at K115 has minimal impact on cell death. Embryonic lethality can be prevented by loss of TNFR1 or simultaneous deletion of Caspase-8 and RIPK3 genes. Elimination of the K376 ubiquitination site in adult mice is tolerated but results in sensitivity to TNF-induced lethality.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Allergy

Bronchiolitis and recurrent wheezing are distinguished by type 2 innate lymphoid cells and immune response

Beatriz Sastre et al.

Summary: The study found that bronchiolitis patients have higher levels of innate lymphoid cells and related mRNA compared to recurrent wheezing patients. The levels of pro-inflammatory and immunomodulatory factors in the supernatant were similar between the two groups, but a significant difference was found in the ratio of prostaglandin E2 and cysteinyl leukotrienes C4.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2021)

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Review Cell Biology

RIP-roaring inflammation: RIPK1 and RIPK3 driven NLRP3 inflammasome activation and autoinflammatory disease

Mary Speir et al.

Summary: Autoinflammatory syndromes are a spectrum of clinical disorders characterized by recurrent inflammatory episodes, many of which are caused by the release of the pro-inflammatory cytokine IL-10. There is a close relationship between inflammation and programmed cell death, with lytic forms of cell death like necroptosis and pyroptosis considered inflammatory due to the release of DAMPs. Recent studies have shown crosstalk between cell death and inflammatory signaling pathways, particularly converging on NLRP3 inflammasome-mediated activation of IL-10.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2021)

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Review Cell Biology

Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning

Daniel J. Drucker

Summary: The increased prevalence of obesity, diabetes, and cardiovascular risk factors in severe COVID-19 patients has sparked interest in the metabolic aspects of SARS-CoV-2-induced pathophysiology. This update focuses on how metabolic disorders and their co-morbidities affect susceptibility, natural history, and treatment of SARS-CoV-2 infection in individuals with obesity and diabetes. New data on genetics, epidemiology, immune responses, disease severity, and therapy are highlighted, informing our understanding of COVID-19 in this vulnerable population.

CELL METABOLISM (2021)

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Article Multidisciplinary Sciences

ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

Hayley Muendlein et al.

Summary: In this study, the TRIF-dependent complex plays a crucial role in cell death and inflammation response, particularly in the context of bacterial infection. The constitutive binding between ZBP1 and RIPK1 is essential for TRIFosome interactions, caspase-8-mediated cell death, and inflammasome activation. This research provides an alternative model of pro-death complex formation reliant on TRIF signaling, demonstrating a non-canonical cell death pathway controlled by a complex of FADD, RIPK1, caspase-8, and ZBP1.

NATURE COMMUNICATIONS (2021)

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Review Immunology

TAK1-TABs Complex: A Central Signalosome in Inflammatory Responses

Yan-Ran Xu et al.

Summary: TAK1, a member of the MAPKKK family, functions by assembling with TAB1, TAB2, and TAB3 and can be activated by various stimuli. Post-translational modifications play important roles in controlling the activity, stability, and assembly of the TAK1-TABs complex.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Rheumatoid Arthritis Synovial Fluid Neutrophils Drive Inflammation Through Production of Chemokines, Reactive Oxygen Species, and Neutrophil Extracellular Traps

Helen L. Wright et al.

Summary: This study analyzed the gene expression differences between blood and synovial fluid neutrophils of rheumatoid arthritis patients, highlighting the overexpression of chemokines, ROS production, and NETs production by synovial fluid neutrophils. The research expands the understanding of molecular changes in neutrophil transcriptome during migration in inflamed joints and altered phenotype in rheumatoid arthritis synovial fluid neutrophils.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Inhibition of the NLRP3 inflammasome prevents ovarian aging

Jose M. Navarro-Pando et al.

Summary: The study demonstrates that the NLRP3 inflammasome plays a crucial role in ovarian aging and female fertility, showing potential as a new therapeutic target for infertility treatment.

SCIENCE ADVANCES (2021)

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Editorial Material Biochemistry & Molecular Biology

Kill Two Birds with One Stone: Role of the RIPK-3 in Necroptosis and Inflammasome Activation

Sagar Paudel et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

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Article Gastroenterology & Hepatology

Oxidized low-density lipoprotein activates extracellular signal-regulated kinase signaling to downregulate sortilin expression in liver sinusoidal endothelial cells

Qi Zhang et al.

Summary: This study found that ox-LDL induced lipid injury in the liver and downregulated the expression of sortilin through the ERK signaling pathway. PD98059, on the other hand, increased sortilin expression by blocking the ERK pathway, thus improving the damage to liver sinusoidal endothelial cells and the integration of the scaffold structure.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Channelling inflammation: gasdermins in physiology and disease

Xing Liu et al.

Summary: Gasdermins have been identified as mediators of inflammatory cell death known as pyroptosis, forming cell membrane pores upon activation to release pro-inflammatory cytokines. They play important roles in autoimmune and inflammatory diseases, infectious diseases, deafness, and cancer, with potential for novel therapeutic avenues.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Pharmacology & Pharmacy

A Study Based on Metabolomics, Network Pharmacology, and Experimental Verification to Explore the Mechanism of Qinbaiqingfei Concentrated Pills in the treatment of Mycoplasma Pneumonia

Zheng Liu et al.

Summary: Qinbaiqingfei concentrated pills (QB) inhibit the NF-κB signaling pathway, regulating immunity, metabolism, and treating diseases.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Genetics & Heredity

Marfan Syndrome Caused by Disruption of the FBN1 Gene due to A Reciprocal Chromosome Translocation

Anna Clara Schnause et al.

Summary: This study reports a mother and daughter with marfanoid habitus, both showing a cytogenetically reciprocal balanced translocation between chromosomes 2 and 15 after no pathogenic variant in the FBN1 gene was found. The breakpoints in the FBN1 gene were identified through various methods, highlighting the importance of structural genome variants as an underlying cause of monogenic diseases.

GENES (2021)

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Article Immunology

Inflammatory Factors of Macular Atrophy in Eyes With Neovascular Age-Related Macular Degeneration Treated With Aflibercept

Tomohito Sato et al.

Summary: In patients with neovascular age-related macular degeneration, changes in predictive cytokines can be used as biomarkers for predicting the occurrence of macula atrophy, with substantial loss of interferon-?-inducible protein 10 (IP-10) effects and persistent inflammation playing an important role in the incidence of macula atrophy.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Regulation of Caspase-8 Activity at the Crossroads of Pro-Inflammation and Anti-Inflammation

Jun-Hyuk Han et al.

Summary: Initially classified as an apoptotic caspase, caspase-8 has now been found to play significant roles in regulating inflammatory processes. Recent research has shown its involvement in modulating inflammatory responses, inflammasome activation, cell death, and cytokine induction. This review summarizes the latest advances in understanding how caspase-8 impacts inflammatory reactions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels

Raminta Vaiciuleviciute et al.

Summary: OA and CVD share many similarities in terms of risk factors and molecular mechanisms. Many cardiovascular drugs affect cell metabolism, cartilage matrix turnover, and inflammation through ion channels modulation, which may impact joint tissues.

CELLS (2021)

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Article Cell Biology

Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1

Xinyue Huang et al.

Summary: Our study reveals a biphasic model of the role of RIPK1 in mediating proinflammatory cytokine production, with distinct temporal roles when caspases are inhibited. Early phase production is NF-κB pathway-mediated and scaffold-dependent, while late phase involves the formation of a novel complex with key signaling mediators. RIPK1 kinase inhibitor Nec-1s can block late phase cytokine production, demonstrating a mechanism for the regulation of inflammatory signaling.

JOURNAL OF CELL BIOLOGY (2021)

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Article Cell Biology

Exosomal circEhmt1 Released from Hypoxia-Pretreated Pericytes Regulates High Glucose-Induced Microvascular Dysfunction via the NFIA/NLRP3 Pathway

Lin Ye et al.

Summary: In this study, the interaction between endothelial cells and pericytes in response to diabetic retinopathy was explored. The research revealed that circEhmt1 played a critical role in retinal microvascular dysfunction by mediating NFIA/NLRP3 signaling pathway.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Medicine, Research & Experimental

miR-489-3p inhibits TLR4/NF-κB signaling to prevent inflammation in psoriasis

Yujian Ye et al.

Summary: In psoriasis, miR-489-3p expression is downregulated, with bioinformatics analysis revealing TLR4 as a direct target. Overexpression of miR-489-3p suppresses the TLR4/NF-kappa B signaling pathway and reduces cell proliferation, while silencing of TLR4 enhances cell proliferation and inflammatory cytokine secretion. MiR-489-3p may be a key effector of psoriasis, serving as a potential prognostic biomarker and therapeutic target for treatment.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Oncology

Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines

Annkathrin Koch et al.

Summary: Burkitt's lymphoma (BL) is a highly aggressive form of B-cell non-Hodgkin's lymphoma. While clinical outcomes in children have improved in recent years, the prognosis for adults remains poor. Research has shown that combination treatment with Smac mimetic BV6 and TRAIL can induce necroptosis in BL, highlighting the potential for novel treatment strategies. These findings demonstrate the critical role of MLKL in necroptotic signaling and suggest that MLKL may serve as a prognostic marker for the success of necroptosis-based therapies in BL.

NEOPLASIA (2021)

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Review Biochemistry & Molecular Biology

Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship

Van-Long Truong et al.

Summary: Tea polyphenols act as direct antioxidants by scavenging reactive oxygen/nitrogen species, chelating transition metals, and inhibiting lipid, protein, and DNA oxidations. They also suppress pro-oxidant enzymes, induce endogenous antioxidants, and cooperate with vitamins. Furthermore, tea polyphenols regulate cellular signaling transduction pathways, significantly contributing to the prevention of chronic diseases and promotion of physiological functions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Mechanics Insights of Alpha-Lipoic Acid against Cardiovascular Diseases during COVID-19 Infection

Luc Rochette et al.

Summary: COVID-19, first reported in Wuhan, China in December 2019, has become a global pandemic. Cardiovascular complications have emerged as a major threat in addition to respiratory issues, especially for patients with existing cardiovascular conditions. The mechanisms behind the severe impact of SARS-CoV-2 infection on these patients remain partially understood.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Upregulation of RIP3 promotes necroptosis via a ROS-dependent NF-κB pathway to induce chronic inflammation in HK-2 cells

Junjun Wei et al.

Summary: The study found that overexpression of RIP3 could significantly increase the phosphorylation level of MLKL, promoting necroptosis. Through ROS-dependent NF-kappa B pathway activation, RIP3 also led to a more severe inflammatory response.

MOLECULAR MEDICINE REPORTS (2021)

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Article Endocrinology & Metabolism

The role of regulated necrosis in endocrine diseases

Wulf Tonnus et al.

Summary: Research on basic cell death has shown that most pathophysiologically significant cell death is necrotic in nature, while regulated necrosis can take different forms such as necroptosis, pyroptosis, and ferroptosis. Necrosis leads to an immune response by releasing damage-associated molecular patterns, and thus the consequences of regulated necrosis in the endocrine environment are specific.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Review Immunology

The 'cytokine storm': molecular mechanisms and therapeutic prospects

Rajendra Karki et al.

Summary: CSS is a collection of clinical manifestations caused by an overactivated immune system, associated with infectious diseases, immunodeficiencies, and therapeutic interventions. Despite the tissue damage and multiorgan failure caused by CS, there is still a lack of systematic understanding of its underlying molecular mechanisms.

TRENDS IN IMMUNOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment

Nur Samsu

Summary: Diabetic nephropathy is the leading cause of end-stage renal disease worldwide and diagnosis and treatment pose challenges, requiring additional therapeutic interventions. In addition to standard therapy, vitamin D receptor activators, incretin-related drugs, and therapies targeting inflammation may also be promising for preventing the progression of DN.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

Nanotherapies for sepsis by regulating inflammatory signals and reactive oxygen and nitrogen species: New insight for treating COVID-19

Li Chen et al.

Summary: The COVID-19 pandemic has led to an increase in cases of sepsis, and the use of nanomaterials in sepsis treatment has shown potential therapeutic effects. Future research should focus on balancing inflammation, pathogens, and patient tolerance to improve treatment efficacy.

REDOX BIOLOGY (2021)

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Review Cell Biology

The Transcription Factor NF-κB in Stem Cells and Development

Christian Kaltschmidt et al.

Summary: NF-kappa B, a transcription factor family, plays critical roles in regulating various processes including immune cell function, proliferation, cancer, neuroprotection, and memory. The REL domain-containing proteins in the NF-kappa B family are evolutionarily conserved across species and are closely related to stem cell development.

CELLS (2021)

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Review Oncology

From Apoptosis to Necroptosis: The Death Wishes to Cancer

Xianmei Meng et al.

Summary: DNA mutations are common in the human body, usually repaired by the DNA damage response program. Severe damages activate cell death, leading to genetic scars that can result in cancer. Apoptosis and necroptosis are the main strategies for optimal cell maintenance and cancer prevention, with apoptosis being the faster and cleaner option for cancer treatment.

CANCER CONTROL (2021)

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Review Pharmacology & Pharmacy

Recent advances in nanotherapeutics for the treatment and prevention of acute kidney injury

Hui Yu et al.

Summary: Nanotherapeutics based on nanotechnology have been proven to be an emerging and promising treatment strategy for AKI, improving drug delivery efficiency, reducing side effects, and achieving better treatment outcomes.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Review Immunology

Determining the effector response to cell death

Carla V. Rothlin et al.

Summary: Cell death is closely associated with immune responses, can be triggered by pathogens or injuries, and is followed by tissue renewal and repair processes initiated by innate immune cells. Recognizing dead cells can lead to various effector responses, depending on the cell's signals, environmental context, and the specific efferocyte involved.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Immunology

Caspases in Cell Death, Inflammation, and Pyroptosis

Sannula Kesavardhana et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

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Article Immunology

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

R. K. Subbarao Malireddi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Urology & Nephrology

Ultrasound super-resolution imaging provides a noninvasive assessment of renal microvasculature changes during mouse acute kidney injury

Qiyang Chen et al.

KIDNEY INTERNATIONAL (2020)

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Article Multidisciplinary Sciences

Regulation of adipose tissue inflammation by interleukin 6

Myoung Sook Han et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Pharmacology & Pharmacy

Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs

Sofie Martens et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

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Article Medicine, Research & Experimental

Tacrolimus reduces atherosclerotic plaque formation in ApoE-/- mice by inhibiting NLRP3 inflammatory corpuscles

Xiao Li et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

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Article Cell Biology

Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation

Hayley I. Muendlein et al.

CELL REPORTS (2020)

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Article Pharmacology & Pharmacy

Arctiin protects rat heart against ischemia/reperfusion injury via a mechanism involving reduction of necroptosis

Heng Chen et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Physiology

NF-κB System Is Chronically Activated and Promotes Glomerular Injury in Experimental Type 1 Diabetic Kidney Disease

Orestes Foresto-Neto et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Pro-survival and anti-inflammatory roles of NF-κB c-Rel in the Parkinson's disease models

Zishan Wang et al.

REDOX BIOLOGY (2020)

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Article Cell Biology

Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease

Haiwei Zhang et al.

CELL REPORTS (2020)

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Article Oncology

Saccharomyces boulardii modulates necrotizing enterocolitis in neonatal mice by regulating the sirtuin 1/NF-κB pathway and the intestinal microbiota

Kun Zhang et al.

MOLECULAR MEDICINE REPORTS (2020)

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Review Cell Biology

The clearance of dead cells by efferocytosis

Emilio Boada-Romero et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Clinical Neurology

The Local and Peripheral Immune Responses to Stroke: Implications for Therapeutic Development

Kristy A. Zera et al.

NEUROTHERAPEUTICS (2020)

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Article Oncology

Serum interleukin-6 and C-reactive protein are associated with survival in melanoma patients receiving immune checkpoint inhibition

Andressa S. Laino et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Review Cell Biology

Microglia: Agents of the CNS Pro-Inflammatory Response

Jose A. Rodriguez-Gomez et al.

CELLS (2020)

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Article Oncology

Effects of simvastatin on iNOS and caspase-3 levels and oxidative stress following smoke inhalation injury

Rong-Qiang Yang et al.

MOLECULAR MEDICINE REPORTS (2020)

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Article Cell Biology

TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity

Joao Paulo Bras et al.

CELL DEATH & DISEASE (2020)

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Article Multidisciplinary Sciences

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

Jesse J. Balic et al.

NATURE COMMUNICATIONS (2020)

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Review Peripheral Vascular Disease

An Update on the Role of PCSK9 in Atherosclerosis

Ece Yurtseven et al.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2020)

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Article Multidisciplinary Sciences

Succination inactivates gasdermin D and blocks pyroptosis

Fiachra Humphries et al.

SCIENCE (2020)

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Article Immunology

Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock

Naoya Sakaguchi et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

Foxp3+Regulatory T Cells Inhibit CCl4-Induced Liver Inflammation and Fibrosis by Regulating Tissue Cellular Immunity

Yoshinobu Ikeno et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Medicine, Research & Experimental

Dysfunction of the neurovascular unit in diabetes-related neurodegeneration

Caochong Yan et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Immunology

The Role of Inflammation in Diabetic Retinopathy

John V. Forrester et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Nutrition & Dietetics

Citrus Peel Flavonoids as Potential Cancer Prevention Agents

Nooshin Koolaji et al.

CURRENT DEVELOPMENTS IN NUTRITION (2020)

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Review Biochemistry & Molecular Biology

Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications

Qingzheng Kang et al.

REDOX BIOLOGY (2020)

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Article Gastroenterology & Hepatology

RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-kappa B Activation

Jerry Wong et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Review Pharmacology & Pharmacy

Programmed necrosis in cardiomyocytes: mitochondria, death receptors and beyond

Junxia Zhang et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

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Review Biochemistry & Molecular Biology

NRF2 and NF-κB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

Farzane Sivandzade et al.

REDOX BIOLOGY (2019)

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Review Biochemistry & Molecular Biology

The Coming Decade of Cell Death Research: Five Riddles

Douglas R. Green

CELL (2019)

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Article Medicine, Research & Experimental

NLRP3 inflammasome and lipid metabolism analysis based on UPLC-Q-TOF-MS in gouty nephropathy

Yan-Zi Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

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Article Cell Biology

Xanthatin inhibits STAT3 and NF-κB signalling by covalently binding to JAK and IKK kinases

Man Liu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Multidisciplinary Sciences

Targeting RIPK1 for the treatment of human diseases

Alexei Degterev et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Chemistry, Medicinal

Caffeic acid phenethyl ester suppressed growth and metastasis of nasopharyngeal carcinoma cells by inactivating the NF-κB pathway

Yushan Liang et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2019)

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Article Oncology

High glucose-induced apoptosis and necroptosis in podocytes is regulated by UCHL1 via RIPK1/RIPK3 pathway

Yuyin Xu et al.

EXPERIMENTAL CELL RESEARCH (2019)

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Review Medicine, Research & Experimental

RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review)

Yuping Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

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Article Biology

Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

Junghyun Lim et al.

ELIFE (2019)

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Article Biochemistry & Molecular Biology

Holothuria Leucospilota Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation

Yiqiong Yuan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Pathology

DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation

Joel Zindel et al.

Annual Review of Pathology-Mechanisms of Disease (2019)

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Article Immunology

A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis

Akio Takezaki et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Article Multidisciplinary Sciences

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis

Xixi Zhang et al.

NATURE COMMUNICATIONS (2019)

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Review Cell Biology

Role of pyroptosis in cardiovascular disease

Zeng Zhaolin et al.

CELL PROLIFERATION (2019)

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Article Cardiac & Cardiovascular Systems

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death

Tom T. P. Seijkens et al.

EUROPEAN HEART JOURNAL (2019)

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Review Neurosciences

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

Junying Yuan et al.

NATURE REVIEWS NEUROSCIENCE (2019)

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Article Medicine, Research & Experimental

Conditional knockout of TGF-βRII/Smad2 signals protects against acute renal injury by alleviating cell necroptosis, apoptosis and inflammation

Qin Yang et al.

THERANOSTICS (2019)

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Review Immunology

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Review Gastroenterology & Hepatology

Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

Wei Jia et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

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Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

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Review Cell Biology

Necroptosis in development and diseases

Bing Shan et al.

GENES & DEVELOPMENT (2018)

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Article Cell Biology

SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages

Maria Yurchenko et al.

JOURNAL OF CELL BIOLOGY (2018)

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Article Oncology

Salidroside prevents skin carcinogenesis induced by DMBA/TPA in a mouse model through suppression of inflammation and promotion of apoptosis

Ying-Hui Kong et al.

ONCOLOGY REPORTS (2018)

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Review Ophthalmology

Optical coherence tomography angiography

Richard F. Spaide et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2018)

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Review Immunology

ZBP1: Innate Sensor Regulating Cell Death and Inflammation

Teneema Kuriakose et al.

TRENDS IN IMMUNOLOGY (2018)

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Article Nutrition & Dietetics

Kahweol Ameliorates the Liver Inflammation through the Inhibition of NF-κB and STAT3 Activation in Primary Kupffer Cells and Primary Hepatocytes

Hye-Young Seo et al.

NUTRIENTS (2018)

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Article Immunology

Experimental Stroke Differentially Affects Discrete Subpopulations of Splenic Macrophages

Laura McCulloch et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

RIP kinases as modulators of inflammation and immunity

Sudan He et al.

NATURE IMMUNOLOGY (2018)

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Article Medicine, General & Internal

Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus

Louise Bowman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Review Medicine, Research & Experimental

AMPK: Potential Therapeutic Target for Ischemic Stroke

Shuai Jiang et al.

THERANOSTICS (2018)

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Article Biochemistry & Molecular Biology

Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells

Yan Jia et al.

REDOX BIOLOGY (2018)

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Article Multidisciplinary Sciences

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway

Emmy Van Quickelberghe et al.

SCIENTIFIC DATA (2018)

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Review Medicine, General & Internal

Necroptosis in inflammatory bowel disease and other intestinal diseases

Sha Li et al.

WORLD JOURNAL OF CLINICAL CASES (2018)

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Review Endocrinology & Metabolism

Metabolomics window into diabetic complications

Tao Wu et al.

JOURNAL OF DIABETES INVESTIGATION (2018)

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Article Medicine, Research & Experimental

RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase

Mitsuru Imamura et al.

JCI INSIGHT (2018)

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Review Oncology

Ubiquitin ligases in oncogenic transformation and cancer therapy

Daniela Senft et al.

NATURE REVIEWS CANCER (2018)

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Review Oncology

Immune cells in liver regeneration

Na Li et al.

ONCOTARGET (2017)

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Article Cardiac & Cardiovascular Systems

The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice

Christine Landlinger et al.

EUROPEAN HEART JOURNAL (2017)

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Review Gastroenterology & Hepatology

Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance

Hilal Ahmad Khan et al.

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL (2017)

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Review Immunology

Caspase-8: regulating life and death

Bart Tummers et al.

IMMUNOLOGICAL REVIEWS (2017)

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Article Immunology

ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death

Sannula Kesavardhana et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Chemistry, Medicinal

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Article Multidisciplinary Sciences

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

Jiefei Geng et al.

NATURE COMMUNICATIONS (2017)

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Article Cell Biology

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1 band NLRC4

Nina Van Opdenbosch et al.

CELL REPORTS (2017)

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Review Biochemistry & Molecular Biology

NF-kappa B signaling in inflammation

Ting Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

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Review Immunology

The non-canonical NF-κB pathway in immunity and inflammation

Shao-Cong Sun

NATURE REVIEWS IMMUNOLOGY (2017)

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Article Immunology

The NLRP3 inflammasome modulates sleep and NREM sleep delta power induced by spontaneous wakefulness, sleep deprivation and lipopolysaccharide

Mark R. Zielinski et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

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Review Cell Biology

Ubiquitin signaling in immune responses

Hongbo Hu et al.

CELL RESEARCH (2016)

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Article Immunology

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4

Malek Najjar et al.

IMMUNITY (2016)

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Article Immunology

Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB

Jo Suda et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Chemistry, Medicinal

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

Philip A. Harris et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

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Article Oncology

Tormentic acid inhibits H2O2-induced oxidative stress and inflammation in rat vascular smooth muscle cells via inhibition of the NF-κB signaling pathway

Yu-Lun Wang et al.

MOLECULAR MEDICINE REPORTS (2016)

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Review Biotechnology & Applied Microbiology

Regulated necrosis: disease relevance and therapeutic opportunities

Marcus Conrad et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

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Review Immunology

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

Francis Ka-Ming Chan et al.

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)

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Article Pharmacology & Pharmacy

Toll-like receptor 4 signaling: A common pathway for interactions between prooxidants and extracellular disulfide high mobility group box 1 (HMGB1) protein-coupled activation

Yan Zhang et al.

BIOCHEMICAL PHARMACOLOGY (2015)

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Article Microbiology

Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection

Rajendra Karki et al.

CELL HOST & MICROBE (2015)

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Article Nutrition & Dietetics

Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion

Jin Ah Cho et al.

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