4.8 Review

Updated roles of cGAS-STING signaling in autoimmune diseases

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Summary: STING-associated vasculopathy with onset in infancy (SAVI) is a type I interferonopathy characterized by severe inflammatory lung disease. The exact mechanisms by which mutations in the STING pathway lead to lung damage are not fully understood, and current treatments are ineffective.
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cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE

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The STING antagonist H-151 ameliorates psoriasis via suppression of STING/NF-κB-mediated inflammation

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