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The role of perivascular adipose tissue-secreted adipocytokines in cardiovascular disease

FRONTIERS IN IMMUNOLOGY (2023)

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Summary: Perivascular adipose tissue (PVAT) is a metabolically active adipose tissue depot surrounding human blood vessels. It plays a role in vascular homeostasis and can contribute to the development of vascular dysfunction. PVAT is composed of white, brown, and beige adipose tissue, and its dysfunction can influence the initiation and growth of atherosclerotic plaque. PVAT interacts with the arterial wall through various mechanisms, including modulation of smooth muscle cell contractility and secretion of anti-inflammatory molecules.

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