☆ 4.8 Article

NK cells in peripheral blood carry trogocytosed tumor antigens from solid cancer cells

FRONTIERS IN IMMUNOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Immunology

Gnawing Between Cells and Cells in the Immune System: Friend or Foe? A Review of Trogocytosis

Siyu Zhao et al.

Summary: Trogocytosis is a phenomenon where one cell quickly nibbles another cell, involving many immune cells and playing a crucial role in the immune system and relevant diseases. The precise mechanism of trogocytosis and its impact on the immune system are still not fully understood despite increasing research studies.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Letter Oncology

Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion

Michael L. Olson et al.

LEUKEMIA (2022)

添加到收藏夹

Article Multidisciplinary Sciences

The metabolism of cells regulates their sensitivity to NK cells depending on p53 status

Sana Belkahla et al.

Summary: Leukemic cells adapt their metabolism to support their fast proliferation and can be recognized by immune cells through activating receptors. The tumor suppressor gene p53 plays a role in cell metabolism and the expression of ligands involved in immune recognition. A chemical compound called dichloroacetate (DCA) induces the expression of these ligands in tumor cells with functional p53, sensitizing them to cytotoxic lymphocytes. DCA treatment also slows down tumor growth in vivo and could potentially enhance the effectiveness of immunotherapies using CAR T cells or NK cells.

SCIENTIFIC REPORTS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer

Mohamed S. Hasim et al.

Summary: This study reveals that lymphocytes can acquire PD-1 and other checkpoint receptors through trogocytosis from leukemia cells, leading to immunoregulation.

SCIENCE ADVANCES (2022)

添加到收藏夹

Review Oncology

Immune-Based Therapy in Triple-Negative Breast Cancer: From Molecular Biology to Clinical Practice

Francesca Carlino et al.

Summary: Triple-negative breast cancer has historically been considered difficult to treat, with chemotherapy as the main treatment option. However, recent advances in genomics and immunology have led to the development of novel therapeutic strategies, such as immunotherapy, to enhance immune response and overcome drug resistance in TNBC. It is crucial to identify more sensitive biomarkers in the field of breast cancer immune oncology to improve patient outcomes.

CANCERS (2022)

添加到收藏夹

Article Immunology

NK Cells Acquire CCR5 and CXCR4 by Trogocytosis in People Living with HIV-1

Dang-Nghiem Vo et al.

Summary: NK cells play a critical role in the antiviral immune response against HIV-1. Impaired NK cell activity is observed in HIV-1 patients, with alterations in NK cell subsets and the emergence of memory NK cells. NK cells can acquire CCR5 and CXCR4 through trogocytosis from T cells, but not CD4. HIV-1 patients exhibit distinct NK cell clusters, with increased expression of CXCR4 and CCR5 in viremic patients. Degranulation and trogocytosis may be linked in HIV-1 infection.

VACCINES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape

Ye Li et al.

Summary: The activation of chimeric antigen receptor (CAR) in natural killer (NK) cells promotes the transfer of tumor-specific antigen from tumor cells to NK cells, resulting in decreased tumor antigen density and impaired CAR-NK cell targeting ability. This phenomenon can lead to self-recognition and continuous CAR-mediated engagement, causing cell death in NK cells expressing the trogocytic antigen (NKTROG+) and reduced NK cell responsiveness. However, a dual-CAR system that incorporates both an activating CAR against the tumor antigen and an inhibitory NK self-recognizing CAR can prevent trogocytic antigen-mediated cell death in NK cells, while maintaining activation signaling against the tumor antigen, thereby enhancing CAR-NK cell activity.

NATURE MEDICINE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Trogocytosis in innate immunity to cancer is an intimate relationship with unexpected outcomes

Fabrizio Mattei et al.

Summary: Trogocytosis is a cellular process in which a cell acquires a membrane fragment from another cell through contact, allowing for the transfer of surface proteins. It plays a role in cell-cell communication, immune regulation, and response to pathogens and cancer cells, but the molecular mechanisms are poorly understood. Eosinophils, except for other immune cells, can engage in trogocytosis with tumor cells by acquiring membrane fragments through the CD11b/CD18 integrin complex. The impact of trogocytosis in innate immune cells on cancer progression is discussed, along with shared and cell-specific mechanisms underlying this process based on in silico modeling.

ISCIENCE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1)

Nerea Allende-Vega et al.

Summary: Solid tumor cells have altered metabolism that can protect them from cytotoxic lymphocytes, but metformin can increase tumor cell sensitivity to cytotoxic lymphocytes. Research shows that metformin induces expression of NKG2DL and ICAM-1, promoting binding between lymphocytes and tumor cells, and reducing the growth of human hematological tumor cells.

SCIENTIFIC REPORTS (2022)

添加到收藏夹

Article Allergy

Glucocorticoids and the cytokines IL-12, IL-15, and IL-18 present in the tumor microenvironment induce PD-1 expression on human natural killer cells

Linda Quatrini et al.

Summary: The induction of PD-1 expression on human NK cells in the tumor setting is dependent on the cooperative action of glucocorticoids and cytokines, leading to enhanced mRNA translation and increased PD-1 levels.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Oncology

Expanded NK cells from umbilical cord blood and adult peripheral blood combined with daratumumab are effective against tumor cells from multiple myeloma patients

Chantal Reina-Ortiz et al.

Summary: The study evaluated the potential of expanded NK cells from two sources combined with mAbs to target primary multiple myeloma cells. Results indicate that umbilical cord blood eNKs are highly cytotoxic against MM cells, while peripheral blood eNKs have significant cytotoxic advantage when combined with daratumumab.

ONCOIMMUNOLOGY (2021)

添加到收藏夹

Article Hematology

Low-density PD-1 expression on resting human natural killer cells is functional and upregulated after transplantation

Zachary Davis et al.

Summary: The study showed that functional PD-1 is expressed on resting human NK cells in healthy individuals and reconstituting NK cells early after allo-HSCT. Blocking PD-1 on resting NK cells enhanced their function against PD-L1-expressing tumor lines, indicating the potential for PD-1 blockade in enhancing NK cell-mediated antitumor control.

BLOOD ADVANCES (2021)

添加到收藏夹

Review Oncology

Human NK Cells in Autologous Hematopoietic Stem Cell Transplantation for Cancer Treatment

Ane Orrantia et al.

Summary: NK cells are important components of the innate immune system that play a key role in tumor immunosurveillance. While the therapeutic potential of NK cells in allogeneic HSCT is well recognized, their significance and effects on outcomes in autologous HSCT are less understood. This review summarizes the diverse functions and roles of NK cells in different HSCT settings.

CANCERS (2021)

添加到收藏夹

Review Cell Biology

The Role of Trogocytosis in the Modulation of Immune Cell Functions

Kensuke Miyake et al.

Summary: Trogocytosis is an active process where one cell extracts cell fragments from another, transferring cell surface molecules and membrane fragments. It can modulate various biological responses, including immune responses, and is evolutionarily conserved from protozoan parasites to eukaryotic cells. This process can result in cell death or grant recipient cells new functions.

CELLS (2021)

添加到收藏夹

Article Cell Biology

High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment

Veronica D. Gonzalez et al.

Summary: Tubo-ovarian high-grade serous carcinoma (HGSC) is resistant to immune checkpoint blockade, despite the presence of exhausted T cells. Researchers have identified decidual-like natural killer (dl-NK) cell subpopulations in HGSC samples that correlate with tumor and transitioning epithelial-mesenchymal cell abundance. In cocultures, NK-92 natural killer cells acquire CD9 from HGSC tumor cells through trogocytosis, leading to reduced anti-tumor cytokine production and cytotoxicity. CD9 represents a potential therapeutic target for overcoming immune suppression in HGSC and improving NK immunotherapy.

CELL REPORTS (2021)

添加到收藏夹

Article Oncology

Hijacking TYRO3 from Tumor Cells via Trogocytosis Enhances NK-cell Effector Functions and Proliferation

Ting Lu et al.

Summary: The study shows that NK cells can acquire TYRO3 from tumor cells via trogocytosis, resulting in enhanced cytotoxicity and IFNγ production. The activation status of NK cells and TYRO3 expression levels on donor cells correlate positively with trogocytosis levels.

CANCER IMMUNOLOGY RESEARCH (2021)

添加到收藏夹

Review Cell Biology

Lymphocytes and Trogocytosis-Mediated Signaling

Jim Reed et al.

Summary: Trogocytosis is a process of intercellular transfer of membrane and membrane-associated molecules that has been studied mainly in immune cells. The impact of trogocytosis on immune response and individual trogocytosis-positive cells is significant but not fully understood.

CELLS (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

NK cells for cancer immunotherapy

Noriko Shimasaki et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

添加到收藏夹

Article Oncology

PD-1+ natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade

Marcel P. Trefny et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

添加到收藏夹

Review Immunology

Non-Genetically Improving the Natural Cytotoxicity of Natural Killer (NK) Cells

Martin Villalba et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

Dissecting the NK Cell Population in Hematological Cancers Confirms the Presence of Tumor Cells and Their Impact on NK Population Function

Dang-Nghiem Vo et al.

VACCINES (2020)

添加到收藏夹

Review Immunology

Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

Simona Sivori et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2019)

添加到收藏夹

Review Cell Biology

Senescent cells: Living or dying is a matter of NK cells

Fabrizio Antonangeli et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

Mohamad Hamieh et al.

NATURE (2019)

添加到收藏夹

Article Oncology

NK cell activation and recovery of NK cell subsets in lymphoma patients after obinutuzumab and lenalidomide treatment

Dang-Nghiem Vo et al.

ONCOIMMUNOLOGY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Expansion of allogeneic NK cells with efficient antibody-dependent cell cytotoxicity against multiple tumors

Diego Sanchez-Martinez et al.

THERANOSTICS (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Roles of cytotoxic and helper innate lymphoid cells in cancer

Camille Guillerey

MAMMALIAN GENOME (2018)

添加到收藏夹

Review Immunology

The Broad Spectrum of Human Natural Killer Cell Diversity

Aharon G. Freud et al.

IMMUNITY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers

Y. Liu et al.

ONCOGENE (2017)

添加到收藏夹

Review Immunology

Human NK Cell Diversity in viral infection: Ramifications of Ramification

Dara M. Strauss-Albee et al.

FRONTIERS IN IMMUNOLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

CD45 Isoform Profile Identifies Natural Killer (NK) Subsets with Differential Activity

Ewelina Krzywinska et al.

PLOS ONE (2016)

添加到收藏夹

Article Oncology

Trogocytosis-mediated expression of HER2 on immune cells may be associated with a pathological complete response to trastuzumab-based primary systemic therapy in HER2-overexpressing breast cancer patients

Eiji Suzuki et al.

BMC CANCER (2015)

添加到收藏夹

Article Biochemical Research Methods

FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data

Sofie Van Gassen et al.

CYTOMETRY PART A (2015)

添加到收藏夹

Article Immunology

Acquisition of Activation Receptor Ligand by Trogocytosis Renders NK Cells Hyporesponsive

Cathrine A. Miner et al.

JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹

Article Medicine, General & Internal

Identification of Anti-tumor Cells Carrying Natural Killer (NK) Cell Antigens in Patients With Hematological Cancers

Ewelina Krzywinska et al.

EBIOMEDICINE (2015)

添加到收藏夹

Article Immunology

CD56brightPerforinlow Noncytotoxic Human NK Cells Are Abundant in Both Healthy and Neoplastic Solid Tissues and Recirculate to Secondary Lymphoid Organs via Afferent Lymph

Paolo Carrega et al.

JOURNAL OF IMMUNOLOGY (2014)

添加到收藏夹

Article Immunology

High-dimensional analysis of the murine myeloid cell system

Burkhard Becher et al.

NATURE IMMUNOLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Automated identification of stratifying signatures in cellular subpopulations

Robert V. Bruggner et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Cell Biology

Clinical recovery from surgery correlates with single-cell immune signatures

Brice Gaudilliere et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

添加到收藏夹

Article Oncology

PD-1 Expression on Peripheral Blood Cells Increases with Stage in Renal Cell Carcinoma Patients and Is Rapidly Reduced after Surgical Tumor Resection

Alexander W. MacFarlane et al.

CANCER IMMUNOLOGY RESEARCH (2014)

添加到收藏夹

Article Hematology

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs

Vivien Beziat et al.

BLOOD (2013)

添加到收藏夹

Article Oncology

Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

Romain Remark et al.

CLINICAL CANCER RESEARCH (2013)

添加到收藏夹

Article Biotechnology & Applied Microbiology

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

El-ad David Amir et al.

NATURE BIOTECHNOLOGY (2013)

添加到收藏夹

Article Cell Biology

Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry

Amir Horowitz et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

添加到收藏夹

Editorial Material Oncology

NK-cell fratricide Dynamic crosstalk between NK and cancer cells

Kyohei Nakamura et al.

ONCOIMMUNOLOGY (2013)

添加到收藏夹

Letter Oncology

Melanoma Cells Inhibit NK Cell Functions-Letter

Giuseppe Sconocchia et al.

CANCER RESEARCH (2012)

添加到收藏夹

Article Immunology

Antigen-Specific Transfer of Functional Programmed Death Ligand 1 from Human APCs onto CD8+ T Cells via Trogocytosis

Regina Gary et al.

JOURNAL OF IMMUNOLOGY (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection

Linda M. Wakim et al.

NATURE (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Natural killer (NK)-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T cells

Masafumi Nakayama et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

添加到收藏夹

Article Immunology

Decrease in intrahepatic CD56+lymphocytes in gastric and colorectal cancer patients with liver metastases

Maya Gulubova et al.

APMIS (2009)

添加到收藏夹

Article Hematology

Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction

Emanuela Marcenaro et al.

BLOOD (2009)

添加到收藏夹

Article Hematology

Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4

Jeffrey M. Milush et al.

BLOOD (2009)

添加到收藏夹

Article Hematology

Capture of plasma membrane fragments from target cells by trogocytosis requires signaling in T cells but not in B cells

Anne Aucher et al.

BLOOD (2008)

添加到收藏夹

Review Immunology

Intercellular trogocytosis plays an important role in modulation of immune responses

Khawaja Ashfaque Ahmed et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

Trogocytosis-based generation of suppressive NK cells

Julien Caumartin et al.

EMBO JOURNAL (2007)

添加到收藏夹

Article Immunology

A very rapid and simple assay based on trogocytosis to detect and measure specific T and B cell reactivity by flow cytometry

AL Puaux et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2006)

添加到收藏夹

Article Multidisciplinary Sciences

Human and murine inhibitory natural killer cell receptors transfer from natural killer cells to target cells

B Vanherberghen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

添加到收藏夹

Article Immunology

Intercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses

LM Carlin et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2001)

添加到收藏夹

Article Immunology

Acquisition of external major histocompatibility complex class I molecules by natural killer cells expressing inhibitory Ly49 receptors

A Sjöström et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2001)

添加到收藏夹

Article Immunology

H-2D ligand expression by Ly49A+ natural killer (NK) cells precludes ligand uptake from environmental cells:: Implications for NK cell function

J Zimmer et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2001)

添加到收藏夹

Article Immunology

Cutting edge: CTLs rapidly capture membrane fragments from target cells in a TCR signaling-dependent manner

D Hudrisier et al.

JOURNAL OF IMMUNOLOGY (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.