期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
卷 10, 期 8, 页码 628-634出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.estlett.3c00388
关键词
black carbon; ocular surface; air pollution; health risk; mass spectrometry imaging
Ambient ultrafine particles in the human body have raised concerns about the risks of air particulate pollution. However, the ocular surface health risks associated with airborne particles are often overlooked. This study identified black carbon particles, a component of PM2.5, on the ocular surface using a mass spectrometry imaging method and found associations with ocular indices and dry eye disease. These findings highlight the potential ocular health risks and provide evidence for the neglected aspect of health impacts from PM2.5 exposure.
Ambient ultrafine particles have been identified in thehuman body,raising serious concerns about the systemic health risks of air particulatepollution. While eyes constantly and directly contact airborne particulatematter, the associated ocular surface health risks are often overlooked.Here, we developed a laser desorption/ionization mass spectrometryimaging method to identify and detect ambient black carbon particles,a typical component of PM2.5, in conjunctival sac washedfluid samples. We have detected black carbon particles in 24 of 55samples (selected from 656 patients), with concentrations rangingfrom 0.31 to 5.1 & mu;g/mL (mean value of 0.95 & mu;g/mL). Thepresence of black carbon particles at the ocular surface was influencedby daily life habits. Moreover, it is associated with some ocularindices and dry eye disease, indicating potential ocular health risks.As this is the first report about the high-frequency presence of blackcarbon at the human ocular surface, our findings not only demonstrateblack carbon as a potential marker of airborne particulates on theocular surface but also provide evidence for a neglected but importantaspect of health impacts associated with PM2.5 exposure.
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