期刊
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
卷 23, 期 12, 页码 1562-1569出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871530323666230623112047
关键词
Hypoglycemia; doege-potter syndrome; non-islet cell tumor hypoglycemia; solitary fibrous tumor; IGF-2; STAT6
Doege-Potter syndrome is a rare paraneoplastic entity that is mostly associated with solitary fibrous tumors. If the cause of hypoglycemia is unexplained, this syndrome should be suspected, and further investigation for unknown tumors should be conducted.
Background: Doege-Potter syndrome is a rare paraneoplastic entity that is often diagnosed incidentally during the work-up of hypoglycemia of unclear etiology. It is characterized by a non-islet cell tumor hypoglycemia mostly associated with solitary fibrous tumors. These uncommon tumors have been reported in <5% of solitary fibrous tumors. Although not unique in its kind, this case is extremely important as this syndrome often conceals unrecognized tumors that can be surgically resolved.Case Presentation: We present the case of a 59-year-old non-diabetic man with a 2-month history of severe and recurrent fasting hypoglycaemia presenting with severe dyspnea and sweating. Further work-up revealed low insulin, C-peptide, and IGF-1 levels and a large right in-trathoracic solitary fibrous tumor. Unfortunately, bioassays for IGF-2 were unavailable at our hos-pital. Nevertheless, as hypoglycemia completely resolved after resection of the mass, Doege-Potter syndrome was highly suspected.Conclusion: Doege-Potter syndrome is a complication of rare tumors. If hy-poglycemia is unexplained, this syndrome should always be suspected, and the presence of un-known masses should be investigated.
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