Dioxin-Linked Covalent Organic Framework-Supported Palladium Complex for Rapid Room-Temperature Suzuki-Miyaura Coupling Reaction

Covalent organic framework (COF)-supported palladium catalysts have garnered enormous attention for cross-coupling reactions. However, the limited linkage types in COF hosts and their suboptimal catalytic performance have hindered their widespread implementation. Herein, we present the first study immobilizing palladium acetate onto a dioxin-linked COF (Pd/COF-318) through a facile solution impregnation approach. By virtue of its permanent porosity, accessible Pd sites arranged in periodic skeletons, and framework robustness, the resultant Pd/COF-318 exhibits exceptionally high activity and broad substrate scope for the Suzuki-Miyaura coupling reaction between aryl bromides and arylboronic acids at room temperature within an hour, rendering it among the most effective Pd/COF catalysts for Suzuki-Miyaura coupling reactions to date. Moreover, Pd/COF-318 demonstrates excellent recyclability, retaining high activity over five cycles without significant deactivation. The leaching test confirms the heterogeneity of the catalyst. This work uncovers the vast potential of dioxin-linked COFs as catalyst supports for highly active, selective, and durable organometallic catalysis.

Automated summary

This study presents the first immobilization of palladium acetate onto a dioxin-linked covalent organic framework (Pd/COF-318) using a facile solution impregnation approach. Pd/COF-318 exhibits high activity and broad substrate scope for Suzuki-Miyaura coupling reactions, making it one of the most effective Pd/COF catalysts to date. It also demonstrates excellent recyclability and heterogeneity of the catalyst, highlighting the potential of dioxin-linked COFs as catalyst supports for organometallic catalysis.