期刊
ADVANCED SCIENCE
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/advs.202302141
关键词
core-shell structures; DNA damage and repair; pyroptosis; radioimmunotherapy; radiosensitization
Au@AgBiS2 nanoparticles, with a core-shell structure of metal-semiconductors, can enhance DNA damage and ROS production in radiotherapy, resulting in improved therapeutic effects. Moreover, these nanoparticles induce pyroptosis and activate the anti-tumor immune response against breast cancer and metastasis.
Radiotherapy (RT), a widely used clinical treatment modality for cancer, uses high-energy irradiation for reactive oxygen species (ROS) production and DNA damage. However, its therapeutic effect is primarily limited owing to insufficient DNA damage to tumors and harmful effects on normal tissues. Herein, a core-shell structure of metal-semiconductors ( Au@AgBiS2 nanoparticles) that can function as pyroptosis inducers to both kill cancer cells directly and trigger a robust anti-tumor immune against 4T1 triple-negative murine breast cancer and metastasis is rationally designed. Metal-semiconductor composites can enhance the generation of considerable ROS and simultaneously DNA damage for RT sensitization. Moreover, Au@AgBiS2, a pyroptosis inducer, induces caspase-3 protein activation, gasdermin E cleavage, and the release of damage-associated molecular patterns. In vivo studies in BALB/c mice reveal that Au@AgBiS2 nanoparticles combined with RT exhibit remarkable antitumor immune activity, preventing tumor growth, and lung metastasis. Therefore, this core-shell structure is an alternative for designing highly effective radiosensitizers for radioimmunotherapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据