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The synthesis and characterization of a series of cocrystals of an isoniazid derivative with butan-2-one and propan-2-one

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INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S2053229623007179

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crystal structure; cocrystal; isoniazid; dicarboxylic acid; pyridine; carbohydrazide; naphthoic acid; thermal analysis

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This study synthesized five cocrystals containing izbt and izact, and characterized them using single-crystal X-ray diffraction, powder X-ray diffraction, and differential scanning calorimetry.
Four cocrystals containing N '-(butan-2-ylidene)pyridine-4-carbohydrazide (izbt) and one cocrystal containing N '-isopropylideneisonicotinohydrazide (izact) were synthesized by reacting isoniazid with either butan-2-one (for the former) or acetone (for the latter). The coformers used to synthesize the izbt cocrystals were 2,4-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid, 2-chloro-4-nitrobenzoic acid and 1-naphthoic acid. 1-Naphthoic acid was also used with izact to form a cocrystal. The 1:1 cocrystals are: N '-(butan-2-ylidene)pyridine-4-carbohydrazide-1-naphthoic acid (izbt-1nta), C10H13N3O center dot C11H8O2, N '-(butan-2-ylidene)pyridine-4-carbohydrazide-2,4-dihydroxybenzoic acid (izbt-2,4-dhba), C10H13N3O center dot C7H6O4, N '-(propan-2-ylidene)pyridine-4-carbohydrazide-1- naphthoic acid (izact-1nta), C9H11N3O center dot C11H8O2, N '-(butan-2-ylidene)pyridine-4-carbohydrazide-2-chloro-4-nitrobenzoic acid (izbt-2c4n), C10H13N3O center dot C7H4ClNO4, and N '-(butan-2-ylidene)pyridine-4-carbohydrazide-2,5-dihydroxybenzoic acid (izbt-2,5-dhba), C10H13N3O center dot C7H6O4. The cocrystals containing izbt were compared to those containing the same (or similar) coformers with izact that have been reported either here or in the Cambridge Structural Database (CSD). Most of the cocrystals showed different packing despite having the same hydrogen-bonding motifs. The cocrystals were characterized by single-crystal X-ray diffraction (SC-XRD), powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC).

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