4.5 Article

The use of non-invasive stool tests for verification of Helicobacter pylori eradication and clarithromycin resistance

期刊

出版社

JOHN WILEY & SONS LTD
DOI: 10.1002/ueg2.12473

关键词

antibiotic resistance; clarithromycin; Faecal Immunochemical Test (FIT); gastric cancer; H. pylori eradication therapy; Helicobacter pylori; stool antigen test; urea breath test

向作者/读者索取更多资源

This study investigates the feasibility of using non-invasive stool tests to verify successful Helicobacter pylori (H. pylori) eradication and determine clarithromycin resistance. The results indicate that H. pylori antigen testing on fecal immunochemical test (FIT) stool samples has similar accuracy as testing on dry stool samples.
Background: Clarithromycin resistance of Helicobacter pylori (H. pylori) represents a major challenge in eradication therapy. In this study, we assessed if non-invasive stool tests can be used to verify successful H. pylori eradication and determine clarithromycin resistance.Materials and methods: In this prospective study, patients undergoing urea breath testing (UBT) for confirmation of H. pylori eradication were asked to collect the stool as both a dry fecal sample and fecal immunochemical test (FIT). Stool H. pylori antigen testing (SAT) was performed on these samples and assessed for its accuracy in eradication verification. Type and duration of antibiotic treatment were retrospectively collected from patient records and compared with clarithromycin resistance determined by PCR of stool samples.Results: H. pylori eradication information was available for a total of 145 patients (42.7% male, median age: 51.2). Successful eradication was achieved in 68.1% of patients. SAT on FIT samples had similar accuracy for eradication assessment compared to dry fecal samples, 72.1% [95% CI 61.4-81.2] versus 72.2% [95% CI 60.9-81.7]. Clarithromycin resistance rate was 13.4%.Conclusion: H. pylori antigen testing on FIT stool samples to verify H. pylori eradication is feasible and has similar accuracy as H. pylori antigen testing on dry stool samples. Dry stool, but not FIT, was suitable for non-invasive identification of H. pylori clarithromycin resistance by rt-PCR personalizing antibiotic treatment strategies without the need for invasive diagnostics is desirable, as the cure rate of first-line empirical H. pylori treatment remains low.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据