期刊
NANOTECHNOLOGY
卷 27, 期 41, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/27/41/412002
关键词
nanomaterials; cellular uptake; protein adsorption; intracellular degradation; cytotoxic effects
资金
- Natural Science Foundation of China [51120135001, 21374097]
- Key Science Technology Innovation Team of Zhejiang Province [2013TD02]
The unique features of nanomaterials have led to their rapid development in the biomedical field. In particular, functionalized nanoparticles (NPs) are extensively used in the delivery of drugs and genes, bio-imaging and diagnosis. Hence, the interaction between NPs and cells is one of the most important issues towards understanding the true nature of the NP-mediated biological effects. Moreover, the intracellular safety concern of the NPs as a result of intracellular NP degradation remains to be clarified in detail. This review presents recent advances in the interactions of designed NPs and cells. The focus includes the governing factors on cellular uptake and the intracellular fate of NPs, and the degradation of NPs and its influence on nanotoxicity. Some basic consideration is proposed for optimizing the NP-cell interaction and designing NPs of better biocompatiblity for biomedical application.
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