4.7 Article

Bioactive Glasses Containing Strontium or Magnesium Ions to Enhance the Biological Response in Bone Regeneration

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Physical

Fabrication, Structural and Biological Characterization of Zinc-Containing Bioactive Glasses and Their Use in Membranes for Guided Bone Regeneration

Silvia R. Gavinho et al.

Summary: Polymeric membranes are commonly used in guided bone regeneration (GBR) in dentistry. The addition of bioactive glasses with therapeutic ions, including zinc, can enhance cell adhesion, proliferation, and differentiation. In this study, bioactive glasses containing different concentrations of zinc were developed, and their structural and biological characteristics were evaluated. The results showed that the zinc-containing bioactive glasses did not exhibit significant antibacterial activity, but the highest concentration of zinc did not compromise bioactivity and promoted cell viability. Cell culture assays using the membranes demonstrated that the addition of zinc improved cell viability and increased alkaline phosphatase production.

MATERIALS (2023)

Article Materials Science, Multidisciplinary

Thermal, Structural, Morphological and Electrical Characterization of Cerium-Containing 45S5 for Metal Implant Coatings

Silvia Rodrigues Gavinho et al.

Summary: Biomaterial coatings on dental implants, particularly using bioglass with therapeutic ions, such as cerium, can improve the integration rate and bond between bone and implant. Cerium oxide addition does not affect the glass structure, but increases the number of non-bridging oxygens. It also enhances the antioxidant and impedance properties of the glass, making it suitable for use as a coating material on dental implants.

COATINGS (2023)

Article Materials Science, Ceramics

Comprehensive assessment of SrO and CuO co-incorporated 50S6P amorphous silicate bioactive glasses in vitro: Revealing bioactivity properties of bone graft biomaterial for bone tissue engineering applications

Ali Can Ozarslan et al.

Summary: In this study, the bioactivity of SrO and CuO co-incorporated 50S6P glasses was comprehensively studied through in vitro experiments. The results showed that the glasses released ions and formed Ca-P layer, indicating their desirable bioactive features for bone tissue engineering application.

CERAMICS INTERNATIONAL (2023)

Article Materials Science, Ceramics

Effects of strontium dopants on the in vitro bioactivity and cytotoxicity of strontium-doped spray-dried bioactive glass microspheres

Henni Setia Ningsih et al.

Summary: This study demonstrated the fabrication of strontium-doped bioactive glass microspheres using the spray drying method, and showed the positive effects of Sr dopant on the in vitro bioactivity and osteoblast cell viability.

JOURNAL OF NON-CRYSTALLINE SOLIDS (2022)

Article Materials Science, Biomaterials

Interaction of monodispersed strontium containing bioactive glass nanoparticles with macrophages

Parichart Naruphontjirakul et al.

Summary: The cellular response of murine primary macrophages to monodisperse strontium containing bioactive glass nanoparticles (SrBGNPs), with diameters of 90 +/- 10 nm and a composition (mol%) of 88.8 SiO2-1.8CaO-9.4SrO (9.4% Sr-BGNPs) was investigated for the first time. The Sr-BGNPs were actively internalised by the macrophages via formation of endosome/lysosome-like vesicles bordered by a membrane inside the cells. When RAW264.7 cells were incubated with Sr-BGNPs, the cells were polarised towards the pro-regenerative M2 population rather than the pro-inflammatory M1 population. Sr-BGNPs are potential biocompatible vehicles for therapeutic cation delivery for applications in bone regeneration.

BIOMATERIALS ADVANCES (2022)

Article Chemistry, Physical

Mechanical Properties, Cytotoxicity, and Fluoride Ion Release Capacity of Bioactive Glass-Modified Methacrylate Resin Used in Three-Dimensional Printing Technology

Zbigniew Raszewski et al.

Summary: This study evaluated the mechanical properties, cytotoxicity, and fluoride ion release capacity of 3D-printed dental resins modified with bioactive glass. The modified resins showed desirable bioactive properties and the potential ability to release fluoride ions in the oral cavity environment. However, there was a mild decrease in physical properties and mild cytotoxicity with direct contact with human cells.

MATERIALS (2022)

Article Materials Science, Ceramics

Hydroxycarbonate apatite formation and 5-fluorouracil delivery by strontium containing mesoporous bioactive glass nanoparticles

Muhammad Asif Tahir et al.

Summary: Strontium-doped mesoporous bioactive glass nanoparticles (Sr-MBG NPs) with a size of 50 +/- 5 nm were successfully prepared using the sol-gel method. The biocompatibility of these nanoparticles was confirmed, and loading them with 5-fluorouracil (5-Fu) resulted in substantial inhibitory effects on cancer cell viability.

CERAMICS INTERNATIONAL (2022)

Article Materials Science, Coatings & Films

Preparation and characterization of polyelectrolyte multilayer coatings on 316L stainless steel for antibacterial and bone regeneration applications

Pranjyan Dash et al.

Summary: A polyelectrolyte multilayer (PEM) coating was fabricated with collagen and poly (gamma-glutamic acid) (gamma-PGA) onto 316L stainless steel, loaded with vancomycin (VA) and strontium containing bioactive glass (SrBG). The films exhibited smooth and uniform surface, good wettability, and enhanced mechanical properties. Biomineralization and apatite layer formation were observed in simulated body fluids. The composite films showed antibacterial properties, excellent biocompatibility with bone marrow mesenchymal stem cells, and enhanced angiogenesis and bone regeneration ability. Thus, the PEM/VA/SrBG composite films have great potential for orthopedic implant applications.

SURFACE & COATINGS TECHNOLOGY (2022)

Article Multidisciplinary Sciences

Physical/mechanical and antibacterial properties of orthodontic adhesives containing Sr-bioactive glass nanoparticles, calcium phosphate, and andrographolide

Wirinrat Chaichana et al.

Summary: This study prepared orthodontic adhesives with added calcium phosphate monohydrate/Sr-bioactive glass nanoparticles and andrographolide, which can promote mineral precipitation and reduce bacterial growth. The additives had an impact on the physical/mechanical properties of the materials, but within an acceptable range.

SCIENTIFIC REPORTS (2022)

Article Materials Science, Multidisciplinary

Osteogenic commitment of strontium nanoparticles doped mesoporous bioactive glass-ceramics

Alesh Kumar et al.

Summary: The present work investigates the use of strontium nanoparticles doped mesoporous bioactive glasses-ceramics (MBGCs) in orthopedic strategies for vascularization. The presence of Sr nanoparticles in the MBGCs is confirmed through X-ray scattering and electron microscopy experiments. The study reports the in-vitro biocompatibility of Sr doped MBGCs and their selective effect on osteoblasts.

MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS (2022)

Article Chemistry, Multidisciplinary

Biocompatibility, Bioactivity, and Antibacterial Behaviour of Cerium-Containing Bioglass®

Silvia R. Gavinho et al.

Summary: The increased use of dental implants in clinical practice is mainly due to aesthetic parameters, with bioactive glass coating being suggested as a method to prevent infectious problems. The addition of cerium to the bioactive glass promotes bone regeneration and has an antibacterial effect. The developed bioactive glass with CeO2 shows an inhibitory effect on important pathogenic bacteria and exhibits bioactivity.

NANOMATERIALS (2022)

Article Multidisciplinary Sciences

Strontium doped bioglass incorporated hydrogel-based scaffold for amplified bone tissue regeneration

Hamed Manoochehri et al.

Summary: Developing new therapeutic approaches, such as tissue engineering using 3D scaffolds, is necessary for repairing large bone injuries. In this study, we successfully fabricated chitosan/alginate/strontium-doped bioglass composite scaffolds and found that Alg/Cs/Sr-BG20 scaffold demonstrated better performance in repairing bone major injuries.

SCIENTIFIC REPORTS (2022)

Article Dentistry, Oral Surgery & Medicine

Effect of strontium-doped bioactive glass-ceramic containing toothpaste on prevention of artificial dentine caries formation: an in vitro study

Lin Lu Dai et al.

Summary: Adding strontium-doped bioactive glass-ceramic to fluoride-free toothpaste has the potential to reduce the formation of dentine lesions. The study findings show that the depth of dentine caries and the amount of mineral loss were significantly lower in the group treated with toothpaste containing HX-BGC compared to the control group.

BMC ORAL HEALTH (2022)

Article Engineering, Biomedical

Biodegradable Mg-Sc-Sr Alloy Improves Osteogenesis and Angiogenesis to Accelerate Bone Defect Restoration

Nadia Aboutalebianaraki et al.

Summary: In this study, a bifunctional Mg-Sc-Sr alloy with osteogenic and angiogenic properties was developed and evaluated in vitro. The alloy showed significantly higher osteogenesis and angiogenesis effects compared to pure Mg and the control group, indicating its potential as a promising candidate for bone implants.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2022)

Review Biochemistry & Molecular Biology

Applications of Biodegradable Magnesium-Based Materials in Reconstructive Oral and Maxillofacial Surgery: A Review

Sanja Vujovic et al.

Summary: This review article analyzes and discusses the applications of magnesium (Mg) and Mg-based materials in reconstructive oral and maxillofacial surgery, including guided bone regeneration, dental implantology, fixation of facial bone fractures, and soft tissue regeneration.

MOLECULES (2022)

Article Materials Science, Biomaterials

Strontium- and peptide-modified silicate nanostructures for dual osteogenic and antimicrobial activity

Isha Mutreja et al.

Summary: Developing multifunctional nanostructures incorporating high levels of strontium in mesoporous bioactive silicate nanostructures can prevent infection and promote bone regeneration.

BIOMATERIALS ADVANCES (2022)

Article Chemistry, Physical

Osteogenic Potential of Magnesium (Mg)-Doped Multicomponent Bioactive Glass: In Vitro and In Vivo Animal Studies

Saeid Kargozar et al.

Summary: This study synthesized magnesium-doped bioactive glasses (BGs) for bone reconstruction and fabricated them into 3D scaffolds using the sponge replica approach. The results showed that the Mg-doped BGs were compatible with human osteosarcoma cells and could promote bone nodule formation in vitro and improve the migratory ability of human umbilical vein endothelial cells. In vivo experiments demonstrated the effectiveness of the BG-based scaffolds in promoting bone regeneration.

MATERIALS (2022)

Article Engineering, Biomedical

Magnesium incorporation into primary dental enamel and its effect on mechanical properties

Viktoria K. Kis et al.

Summary: The study found that magnesium incorporation can significantly affect the hardness properties of healthy primary dental enamel, resulting in an increase of approximately 20%. Through magnesium ion exchange experiments, the study provides additional evidence for the structure of poorly ordered magnesium-containing intergranular phase and deepens the understanding of dental enamel structure.

ACTA BIOMATERIALIA (2021)

Review Materials Science, Ceramics

Current advances concerning the most cited metal ions doped bioceramics and silicate-based bioactive glasses for bone tissue engineering

Vanessa Modelski Schatkoski et al.

Summary: The research on biomaterials has shown significant improvement in the quality of life for individuals requiring surgery. Bioceramics and bioactive glasses play a key role in hard tissue engineering, promoting tissue regeneration and multifunctionality when implanted. Incorporating specific metal ions into these biomaterials enhances their properties and expands their applications, including in cancer treatment and drug delivery.

CERAMICS INTERNATIONAL (2021)

Review Biochemistry & Molecular Biology

Strategies for Bone Regeneration: From Graft to Tissue Engineering

Giulia Battafarano et al.

Summary: Bone is a regenerative organ with self-renewal ability, but impaired bone healing may require medical intervention using natural or synthetic bone grafts for regeneration. Tissue engineering relies on the combination of cells, growth factors, and scaffold materials, with various materials and cell types being investigated for bone regeneration strategies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

An In Vitro Evaluation of the Biological and Osteogenic Properties of Magnesium-Doped Bioactive Glasses for Application in Bone Tissue Engineering

Frederike Hohenbild et al.

Summary: Magnesium plays a crucial role in bone tissue engineering and its incorporation in bioactive glasses (BGs) has a positive impact on mesenchymal stromal cells (MSCs), promoting osteogenic differentiation. However, the moderate release of magnesium ions from BGs may limit the overall enhancement of gene expression related to extracellular matrix (ECM) proteins. Future studies could explore the use of other BG types such as mesoporous BGs for a higher local presence of therapeutically active ions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Dentistry, Oral Surgery & Medicine

The use of bioactive glass (BAG) in dental composites: A critical review

Melissa Tiskaya et al.

Summary: Bioactive glasses (BAGs) have been studied as remineralizing additives in dental composites, particularly those prepared through the melt-quench route. These materials release ions and form apatite, but variations in glass compositions and testing conditions make comparisons challenging. It is recommended that future studies focus on mimicking clinical conditions by immersing samples in physiological solutions for longer periods.

DENTAL MATERIALS (2021)

Review Materials Science, Multidisciplinary

Effect of Magnesium-Based Coatings on Titanium or Zirconia Substrates on Bone Regeneration and Implant Osseointegration- A Systematic Review

Ahmad H. Almehmadi

Summary: Magnesium (Mg) plays an important role in bone metabolism and is being studied for its potential as a dental implant surface coating. Studies have shown that Mg-based coatings can improve cell behavior, enhance osseointegration, and promote osteogenic markers in bone-implant integration.

FRONTIERS IN MATERIALS (2021)

Article Materials Science, Biomaterials

Effect of Magnesium on Dentinogenesis of Human Dental Pulp Cells

Rania M. Salem et al.

Summary: The study investigated the effects of magnesium (Mg2+) on human dental pulp cells (HDPCs) in terms of cell attachment, proliferation, differentiation, and mineralization. Results showed that optimal concentrations of supplemental Mg2+ (0.5-2 mM) significantly enhanced HDPCs by promoting cell attachment, proliferation rate, alkaline phosphatase activity, and mineralization.

INTERNATIONAL JOURNAL OF BIOMATERIALS (2021)

Review Cell Biology

Recent Trends in the Development of Bone Regenerative Biomaterials

Guoke Tang et al.

Summary: The goal of biomaterials is to support bone tissue regeneration at defect sites and eventually degrade in situ to be replaced by newly generated bone tissue. Challenges include engineering biomaterials to match the mechanical and biological context of bone tissue and support vascularization of large tissue constructs. New biofunctional biomaterials aim to recreate nanoscale cues from the extracellular environment for bone regeneration.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Materials Science, Ceramics

Structural, thermal, morphological and dielectric investigations on 45S5 glass and glass-ceramics

S. R. Gavinho et al.

Summary: The study investigated the structural characteristics of 45S5 Bioglass, and found that treatments above 600°C lead to glass crystallization, with the main phase being Na2Ca2Si3O9 and a secondary phase appearing in samples treated above 900°C. The electrical measurements revealed that the crystal phase dominates the conduction process and dipoles lead to relaxations phenomena at the interfaces.

JOURNAL OF NON-CRYSTALLINE SOLIDS (2021)

Article Chemistry, Physical

Effect of Strontium-Doped Bioactive Glass on Preventing Formation of Demineralized Lesion

Lin-Lu Dai et al.

Summary: The study investigated the effect of strontium-doped bioactive glass on the formation of dental demineralized lesions. Results showed that the bioactive glass had a preventive effect on demineralized lesions in both enamel and dentine. Different groups were observed and analyzed for surface morphology and mineral loss values to evaluate the effectiveness of the bioactive glass.

MATERIALS (2021)

Article Materials Science, Ceramics

Development of mesoporous borosilicate bioactive glass nanoparticles containing Mg2+ and Zn2+ : biocompatibility, bioactivity and antibacterial activity

Andrada Ioana Damian-Buda et al.

Summary: In this study, mesoporous bioactive glass nanoparticles (MBGNs) were successfully synthesized using a microemulsion assisted sol-gel method, showing good bioactivity and biocompatibility in vitro. Samples containing MgO increased cell viability, while MBGNs with ZnO exhibited higher antibacterial activity against Escherichia coli.

JOURNAL OF NON-CRYSTALLINE SOLIDS (2021)

Review Materials Science, Biomaterials

Multifarious applications of bioactive glasses in soft tissue engineering

Shreyasi Majumdar et al.

Summary: Bioactive glasses (BGs) show promising potential in soft tissue regeneration, promoting neovascularization and tissue healing. They have been reported to aid in regeneration of tissues with minimal renewal capacity like the heart and lungs. BGs have also shown peripheral nerve and musculoskeletal reparative properties, making them suitable biomaterial scaffolds for tissue engineering.

BIOMATERIALS SCIENCE (2021)

Article Engineering, Biomedical

Influence of low amounts of zinc or magnesium substitution on ion release and apatite formation of Bioglass 45S5

R. Wetzel et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2020)

Proceedings Paper Chemistry, Multidisciplinary

Fabrication and Characterization of 45S5 Bioactive Glass Microspheres

Nursyazwani Ismail et al.

3RD INTERNATIONAL POSTGRADUATE CONFERENCE ON MATERIALS, MINERALS & POLYMER (MAMIP) 2019 (2020)

Article Multidisciplinary Sciences

The antibacterial and angiogenic effect of magnesium oxide in a hydroxyapatite bone substitute

Catarina C. Coelho et al.

SCIENTIFIC REPORTS (2020)

Article Biochemical Research Methods

Preconditioning of Bioactive Glasses before Introduction to Static Cell Culture: What Is Really Necessary?

Frederike Hohenbild et al.

METHODS AND PROTOCOLS (2020)

Article Materials Science, Ceramics

Nontoxic glasses: Preparation, structural, electrical and biological properties

Silvia R. Gavinho et al.

INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY (2019)

Article Materials Science, Biomaterials

Antibacterial bone substitute of hydroxyapatite and magnesium oxide to prevent dental and orthopaedic infections

Catarina C. Coelho et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Article Materials Science, Biomaterials

Electrospun biodegradable chitosan based-poly(urethane urea) scaffolds for soft tissue engineering

Tania Vieira et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Article Materials Science, Multidisciplinary

MgO enables enhanced bioactivity and antimicrobial activity of nano bioglass for bone tissue engineering application

Amit Kumar Singh et al.

MATERIALS TECHNOLOGY (2019)

Review Materials Science, Multidisciplinary

State-of-Art Functional Biomaterials for Tissue Engineering

Krati Sharma et al.

FRONTIERS IN MATERIALS (2019)

Review Engineering, Biomedical

Tackling bioactive glass excessive in vitro bioreactivity: Preconditioning approaches for cell culture tests

Francesca E. Ciraldo et al.

ACTA BIOMATERIALIA (2018)

Review Engineering, Biomedical

Bioactive Glasses: From Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies

Elisa Fiume et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2018)

Editorial Material Dentistry, Oral Surgery & Medicine

Strontium-substituted bioactive glasses in vitro osteogenic and antibacterial effects

Jie Liu et al.

DENTAL MATERIALS (2016)

Article Materials Science, Ceramics

Bioglass and Bioactive Glasses and Their Impact on Healthcare

Julian R. Jones et al.

INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE (2016)

Article Engineering, Biomedical

Reprint of: Review of bioactive glass: From Hench to hybrids

Julian R. Jones

Acta Biomaterialia (2015)

Article Biotechnology & Applied Microbiology

Electrophoretic deposition of chitosan/45S5 bioactive glass composite coatings doped with Zn and Sr

Marta Miola et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2015)

Article Engineering, Biomedical

Improvement of dual-leached polycaprolactone porous scaffolds by incorporating with hydroxyapatite for bone tissue regeneration

Napaphat Thadavirul et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2014)

Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

Review Engineering, Biomedical

Bioceramics of calcium orthophosphates

Sergey V. Dorozhkin

BIOMATERIALS (2010)

Article Materials Science, Ceramics

Influence of magnesia on the structure and properties of bioactive glasses

S. J. Watts et al.

JOURNAL OF NON-CRYSTALLINE SOLIDS (2010)

Article Materials Science, Ceramics

Strontium containing bioactive glasses: Glass structure and physical properties

Yann C. Fredholm et al.

JOURNAL OF NON-CRYSTALLINE SOLIDS (2010)

Article Chemistry, Physical

Sintering, crystallisation and biodegradation behaviour of Bioglass®-derived glass-ceramics

Aldo R. Boccaccini et al.

FARADAY DISCUSSIONS (2007)

Article Engineering, Biomedical

The story of Bioglass®

Larry L. Hench

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2006)

Article Engineering, Biomedical

How useful is SBF in predicting in vivo bone bioactivity?

T Kokubo et al.

BIOMATERIALS (2006)