A retrospective claims analysis of fatigue in patients with multiple sclerosis on disease-modifying therapy

Review Clinical Neurology

What's in a name? That which we callMultiple Sclerosis Fatigue

Amy Lynn Hubbard et al.

Summary: Limited progress has been made in treating the debilitating symptoms of Multiple Sclerosis (MS), including motor, sensory, and cognitive impairments, as well as fatigue. There is an ongoing need for conceptual and applied change in defining, measuring, and treating this fatigue, which is a major challenge for patients and healthcare providers.

MULTIPLE SCLEROSIS JOURNAL (2021)

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Article Pharmacology & Pharmacy

Retrospective Claims Analysis of Treatment Patterns, Relapse, Utilization, and Cost Among Patients with Multiple Sclerosis Initiating Second-Line Disease-Modifying Therapy

Leorah Freeman et al.

Summary: The study revealed that low adherence and poor persistence persist following an initial disease-modifying therapy (DMT) switch in multiple sclerosis (MS) patients. However, patients who switched to oral DMTs demonstrated higher persistence and adherence.

DRUGS-REAL WORLD OUTCOMES (2021)

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Review Clinical Neurology

Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review

Abril Oliva Ramirez et al.

Summary: Fatigue is a prevalent symptom in pwMS and is associated with considerable QoL and economic burden. Studies have shown that MS-related fatigue is consistently associated with lower QoL and significant impact on employment status, capacity to work, and sick leave. However, there is a lack of evidence regarding the direct costs of MS-related fatigue and the burden experienced by caregivers of pwMS.

BMC NEUROLOGY (2021)

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Review Clinical Neurology

Comprehensive Approach to Management of Multiple Sclerosis: Addressing Invisible Symptoms-A Narrative Review

Lynsey Lakin et al.

Summary: Multiple sclerosis is a chronic autoimmune inflammatory disease that can cause a variety of invisible symptoms, impacting patient quality of life. Despite gaps in awareness and management, a team-based approach is recommended for comprehensive care that addresses these hidden symptoms. Open communication, stigma mitigation, and shared decision-making are key strategies for managing invisible symptoms effectively.

NEUROLOGY AND THERAPY (2021)

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Article Clinical Neurology