☆ 4.7 Editorial Material

SINEUPs to boost translation

MOLECULAR THERAPY-NUCLEIC ACIDS (2023)

m6A-modification of cyclin D1 and c-myc IRESs in glioblastoma controls ITAF activity and resistance to mTOR inhibition

Angelica Benavides-Serrato et al.

Summary: A salvage pathway stimulated by mTOR inhibitors activates internal ribosome entry site (IRES)-mediated mRNA translation, promoting resistance of glioblastoma (GBM). Modification of IRES RNAs with m6A enhances IRES activity and increases resistance to mTOR inhibition. YTHDF3 interacts with hnRNP A1 and together regulate GBM responses to mTOR inhibitors.

CANCER LETTERS (2023)

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Article Medicine, Research & Experimental

SINEUP non-coding RNA activity depends on specific N6-methyladenosine nucleotides

Bianca Pierattini et al.

Summary: SINEUPs are natural and synthetic antisense long non-coding RNAs (lncRNAs) that selectively enhance translation of target mRNAs. This is achieved by increasing their association with polysomes through two RNA domains: an embedded inverted SINEB2 element and an antisense region. It has been found that SINEUPs are N6-methyladenosine (m6A) modified by the METTL3 enzyme, and this modification is necessary for their activity.

MOLECULAR THERAPY-NUCLEIC ACIDS (2023)

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Article Cell Biology