☆ 4.3 Article

Alterations in the Gut-Liver Axis on Rats with Immunological Hepatic Fibrosis

JOURNAL OF IMMUNOLOGY RESEARCH (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Gastroenterology & Hepatology

Hepatic fibrosis: 2022 Unmet needs and a blueprint for the future

Scott L. Friedman et al.

Summary: Steady progress has been made in understanding the pathogenesis and clinical consequences of hepatic fibrosis, but effective antifibrotic drugs are yet to be approved. This article highlights the successes and identifies gaps and unmet needs in both experimental and clinical aspects. Clarifying the mechanisms of fibrosis regression and developing better models will expedite drug development, while improving diagnostics and utilizing digital pathology methods can enhance prognostic information and better quantify therapeutic responses.

HEPATOLOGY (2022)

添加到收藏夹

Article Virology

Dynamic changes of serum metabolites associated with infection and severity of patients with acute hepatitis E infection

Jian Wu et al.

Summary: This study investigates the dynamic changes in metabolites associated with liver disease progression, particularly in predicting the prognosis of hepatitis E virus acute liver failure (HEV-ALF). Ultra-performance liquid chromatography-mass spectroscopy was used to evaluate serum metabolites in healthy controls (HC), acute hepatitis E (AHE) patients, and HEV-ALF patients. Significant differences in metabolite components were observed between AHE patients and HC, as well as between HEV-ALF and AHE patients. Pathway enrichment analysis revealed altered linoleic acid metabolism and phenylalanine, tyrosine, and tryptophan biosynthesis pathways in AHE patients compared to HC. In HEV-ALF, the linoleic acid metabolism and porphyrin and chlorophyll metabolism pathways differed significantly from AHE patients. Differential metabolites such as taurocholic acid, glycocholic acid, glycochenodeoxycholate-3-sulfate, and docosahexaenoic acid showed discriminatory performance in distinguishing HEV-ALF from AHE patients. Serum levels of specific metabolites were associated with the prognosis of HEV-ALF patients. The dynamic changes in serum metabolites were found to be associated with AHE infection and severity, and the identified metabolites have the potential to be used for diagnosis and prognosis prediction of HEV-ALF.

JOURNAL OF MEDICAL VIROLOGY (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Bacteroides acidifaciens in the gut plays a protective role against CD95-mediated liver injury

Hesuiyuan Wang et al.

Summary: The intestinal flora plays a crucial role in the development of liver diseases. In this study, a specific murine intestinal bacterial strain, BA, was found to alleviate liver injury by reducing hepatocyte apoptosis and showed protective effects against alcoholic liver injury. Understanding the function of BA may provide potential opportunities for treating liver diseases.

GUT MICROBES (2022)

添加到收藏夹

Article Immunology

Untargeted Plasma Metabolomics Reveals Extensive Metabolic Alterations Among Treatment-Naive Human Immunodeficiency Virus/Hepatitis C Virus Co-Infected Patients with Liver Disease Progression

Jiayu He et al.

Summary: This study aims to analyze the differences in metabolites among HIV/HCV co-infected patients with and without liver disease progression (LDP) and HIV mono-infected patients. The findings reveal a novel set of metabolites that can distinguish different patient groups and may have mechanistic and interventional implications.

AIDS RESEARCH AND HUMAN RETROVIRUSES (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

The effect of biliary obstruction, biliary drainage and bile reinfusion on bile acid metabolism and gut microbiota in mice

Rui Wu et al.

Summary: The study investigated the effects of biliary obstruction, biliary drainage, and bile reinfusion on bile acid metabolism and gut microbiota. Short-term bile reinfusion was found to partially benefit the recovery of secondary bile acids in the liver and bile, but had limited effect on patient's perioperative recovery and long-term survival.

LIVER INTERNATIONAL (2022)

添加到收藏夹

Article Immunology

Pathophysiology and system biology of rat c-BSA induced immune complex glomerulonephritis and pathway comparison with human gene sequencing data

Haijie Wu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

添加到收藏夹

Review Gastroenterology & Hepatology

Epidemiologic and socioeconomic factors impacting hepatitis B virus and related hepatocellular carcinoma

Bipul Gnyawali et al.

Summary: Chronic Hepatitis B is a globally prevalent disease that poses a significant healthcare burden, especially in low-resource regions where access to diagnosis, vaccination, screening, and treatment is limited. Mitigating the impact of the disease includes increasing screening in high-risk groups, improving health literacy in vulnerable populations, and developing robust vaccination programs in underserved areas.

WORLD JOURNAL OF GASTROENTEROLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Beneficial Effects of Natural Extracts and Bioactive Compounds on the Gut-Liver Axis: A Promising Intervention for Alcoholic Liver Disease

Liang Zhao et al.

Summary: Alcoholic liver disease is a major global health issue associated with various severe liver diseases. Alcohol consumption can disturb the composition of gut microbiota, affecting the treatment of ALD. Plant natural products and polyphenolic compounds have beneficial effects on ALD-related disorders and may act through modulating the gut-liver axis.

ANTIOXIDANTS (2022)

添加到收藏夹

Review Oncology

Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives

Yuqiu Han et al.

Summary: This article summarizes the role of Akkermansia muciniphila (A. muciniphila) in the progression of nonalcoholic fatty liver disease (NAFLD). The study found that the abundance of A. muciniphila is decreased in NAFLD patients, and its recovery can prevent hepatic fat accumulation and inflammation. Furthermore, the article discusses how microbes regulate hepatic immunity and lipid accumulation in NAFLD. The study suggests that A. muciniphila improves hepatic inflammation by modulating inflammatory cytokines and LPS signals, as well as innate immune cells related to gut microbiota.

FRONTIERS OF MEDICINE (2022)

添加到收藏夹

Review Microbiology

Gut Bacteria and Neurotransmitters

Leon M. T. Dicks

Summary: Gut bacteria communicate with the central nervous system through the production of specific metabolic compounds and the transmission of signals via the vagus nerve. The gut microbiota also influences the central nervous system by controlling the regulation and development of gut neurons. Additionally, the metabolites produced by gut bacteria interact with intestinal epithelial cells and neurons, affecting the synthesis and degradation of neurotransmitters.

MICROORGANISMS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Research progress on the relationship between intestinal microecology and intestinal bowel disease

Qianhui Fu et al.

Summary: Intestinal microecology, consisting of intestinal microbiota, intestinal epithelial cells, and intestinal mucosal immune system, is a crucial component of human microecology. It plays a significant role in digestion and absorption, material metabolism, and acts as a natural immune barrier. Disturbances in the intestinal microecology can lead to various diseases, such as obesity, diabetes, irritable bowel syndrome, inflammatory bowel disease (IBD), and colorectal malignancy. This article systematically discusses the research progress on the relationship between IBD and intestinal microecology, including pathogenesis, treatment methods, and changes in intestinal microbiota.

ANIMAL MODELS AND EXPERIMENTAL MEDICINE (2022)

添加到收藏夹

Review Medicine, General & Internal

Epidemiology, risk factors, and pathogenesis associated with a superbug: A comprehensive literature review on hepatitis C virus infection

Mehlayl Tariq et al.

Summary: Viral hepatitis, especially hepatitis C, is a major public health concern with increasing cases in developing countries like Pakistan. Its transmission is primarily through intravenous drug abuse, street barbers, and unsafe blood transfusions. Symptoms of hepatitis C infection include fatigue and jaundice, and treatment relies on antiviral drugs.

SAGE OPEN MEDICINE (2022)

添加到收藏夹

Article Agriculture, Dairy & Animal Science

Gama-aminobutyric acid (GABA) alleviates hepatic inflammation via GABA receptors/TLR4/NF-κB pathways in growing-finishing pigs generated by super-multiparous sows

Shumin Zhang et al.

Summary: The offspring of super-multiparous sows face liver inflammation, which can be improved by GABA supplementation through enhancing antioxidant enzyme activity, reducing the expression of pro-inflammatory cytokines, and regulating the TLR4/NF-κB signaling pathway.

ANIMAL NUTRITION (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Gut Microbiota in Intestinal and Liver Disease

Rheinallt M. Jones et al.

Summary: The gut microbiota plays a crucial role in the normal physiology of the gastrointestinal tract and liver, with disruptions in its community structure potentially leading to inflammation and immune activation. Long-term evolution has established a stable equilibrium between host and microbial influences, but alterations in this balance can result in a wide range of diseases.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021 (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome

Laura A. Bolte et al.

Summary: The study revealed correlations between dietary patterns and microbial clusters, as well as associations between individual foods and nutrients with bacterial species and metabolic pathways. Processed and animal-derived foods were linked to certain bacteria and endotoxin synthesis pathways, while plant foods and fish were associated with different bacteria and pathways related to nutrient metabolism. These findings provide insights into how diet affects gut inflammation and suggest directions for future intervention studies.

GUT (2021)

添加到收藏夹

Review Nutrition & Dietetics

The Gut-Liver Axis in Cholestatic Liver Diseases

Andreas Blesl et al.

Summary: The gut-liver axis is a crucial physiological interplay between the gut and liver, with disruptions playing a key role in the evolution and progression of chronic cholestatic liver diseases. Key features of this cycle include the gut microbiome, gut barrier, bacterial translocation, and bile acid metabolism. Understanding of the alterations in the gut-liver axis has significantly increased, influencing the pathogenesis and outcome of these diseases. Therapeutic implications and future scientific objectives are also outlined in this review.

NUTRIENTS (2021)

添加到收藏夹

Review Oncology

Gut-liver axis-mediated mechanism of liver cancer: A special focus on the role of gut microbiota

Naoko Ohtani et al.

Summary: The symbiotic relationship between gut microbiota and the mammalian host is important for digestion of nutrients and production of metabolites. Metabolites such as short-chain fatty acids and secondary bile acids produced by gut bacteria may influence liver function through various mechanisms, including inflammation and DNA damage in the tumor microenvironment. Additionally, components like lipopolysaccharides and lipoteichoic acid from gut bacteria can trigger inflammatory signaling through innate immune receptors.

CANCER SCIENCE (2021)

添加到收藏夹

Review Nutrition & Dietetics

Bariatric Surgery and Liver Disease: General Considerations and Role of the Gut-Liver Axis

Maria Cerreto et al.

Summary: Weight loss through bariatric surgery is a therapeutic solution for metabolic disorders such as obesity and non-alcoholic fatty liver disease. While associated with benefits like improved liver health, not all surgeries are beneficial for the liver and may even worsen liver conditions. Further research is needed to fully understand the risks and benefits of bariatric surgery in patients with liver disease.

NUTRIENTS (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain

Yuanyuan Deng et al.

Summary: The research found that long-term stress disrupts Kyn metabolism and endocrine function, accompanied by disrupted homeostasis of certain microbiota, collectively contributing to the development of depression-like behavior.

GUT MICROBES (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Molecular and cellular mechanisms of liver fibrosis and its regression

Tatiana Kisseleva et al.

Summary: Chronic liver injury results in liver inflammation and fibrosis, which can be reversed by eliminating activated myofibroblasts and resorbing the fibrous scar. Understanding the molecular mechanisms underlying liver fibrosis and its reversibility can lead to the identification of new therapeutic targets for liver fibrosis treatment.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Blautia-a new functional genus with potential probiotic properties?

Xuemei Liu et al.

Summary: Blautia is an anaerobic bacteria genus with probiotic characteristics that can regulate host health and alleviate metabolic syndrome. Recent research has focused on its biological characteristics and probiotic effects.

GUT MICROBES (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

The gut-liver axis in liver disease: Pathophysiological basis for therapy

Agustin Albillos et al.

JOURNAL OF HEPATOLOGY (2020)

添加到收藏夹

Review Gastroenterology & Hepatology

Diversification of host bile acids by members of the gut microbiota

Jenessa A. Winston et al.

GUT MICROBES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

Ina Nemet et al.

CELL (2020)

添加到收藏夹

Article Medicine, General & Internal

Modulating the gut-liver axis and the pivotal role of the faecal microbiome in cirrhosis

Charlotte Woodhouse et al.

CLINICAL MEDICINE (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Leaky Gut and Gut-Liver Axis in Liver Cirrhosis: Clinical Studies Update

Hiroshi Fukui

Gut and Liver (2020)

添加到收藏夹

Review Biochemical Research Methods

Multiomic analysis of cytokines in immuno-oncology

Vladimir Jurisic

EXPERT REVIEW OF PROTEOMICS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structural variation in the gut microbiome associates with host health

David Zeevi et al.

NATURE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone

Fan Yang et al.

EMBO JOURNAL (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease

Christoph Grander et al.

GUT (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction

Da Jung Kim et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Review Medicine, General & Internal

Chronic hepatitis B virus infection

Wai-Kay Seto et al.

LANCET (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

Gut Microbiota Profiling of Pediatric Nonalcoholic Fatty Liver Disease and Obese Patients Unveiled by an Integrated Meta-omics-Based Approach

Federica Del Chierico et al.

HEPATOLOGY (2017)

添加到收藏夹

Article Genetics & Heredity

A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients

Andrew Brantley Hall et al.

GENOME MEDICINE (2017)

添加到收藏夹

Article Endocrinology & Metabolism

Paracrine GABA and insulin regulate pancreatic alpha cell proliferation in a mouse model of type 1 diabetes

Allen L. Feng et al.

DIABETOLOGIA (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

Weifei Zhu et al.

CELL (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Preventive effects of phenylethanol glycosides from Cistanche tubulosa on bovine serum albumin-induced hepatic fibrosis in rats

Shu-Ping You et al.

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

添加到收藏夹

Article Biochemical Research Methods

STAMP: statistical analysis of taxonomic and functional profiles

Donovan H. Parks et al.

BIOINFORMATICS (2014)

添加到收藏夹

Article Cell Biology

Gabapentin, a Synthetic Analogue of Gamma Aminobutyric Acid, Reverses Systemic Acute Inflammation and Oxidative Stress in Mice

Jordana Maia Dias et al.

INFLAMMATION (2014)

添加到收藏夹

Article Acoustics

Doppler Assessment of Splanchnic Arterial Flow in Patients with Liver Cirrhosis: Correlation with Ammonia Plasma Levels and MELD Score

Tijana M. Glisic et al.

JOURNAL OF CLINICAL ULTRASOUND (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Alterations of the human gut microbiome in liver cirrhosis

Nan Qin et al.

NATURE (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

Microbiota and the gut-liver axis: Bacterial translocation, inflammation and infection in cirrhosis

Valerio Giannelli et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

添加到收藏夹

Article Plant Sciences

Effects of bicyclol on immunological liver fibrosis in rats

Yu Gu et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2010)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.