Adolescent polycystic ovary syndrome without obesity: HOTAIR rs1443512 genotype relates to fat mass and to the redistribution of fat mass on low-dose pioglitazone

Review Biochemistry & Molecular Biology

Adolescent PCOS: a postpubertal central obesity syndrome

Lourdes Ibanez et al.

Summary: Adolescent polycystic ovary syndrome (PCOS) is a common hormonal disorder caused by ectopic fat, often due to a mismatch between early adipogenesis and later lipogenesis. It is characterized by menstrual irregularity and excess androgen. Diagnosis usually occurs during late adolescence or early adulthood, about 2 to 8 years after menarche. Treatment should focus on reducing ectopic fat and addressing symptoms for overall preconception health.

TRENDS IN MOLECULAR MEDICINE (2023)

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Article Multidisciplinary Sciences

Long non-coding RNA HOTAIR regulates cytoskeleton remodeling and lipid storage capacity during adipogenesis

Evdokiia Potolitsyna et al.

Summary: HOTAIR plays important regulatory roles in adipogenesis, influencing protein synthesis pathways and cytoskeleton remodeling, which subsequently impact the lipid storage capacity of mature adipocytes.

SCIENTIFIC REPORTS (2022)

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Article Cell Biology

HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution

Feng-Chih Kuo et al.

Summary: This study identifies the long non-coding RNA HOTAIR as a key regulator of adipocyte development and gene expression in gluteal adipose tissue. HOTAIR interacts with PRC2 to repress target genes involved in adipocyte lineage determination and modifies the transcriptome through alternative splicing. HOTAIR expression is maintained by open chromatin regions and can be influenced by hormonal and genetic factors.

CELL REPORTS (2022)

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Article Endocrinology & Metabolism

Adipose depot-specific effects of 16 weeks of pioglitazone on in vivo adipogenesis in women with obesity: a randomised controlled trial

Ursula White et al.

Summary: Pioglitazone may elicit distinct differences in in vivo adipogenesis in subcutaneous adipose depots in women with obesity, with increased rates in the protective scFEM.

DIABETOLOGIA (2021)

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Article Endocrinology & Metabolism