期刊
NANOTECHNOLOGY
卷 27, 期 22, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/27/22/225101
关键词
polyaniline; hyaluronic acid; cancer; colorimetric probes; redox environment
资金
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT, and Future Planning [2015R1A2A1A05001887, 2014R1A1A2059806]
- National Research Foundation of Korea [2014R1A1A2059806, 2015R1A2A1A05001887] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Stem-like cancer cells possess intrinsic features and their CD44 regulate redox balance in cancer cells to survive under stress conditions. Thus, we have fabricated biomarker-specific conjugated polyplexes using CD44-targetable hyaluronic acid and redox-sensible polyaniline based on a nanoemulsion method. For the most sensitive recognition of the cellular redox at a single nanoparticle scale, a nano-scattering spectrum imaging analyzer system was introduced. The conjugated polyplexes showed a specific targeting ability toward CD44-expressing cancer cells as well as a dramatic change in its color, which depended on the redox potential in the light-scattered images. Therefore, these polyaniline-based conjugated polyplexes as well as analytical processes that include light-scattering imaging and measurements of scattering spectra, clearly establish a systematic method for the detection and monitoring of cancer microenvironments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据