4.6 Article

High efficacy of chlorfenapyr-based net Interceptor((R)) G2 against pyrethroid-resistant malaria vectors from Cameroon

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biology

Molecular drivers of insecticide resistance in the Sahelo-Sudanian populations of a major malaria vector Anopheles coluzzii

Sulaiman S. Ibrahim et al.

Summary: Transcriptional analysis of Anopheles coluzzii populations from the Sahel region revealed overexpression of genes associated with insecticide resistance, including CYP450s, glutathione S-transferases, carboxylesterases, and cuticular proteins. High frequencies of known markers of resistance were also observed. These findings have important implications for malaria control efforts and regional collaboration.

BMC BIOLOGY (2023)

Article Infectious Diseases

High vector diversity and malaria transmission dynamics in five sentinel sites in Cameroon

Etienne Fondjo et al.

Summary: A two-year malaria vector surveillance was conducted in Cameroon to inform vector control intervention decision making. The study revealed high intensity malaria transmission in Cameroon and the importance of different mosquito species as malaria vectors in different areas. These findings will support the National Malaria Control Program in designing evidence-based malaria vector control strategies and reducing malaria transmission and burden.

MALARIA JOURNAL (2023)

Article Infectious Diseases

Comparative study of the effect of solvents on the efficacy of neonicotinoid insecticides against malaria vector populations across Africa

Magellan Tchouakui et al.

Summary: This study compares the susceptibility of malaria vectors to neonicotinoids using three different solvents. The results show that different solvents lead to different mortality rates, and it is recommended to use both acetone alone and acetone + MERO to monitor the resistance profile of mosquito populations.

INFECTIOUS DISEASES OF POVERTY (2022)

Article Multidisciplinary Sciences

Fitness cost of target-site and metabolic resistance to pyrethroids drives restoration of susceptibility in a highly resistant Anopheles gambiae population from Uganda

Magellan Tchouakui et al.

Summary: The An gambiae population in Uganda exhibits high intensity of resistance to certain insecticides, resulting in the loss of efficacy of long-lasting insecticidal nets. However, the susceptibility to most insecticides can be restored in less than 10 generations in the absence of selection pressure. Early rotation of insecticides can help manage resistance to insecticides.

PLOS ONE (2022)

Article Genetics & Heredity

Molecular Drivers of Multiple and Elevated Resistance to Insecticides in a Population of the Malaria Vector Anopheles gambiae in Agriculture Hotspot of West Cameroon

Arnaud Tepa et al.

Summary: The main malaria vector Anopheles gambiae in a pesticide-driven agricultural hotspot in Cameroon has developed resistance to multiple insecticides, leading to a loss in the efficacy of control interventions.
Article Infectious Diseases

Escalating pyrethroid resistance in two major malaria vectors Anopheles funestus and Anopheles gambiae (s.l.) in Atatam, Southern Ghana

Leon M. J. Mugenzi et al.

Summary: This study investigated the intensity of insecticide resistance in two major malaria vectors collected in southern Ghana and assessed the effectiveness of long-lasting insecticidal nets (LLINs) against these mosquitoes. The results showed that both species exhibited high levels of resistance to certain insecticide classes, leading to a reduction in the effectiveness of LLINs. Furthermore, the study characterized the molecular markers associated with insecticide resistance in these mosquitoes.

BMC INFECTIOUS DISEASES (2022)

Article Biochemistry & Molecular Biology

The cytochrome P450 CYP325A is a major driver of pyrethroid resistance in the major malaria vector Anopheles funestus in Central Africa

Amelie N. R. Wamba et al.

Summary: The study confirmed the overexpression of CYP325A in pyrethroid-resistant Anopheles funestus from Cameroon, leading to metabolic resistance to insecticides. High genetic polymorphism was observed, along with noticeable geographical amino acid changes. Analysis of the promoter region of CYP325A suggested a potential selective sweep in resistant mosquitoes.

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

Article Infectious Diseases

Assessing the efficacy of two dual-active ingredients long-lasting insecticidal nets for the control of malaria transmitted by pyrethroid-resistant vectors in Benin: study protocol for a three-arm, single-blinded, parallel, cluster-randomized controlled trial

Manfred Accrombessi et al.

Summary: This study in Benin aims to assess the impact of two novel LLINs on malaria transmission. The three study arms will use different formulations of LLINs and monitor malaria incidence and mosquito populations over 24 months. The results will contribute to shaping future malaria control strategies in sub-Saharan Africa.

BMC INFECTIOUS DISEASES (2021)

Article Infectious Diseases

Efficacy of interceptor® G2, a long-lasting insecticide mixture net treated with chlorfenapyr and alpha-cypermethrin against Anopheles funestus: experimental hut trials in north-eastern Tanzania

Patrick K. Tungu et al.

Summary: The study demonstrates that the Interceptor G2 LLIN has high efficacy against pyrethroid-resistant Anopheles funestus, primarily due to the chlorfenapyr component. In addition, IG2 can effectively inhibit blood-feeding behavior of pyrethroid-resistant mosquitoes, making it a promising malaria control method.

MALARIA JOURNAL (2021)

Article Microbiology

Pyrethroid Resistance Aggravation in Ugandan Malaria Vectors Is Reducing Bednet Efficacy

Magellan Tchouakui et al.

Summary: The study revealed high intensity of pyrethroid resistance in major malaria vectors in Uganda, leading to reduced effectiveness of insecticide-treated nets. The over-expression of cytochrome P450 genes may not be the only resistance mechanism involved in this case. Urgent action should be taken to prevent the spread of super-resistance in malaria vectors.

PATHOGENS (2021)

Article Biochemistry & Molecular Biology

Pyrethroid and Etofenprox Resistance in Anopheles gambiae and Anopheles coluzzii from Vegetable Farms in Yaounde, Cameroon: Dynamics, Intensity and Molecular Basis

Michael Piameu et al.

Summary: A study conducted in a city in Cameroon revealed widespread insecticide resistance in malaria vector populations, with fluctuating resistance intensity, detection of multiple resistance-associated molecular markers, and highly upregulated gene expression levels, posing potential challenges for future malaria control interventions.

MOLECULES (2021)

Review Medicine, General & Internal

Piperonyl butoxide (PBO) combined with pyrethroids in insecticide-treated nets to prevent malaria in Africa

Katherine Gleave et al.

Summary: The addition of the synergist Piperonyi butoxide (PBO) to pyrethroid long-lasting insecticidal nets (LLINs) significantly improves efficacy in areas with high Anopheles mosquito insecticide resistance, but the effects vary based on the level of resistance in different areas.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2021)

Article Medicine, General & Internal

Averting a malaria disaster: will insecticide resistance derail malaria control?

Janet Hemingway et al.

LANCET (2016)

Review Medicine, General & Internal

Indoor residual spraying for preventing malaria

Bianca Pluess et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2010)

Editorial Material Infectious Diseases

Lessons from the past: managing insecticide resistance in malaria control and eradication programmes

Louise Kelly-Hope et al.

LANCET INFECTIOUS DISEASES (2008)

Article Entomology

Insecticide-treated bed nets and curtains for preventing malaria

BG Koudou et al.

MEDICAL AND VETERINARY ENTOMOLOGY (2005)

Review Entomology

Safety of pyrethroid-treated mosquito nets

M Zaim et al.

MEDICAL AND VETERINARY ENTOMOLOGY (2000)