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Review
Genetics & Heredity
E. Sila Ozdemir et al.
Summary: The formation of Ras multimers, such as dimers and nanoclusters, is a new and exciting research area in the field of Ras biomedicine. Significant progress has been made in understanding the structure of Ras multimers and the mechanisms that regulate their formation. This article synthesizes current knowledge on Ras multimers, particularly the presence of multiple G-domain interfaces, and explores how membrane nanodomain composition and structure influence their formation.
Review
Genetics & Heredity
Ana Herrero et al.
Summary: Signals transmitted through the RAS-ERK pathway play a crucial role in cancer-related cellular processes. RAS dimerization, especially at membrane microdomains, is essential for RAF activation and can be targeted pharmacologically to prevent tumorigenesis.
Review
Genetics & Heredity
Erin Sheffels et al.
Summary: The non-mutated wild-type (WT) RAS proteins in RAS-mutated cancers play an important role in modulating downstream effector signaling and driving therapeutic resistance, with different WT RAS family members having opposing functions. Researchers have renewed interest in upstream signaling molecules as potential therapeutic targets in RAS-mutated cancers.
Review
Genetics & Heredity
Alberto Fernandez-Medarde et al.
Summary: Since the early 1980s, research on the RAS family of small GTPases has significantly advanced our understanding of cancer biology. Despite the vast amount of available basic knowledge, specific effective treatments for RAS-driven cancers are still lacking.
Review
Genetics & Heredity
Olga Soriano et al.
Summary: Ras and Rho proteins, which are GTP-regulated molecular switches in eukaryotic cells, control multiple signaling pathways. Ras mainly promotes proliferation and survival through the MAPK and PI3K/AKT pathways, while Rho critically regulates microfilament dynamics. These two pathways intersect at various points and jointly drive oncogenic transformation.
Review
Genetics & Heredity
Cristina Cuesta et al.
Summary: Ras proteins play a crucial role in cellular processes and their dysregulation is often associated with cancer. While the approval of the first Ras G12C inhibitor is a significant milestone, only a small percentage of patients will benefit. Understanding the context in which Ras operates in different tumor types, along with the outcomes mediated by each effector pathway, may help identify additional strategies and targets for treating Ras-driven tumors.
Review
Genetics & Heredity
Miriam Molina-Arcas et al.
Summary: This article discusses the treatment of RAS mutations and the progress in developing KRAS-G12C inhibitors, exploring potential approaches to overcome resistance and extend durability of response through combination therapy. It also mentions novel targeting approaches for non-G12C mutations.
Review
Genetics & Heredity
Jose M. Munoz-Felix et al.
Summary: Renal fibrosis is a complex process, with signaling pathways mediated by transforming growth factor-beta 1 (TGF-beta 1) and Ras GTPases playing key roles in the regulation of kidney pathological processes.
