☆ 4.6 Article

Obesity Contributes to Transformation of Myometrial Stem-Cell Niche to Leiomyoma via Inducing Oxidative Stress, DNA Damage, Proliferation, and Extracellular Matrix Deposition

GENES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Nutrition & Dietetics

Adipocyte and Adipokines Promote a Uterine Leiomyoma Friendly Microenvironment

Sadia Afrin et al.

Summary: This study investigated the effects of adipocyte coculture and leptin treatment on human myometrium and leiomyoma cells. The results showed that coculture and leptin treatment increased the expression of JAK2/STAT3, MAPK/ERK, and PI3k/AKT signaling pathways, as well as promoting the upregulation of tumor-related inflammatory, fibrotic, and angiogenic factors, and increasing leiomyoma cell growth. These findings suggest that adipocytes or their secreted hormones may contribute to leiomyoma development and growth by activating leptin receptor signaling pathways.

NUTRIENTS (2023)

添加到收藏夹

Article Medicine, General & Internal

Correlation between inflammatory marker and lipid metabolism in patients with uterine leiomyomas

Yanan Duan et al.

Summary: There is an independent relationship between inflammatory markers and triglycerides (TG) in patients with uterine leiomyoma (UL).

FRONTIERS IN MEDICINE (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Adipocyte coculture induces a pro-inflammatory, fibrotic, angiogenic, and proliferative microenvironment in uterine leiomyoma cells

Sadia Afrin et al.

Summary: The aim of this study was to determine the cellular and molecular mechanisms by which adipocytes contribute to the initiation and promotion of uterine leiomyoma tumors. The results showed that adipocytes promote inflammation, fibrosis, and angiogenesis in leiomyoma cells by upregulating associated factors and transferring free fatty acids. Adipocyte-leiomyoma cell interaction increases the phosphorylation of NF-.B and enhances cell proliferation.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2023)

添加到收藏夹

Review Biology

Uterine Transcriptome: Understanding Physiology and Disease Processes

Gregory W. Kirschen et al.

Summary: RNA sequencing has advanced our understanding of the cellular complexity and dynamics underlying normal menstruation and gynecological disorders. Single-cell RNA sequencing has revealed novel endometrial cell subpopulations and their aberrant activity in pathological states, providing insights for developing novel therapeutic interventions.

BIOLOGY-BASEL (2023)

添加到收藏夹

Article Obstetrics & Gynecology

Beta blockers reduce uterine fibroid incidence in hypertensive women

Nicole M. Fischer et al.

Summary: This study found that hypertensive women using beta blockers had a 15% lower odds of developing clinically recognized leiomyomas compared to non-users, especially in the age group of 30-39. Propranolol and metoprolol showed significant associations with reduced uterine fibroid incidence. These findings have clinical relevance for hypertensive women as beta blocker use can both manage hypertension and curb the increased risk of leiomyomas.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2023)

添加到收藏夹

Article Chemistry, Medicinal

PEGylated Polymeric Nanoparticles Loaded with 2-Methoxyestradiol for the Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model

Sanaalarab Al Enazy et al.

Summary: This study evaluated the in vivo effect of biodegradable and biocompatible 2-ME-loaded polymeric nanoparticles in a patient-derived leiomyoma xenograft mouse model. The results showed that the nanoparticles effectively inhibited the growth of xenografted tumors, indicating their potential as a novel treatment for uterine fibroids.

JOURNAL OF PHARMACEUTICAL SCIENCES (2023)

添加到收藏夹

Article Obstetrics & Gynecology

Cardiometabolic profile of women with uterine leiomyoma: a cross-sectional study

Abdelrahman Alashqar et al.

Summary: This study found that uterine leiomyoma is associated with cardiometabolic comorbidities such as obesity, metabolic syndrome, hypertension, diabetes mellitus, and hyperlipidemia. Additionally, the use of statins was found to be associated with a lower risk of uterine leiomyoma.

MINERVA OBSTETRICS AND GYNECOLOGY (2023)

添加到收藏夹

Article Cell Biology

The miR-23-27-24 clusters drive lipid-associated macrophage proliferation in obese adipose tissue

Neil T. Sprenkle et al.

Summary: This study shows that knockout of the miR-23-27-24 miRNA gene cluster in mice leads to reduced weight gain on a high-fat diet but worsened glucose and insulin tolerance. Further analysis reveals decreased numbers and proliferation of a subset of lipid-associated CD9+Trem2+ ATMs in the adipose tissue of these mice. The researchers identify Eif4ebp2 mRNA as a direct target of miR-23, a gene that regulates protein synthesis and proliferation in macrophages. Overall, this study highlights the importance of noncoding RNAs in controlling the proliferation of protective macrophages in adipose tissue, thus impacting metabolic dysfunction associated with diet-induced obesity.

CELL REPORTS (2023)

添加到收藏夹

Article Cell Biology

Simvastatin inhibits stem cell proliferation in human leiomyoma via TGF-beta 3 and Wnt/beta-Catenin pathways

Sadia Afrin et al.

Summary: The study found that simvastatin has anti-proliferative and apoptosis-inducing effects on uterine leiomyoma stem cells. It also suppressed the expression of stemness markers and key extracellular matrix proteins. Additionally, simvastatin inhibited the expression of key genes and/or proteins in the TGF-beta and Wnt4 pathways.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hypoxia induces proliferation via NOX4-Mediated oxidative stress and TGF-β3 signaling in uterine leiomyoma cells

Mariko Miyashita-Ishiwata et al.

Summary: This study demonstrates that hypoxia induces proliferation and inhibits apoptosis in leiomyoma cells, possibly mediated by increased ROS generation and NOX4 expression. It also identifies a novel autocrine mechanism involving TGF-beta 3, which plays a crucial role in hypoxia-induced effects. Inhibition of this autocrine factor attenuates hypoxia-induced NOX4 expression and cell proliferation.

FREE RADICAL RESEARCH (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Myometrial oxidative stress drives MED12 mutations in leiomyoma

Yinuo Li et al.

Summary: The study identified a clear connection between increased oxidative stress in myometrial cells and a high rate of MED12 mutations, which may explain the risk and severity of leiomyomas in women of reproductive age.

CELL AND BIOSCIENCE (2022)

添加到收藏夹

Article Genetics & Heredity

A Possible Cause for the Differential Expression of a Subset of miRNAs in Mesenchymal Stem Cells Derived from Myometrium and Leiomyoma

Mariangela Di Vincenzo et al.

Summary: This study investigates the role of miRNA in the development of leiomyoma, suggesting that differentially regulated miRNA may be involved in both the initiation and exacerbation of the disease, and that miRNA may be related to epigenetic predisposition.

GENES (2022)

添加到收藏夹

Article Medicine, General & Internal

The Potential of Transforming Growth Factor-beta Inhibitor and Vascular Endothelial Growth Factor Inhibitor as Therapeutic Agents for Uterine Leiomyoma

Jung Yoon Park et al.

Summary: This study evaluated the expression of various growth factors in uterine leiomyoma and compared the effects of existing medication and specific growth factor inhibitors on leiomyoma and normal myometrium. TGF-beta and VEGF inhibitors showed stronger therapeutic effects than the conventional drug UPA for treating uterine leiomyoma.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Angiotensin-Converting Enzyme Inhibitors Reduce Uterine Fibroid Incidence in Hypertensive Women

Nicole M. Fischer et al.

Summary: The study found that adult hypertensive women who used ACE inhibitors had a reduced odds of developing clinically recognized leiomyoma compared to non-users by approximately 31.8%. This association was significant across all age groups (30-39 years, 40-49 years, 50-59 years, 60-65 years). Specifically, lisinopril, quinapril, and ramipril were significantly associated with reduced leiomyoma incidence.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

添加到收藏夹

Review Reproductive Biology

Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies

Abdelrahman AlAshqar et al.

Summary: Inflammation plays a crucial role in the development of common benign gynecologic disorders by promoting proliferation, angiogenesis, and lesion progression. The interaction between inflammation and benign gynecologic disorders is influenced by various factors such as sex steroids, genetics, epigenetics, extracellular matrix, stem cells, cardiometabolic risk factors, diet, vitamin D, and the immune system.

BIOLOGY OF REPRODUCTION (2021)

添加到收藏夹

Review Medicine, Research & Experimental

The complex role of adipokines in obesity, inflammation, and autoimmunity

Erin B. Taylor

Summary: The global obesity epidemic contributes to chronic low-grade inflammation and disease pathology through the dysregulation of adipokine production. Adipokines play a crucial role in immune response modulation, with implications in rheumatic and autoimmune diseases.

CLINICAL SCIENCE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

New Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes

Adela-Viviana Sitar-Taut et al.

Summary: The study aimed to assess the relationship between adipokines such as leptin and ghrelin and their ratio with obesity and diabetes. Results showed that obese patients had higher leptin values and leptin/ghrelin ratios, with significant differences found in analyses stratified by obesity and gender. Obesity and diabetes were associated with changes in the levels of adipokines, even in overweight subjects, indicating a basis for early intervention in diabetic and obese patients.

BIOMEDICINES (2021)

添加到收藏夹

Review Endocrinology & Metabolism

Leptin and Obesity: Role and Clinical Implication

Milan Obradovic et al.

Summary: Leptin, a peptide hormone, regulates food intake, body mass, and reproductive function, playing a crucial role in fetal growth, immune responses, angiogenesis, and lipolysis. Leptin resistance can lead to reduced satiety, overconsumption of nutrients, and increased body mass, potentially causing obesity. Combining leptin therapies with sensitizers may help overcome resistance and treat obesity effectively.

FRONTIERS IN ENDOCRINOLOGY (2021)

添加到收藏夹

Review Developmental Biology

Vascular biology of uterine fibroids: connecting fibroids and vascular disorders

Gregory W. Kirschen et al.

Summary: Fibroids are benign tumors caused by the proliferation of myometrial smooth muscle cells in the uterus, potentially linked with the systemic vasculature system. They are associated with essential hypertension, preeclampsia, and atherosclerosis. Factors such as the renin-angiotensin-aldosterone system, estrogen, and endothelial dysfunction likely play a role in fibroid pathogenesis.

REPRODUCTION (2021)

添加到收藏夹

Review Nutrition & Dietetics

Diet and Nutrition in Gynecological Disorders: A Focus on Clinical Studies

Sadia Afrin et al.

Summary: Nutritional factors and dietary habits play a significant role in the development of gynecological diseases, with diets rich in fruits, vegetables, green tea, and vitamin D potentially having a positive impact, while fats, red meat, alcohol, and coffee may contribute to disease development. Conflicting data on the association between dietary habits and gynecological disorders indicate the need for further research to clarify the impact of various factors in disease prevention and development.

NUTRIENTS (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Relationship between early follicular serum estrone level and other hormonal or ultrasonographic parameters in women with polycystic ovary syndrome

Sungwook Chun

GYNECOLOGICAL ENDOCRINOLOGY (2020)

添加到收藏夹

Article Obstetrics & Gynecology

CXCL12 Attracts Bone Marrow-Derived Cells to Uterine Leiomyomas

Irene Moridi et al.

REPRODUCTIVE SCIENCES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Differential contribution of Nox1, Nox2 and Nox4 to kidney vascular oxidative stress and endothelial dysfunction in obesity

Mercedes Munoz et al.

REDOX BIOLOGY (2020)

添加到收藏夹

Article Biology

Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes

Ryogo Furuhata et al.

COMMUNICATIONS BIOLOGY (2020)

添加到收藏夹

Article Obstetrics & Gynecology

Lower prevalence of non-cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility

Hao Huang et al.

FERTILITY AND STERILITY (2019)

添加到收藏夹

Article Obstetrics & Gynecology

Cardiometabolic Risk Factors and Benign Gynecologic Disorders

Abdelrahman AlAshqar et al.

OBSTETRICAL & GYNECOLOGICAL SURVEY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Pathogenomics of Uterine Fibroids Development

Vladislav S. Baranov et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Role of Tumor Necrosis Factor in the Biology of Uterine Fibroids and the Related Symptoms

Michal Ciebiera et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Review Obstetrics & Gynecology

Estrogen Receptors and Signaling in Fibroids: Role in Pathobiology and Therapeutic Implications

Mostafa A. Borahay et al.

REPRODUCTIVE SCIENCES (2017)

添加到收藏夹

Review Obstetrics & Gynecology

Activin A in Inflammation, Tissue Repair, and Fibrosis: Possible Role as Inflammatory and Fibrotic Mediator of Uterine Fibroid Development and Growth

Olga Protic et al.

SEMINARS IN REPRODUCTIVE MEDICINE (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Leptin in inflammation and autoimmunity

Antonio La Cava

CYTOKINE (2017)

添加到收藏夹

Review Obstetrics & Gynecology

Combined Oral Contraceptive for Treatment of Women with Uterine Fibroids and Abnormal Uterine Bleeding: A Systematic Review

Rafael M. Moroni et al.

GYNECOLOGIC AND OBSTETRIC INVESTIGATION (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells

Jeong Seon Kim et al.

MOLECULAR CANCER (2015)

添加到收藏夹

Article Agriculture, Dairy & Animal Science

The effect of equine metabolic syndrome on the ovarian follicular environment

D. R. Sessions-Bresnahan et al.

JOURNAL OF ANIMAL SCIENCE (2014)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Pro- and anti-inflammatory cytokine gene expression in subcutaneous and visceral fat in severe obesity

B. Spoto et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2014)

添加到收藏夹

Article Multidisciplinary Sciences

miR-200c Regulates IL8 Expression by Targeting IKBKB: A Potential Mediator of Inflammation in Leiomyoma Pathogenesis

Tsai-Der Chuang et al.

PLOS ONE (2014)

添加到收藏夹

Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

添加到收藏夹

Article Public, Environmental & Occupational Health

Prevalence, symptoms and management of uterine fibroids: an international internet-based survey of 21,746 women

Anne Zimmermann et al.

BMC WOMENS HEALTH (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Functional relevance of the histone γH2Ax in the response to DNA damaging agents

Ingrid Revet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

添加到收藏夹

Article Multidisciplinary Sciences

MED12, the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas

Netta Makinen et al.

SCIENCE (2011)

添加到收藏夹

Article Obstetrics & Gynecology

BMI and Uterine Size: Is There Any Relationship?

Vani Dandolu et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY (2010)

添加到收藏夹

Article Obstetrics & Gynecology

Relationship between metabolic syndrome and uterine leiomyomas: A case-control study

Takashi Takeda et al.

GYNECOLOGIC AND OBSTETRIC INVESTIGATION (2008)

添加到收藏夹

Article Obstetrics & Gynecology

Polycystic ovary syndrome and risk of uterine leiomyomata

Lauren A. Wise et al.

FERTILITY AND STERILITY (2007)

添加到收藏夹

Article Immunology

A key role of leptin in the control of regulatory T cell proliferation

Veronica De Rosa et al.

IMMUNITY (2007)

添加到收藏夹

Article Cell Biology

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

KD Martyn et al.

CELLULAR SIGNALLING (2006)

添加到收藏夹

Article Public, Environmental & Occupational Health

Influence of body size and body fat distribution on risk of uterine leiomyomata in US Black women

LA Wise et al.

EPIDEMIOLOGY (2005)

添加到收藏夹

Review Endocrinology & Metabolism

Adiponectin and adiponectin receptors

T Kadowaki et al.

ENDOCRINE REVIEWS (2005)

添加到收藏夹

Article Endocrinology & Metabolism

Adiponectin is associated with vascular function independent of insulin sensitivity

JM Fernández-Real et al.

DIABETES CARE (2004)

添加到收藏夹

Article Endocrinology & Metabolism

Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation

KCB Tan et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)

添加到收藏夹

Article Endocrinology & Metabolism

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets:: Possible role of oxidative stress

S Piro et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2002)

添加到收藏夹

Article Medicine, Research & Experimental

Elevated serum leptin concentrations induced by experimental acute inflammation

O Gualillo et al.

LIFE SCIENCES (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.