期刊
GENES
卷 14, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/genes14101913
关键词
Parkinson's disease; telomere length; mitochondrial DNA copy number; dopaminergic replacement therapy; aging; inflammatory index; IL-17A
This study measured mtDNA-CN and TL in PBMCs of PD patients and found shorter TL in patients compared to controls at all time points, while mtDNA-CN showed no differences. Treated patients had increased mtDNA-CN and TL, and there was a strong correlation between TL and mtDNA-CN. IL-17A levels were positively correlated with mtDNA-CN only in untreated patients.
Parkinson's disease (PD) pathophysiology includes mitochondrial dysfunction, neuroinflammation, and aging as its biggest risk factors. Mitochondrial DNA copy number (mtDNA-CN) and telomere length (TL) are biological aging markers with inconclusive results regarding their association with PD. A case-control study was used to measure TL and mtDNA-CN using qPCR in PBMCs. PD patients were naive at baseline (T0) and followed-up at one (T1) and two (T2) years after the dopaminergic treatment (DRT). Plasmatic cytokines were determined by ELISA in all participants, along with clinical parameters of patients at T0. While TL was shorter in patients vs. controls at all time points evaluated (p < 0.01), mtDNA-CN showed no differences. An increase in mtDNA-CN and TL was observed in treated patients vs. naive ones (p < 0.001). Our statistical model analyzed both aging markers with covariates, showing a strong correlation between them (r = 0.57, p < 0.01), and IL-17A levels positively correlating with mtDNA-CN only in untreated patients (r = 0.45, p < 0.05). TL and mtDNA-CN could be useful markers for monitoring inflammation progression or treatment response in PD. DRT might modulate TL and mtDNA-CN, reflecting a compensatory mechanism to counteract mitochondrial dysfunction in PD, but this needs further investigation.
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