期刊
GENES
卷 14, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/genes14071319
关键词
multiple sclerosis; neuromyelitis optica spectrum disorders; genetic basis; inflammatory demyelinating disease; genes
Demyelinating diseases affect the myelin or coating of nerve fibers in the central and peripheral nervous systems. Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are two distinct disease categories with similar underlying mechanisms. By studying genetic factors, clinical manifestations, and lesion pathology, researchers have made progress in differential diagnosis and understanding disease pathogenesis.
Demyelinating diseases alter myelin or the coating surrounding most nerve fibers in the central and peripheral nervous systems. The grouping of human central nervous system demyelinating disorders today includes multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) as distinct disease categories. Each disease is caused by a complex combination of genetic and environmental variables, many involving an autoimmune response. Even though these conditions are fundamentally similar, research into genetic factors, their unique clinical manifestations, and lesion pathology has helped with differential diagnosis and disease pathogenesis knowledge. This review aims to synthesize the genetic approaches that explain the differential susceptibility between these diseases, explore the overlapping clinical features, and pathological findings, discuss existing and emerging hypotheses on the etiology of demyelination, and assess recent pathogenicity studies and their implications for human demyelination. This review presents critical information from previous studies on the disease, which asks several questions to understand the gaps in research in this field.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据