4.7 Article

Inadequate gastric preparation and its associated factors for magnetically controlled capsule endoscopy

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FRONTIERS IN PHARMACOLOGY
卷 14, 期 -, 页码 -

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FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2023.1184754

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magnetically controlled capsule endoscopy; gastric disease; preparation; proton pump inhibitor; simethicone

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This study aimed to explore factors associated with inadequate gastric preparation for magnetically controlled capsule endoscopy (MCE). The use of proton pump inhibitors (PPIs) and premedication time less than 30 minutes were identified as independent risk factors for inadequate gastric preparation. The quality of gastric preparation may be influenced by the type, dose, duration, and discontinuation time of PPIs. Appropriate control of premedication type and time may be crucial for improving overall gastric cleanliness.
Goals: To explore factors associated with inadequate gastric preparation for MCE.Background: Factors associated with inadequate gastric preparation for magnetically controlled capsule endoscopy (MCE) remains unclear.Study: Data of patients who underwent MCE from June 2021 to July 2022 were prospectively collected. The gastric cleanliness score (GCS) of the six stomach regions (gastric cardia, fundus, body, angulus, antrum, and pylorus) was recorded. Patients with GCS score =18 were defined as the adequate preparation. Factors related to inadequate gastric preparation were analyzed using a logistic regression model with estimated odds ratios (OR).Results: The mean GCS score of 211 patients was 17.01 & PLUSMN; 2.82. In the multivariable analysis, proton pump inhibitor (PPI) use (OR 3.57; 95% CI 1.69-7.95; p < 0.01) and premedication time after administering simethicone <30 min (OR 2.86; 95% CI 1.10-7.39; p = 0.03) were independent risk factors for inadequate gastric preparation. Comparing the gastric cleanliness of different locations, the median GCS of the lower stomach [10.00, IQR (9.50, 11.00)] was significantly higher than that of the upper stomach [7.00, IQR (6.00, 8.00)] (p <0.001).Conclusion: PPI use and inadequate premedication time (<30 min) may reduce the quality of gastric preparation for MCE. The type, dose, duration of medication, and discontinuation time of PPIs was well worth further exploration. Appropriate control of the type and time of premedication may be the key to improving overall gastric cleanliness.

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