期刊
FRONTIERS IN PHARMACOLOGY
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2023.1186712
关键词
TME; tumor microenvironment; ECM; extracellular matrix; CAFs; cancer-associated fibroblasts; TAMs; tumor-associated macrophages; HA; hyaluronic acid; MMPs; matrix metalloproteinases; HSPGs; heparan sulfate proteoglycans; TGF & beta;; transforming growth factor beta
The extracellular matrix (ECM) plays a crucial role in the tumor microenvironment (TME) and has become the focus of cancer research and treatment. Multiple cell signaling pathways in ECM remodeling contribute to uncontrolled cancer growth, metastasis, immune evasion, and drug resistance. Targeting ECM remodeling could be a novel strategy for different stages of cancer and overcoming drug resistance.
Extracellular matrix (ECM) plays a pivotal and dynamic role in the construction of tumor microenvironment (TME), becoming the focus in cancer research and treatment. Multiple cell signaling in ECM remodeling contribute to uncontrolled proliferation, metastasis, immune evasion and drug resistance of cancer. Targeting trilogy of ECM remodeling could be a new strategy during the early-, middle-, advanced-stages of cancer and overcoming drug resistance. Currently nearly 60% of the alternative anticancer drugs are derived from natural products or active ingredients or structural analogs isolated from plants. According to the characteristics of ECM, this manuscript proposes three phases of whole-process management of cancer, including prevention of cancer development in the early stage of cancer (Phase I); prevent the metastasis of tumor in the middle stage of cancer (Phase II); provide a novel method in the use of immunotherapy for advanced cancer (Phase III), and present novel insights on the contribution of natural products use as innovative strategies to exert anticancer effects by targeting components in ECM. Herein, we focus on trilogy of ECM remodeling and the interaction among ECM, cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs), and sort out the intervention effects of natural products on the ECM and related targets in the tumor progression, provide a reference for the development of new drugs against tumor metastasis and recurrence.
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