Therapeutic mechanisms of ginseng in coronary heart disease

Article Endocrinology & Metabolism

Association between sensitivity to thyroid hormones and risk of arrhythmia in patients with coronary heart disease: a RCSCD-TCM study in China

Fanfan Liu et al.

Summary: There is a significant association between sensitivity to thyroid hormone and risk of arrhythmia in patients with coronary heart disease (CHD), especially among women, elderly individuals, and those with dyslipidemia or diabetes.

ENDOCRINE (2023)

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Review Mathematical & Computational Biology

Research Progress of Machine Learning and Deep Learning in Intelligent Diagnosis of the Coronary Atherosclerotic Heart Disease

Haoxuan Lu et al.

Summary: Early, precise, and comprehensive diagnosis of coronary atherosclerotic heart disease is of great significance. Artificial intelligence has made significant progress in this field, including the construction of intelligent diagnostic models and the application of various imaging techniques.

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE (2022)

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Review Plant Sciences

Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles

Sun Hee Hyun et al.

Summary: Asian ginseng or Korean ginseng, Panax ginseng, has been traditionally used in Korea and China for the treatment of various diseases. Its main active component, ginsenoside, is known for its pharmacological effects such as antioxidant, anti-inflammatory, and anti-diabetic properties, which can prevent cardiovascular diseases and oxidative stress-related damage.

JOURNAL OF GINSENG RESEARCH (2022)

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Article Endocrinology & Metabolism

Residual Risk of Coronary Atherosclerotic Heart Disease and Severity of Coronary Atherosclerosis Assessed by ApoB and LDL-C in Participants With Statin Treatment: A Retrospective Cohort Study

Tianci Yao et al.

Summary: Elevated apoB levels are associated with the severity and residual risk of coronary atherosclerotic heart disease in participants with statin treatment, while elevated LDL-C levels are not significantly associated with these outcomes.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Review Medicine, General & Internal

How to fill the GAPS-I in secondary prevention: application of a strategy based on GLP1 analogues, antithrombotic agents, PCSK9 inhibitors, SGLT2 inhibitors and immunomodulators

Pierre Sabouret et al.

Summary: The continuous progress in cardiovascular risk prevention strategies has led to a reduction in mortality and recurrent ischemic events in patients with coronary artery disease (CAD). However, the control of several cardiovascular risk factors remains suboptimal in many CAD patients. The GAPS-I strategy offers a promising potential in patients with high residual cardiovascular risk, by addressing their individual risk factors.

PANMINERVA MEDICA (2022)

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Article Medicine, Research & Experimental

Ginsenoside Rb3 upregulates sarcoplasmic reticulum Ca2+-ATPase expression and improves the contractility of cardiomyocytes by inhibiting the NF-?B pathway

Mingyan Shao et al.

Summary: This study found that G-Rb3 improves cardiac function and reduces inflammation by inhibiting the nuclear translocation of NF-KB p65, reducing the levels of the inflammatory marker CD45, and enhancing the expression of key proteins in the contraction unit. Further experiments confirmed that G-Rb3 improves cardiac function by suppressing the blockage of NF-KB p65 on the SERCA2a promoter and increasing SERCA2a expression.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Pharmacology & Pharmacy

Ginsenoside Rc ameliorated atherosclerosis via regulating gut microbiota and fecal metabolites

Bin Xie et al.

Summary: This study investigated the potential mechanism of ginsenoside Rc (GRc) in treating cardiovascular diseases by examining its effects on atherosclerosis and gut microbiota in mice. The results showed that GRc alleviated atherosclerotic injury and regulated the composition and metabolomic changes of gut microbiota.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

A New Mechanism for Ginsenoside Rb1 to Promote Glucose Uptake, Regulating Riboflavin Metabolism and Redox Homeostasis

Yihan Liu et al.

Summary: This study identified saponins in American ginseng as potential promoters of glucose uptake, with riboflavin metabolism playing a key role in the facilitation of glucose transport.

METABOLITES (2022)

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Review Cardiac & Cardiovascular Systems

Dual pathway inhibition for atherosclerotic cardiovascular disease: Recent advances

Stephanie Carlin et al.

Summary: Atherosclerotic cardiovascular disease (ASCVD) is a serious condition that is associated with significant morbidity, mortality, and healthcare costs. Antiplatelet therapy, especially the dual pathway inhibition (DPI) strategy of combining aspirin and low-dose rivaroxaban, has shown benefits and cost-effectiveness in preventing ASCVD events. The absolute benefits of DPI therapy vary depending on the type and history of the disease. Additional trials are being conducted to assess the impact of DPI therapy in other populations of interest.

KARDIOLOGIA POLSKA (2022)

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Article Medicine, General & Internal

Acute Myocardial Infarction Associated With a Mobile Left Ventricular Thrombi

Gaspar Del Rio-Pertuz et al.

Summary: The majority of acute coronary syndromes are caused by thrombotic occlusions in the coronary artery as a result of plaque erosion or rupture. Coronary embolism, which is often overlooked, can also be an important underlying cause of acute coronary syndrome. This case report describes a young patient with ST elevation myocardial infarction suspected to be caused by coronary embolization originating from a left ventricular thrombus.

JOURNAL OF INVESTIGATIVE MEDICINE HIGH IMPACT CASE REPORTS (2022)

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Review Hematology

Interplay between platelets and coagulation

Yaqiu Sang et al.

Summary: Haemostasis is a regulated physiological process involving interactions between endothelial cells, platelets, von Willebrand factor, and coagulation factors. Platelets and coagulation mutually influence each other to effectively stop bleeding by forming a platelet plug.

BLOOD REVIEWS (2021)

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Review Pharmacology & Pharmacy

Ginsenosides for cardiovascular diseases; update on pre-clinical and clinical evidence, pharmacological effects and the mechanisms of action

Michael Sarhene et al.

Summary: Cardiovascular disease is a major cause of global mortality, with ginseng and ginsenosides showing potential benefits in preclinical studies. However, more research and large-scale clinical trials are needed before they can be effectively utilized in the treatment of CVDs.

PHARMACOLOGICAL RESEARCH (2021)

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Review Medicine, General & Internal

PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews

Matthew J. Page et al.

Summary: The methods and results of systematic reviews should be reported in sufficient detail to allow users to assess trustworthiness. PRISMA 2020 aims to improve the transparency and completeness of systematic review reporting, in hopes of guiding more accurate and transparent reporting.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Food Science & Technology

Protective effects of ginsenoside Rc against acute cold exposure-induced myocardial injury in rats

Yan Xue et al.

Summary: The study found that ginsenoside Rc could alleviate acute cold exposure-induced myocardial injury in rats by regulating SIRT1 expression and attenuating inflammatory responses.

JOURNAL OF FOOD SCIENCE (2021)

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Review Food Science & Technology

The effects of ginseng on the metabolic syndrome: An updated review

Tahereh Aminifard et al.

Summary: Metabolic syndrome is a group of risk factors including high blood glucose, dyslipidemia, high blood pressure, and high body weight, increasing the risk of diabetes and cardiovascular disorders. Ginseng and its active constituents such as ginsenosides have shown antihyperlipidemia, antihypertension, antihyperglycemic, and anti-obesity effects, which can control metabolic syndrome and related diseases.

FOOD SCIENCE & NUTRITION (2021)

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Article Cardiac & Cardiovascular Systems

Ginsenoside Re Preserves Cardiac Function and Ameliorates Left Ventricular Remodeling in a Rat Model of Myocardial Infarction

Yu Yonghui et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)

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Review Integrative & Complementary Medicine

The efficacy of ginseng supplementation on plasma lipid concentration in adults: A systematic review and meta-analysis

Rahele Ziaei et al.

COMPLEMENTARY THERAPIES IN MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Ginsenoside Rg2 attenuates myocardial fibrosis and improves cardiac function after myocardial infarction via AKT signaling pathway

Xianghai Li et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2020)

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Review Cell Biology

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

Xing Chang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Review Medicine, Research & Experimental

Panax ginseng clinical trials: Current status and future perspectives

Shasha Fan et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Integrative & Complementary Medicine

Academician kai-xian chen talks about the development of traditional chinese medicine and global medicine

Kai-Xian Chen

WORLD JOURNAL OF TRADITIONAL CHINESE MEDICINE (2020)

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Review Pharmacology & Pharmacy

Chemical constituents of Panax ginseng and Panax notoginseng explain why they differ in therapeutic efficacy

Hanbing Liu et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Cell Biology

The role of intestinal microbiota in cardiovascular disease

Mengchao Jin et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Review Peripheral Vascular Disease

Statins in the Prevention and Treatment of Heart Failure: a Review of the Evidence

Matthew M. Y. Lee et al.

CURRENT ATHEROSCLEROSIS REPORTS (2019)

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Article Food Science & Technology

Antihypertensive effects of Korean wild simulated ginseng (Sanyangsam) extracts in spontaneously hypertensive rats

Jae-Nam Moon et al.

FOOD SCIENCE AND BIOTECHNOLOGY (2019)

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Review Cardiac & Cardiovascular Systems

Role of Platelet Activation and Oxidative Stress in the Evolution of Myocardial Infarction

Eduardo Fuentes et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2019)

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Editorial Material Cardiac & Cardiovascular Systems

Cholesterol and Atherosclerotic Cardiovascular Disease: A Lifelong Problem

Samuel S. Gidding et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2019)

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Article Cardiac & Cardiovascular Systems

Aerobic exercise reduces triglycerides by targeting apolipoprotein C3 in patients with coronary heart disease

Yating Wang et al.

CLINICAL CARDIOLOGY (2019)

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Review Cardiac & Cardiovascular Systems

The evolving view of coronary artery calcium and cardiovascular disease risk

Isac C. Thomas et al.

CLINICAL CARDIOLOGY (2018)

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Review Biochemistry & Molecular Biology

The gut microbiota as a novel regulator of cardiovascular function and disease

Micah L. Battson et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2018)

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Article Medicine, General & Internal

Improved survival of hospitalized patients with cardiac arrest due to coronary heart disease after implementation of post-cardiac arrest care A population-based study

Yu Lin et al.

MEDICINE (2018)

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Article Veterinary Sciences

Ginsenoside Rb1 improves cardiac function and remodeling in heart failure

Xian Zheng et al.

EXPERIMENTAL ANIMALS (2017)

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Review Medicine, Research & Experimental

Animal models of coronary heart disease

Jiawei Liao et al.

JOURNAL OF BIOMEDICAL RESEARCH (2017)

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Article Cardiac & Cardiovascular Systems

The utility of the apolipoprotein A1 remnant ratio in predicting incidence coronary heart disease in a primary prevention cohort: The Jackson Heart Study

Heidi T. May et al.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2016)

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Article Integrative & Complementary Medicine

Ginsenoside Rg3 Improves Cardiac Function after Myocardial Ischemia/Reperfusion via Attenuating Apoptosis and Inflammation

Li-ping Zhang et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

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Article Peripheral Vascular Disease

Blood pressure-lowering effect of Korean red ginseng associated with decreased circulating Lp-PLA2 activity and lysophosphatidylcholines and increased dihydrobiopterin level in prehypertensive subjects

Tae Woong Cha et al.

HYPERTENSION RESEARCH (2016)

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Review Peripheral Vascular Disease

The effect of ginseng (genus Panax) on blood pressure: a systematic review and meta-analysis of randomized controlled clinical trials

A. M. Komishon et al.

JOURNAL OF HUMAN HYPERTENSION (2016)

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Article Plant Sciences

Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine-fructose

Kyung Hee Lee et al.

JOURNAL OF GINSENG RESEARCH (2016)

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Article Pharmacology & Pharmacy

An overview on adverse drug reactions to traditional Chinese medicines

Kelvin Chan et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2015)

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Meeting Abstract Cardiac & Cardiovascular Systems

INDUCTION OF PERTURBED SHEAR STRESS LEADS TO FOCAL ADVANCED ATHEROSCLEROTIC PLAQUE FORMATION IN TRANSGENIC MINIPIGS WITH HYPERCHOLESTEROLEMIA

Christian Bo Poulsen et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

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Article Nutrition & Dietetics

Maltol, a Food Flavoring Agent, Attenuates Acute Alcohol-Induced Oxidative Damage in Mice

Ye Han et al.

NUTRIENTS (2015)

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Review Plant Sciences

Review of cases of patient risk associated with ginseng abuse and misuse

Doo Jin Paik et al.

JOURNAL OF GINSENG RESEARCH (2015)

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Article Endocrinology & Metabolism

Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study

Danish Saleheen et al.

LANCET DIABETES & ENDOCRINOLOGY (2015)

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Review Chemistry, Medicinal

Phytochemistry, Metabolism, and Metabolomics of Ginseng

Xiao-peng Chen et al.

CHINESE HERBAL MEDICINES (2015)

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Article Cardiac & Cardiovascular Systems

Modulation of Endothelial Function by Korean Red Ginseng (Panax ginseng CA Meyer) and its Components in Healthy Individuals: A Randomized Controlled Trial

Elena Jovanovski et al.

CARDIOVASCULAR THERAPEUTICS (2014)

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Article Cardiac & Cardiovascular Systems

Mechanisms of Plaque Formation and Rupture

Jacob Fog Bentzon et al.

CIRCULATION RESEARCH (2014)

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Article Biochemistry & Molecular Biology

Relationship between the cholesterol ester transfer protein TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease

J. Li et al.

GENETICS AND MOLECULAR RESEARCH (2014)

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Article Geriatrics & Gerontology

The Role of Macromolecular Damage in Aging and Age-related Disease

Arlan G. Richardson et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)

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Article Nutrition & Dietetics

Anti-inflammation effect of Exercise and Korean red ginseng in aging model rats with diet-induced atherosclerosis

Jin Lee et al.

NUTRITION RESEARCH AND PRACTICE (2014)

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Article Biotechnology & Applied Microbiology

Ginseng Is Useful to Enhance Cardiac Contractility in Animals

Jia-Wei Lin et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Review Biochemistry & Molecular Biology

Oxidative Stress in Aging-Matters of the Heart and Mind

Krishnan Venkataraman et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

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Article Cardiac & Cardiovascular Systems

The Ginsenoside Rg1 Prevents Transverse Aortic Constriction-Induced Left Ventricular Hypertrophy and Cardiac Dysfunction by Inhibiting Fibrosis and Enhancing Angiogenesis

Yao-Jun Zhang et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2013)

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Review Plant Sciences

Advances in study of ginsenoside biosynthesis pathway in Panax ginseng C. A. Meyer

Juan Wang et al.

ACTA PHYSIOLOGIAE PLANTARUM (2012)

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Article Biochemistry & Molecular Biology

Protective Effect of Ginsenoside R0 on Anoxic and Oxidative Damage In vitro

Zhou Jiang et al.

BIOMOLECULES & THERAPEUTICS (2012)

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Article Food Science & Technology

Subchronic toxicity studies with ginsenoside compound K delivered to dogs via intravenous administration

Y. L. Gao et al.

FOOD AND CHEMICAL TOXICOLOGY (2011)

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Article Peripheral Vascular Disease

Effects of Korean Red Ginseng (Panax ginseng CA Mayer) and Its Isolated Ginsenosides and Polysaccharides on Arterial Stiffness in Healthy Individuals

Elena Jovanovski et al.

AMERICAN JOURNAL OF HYPERTENSION (2010)

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Article Chemistry, Medicinal

Effect of Korean Red Ginseng on Blood Pressure and Aortic Vascular(endothelial) Histological Changes in Rats

Journal of Ginseng Research (2010)

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Article Pharmacology & Pharmacy

Inhibitory mechanisms of dihydroginsenoside Rg3 in platelet aggregation: Critical roles of ERK2 and cAMP

Whi Min Lee et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2008)

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Article Chemistry, Medicinal

Korean red ginseng attenuates hypercholesterolemia-enhanced platelet aggregation through suppression of diacylglycerol liberation in high-cholesterol-diet-fed rabbits

Seock-Yeon Hwang et al.

PHYTOTHERAPY RESEARCH (2008)

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Article Engineering, Chemical

Parameters affecting the extraction of ginsenosides from the adventitious roots of ginseng (Panax ginseng CA Meyer)

Sun-Ja Kim et al.

SEPARATION AND PURIFICATION TECHNOLOGY (2007)

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Review Peripheral Vascular Disease

Aspirin for primary prevention of atherosclerotic disease in Japan

Takeshi Morimoto et al.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2007)

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Article Biology

Antioxidative activity of selected fruits and vegetables

Ingrid Zitnanova et al.

BIOLOGIA (2006)

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Review Cardiac & Cardiovascular Systems

Benefits, adverse effects and drug interactions of herbal therapies with cardiovascular effects

G Valli et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2002)

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Article Medicine, General & Internal

Use of lipid lowering drugs for primary prevention of coronary heart disease: meta-analysis of randomised trials

M Pignone et al.

BRITISH MEDICAL JOURNAL (2000)

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Therapeutic mechanisms of ginseng in coronary heart disease

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