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Should oncologists trust cannabinoids?

FRONTIERS IN PHARMACOLOGY (2023)

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Article Oncology

Phase IIb Randomized, Placebo-Controlled, Dose-Escalating, Double-Blind Study of Cannabidiol Oil for the Relief of Symptoms in Advanced Cancer (MedCan1-CBD)

Janet Hardy et al.

Summary: This study examined whether cannabidiol (CBD) oil can improve symptom distress in patients with advanced cancer receiving palliative care. The results showed that CBD oil did not provide additional reduction in symptom distress, indicating that its use in combination with specialist palliative care has no practical value.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Article Oncology

The Effect of Cannabis Plant Extracts on Head and Neck Squamous Cell Carcinoma and the Quest for Cannabis-Based Personalized Therapy

Kifah Blal et al.

Summary: The survival rate of head and neck cancer has only improved slightly over the last 25 years, highlighting the need for new treatment options. This research found that decarboxylated CBD-rich extracts had the strongest anti-tumor effects on head and neck cancer cells, and combining CBD with CBC in a 2:1 ratio enhanced the effect. These findings can help in developing better treatment options for head and neck cancer patients.

CANCERS (2023)

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Article Medicine, Research & Experimental

The protective effect of cannabinoids against colorectal cancer cachexia through modulation of inflammation and immune responses

Shang-Kok Ng et al.

Summary: Cancer cachexia is a complex disorder characterized by weight loss and muscle wasting, with no approved medications available. This study found that six cytokines were upregulated in colorectal cancer patients and mouse models. These cytokines were involved in regulating T cell proliferation, and the infiltration of CD8(+) T cells was associated with muscle atrophy. Cannabinoids were found to attenuate this muscle atrophy via the CB2 pathway. Serum levels of the cytokines may serve as potential biomarkers for the therapeutic effects of cannabinoids in cancer cachexia.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Review Oncology

Multinational Association of Supportive Care in Cancer (MASCC) guidelines: cannabis for psychological symptoms including insomnia, anxiety, and depression

Giulia De Feo et al.

Summary: During cancer treatment, 18% of patients use cannabis to manage symptoms. Anxiety, depression, and sleep disturbances are common psychological symptoms in cancer patients. A systematic review was conducted to assess the evidence for using cannabis to manage psychological symptoms in cancer patients and to develop guidelines.

SUPPORTIVE CARE IN CANCER (2023)

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Review Clinical Neurology

Mechanisms of cancer pain

Rayan Haroun et al.

Summary: Personalized and targeted interventions have improved cancer treatment, but effective pain management for cancer patients is still an issue. Current guidelines fail to address the heterogeneity of cancer pain, and alternative therapeutic targets are needed.

FRONTIERS IN PAIN RESEARCH (2023)

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Editorial Material Psychiatry

Cannabis and Psychosis: Recent Epidemiological Findings Continuing the Causality Debate

Suhas Ganesh et al.

AMERICAN JOURNAL OF PSYCHIATRY (2022)

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Editorial Material Public, Environmental & Occupational Health

PerspectivesRe-legalizing cannabis for medical use in the USA

Brenda Victor et al.

Summary: This paper discusses the history, benefits, and risks of cannabis, as well as the background of the federal re-legalization of cannabis for medical use in the USA. Research data show that medical marijuana may help decrease the use of opioids and benzodiazepines, as well as reduce related overdose deaths.

JOURNAL OF PUBLIC HEALTH (2022)

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Review Chemistry, Medicinal

The Safety of Dronabinol and Nabilone: A Systematic Review and Meta-Analysis of Clinical Trials

Akos Bajtel et al.

Summary: This study systematically evaluated the frequency of adverse events related to dronabinol or nabilone treatment compared to placebo. The results showed that both drugs were associated with higher risk of drowsiness, dizziness, dry mouth, and headache compared to placebo. These adverse effects were generally mild-to-moderate and transient. However, more studies are needed to provide a more accurate assessment of the side effect profiles of these two compounds.

PHARMACEUTICALS (2022)

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Article Psychiatry

Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife

Madeline H. Meier et al.

Summary: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife, which may increase the risk of dementia.

AMERICAN JOURNAL OF PSYCHIATRY (2022)

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Review Oncology

Routes of administration, reasons for use, and approved indications of medical cannabis in oncology: a scoping review

Billy Vinette et al.

Summary: This scoping review examined the use of medical cannabis in oncological settings based on the experiences of patients diagnosed with cancer and their healthcare providers. The study found that medical cannabis is primarily used to minimize the impacts and side effects of cancer and to stay connected to others. It is commonly prescribed for managing refractory nausea and vomiting, complementing pain management, and improving appetite and food intake. Oils and oral solutions are the most frequently reported routes of administration.

BMC CANCER (2022)

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Review Oncology

Cannabinoids as anticancer drugs: current status of preclinical research

Burkhard Hinz et al.

Summary: Cannabinoid compounds have shown potential as pharmacological options to combat cancer and improve the life quality of cancer patients. They can inhibit tumor growth and spread through different signal transduction mechanisms, including suppressing tumor cell proliferation, invasion and metastasis, inducing apoptosis, and more.

BRITISH JOURNAL OF CANCER (2022)

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Review Oncology

Does Cannabidiol Have a Benefit as a Supportive Care Drug in Cancer?

Sarah Lord et al.

Summary: Cannabinoids are believed to have potential therapeutic uses in treating cancer symptoms, especially CBD due to its lack of psychoactive side effects. However, there is limited evidence to support these claims and many unknowns remain about CBD, including the best uses, dosing, and route of administration. Nevertheless, CBD has shown promise in alleviating psychological symptoms in patients with advanced cancer.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Exploration of Multiverse Activities of Endocannabinoids in Biological Systems

Tapan Behl et al.

Summary: In the last 25 years, the human endocannabinoid system (ECS) has been recognized as an important neuro-modulatory system. It consists of endogenous cannabinoids, cannabinoid receptors, and associated enzymes responsible for its synthesis and breakdown. The ECS plays a crucial role in managing various chronic conditions related to the nervous system, cardiovascular system, immune system, and others. Endocannabinoids are lipid molecules that interact with cannabinoid receptors and influence behavior and physiological processes. The functioning, synthesis, and degradation of endocannabinoids and their role in biological systems are discussed in this review.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Medicine, General & Internal

Management of common clinical problems experienced by survivors of cancer

Jon Emery et al.

Summary: Improvements in early detection and treatment have led to a growing number of cancer survivors worldwide. However, existing models of care do not adequately address the diverse physical, psychosocial, and supportive care needs of these survivors. This paper summarizes the evidence on the management of common clinical problems faced by adult cancer survivors and provides guidance on addressing these issues in consultations.

LANCET (2022)

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Review Biochemistry & Molecular Biology

The Medicinal Natural Products of Cannabis sativa Linn.: A Review

Anwuli Endurance Odieka et al.

Summary: Cannabis sativa has a long history of medicinal use in various cultures. This review highlights the potential of different parts of the plant and techniques for extracting and characterizing its compounds. The study of cannabinoids and non-cannabinoid phenols in the prevention and treatment of life-threatening diseases is significant.

MOLECULES (2022)

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Review Neurosciences

Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies

Suzanne Nielsen et al.

Summary: Cannabinoid co-administration may potentially reduce opioid doses for analgesia, as shown in preclinical studies. However, high-quality randomized controlled trials did not provide evidence of opioid-sparing effects in acute and cancer pain. Observational studies indicated that a certain proportion of individuals reduced or ceased opioid use.

NEUROPSYCHOPHARMACOLOGY (2022)

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Review Allergy

Inhaled Marijuana and the Lung

Donald P. Tashkin et al.

Summary: Smoking marijuana can produce short-term bronchodilation and may lead to symptoms of chronic bronchitis, with modest effects on lung function. The association between smoking marijuana and lung cancer or asthma remains unclear and requires further investigation.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

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Article Oncology

Unacceptable pain in oncology: The patients' perspective on reasons for absence of pain interventions

Hester Stoorvogel et al.

Summary: The study investigates the reasons for the absence of pain intervention among oncology patients who reported unacceptable pain. The results show that the absence of pain intervention is due to various factors, including patient's reluctance to discuss pain, patient preference for no treatment, physician focus on disease treatment, difficulty or impossibility of pain treatment, and perception that pain is an inevitable consequence of cancer treatment. About 50% of patients consider the physician responsible for the absence of pain intervention.

EUROPEAN JOURNAL OF CANCER CARE (2022)

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Review Medicine, General & Internal

Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications

Ainhoa Bilbao et al.

Summary: This study conducted a systematic review and meta-analyses of medical cannabinoids based on their pharmacology, analyzing 152 randomized controlled trials. The results showed that medical cannabinoids have varying therapeutic effects and adverse events in different medical conditions, based on their specific pharmacological properties.

BMC MEDICINE (2022)

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Article Medicine, General & Internal

Marijuana and the Lung Evolving Understandings

Manish Joshi et al.

MEDICAL CLINICS OF NORTH AMERICA (2022)

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Review Oncology

Use of Cannabis and Cannabinoids for Treatment of Cancer

Viktoriia Cherkasova et al.

Summary: This article reviews the potential use of cannabinoids in cancer treatment, including controlling side effects and tumor shrinkage, as well as the role of the endocannabinoid system in the development of cancer. Knowledge about using cannabinoids for cancer therapy is crucial for prolonging the lives of cancer patients.

CANCERS (2022)

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Review Medicine, General & Internal

The effect of medical cannabis on cognitive functions: a systematic review

Anders Wieghorst et al.

Summary: Research findings on the impact of cannabis-based medicines on cognitive functioning show a minor negative impact overall, with potential adverse effects from long-term use. Studies reporting impaired cognitive functioning find that test scores are generally within normal range or below what would be considered as cognitive impairment.

SYSTEMATIC REVIEWS (2022)

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Article Oncology

Cannabis, Cannabinoids and Cannabis-Based Medicines in Cancer Care Comment

Donald I. Abrams

Summary: With the legalization of medical cannabis in more states, cancer patients are interested in its potential uses in their treatment. However, oncologists lack adequate information to guide patients due to the lack of published literature on the benefits of medical cannabis. Further research is needed to determine its effectiveness in cancer treatment.

INTEGRATIVE CANCER THERAPIES (2022)

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Review Pharmacology & Pharmacy

Medical cannabis regulation: an overview of models around the world with emphasis on the Brazilian scenario

Maira Ribeiro de Souza et al.

Summary: Cannabis sativa has been used by humans for centuries, and there has been an increased demand for medical cannabis and its derivatives in recent decades. Different countries have adopted regulatory frameworks for medical cannabis, with variations in the types of products available and the regulations for cultivation and distribution. The regulatory framework for medical cannabis in Brazil has improved since 2015, but there are still some pending issues.

JOURNAL OF CANNABIS RESEARCH (2022)

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Article Clinical Neurology

The Effectiveness and Safety of Medical Cannabis for Treating Cancer Related Symptoms in Oncology Patients

Joshua Aviram et al.

Summary: The use of medical cannabis to treat cancer-related symptoms is increasing. This study prospectively followed up on the effectiveness and safety of medical cannabis treatment in oncology patients. The results showed that most patients experienced significant improvement in symptoms during medical cannabis treatment, with common but non-serious adverse effects.

FRONTIERS IN PAIN RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2

Xinxin Xiong et al.

Summary: The combination of immune checkpoint blockade and chemotherapy improves cancer treatment, but the use of drugs managing chemotherapy side effects may impede immunotherapy. This study shows that THC and endogenous cannabinoid anandamide reduce the therapeutic effect of PD-1 blockade and hinder antitumor immunity. The cannabinoid system plays an immunosuppressive role against cancer, and cannabinoids impair the function of tumor-specific T cells through CNR2.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Pharmacology & Pharmacy

Cannabis as an Anticancer Agent: A Review of Clinical Data and Assessment of Case Reports

Jordan Guggisberg et al.

Summary: This review examined the literature on the anticancer potential of cannabinoids, finding that most peer-reviewed case reports lack sufficient evidence to support cannabis as an anticancer agent. Strong clinical trial data are needed to confirm pre-clinical studies suggesting anticancer benefits of cannabinoids.

CANNABIS AND CANNABINOID RESEARCH (2022)

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Article Clinical Neurology

Discontinuing cannabis improves depression in people with multiple sclerosis: A short report

Anthony Feinstein et al.

Summary: A study found that symptoms of depression improved in multiple sclerosis patients after discontinuing cannabis use, even though they were using cannabis to manage their depression. This suggests potential risks of using cannabis in treating depression symptoms in multiple sclerosis patients.

MULTIPLE SCLEROSIS JOURNAL (2021)

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Review Primary Health Care

Physicians' experiences, attitudes, and beliefs towards medical cannabis: a systematic literature review

Sabrina Trappaud Ronne et al.

Summary: Hospital physicians and GPs frequently encounter patient demands for medical cannabis and are somewhat open to using it, but generally lack knowledge of its clinical effects and how to advise patients, which may hinder prescribing practices.

BMC FAMILY PRACTICE (2021)

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Article Biochemistry & Molecular Biology

Cannabis-Derived Compounds Cannabichromene and Δ9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization

Omer Anis et al.

Summary: This study aimed to identify cannabis compounds and combinations with cytotoxicity against bladder urothelial carcinoma (UC). The most active extract fraction contained cannabichromene (CBC) and Delta 9-tetrahydrocannabinol (THC), with synergistic interaction demonstrated between CBC + THC leading to cell apoptosis and migration inhibition. Targeting active plant ingredients from cannabis could form the basis for pre-clinical trials for UC treatment.

MOLECULES (2021)

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Article Cell Biology

ACPA decreases non-small cell lung cancer line growth through Akt/PI3K and JNK pathways in vitro

OEzge Boyacioglu et al.

Summary: Therapeutic agents for NSCLC have limited efficacy and may cause serious adverse effects. Cannabinoid ligands, particularly ACPA, have shown promise in inhibiting proliferation and inducing apoptosis in NSCLC cells. Activation of pro-apoptotic pathways and inhibition of key metabolic processes by ACPA suggest its potential as a novel therapy for NSCLC.

CELL DEATH & DISEASE (2021)

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Article Oncology

Synthetic Cannabinoids Induce Autophagy and Mitochondrial Apoptotic Pathways in Human Glioblastoma Cells Independently of Deficiency in TP53 or PTEN Tumor Suppressors

Aleksandra Ellert-Miklaszewska et al.

Summary: Glioblastomas are aggressive brain tumors with frequent genetic defects in TP53 and PTEN, rendering resistance to standard chemotherapeutics. Synthetic cannabinoids show high susceptibility in killing glioblastoma cells, despite genetic defects contributing to apoptosis resistance, making cannabinoids a promising therapeutic option.

CANCERS (2021)

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Article Neurosciences

Inhaled Cannabis Suppresses Chemotherapy-Induced Neuropathic Nociception by Decoupling the Raphe Nucleus: A Functional Imaging Study in Rats

Ilayda Alkislar et al.

Summary: The study found that inhaled vaporized cannabis can reduce neuropathic pain by reducing functional coupling in the brain, normalizing hyperconnectivity caused by nerve damage.

BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING (2021)

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Article Cell Biology

Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4

Tengfei Huang et al.

Summary: This study revealed that CBD inhibits glioma growth through lethal mitophagy and identified TRPV4 as a potential molecular target and biomarker of CBD in glioma. Combination therapy of CBD and temozolomide showed significant synergistic effects in controlling tumor size and improving survival in preclinical models.

AUTOPHAGY (2021)

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Article Oncology

A phase 1b randomised, placebo-controlled trial of nabiximols cannabinoid oromucosal spray with temozolomide in patients with recurrent glioblastoma

Chris Twelves et al.

Summary: The study found that with personalized dosing, nabiximols demonstrated acceptable safety and tolerability with no drug-drug interactions identified. The observed survival differences support further exploration in a well-powered randomized controlled trial.

BRITISH JOURNAL OF CANCER (2021)

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Article Psychology, Developmental

Cannabis, Vaping, and Respiratory Symptoms in a Probability Sample of US Youth

Carol J. Boyd et al.

Summary: The study suggests that adolescents' cannabis use with ENDS may have negative health consequences, while e-cigarettes and cigarettes did not show significant associations with respiratory symptoms.

JOURNAL OF ADOLESCENT HEALTH (2021)

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Review Health Care Sciences & Services

Cannabidiol Interactions with Medications, Illicit Substances, and Alcohol: a Comprehensive Review

Premalatha Balachandran et al.

Summary: CBD, a non-intoxicating phytocannabinoid, has therapeutic effects and has been approved by the FDA for the treatment of two severe forms of pediatric epilepsy. Despite its widespread use for various indications, it can interact with common medications and substances such as acetaminophen and alcohol.

JOURNAL OF GENERAL INTERNAL MEDICINE (2021)

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Article Medicine, General & Internal

Cannabis use and cannabis use disorder

Jason P. Connor et al.

Summary: Cannabis use disorder affects approximately 10% of global cannabis users, and while there are treatment methods available, enduring abstinence is not common. Legalization of non-medical cannabis use may increase the prevalence of CUD.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Article Oncology

THC Reduces Ki67-Immunoreactive Cells Derived from Human Primary Glioblastoma in a GPR55-Dependent Manner

Marc Richard Kolbe et al.

Summary: Glioblastoma (GBM) is the most common malignant brain tumor in humans with a median survival time of less than 15 months. Cannabinoids, such as THC and CBD, have shown therapeutic potential by binding to specific receptors like GPR55, suggesting a promising alternative treatment option for GBM patients.

CANCERS (2021)

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Article Substance Abuse

The relationship between cannabis and schizophrenia: a genetically informed perspective

Emma C. Johnson et al.

Summary: Genetic liability for cannabis use disorder is significantly associated with schizophrenia, even when considering additional risk factors such as cannabis ever-use, regular smoking, and nicotine dependence. There is mixed evidence regarding a causal relationship between cannabis use disorder and schizophrenia, with further research needed to clarify this association.

ADDICTION (2021)

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Review Pharmacology & Pharmacy

Cyclin-Dependent Kinase Inhibitors and Their Therapeutic Potential in Colorectal Cancer Treatment

Oana-Maria Thoma et al.

Summary: CDKs play a key role in cell cycle regulation, with aberrant expression potentially leading to cancer development. CDK inhibitors, such as CDK4/6 inhibitors, are being investigated as novel cancer therapies.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Molecular Mechanism of Cannabinoids in Cancer Progression

Cristina Pagano et al.

Summary: Cannabinoids exert anticancer action by modulating signaling pathways involved in cancer progression, with effects depending on both the type of tumor and their action on the components of the endocannabinoid system.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Pharmacology & Pharmacy

Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?

Leontina Elena Filipiuc et al.

Summary: The discovery of the pharmacological effects of cannabis, traditionally used in Asia, has led to the development of new compounds for treating various diseases. Recent research suggests that these effects may not only involve cannabinoid receptors, but also other mechanisms yet to be fully understood.

PHARMACEUTICS (2021)

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Review Cell Biology

The Potential Use of Cannabis in Tissue Fibrosis

Nazar Pryimak et al.

Summary: Fibrosis is a pathological process characterized by thickening or scarring of various tissues, and it is a major cause of morbidity and mortality. Current treatments for fibrosis are limited, but anti-inflammatory and immunosuppressive drugs, as well as cannabinoids and extracts of Cannabis sativa, show potential in prevention and treatment.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Chemistry, Medicinal

Pharmacological and Toxicological Effects of Phytocannabinoids and Recreational Synthetic Cannabinoids: Increasing Risk of Public Health

Vidyasagar Naik Bukke et al.

Summary: Synthetic cannabinoids are a type of psychoactive substances that have rapidly evolved with diverse structural modifications, potentially leading to serious adverse health effects. These substances are sprayed on harmless natural herbs to mimic the euphoric effect of Cannabis, and due to their stronger potency, they have been increasingly associated with intoxications and deaths.

PHARMACEUTICALS (2021)

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Review Anesthesiology

Cannabinoids, the endocannabinoid system, and pain: a review of preclinical studies

David P. Finn et al.

Summary: This review from the International Association for the Study of Pain discusses the use of cannabis, cannabinoids, and cannabis-based medicines for pain management. It outlines the potential of cannabinoids and endogenous cannabinoid system modulators in animal models while also highlighting the challenges in translating this knowledge into clinically useful medicines.

PAIN (2021)

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Review Biochemistry & Molecular Biology

Cancer Cachexia: Its Mechanism and Clinical Significance

Hiroki Nishikawa et al.

Summary: Cachexia is a malnutrition associated with chronic diseases, characterized by decreased skeletal muscle mass and weight loss. Current standard treatments are lacking due to the complexity of its pathogenesis, which involves multiple etiologies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Cannabinoids in the landscape of cancer

Nagina Mangal et al.

Summary: Cannabinoids, including phyto-, endogenous, and synthetic types, have demonstrated anti-tumor effects in both in vitro and in vivo studies. The mechanism of action for synthetic cannabinoids, such as Delta(9)-THC and CBD, is mainly described through traditional cannabinoid receptors like CB1 and CB2. Further research is needed to understand the molecular level mode of action and effective dosages for cannabinoids in cancer treatment.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

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Correction Multidisciplinary Sciences

Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures (vol 10, 2687, 2020)

Vladimir N. Ivanov et al.

SCIENTIFIC REPORTS (2021)

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Review Medicine, General & Internal

Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials

Li Wang et al.

Summary: The systematic review and meta-analysis examined the benefits and harms of medical cannabis and cannabinoids for chronic pain, finding that non-inhaled medical cannabis or cannabinoids resulted in a small to very small improvement in pain relief, physical functioning, and sleep quality among patients with chronic pain, along with several transient adverse side effects.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Editorial Material Medicine, General & Internal

Medical cannabis or cannabinoids for chronic pain: a clinical practice guideline

Jason W. Busse et al.

Summary: The weak recommendation for a trial of non-inhaled medical cannabis or cannabinoids for chronic pain in cancer or non-cancer patients reflects a careful balance between benefits and harms, emphasizing small improvements in pain intensity, physical functioning, and sleep quality, with a willingness to accept a small to modest risk of temporary harms. Further research is needed to potentially alter this recommendation.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Psychiatry

Antidepressant and Anxiolytic Effects of Medicinal Cannabis Use in an Observational Trial

Erin L. Martin et al.

Summary: This study found that medicinal cannabis use was associated with lower depression symptoms, but not anxiety. Medicinal cannabis users reported better sleep, quality of life, and less pain on average. Initiating medicinal cannabis during the follow-up period was linked to significantly decreased anxiety and depressive symptoms.

FRONTIERS IN PSYCHIATRY (2021)

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Article Oncology

A Phase 2 Randomised Clinical Trial Assessing the Tolerability of Two Different Ratios of Medicinal Cannabis in Patients With High Grade Gliomas

Janet Schloss et al.

Summary: This study showed that a single nightly dose of THC-containing medicinal cannabis was safe, well-tolerated, and significantly improved sleep, functional well-being, and quality of life in patients.

FRONTIERS IN ONCOLOGY (2021)

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Article Plant Sciences

Shape Matters: Plant Architecture Affects Chemical Uniformity in Large-Size Medical Cannabis Plants

Nadav Danziger et al.

Summary: Plant organs sense their environment locally, leading to spatial variability in plant tissue physiology and secondary metabolism due to gradients of micro-climates in the plant shoot; Plant architecture, affecting micro-climate in the shoot, significantly impacts the uniformity of cannabinoids in Cannabis sativa plants; Manipulations of plant architecture that increase light penetration can enhance cannabinoid uniformity and yield biomass in large cannabis plants.

PLANTS-BASEL (2021)

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Article Oncology

Cancer cachexia in adult patients: ESMO Clinical Practice Guidelines

J. Arends et al.

ESMO OPEN (2021)

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Article Oncology

Topical Cannabinoids for Treating Chemotherapy-Induced Neuropathy: A Case Series

Stacy D'Andre et al.

Summary: Topical cannabinoids may be helpful for patients with chemotherapy-induced peripheral neuropathy, with further research needed to determine their efficacy and mechanisms of action.

INTEGRATIVE CANCER THERAPIES (2021)

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Review Pharmacology & Pharmacy

A Review of Hemp as Food and Nutritional Supplement

Pellegrino Cerino et al.

Summary: Hemp is a valuable crop with a wide range of uses, including food, textiles, and biofuels. Different parts of the hemp plant contain beneficial compounds such as nonpsychoactive cannabinoids in the inflorescence and essential nutrients in hempseed. The marketing of hemp-derived products is regulated worldwide due to various factors, including the presence of CBD and restrictions on Cannabis inflorescence.

CANNABIS AND CANNABINOID RESEARCH (2021)

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Article Oncology

Effect of cannabis on oxaliplatin-induced peripheral neuropathy among oncology patients: a retrospective analysis

Barliz Waissengrin et al.

Summary: This study investigated the effect of cannabis on oncologic patients with CIPN, showing that patients treated with cannabis had a lower rate of neuropathy, especially those who used cannabis prior to oxaliplatin treatment. Further large prospective trials are planned to confirm these findings.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2021)

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Article Oncology

Depression and anxiety in long-term survivors 5 and 10 years after cancer diagnosis

Heide Goetze et al.

SUPPORTIVE CARE IN CANCER (2020)

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Review Biochemistry & Molecular Biology

Depression and anxiety in relation to cancer incidence and mortality: a systematic review and meta-analysis of cohort studies

Yun-He Wang et al.

MOLECULAR PSYCHIATRY (2020)

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Article Biochemistry & Molecular Biology

Treatment with Cannabinoids as a Promising Approach for Impairing Fibroblast Activation and Prostate Cancer Progression

Laura Pietrovito et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Pharmacology & Pharmacy

The Endocannabinoid System Alleviates Pain in a Murine Model of Cancer-Induced Bone Pain

A. L. Thompson et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2020)

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Review Medicine, General & Internal

Challenges and Opportunities in Preclinical Research of Synthetic Cannabinoids for Pain Therapy

Bogdan Ionel Tamba et al.

MEDICINA-LITHUANIA (2020)

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Article Multidisciplinary Sciences

Cannabinoid receptor expression in non-small cell lung cancer. Effectiveness of tetrahydrocannabinol and cannabidiol inhibiting cell proliferation and epithelial-mesenchymal transition in vitro

Lara Milian et al.

PLOS ONE (2020)

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Article Multidisciplinary Sciences

Secondary Metabolites Profiled in Cannabis Inflorescences, Leaves, Stem Barks, and Roots for Medicinal Purposes

Dan Jin et al.

SCIENTIFIC REPORTS (2020)

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Article Biochemistry & Molecular Biology

CBD Reverts the Mesenchymal Invasive Phenotype of Breast Cancer Cells Induced by the Inflammatory Cytokine IL-1β

Lazaro Garcia-Morales et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Oncology

Management of Cancer Cachexia: ASCO Guideline

Eric J. Roeland et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Review Medicine, General & Internal

Herbal Preparations of Medical Cannabis: A Vademecum for Prescribing Doctors

Pietro Brunetti et al.

MEDICINA-LITHUANIA (2020)

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Article Oncology

Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial

P. Grimison et al.

ANNALS OF ONCOLOGY (2020)

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Article Pharmacology & Pharmacy

Win 55,212-2, atenolol and subdiaphragmatic vagotomy prevent acceleration of gastric emptying induced by cachexia via Yoshida-AH-130 cells in rats

Mickael Laudrup de Sousa Cavalcante et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Oncology

Medical Care Costs Associated with Cancer Survivorship in the United States

Angela B. Mariotto et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2020)

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Article Oncology

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update

Charles L. Loprinzi et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Review Multidisciplinary Sciences

Cannabinoids and Cannabinoid Receptors: The Story so Far

Fred Shahbazi et al.

ISCIENCE (2020)

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Review Anesthesiology

The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises

Srinivasa N. Raja et al.

PAIN (2020)

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Review Pharmacology & Pharmacy

TRPM8 channels: A review of distribution and clinical role

Yuqian Liu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Cannabis, a cause for anxiety? A critical appraisal of the anxiogenic and anxiolytic properties

Lara Sharpe et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Review Behavioral Sciences

Therapeutic potential and safety considerations for the clinical use of synthetic cannabinoids

Dennis J. Sholler et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2020)

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Article Oncology

Cannabis Consumption Used by Cancer Patients during Immunotherapy Correlates with Poor Clinical Outcome

Gil Bar-Sela et al.

CANCERS (2020)

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Article Oncology

Targeting CYP2J2 to Enhance the Anti-Glioma Efficacy of Cannabinoid Receptor 2 Stimulation by Inhibiting the Pro-Angiogenesis Function of M2 Microglia

Xuejiao Lei et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Nutrition & Dietetics

Nutritional Interventions in Cancer Cachexia: Evidence and Perspectives From Experimental Models

Wouter R. P. H. van de Worp et al.

FRONTIERS IN NUTRITION (2020)

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Article Biochemistry & Molecular Biology

Cannabinoids Inhibited Pancreatic Cancer via P-21 Activated Kinase 1 Mediated Pathway

Yang Yang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Neurosciences

The endocannabinoid system in modulating fear, anxiety, and stress

Rafael Maldonado et al.

DIALOGUES IN CLINICAL NEUROSCIENCE (2020)

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Review Oncology

An Overview of Current Recommendations and Options for the Management of Cancer Pain: A Comprehensive Review

Kyle L. Gress et al.

ONCOLOGY AND THERAPY (2020)

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Article Neurosciences

History of cannabis and the endocannabinoid system

Marc-Antoine Crocq

DIALOGUES IN CLINICAL NEUROSCIENCE (2020)

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Review Anesthesiology

Chemotherapy-Induced Peripheral Neuropathy: Causative Agents, Preventative Strategies, and Treatment Approaches

Rishi Kachrani et al.

JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY (2020)

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Article Pharmacology & Pharmacy

The effectiveness of inhaled Cannabis flower for the treatment of agitation/irritability, anxiety, and common stress

Sarah S. Stith et al.

JOURNAL OF CANNABIS RESEARCH (2020)

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Review Pharmacology & Pharmacy

Medical cannabis use in the United States: a retrospective database study

V. Kishan Mahabir et al.

JOURNAL OF CANNABIS RESEARCH (2020)

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Article Chemistry, Analytical

A Brief Background on Cannabis: From Plant to Medical Indications

Linda E. Klumpers et al.

JOURNAL OF AOAC INTERNATIONAL (2019)

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Article Endocrinology & Metabolism

Cannabinoid WIN 55,212-2 induces cell cycle arrest and apoptosis, and inhibits proliferation, migration, invasion, and tumor growth in prostate cancer in a cannabinoid-receptor 2 dependent manner

Domenica Roberto et al.

PROSTATE (2019)

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Article Biochemistry & Molecular Biology

Δ9-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPARα induction: A possible evidence for the cancellation of PPARβ/δ-mediated inhibition of PPARα in MDA-MB-231 cells

Masayo Hirao-Suzuki et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

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Review Nutrition & Dietetics

Mediators of cachexia in cancer patients

Josep M. Argiles et al.

NUTRITION (2019)

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Article Multidisciplinary Sciences

Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer

Sandra Blasco-Benito et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Biology

MDA19, a novel CB2 agonist, inhibits hepatocellular carcinoma partly through inactivation of AKT signaling pathway

Mei Rao et al.

BIOLOGY DIRECT (2019)

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Review Psychology, Biological

The Use of Cannabinoids for Sleep: A Critical Review on Clinical Trials

Nirushi Kuhathasan et al.

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY (2019)

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Article Nursing

Cancer Pain and Quality of Life

Carmen Rodriguez et al.

JOURNAL OF HOSPICE & PALLIATIVE NURSING (2019)

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Review Anesthesiology

Efficacy, tolerability and safety of cannabis-based medicines for cancer pain A systematic review with meta-analysis of randomised controlled trials

Winfried Haeuser et al.

SCHMERZ (2019)

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Article Geriatrics & Gerontology

Chemotherapy-induced cachexia dysregulates hypothalamic and systemic lipoamines and is attenuated by cannabigerol

Daniel I. Brierley et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)

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Review Pharmacology & Pharmacy

The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?

Estefania Moreno et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Medicine, Research & Experimental

The role of 2-arachidonoylglycerol in the regulation of the tumor-immune microenvironment in murine models of pancreatic cancer

Chongyang Qiu et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Neurosciences

Cannabidiol Adverse Effects and Toxicity

Marilyn A. Huestis et al.

CURRENT NEUROPHARMACOLOGY (2019)

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Review Obstetrics & Gynecology

Marijuana Use in Pregnancy: A Review

Rebecca Thompson et al.

OBSTETRICAL & GYNECOLOGICAL SURVEY (2019)

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Review Oncology

Akt in cancer: Mediator and more

Sundaramoorthy Revathidevi et al.

SEMINARS IN CANCER BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells

Xin Zhang et al.

BIOMOLECULES (2019)

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Review Chemistry, Medicinal

Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: implications for drug discovery

Francesca Gado et al.

FUTURE MEDICINAL CHEMISTRY (2019)

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Article Oncology

Depression and anxiety among people living with and beyond cancer: a growing clinical and research priority

Claire L. Niedzwiedz et al.

BMC CANCER (2019)

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Article Agronomy

Apical bud removal increased seed yield in hemp (Cannabis sativa L.)

Darja Kocjan Acko et al.

ACTA AGRICULTURAE SCANDINAVICA SECTION B-SOIL AND PLANT SCIENCE (2019)

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Article Pharmacology & Pharmacy

2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels

Hagit Neumann-Raizel et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Oncology

Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells

Soyeon Jeong et al.

CANCER LETTERS (2019)

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Article Oncology

Cannabis Impacts Tumor Response Rate to Nivolumab in Patients with Advanced Malignancies

Tarek Taha et al.

ONCOLOGIST (2019)

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Article

Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells

Esraah Alharris et al.

Oncotarget (2019)

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Review Health Care Sciences & Services

Health-related quality of life across cancer cachexia stages

Popi Kasvis et al.

ANNALS OF PALLIATIVE MEDICINE (2019)

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Review Medicine, General & Internal

Association Between Marijuana Use and Risk of Cancer A Systematic Review and Meta-analysis

Mehrnaz Ghasemiesfe et al.

JAMA NETWORK OPEN (2019)

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Article Oncology

Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines

M. Fallon et al.

ANNALS OF ONCOLOGY (2018)

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Article Cell Biology

AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells

Nina Meyer et al.

AUTOPHAGY (2018)

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Article Pharmacology & Pharmacy

Appraising the entourage effect: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer

Sandra Blasco-Benito et al.

BIOCHEMICAL PHARMACOLOGY (2018)

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Review Medicine, General & Internal

Cannabinoids and cancer pain: A new hope or a false dawn?

Matthew R. D. Brown et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2018)

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Review Medicine, General & Internal

Medical use of cannabis and cannabinoids containing products - Regulations in Europe and North America

Ran Abuhasira et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2018)

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Article Oncology

Medical Oncologists' Beliefs, Practices, and Knowledge Regarding Marijuana Used Therapeutically: A Nationally Representative Survey Study

Ilana M. Braun et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Article Health Care Sciences & Services

Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain

Aron H. Lichtman et al.

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT (2018)

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Article Biochemistry & Molecular Biology

Cannabinoid-induced cell death in endometrial cancer cells: involvement of TRPV1 receptors in apoptosis

B. M. Fonseca et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Oncology

The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: a randomized, double-blind clinical trial

Jenny G. Turcott et al.

SUPPORTIVE CARE IN CANCER (2018)

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Review Health Care Sciences & Services

Dronabinol oral solution in the management of anorexia and weight loss in AIDS and cancer

Melissa E. Badowski et al.

THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2018)

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Article Pharmacology & Pharmacy

Targeting Glioma Initiating Cells with A combined therapy of cannabinoids and temozolomide

Israel Lopez-Valero et al.

BIOCHEMICAL PHARMACOLOGY (2018)

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Review Biochemistry & Molecular Biology

Cannabinoid Delivery Systems for Pain and Inflammation Treatment

Natascia Bruni et al.

MOLECULES (2018)

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Review Clinical Neurology

Targeting the Endocannabinoid System for Prevention or Treatment of Chemotherapy-Induced Neuropathic Pain: Studies in Animal Models

Willias Masocha

PAIN RESEARCH & MANAGEMENT (2018)

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Article Pharmacology & Pharmacy

Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer

Uchini S. Kosgodage et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Public, Environmental & Occupational Health

A Public Health Strategy for the Opioid Crisis

Brendan Saloner et al.

PUBLIC HEALTH REPORTS (2018)

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Review Pharmacology & Pharmacy

A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans

Sophie A. Millar et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Pharmacology & Pharmacy

Identification of Synergistic Interaction Between Cannabis-Derived Compounds for Cytotoxic Activity in Colorectal Cancer Cell Lines and Colon Polyps That Induces Apoptosis-Related Cell Death and Distinct Gene Expression

Rameshprabu Nallathambi et al.

CANNABIS AND CANNABINOID RESEARCH (2018)

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Article Pharmacology & Pharmacy

Focus on Cannabinoids and Synthetic Cannabinoids

R. Le Boisselier et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2017)

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Article Oncology

Patients' perception of chemotherapy side effects: Expectations, doctor-patient communication and impact on quality of life - An Italian survey

Domenica Lorusso et al.

EUROPEAN JOURNAL OF CANCER CARE (2017)

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Article Oncology

Cannabinoid derivatives exert a potent anti-myeloma activity both in vitro and in vivo

M. Victoria Barbado et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

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Review Neurosciences

Opioid-Sparing Effect of Cannabinoids: A Systematic Review and Meta-Analysis

Suzanne Nielsen et al.

NEUROPSYCHOPHARMACOLOGY (2017)

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Article Rheumatology

Cannabis and Cannabinoids for Chronic Pain

E. Alfonso Romero-Sandoval et al.

CURRENT RHEUMATOLOGY REPORTS (2017)

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Review Health Care Sciences & Services

A selective review of medical cannabis in cancer pain management

Alexia Blake et al.

ANNALS OF PALLIATIVE MEDICINE (2017)

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Article Chemistry, Multidisciplinary

Chemical Profiling of Medical Cannabis Extracts

Melissa M. Lewis et al.

ACS OMEGA (2017)

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Review Pharmacology & Pharmacy

Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain

Natasha R. Ryz et al.

CANNABIS AND CANNABINOID RESEARCH (2017)

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Article Pharmacology & Pharmacy

Delta-9-Tetrahydrocannabinol/Cannabidiol Oromucosal Spray (Sativex®): A Review in Multiple Sclerosis-Related Spasticity

Gillian M. Keating

DRUGS (2017)

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Review Psychology, Clinical

Medical cannabis and mental health: A guided systematic review

Zach Walsh et al.

CLINICAL PSYCHOLOGY REVIEW (2017)

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Review Toxicology

A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatment

Robert J. Tait et al.

CLINICAL TOXICOLOGY (2016)

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Article Anesthesiology

Neuropathic Pain Components in Patients with Cancer: Prevalence, Treatment, and Interference with Daily Activities

Anne Oosterling et al.

PAIN PRACTICE (2016)

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Article Cell Biology

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

Sonia Hernandez-Tiedra et al.

AUTOPHAGY (2016)

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Review Neurosciences

The Role of Cannabinoids in Neuroanatomic Alterations in Cannabis Users

Valentina Lorenzetti et al.

BIOLOGICAL PSYCHIATRY (2016)

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Review Neurosciences

Acute and Chronic Effects of Cannabinoids on Human Cognition-A Systematic Review

Samantha J. Broyd et al.

BIOLOGICAL PSYCHIATRY (2016)

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Article Integrative & Complementary Medicine

Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells

Sindiswa T. Lukhele et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

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Review Oncology

Impact of chemotherapy-induced nausea and vomiting on health-related quality of life and resource utilization: A systematic review

Silvia Sommariva et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2016)

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Review Oncology

A user's guide to cannabinoid therapies in oncology

V. Maida et al.

CURRENT ONCOLOGY (2016)

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Article Biochemistry & Molecular Biology

Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression

Christopher J. Coke et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Review Health Care Sciences & Services

Update on Prevalence of Pain in Patients With Cancer: Systematic Review and Meta-Analysis

Marieke H. J. van den Beuken-van Everdingen et al.

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT (2016)

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Review Oncology

Dronabinol for chemotherapy-induced nausea and vomiting unresponsive to antiemetics

Megan Brafford May et al.

CANCER MANAGEMENT AND RESEARCH (2016)

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Article Oncology

In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma

T. Fisher et al.

CURRENT ONCOLOGY (2016)

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Article Psychiatry

Marijuana use and use disorders in adults in the USA, 2002-14: analysis of annual cross-sectional surveys

Wilson M. Compton et al.

LANCET PSYCHIATRY (2016)

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Article Neurosciences

Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1-Dependent Withdrawal

Liting Deng et al.

BIOLOGICAL PSYCHIATRY (2015)

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Article Hematology

Cannabidiol for the Prevention of Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation: Results of a Phase II Study

Moshe Yeshurun et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2015)

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Article Oncology

Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner

Massimo Nabissi et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

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Article Pharmacology & Pharmacy

In vitro and in vivo evaluation of Δ9-tetrahidrocannabinol/PLGA nanoparticles for cancer chemotherapy

L. Martin-Banderas et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

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Review Medicine, General & Internal

Cannabinoids for Medical Use A Systematic Review and Meta-analysis

Penny F. Whiting et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

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Review Clinical Neurology

Cannabis use and mania symptoms: A systematic review and meta-analysis

Melanie Gibbs et al.

JOURNAL OF AFFECTIVE DISORDERS (2015)

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Review Neurosciences

Effects of Cannabinoids on T-cell Function and Resistance to Infection

Toby K. Eisenstein et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2015)

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Article Oncology

Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: Novel anti-tumor mechanisms of Cannabidiol in breast cancer

Mohamad Elbaz et al.

MOLECULAR ONCOLOGY (2015)

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Review Clinical Neurology

Safety and Toxicology of Cannabinoids

Jane Sachs et al.

NEUROTHERAPEUTICS (2015)

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Article Psychiatry

Role of Psychosocial Variables on Chemotherapy-Induced Nausea and Vomiting and Health-Related Quality of Life among Cancer Patients: A European Study

Luigi Grassi et al.

PSYCHOTHERAPY AND PSYCHOSOMATICS (2015)

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Article Cell Biology

Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma

E. Singer et al.

CELL DEATH & DISEASE (2015)

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Review Pharmacology & Pharmacy

Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications

N. T. Burford et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

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Article Psychiatry

How Cannabis Causes Paranoia: Using the Intravenous Administration of a†9-Tetrahydrocannabinol (THC) to Identify Key Cognitive Mechanisms Leading to Paranoia

Daniel Freeman et al.

SCHIZOPHRENIA BULLETIN (2015)

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Article Psychiatry

Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: a case-control study

Marta Di Forti et al.

LANCET PSYCHIATRY (2015)

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Article Cardiac & Cardiovascular Systems

Adverse Cardiovascular, Cerebrovascular, and Peripheral Vascular Effects of Marijuana Inhalation: What Cardiologists Need to Know

Grace Thomas et al.

AMERICAN JOURNAL OF CARDIOLOGY (2014)

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Article Pharmacology & Pharmacy

Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1

Maria Haustein et al.

BIOCHEMICAL PHARMACOLOGY (2014)

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Article Pharmacology & Pharmacy

Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer

Ryuichi Murase et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

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Article Neurosciences

Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa

Alexandre R. de Mello Schier et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2014)

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Article Biochemistry & Molecular Biology

Allosteric Modulation of a Cannabinoid G Protein-coupled Receptor BINDING SITE ELUCIDATION AND RELATIONSHIP TO G PROTEIN SIGNALING

Derek M. Shore et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Article Toxicology

Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells

Shuso Takeda et al.

JOURNAL OF TOXICOLOGICAL SCIENCES (2014)

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Article Oncology

The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model

Katherine A. Scott et al.

MOLECULAR CANCER THERAPEUTICS (2014)

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Article Neurosciences

Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery

Elizabeth J. Rahn et al.

MOLECULAR PAIN (2014)

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Review Biotechnology & Applied Microbiology

Inflammation Based Regulation of Cancer Cachexia

Jill K. Onesti et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Article Cardiac & Cardiovascular Systems

Marijuana use and long-term mortality among survivors of acute myocardial infarction

Lauren Frost et al.

AMERICAN HEART JOURNAL (2013)

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Article Pharmacology & Pharmacy

Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms

Luciano De Petrocellis et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

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Article Oncology

Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents

Massimo Nabissi et al.

CARCINOGENESIS (2013)

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Article Clinical Neurology

Biphasic effects of Δ9-tetrahydrocannabinol on brain stimulation reward and motor activity

Vicky Katsidoni et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2013)

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Article Pharmacology & Pharmacy

Preparation and characterization of Δ9-tetrahydrocannabinol-loaded biodegradable polymeric microparticles and their antitumoral efficacy on cancer cell lines

Dolores Hernan Perez de la Ossa et al.

JOURNAL OF DRUG TARGETING (2013)

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Article Oncology

COX-2 and PPAR-γ Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells

Robert Ramer et al.

MOLECULAR CANCER THERAPEUTICS (2013)

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Article Multidisciplinary Sciences

Local Delivery of Cannabinoid-Loaded Microparticles Inhibits Tumor Growth in a Murine Xenograft Model of Glioblastoma Multiforme

Dolores Hernan Perez de la Ossa et al.

PLOS ONE (2013)

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Review Pharmacology & Pharmacy

The Pharmacologic and Clinical Effects of Medical Cannabis

Laura M. Borgelt et al.

PHARMACOTHERAPY (2013)

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Review Biochemistry & Molecular Biology

Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators

Iain Brown et al.

PROGRESS IN LIPID RESEARCH (2013)

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Article Pharmacology & Pharmacy

A global toxicogenomic analysis investigating the mechanistic differences between tobacco and marijuana smoke condensates in vitro

Rebecca M. Maertens et al.

TOXICOLOGY (2013)

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Article Cell Biology

Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells

I. Dando et al.

CELL DEATH & DISEASE (2013)

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Article Oncology

Ceramide and Apoptosis: Exploring the Enigmatic Connections between Sphingolipid Metabolism and Programmed Cell Death

Thomas D. Mullen et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2012)

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Review Medicine, General & Internal

The Therapeutic Potential of Cannabis and Cannabinoids

Franjo Grotenhermen et al.

DEUTSCHES ARZTEBLATT INTERNATIONAL (2012)

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Article Biochemistry & Molecular Biology

Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1

Robert Ramer et al.

FASEB JOURNAL (2012)

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Article Toxicology

Synthetic cannabinoid and marijuana exposures reported to poison centers

M. B. Forrester et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2012)

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Article Genetics & Heredity

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer

Gabriella Aviello et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2012)

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Article Clinical Neurology

Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial

Russell K. Portenoy et al.

JOURNAL OF PAIN (2012)

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Article Neurosciences

Grey matter alterations associated with cannabis use: Results of a VBM study in heavy cannabis users and healthy controls

Janna Cousijn et al.

NEUROIMAGE (2012)

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Review Oncology

Towards the use of cannabinoids as antitumour agents

Guillermo Velasco et al.

NATURE REVIEWS CANCER (2012)

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Article Behavioral Sciences

CB1 and CB2 receptor agonists promote analgesia through synergy in a murine model of tumor pain

Iryna A. Khasabova et al.

BEHAVIOURAL PHARMACOLOGY (2011)

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Article Pharmacology & Pharmacy

Cannabis-related hospitalizations: unexpected serious events identified through hospital databases

Emilie Jouanjus et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2011)

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Review Pharmacology & Pharmacy

Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials

Mary E. Lynch et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2011)

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Article Biochemistry & Molecular Biology

Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy

D. Vara et al.

CELL DEATH AND DIFFERENTIATION (2011)

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Article Emergency Medicine

SPICE GIRLS: SYNTHETIC CANNABINOID INTOXICATION

Aaron B. Schneir et al.

JOURNAL OF EMERGENCY MEDICINE (2011)

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Article Oncology

A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma

Sofia Torres et al.

MOLECULAR CANCER THERAPEUTICS (2011)

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Article Oncology

Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy

Ashutosh Shrivastava et al.

MOLECULAR CANCER THERAPEUTICS (2011)

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Article Neurosciences

Cannabinoids attenuate cancer pain and proliferation in a mouse model

Negin Saghafi et al.

NEUROSCIENCE LETTERS (2011)

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Article Pharmacology & Pharmacy

Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1

Robert Ramer et al.

BIOCHEMICAL PHARMACOLOGY (2010)

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Article Psychiatry

Impact of cannabidiol on the acute and psychotomimetic effects of smoked cannabis: naturalistic study

Celia J. A. Morgan et al.

BRITISH JOURNAL OF PSYCHIATRY (2010)

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Article Oncology

The Dual Effects of δ9-Tetrahydrocannabinol on Cholangiocarcinoma Cells: Anti-Invasion Activity at Low Concentration and Apoptosis Induction at High Concentration

Surang Leelawat et al.

CANCER INVESTIGATION (2010)

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Article Respiratory System

Effects of cannabis on lung function: a population-based cohort study

R. J. Hancox et al.

EUROPEAN RESPIRATORY JOURNAL (2010)

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Article Health Care Sciences & Services

Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients with Intractable Cancer-Related Pain

Jeremy R. Johnson et al.

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT (2010)

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Article Biochemistry & Molecular Biology

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition

Maria M. Caffarel et al.

MOLECULAR CANCER (2010)

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Article Oncology

Cannabidiol Enhances the Inhibitory Effects of Delta(9)-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival

Jahan P. Marcu et al.

MOLECULAR CANCER THERAPEUTICS (2010)

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Article Chemistry, Multidisciplinary

Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells

Robert Ramer et al.

PHARMACEUTICAL RESEARCH (2010)

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Editorial Material Cell Biology

TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action

Maria Salazar et al.

AUTOPHAGY (2009)

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Article Behavioral Sciences

Δ9-Tetrahydrocannabinol suppresses vomiting behavior and Fos expression in both acute and delayed phases of cisplatin-induced emesis in the least shrew

Andrew P. Ray et al.

BEHAVIOURAL BRAIN RESEARCH (2009)

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Article Oncology

Depression as a Predictor of Disease Progression and Mortality in Cancer Patients

Jillian R. Satin et al.

CANCER (2009)

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Article Pharmacology & Pharmacy

Modulation of Δ9-tetrahydrocannabinol-induced MCF-7 breast cancer cell growth by cyclooxygenase and aromatase

Shuso Takeda et al.

TOXICOLOGY (2009)

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Article Psychiatry

Cannabinoids and appetite: Food craving and food pleasure

Tim C. Kirkham

INTERNATIONAL REVIEW OF PSYCHIATRY (2009)

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Article Oncology

Loss of cannabinoid receptor 1 accelerates intestinal tumor growth

Dingzhi Wang et al.

CANCER RESEARCH (2008)

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Article Chemistry, Medicinal

A comparison of mainstream and sidestream marijuana and tobacco cigarette smoke produced under two machine smoking conditions

David Moir et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2008)

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Review Psychiatry

Major depression after breast cancer: a review of epidemiology and treatment

Jesse R. Fann et al.

GENERAL HOSPITAL PSYCHIATRY (2008)

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Article Oncology

Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1

Robert Ramer et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2008)

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Article Biochemistry & Molecular Biology

Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo

A. Preet et al.

ONCOGENE (2008)

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Article Oncology

Cannabidiol as a novel inhibitor of ld-1 gene expression in aggressive breast cancer cells

Sean D. McAllister et al.

MOLECULAR CANCER THERAPEUTICS (2007)

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Article Neurosciences

Cannabinoids elicit antidepressant-like Behavior and activate Serotonergic neurons through the medial prefrontal cortex

Francis Rodriguez Bambico et al.

JOURNAL OF NEUROSCIENCE (2007)

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Article Neurosciences

Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Δ9-tetrahydrocannabinol in rats

Tiziana Rubino et al.

NEUROPSYCHOPHARMACOLOGY (2007)

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Article Plant Sciences

Cannabis tea revisited: A systematic evaluation of the cannabinoid composition of cannabis tea

Arno Hazekamp et al.

JOURNAL OF ETHNOPHARMACOLOGY (2007)

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Article Pharmacology & Pharmacy

Synergy between Δ9-tetrahydrocannabinol and morphine in the arthritic rat

Melinda L. Cox et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2007)

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Review Biochemistry & Molecular Biology

Cannabidiol - Recent advances

Raphael Mechoulam et al.

CHEMISTRY & BIODIVERSITY (2007)

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Review Biochemistry & Molecular Biology

The toxicology of cannabis and cannabis prohibition

Franjo Grotenhermen

CHEMISTRY & BIODIVERSITY (2007)

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Article Pharmacology & Pharmacy

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma

Alessia Ligresti et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)

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Article Oncology

Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: A multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the cannabis-in-cachexia-study-group

Florian Strasser et al.

JOURNAL OF CLINICAL ONCOLOGY (2006)

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Article Oncology

A pilot clinical study of Δ9- tetrahydrocannabinol in patients with recurrent glioblastoma multiforme

M. Guzman et al.

BRITISH JOURNAL OF CANCER (2006)

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Article Oncology

Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes

Arkaitz Carracedo et al.

CANCER RESEARCH (2006)

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Article Oncology

Δ9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation

Maria M. Caffarel et al.

CANCER RESEARCH (2006)

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Article Psychiatry

History of cannabis as a medicine:: a review

Antonio Waldo Zuardi

REVISTA BRASILEIRA DE PSIQUIATRIA (2006)

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Article Oncology

The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells

A Carracedo et al.

CANCER CELL (2006)

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Article Pharmacology & Pharmacy

Enhancement of transdermal fentanyl and buprenorphine antinociception by transdermal Δ9-tetrahydrocannabinol

DL Cichewicz et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2005)

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Article Anesthesiology

A cannabinoid agonist, WIN 55,212-2, reduces neuropathic nociception induced by paclitaxel in rats

D Pascual et al.

PAIN (2005)

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Article Oncology

Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells

SD McAllister et al.

JOURNAL OF NEURO-ONCOLOGY (2005)

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Article Immunology

Δ-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response

RJ McKallip et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Neurosciences

Delta 9-tetrahydrocannabinol increases C6 glioma cell death produced by oxidative stress

I Goncharov et al.

NEUROSCIENCE (2005)

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Article Oncology

Cannabinoids induce cancer cell proliferation via tumor necrosis factor α-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor

S Hart et al.

CANCER RESEARCH (2004)

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Article Pharmacology & Pharmacy

Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines

P Massi et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)

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Article Behavioral Sciences

Involvement of 5-HT1A receptors in behavioural effects of the cannabinoid receptor agonist CP 55,940 in male rats

EM Marco et al.

BEHAVIOURAL PHARMACOLOGY (2004)

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Article Oncology

Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas

C Blázquez et al.

CANCER RESEARCH (2004)

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Article Neurosciences

A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew)

M Kwiatkowska et al.

PSYCHOPHARMACOLOGY (2004)

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Article Anesthesiology

Topical cannabinoid enhances topical morphine antinociception

O Yesilyurt et al.

PAIN (2003)

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Article Gastroenterology & Hepatology

Δ9-tetrahydrocannabinol selectively acts on CB1 receptors in specific regions of dorsal vagal complex to inhibit emesis in ferrets

MD Van Sickle et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)

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Article Anesthesiology

A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain

LJ Kehl et al.

PAIN (2003)

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Article Behavioral Sciences

Involvement of the κ-opioid receptor in the anxiogenic-like effect of CP 55,940 in male rats

S Marín et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2003)

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Article Medicine, General & Internal

Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study

L Arseneault et al.

BRITISH MEDICAL JOURNAL (2002)

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Article Neurosciences

Involvement of the opioid system in the anxiolytic-like effects induced by Δ9-tetrahydrocannabinol

F Berrendero et al.

PSYCHOPHARMACOLOGY (2002)

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Article Biochemistry & Molecular Biology

Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis

GA McMahon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Anesthesiology

The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets

II Simoneau et al.

ANESTHESIOLOGY (2001)

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Article Pharmacology & Pharmacy

Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability

SOP Jacobsson et al.

BIOCHEMICAL PHARMACOLOGY (2000)

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Article Immunology

Δ-9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway

LX Zhu et al.

JOURNAL OF IMMUNOLOGY (2000)

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Article Biochemistry & Molecular Biology

Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation

I Galve-Roperh et al.

NATURE MEDICINE (2000)

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