☆ 4.7 Article

Exploring the perspectives of pharmaceutical experts and healthcare practitioners on senolytic drugs for vascular aging-related disorder: a qualitative study

FRONTIERS IN PHARMACOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Cell Biology

Senescent Cells: A Therapeutic Target in Cardiovascular Diseases

Masayoshi Suda et al.

Summary: Senescent cell accumulation is observed in age-associated diseases including cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence-associated secretory phenotype (SASP) factors that may cause or worsen cardiovascular diseases. Therapies targeting senescent cells, especially senolytic drugs, have shown potential in delaying or treating age-associated diseases.

CELLS (2023)

添加到收藏夹

Correction Geriatrics & Gerontology

Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction (vol 9, 15, 2023)

Rachael E. E. Redgrave et al.

NPJ AGING (2023)

添加到收藏夹

Article Geriatrics & Gerontology

Geroscience: the need to address some issues

Eric Le Bourg

Summary: The geroscience field suggests that delaying the ageing process itself could potentially delay all age-related diseases, instead of individually treating each disease. However, there are some issues that temporarily hinder full adherence to this perspective, such as the risk of over-enthusiasm or scientism, and the assumption that animal model results can easily be applied to humans.

BIOGERONTOLOGY (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age

Fabiola Marino et al.

Summary: Diabetes mellitus affects the biology of cardiac stem/progenitor cells, inhibiting their regenerative potential. By clearing senescent cells, the function of these cells can be restored, resulting in improved cardiac function in diabetic patients.

DIABETES (2022)

添加到收藏夹

Article Cell Biology

Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice

Nadia Salerno et al.

Summary: Cardiovascular diseases are closely related to aging, and the interaction between sex and age plays an important role in the development and progression of these diseases. Cardiac male aging is characterized by the accumulation of senescent cells, but it is unclear whether this is also a significant feature in the aged female heart, and whether senolytics can promote myocardial repair and regeneration in aged female mice after myocardial infarction. The study found that senescent cells accumulate in the aged female hearts, and removing these cells is a key therapeutic target for efficient repair of the aged female heart.

MECHANISMS OF AGEING AND DEVELOPMENT (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms

Sheng Chen et al.

Summary: Aging is a natural process that plays a critical role in the development of various diseases. Metformin, an antidiabetic drug, has been reported to delay aging and provide protection against aging-related diseases by impacting key events in the aging process.

THERANOSTICS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Senescence in Post-Mitotic Cells: A Driver of Aging?

Thomas von Zglinicki et al.

Summary: Cell senescence is not limited to proliferating cells, but can also occur in non-dividing cells. Different senescence domains interact with each other and may play a significant role in mammalian aging.

ANTIOXIDANTS & REDOX SIGNALING (2021)

添加到收藏夹

Article Cell Biology

Strategies for late phase preclinical and early clinical trials of senolytics

Erin O. Wissler Gerdes et al.

Summary: Accumulation of senescent cells is associated with various age-related and chronic diseases, making them potential targets for intervention. Preclinical and early clinical trials with senolytics have shown promising results, but more clinical trials are needed to further evaluate their efficacy across different aging and disease models.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

添加到收藏夹

Article Cell Biology

Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls

W. Andrew Owens et al.

Summary: Ageing is linked to increased risk of cardiovascular diseases, with cell senescence believed to play a role in the development of these diseases. Senolytics targeting aging cells show promise as a potential treatment for cardiovascular diseases, but may also pose complications that need to be considered in the context of the cardiovascular system.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

添加到收藏夹

Review Cell Biology

The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets

Martina Rossi et al.

Summary: Senetherapeutics are emerging to suppress the detrimental effects of senescence by targeting either senomorphics or senolytics. The main goal is to suppress the proinflammatory senescence-associated secretory phenotype and promote immune recognition and elimination of senescent cells. One attractive approach is targeting specific molecules or proteins on the surface of senescent cells for senolysis.

CELLS (2021)

添加到收藏夹

Review Cell Biology

Targeting senescent cells to attenuate cardiovascular disease progression

Ping Song et al.

AGEING RESEARCH REVIEWS (2020)

添加到收藏夹

Article Cell Biology

Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery

Emily Dookun et al.

AGING CELL (2020)

添加到收藏夹

Review Cell Biology

Senescence and the SASP: many therapeutic avenues

Jodie Birch et al.

GENES & DEVELOPMENT (2020)

添加到收藏夹

Review Biology

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases

Lorenzo Cuollo et al.

BIOLOGY-BASEL (2020)

添加到收藏夹

Article Communication

The Effects of Patient-Centered Communication: Exploring the Mediating Role of Trust in Healthcare Providers

Hyehyun Hong et al.

HEALTH COMMUNICATION (2020)

添加到收藏夹

Article Immunology

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

Larissa G.P. Langhi Prata et al.

SEMINARS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis et al.

CELL (2019)

添加到收藏夹

Review Cell Biology

Senescence and aging: Causes, consequences, and therapeutic avenues

Domhnall McHugh et al.

JOURNAL OF CELL BIOLOGY (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Socioeconomic Status and Cardiovascular Outcomes Challenges and Interventions

William M. Schultz et al.

CIRCULATION (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Senotherapeutics for healthy ageing

Laura J. Niedernhofer et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

添加到收藏夹

Review Radiology, Nuclear Medicine & Medical Imaging

A Review of Medical Doppler Ultrasonography of Blood Flow in General and Especially in Common Carotid Artery

Ammar A. Oglat et al.

JOURNAL OF MEDICAL ULTRASOUND (2018)

添加到收藏夹

Article Geriatrics & Gerontology

The Clinical Potential of Senolytic Drugs

James L. Kirkland et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2017)

添加到收藏夹

Article Cell Biology

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu et al.

AGING CELL (2015)

添加到收藏夹

Review Health Care Sciences & Services

Factors affecting the uptake of new medicines: a systematic literature review

Agnes Lubloy

BMC HEALTH SERVICES RESEARCH (2014)

添加到收藏夹

Review Medical Laboratory Technology

Drugs that modulate aging: the promising yet difficult path ahead

Brian K. Kennedy et al.

TRANSLATIONAL RESEARCH (2014)

添加到收藏夹

Article Cell Biology

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Juan Carlos Acosta et al.

NATURE CELL BIOLOGY (2013)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Assessment of Vascular Endothelial Function With Peripheral Arterial Tonometry Information at Your Fingertips?

Eshan A. Patvardhan et al.

CARDIOLOGY IN REVIEW (2010)

添加到收藏夹

Article Pharmacology & Pharmacy

Flow-mediated dilatation

OT Raitakari et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.