4.6 Review

Activated protein C in epilepsy pathophysiology

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cardiac & Cardiovascular Systems

Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging

Di Ren et al.

Summary: This study investigates the role of the APC-EPCR axis in ischemic insults in aging. The results show that APC activity is reduced during cardiac ischemia and reperfusion, and this reduction is more pronounced in aged hearts. Administration of APC prevents the shedding of EPCR induced by I/R and improves cardiac dysfunction in both young and aged mice. However, these cardioprotective effects of APC are diminished in EPCRR84A/R84A mice. AMPK mediates acute adaptive response while AKT is involved in chronic metabolic programming in APC-treated hearts.

CIRCULATION RESEARCH (2022)

Article Neurosciences

3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice

Yaoming Wang et al.

Summary: Pericyte deficiency can result in brain injury, breakdown of the blood-brain barrier, and neuronal degeneration. Treatment with 3K3A-APC may protect the brain from injury caused by pericyte deficiency.

FRONTIERS IN NEUROSCIENCE (2022)

Article Immunology

Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C

Mikko T. Huuskonen et al.

Summary: 3K3A-APC holds promise as a therapeutic agent for preventing and treating white matter strokes, a major cause of human disability. It activates certain receptors to protect white matter fibers and oligodendrocytes, improving neuropathologic and functional outcomes.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Review Urology & Nephrology

Anticoagulation strategies in continuous renal replacement therapy

Matthieu Legrand et al.

Summary: The choice of anticoagulant for CRRT should be based on patient characteristics, local expertise, and monitoring convenience. The KDIGO guidelines recommend using RCA instead of UFH in patients without increased risk of bleeding.

SEMINARS IN DIALYSIS (2021)

Review Biochemistry & Molecular Biology

Protease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves

Elena Pompili et al.

Summary: Schwann cells play a crucial role in peripheral nerve regeneration by promptly activating, dedifferentiating, and assisting axon regrowth after nerve injury. PAR1, a thrombin receptor present on Schwann cell plasma membrane, is emerging as a possible regulator of Schwann cells' pro-regenerative capacity. This review summarizes recent literature on the contribution of PAR1 and PAR1-activating proteases in regulating peripheral nerve regeneration.

BIOMOLECULES (2021)

Review Cell Biology

Pro- and anti-epileptic roles of microglia

Shinichi Kinoshita et al.

Summary: Microglia in the epileptic brain exhibit different activation phenotypes, but their exact roles remain unclear.

NEURAL REGENERATION RESEARCH (2021)

Review Biochemistry & Molecular Biology

Oligodendrocyte lineage cells and depression

Butian Zhou et al.

Summary: Depression is a common mental illness affecting over 300 million people worldwide. Various theories exist regarding its pathogenesis, including the monoamine hypothesis, changes in the hypothalamic-pituitary-adrenal axis, inflammation, immune system alterations, and abnormalities of neurogenesis. In addition to well-known theories, there are also less widely recognized theories of depression causation.

MOLECULAR PSYCHIATRY (2021)

Review Clinical Neurology

Emerging Roles for Microglial Phagocytic Signaling in Epilepsy

Season K. Wyatt-Johnson et al.

EPILEPSY CURRENTS (2020)

Review Pharmacology & Pharmacy

Microglia modulate the structure and function of the hippocampus after early-life seizures

Megumi Andoh et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2020)

Review Neurosciences

A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity

Hossam Kadry et al.

FLUIDS AND BARRIERS OF THE CNS (2020)

Review Medicine, General & Internal

Protein C Deficiency as a Risk Factor for Stroke in Young Adults: A Review

Zainab Majid et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2020)

Review Biochemistry & Molecular Biology

The Cardioprotective Signaling Activity of Activated Protein C in Heart Failure and Ischemic Heart Diseases

Di Ren et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Neurosciences

Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance

Elizabeth M. Rhea et al.

FRONTIERS IN NEUROSCIENCE (2019)

Review Behavioral Sciences

Blood-brain barrier dysfunction in status epileptics: Mechanisms and role in epileptogenesis

Evyatar Swissa et al.

EPILEPSY & BEHAVIOR (2019)

Editorial Material Hematology

Cell biology of activated protein C

Khurrum Shahzad et al.

CURRENT OPINION IN HEMATOLOGY (2019)

Article Cell Biology

Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy

Xiaofeng Zhao et al.

CELL REPORTS (2018)

Review Cell Biology

Microglia after Seizures and in Epilepsy

Toshimitsu Hiragi et al.

Review Neurosciences

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

Sara Bachiller et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Review Neurosciences

Inflammation: A Network in the Pathogenesis of Status Epilepticus

Ming Wang et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

Article Biochemistry & Molecular Biology

Foxp3 exhibits antiepileptic effects in ictogenesis involved in TLR4 signaling

Fa-Xiang Wang et al.

FASEB JOURNAL (2017)

Review Neurosciences

Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation

Sarah Jakel et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1

Hanna M. Eilken et al.

NATURE COMMUNICATIONS (2017)

Article Neurosciences

Blood-Brain Barrier Disruption

Dan Z. Milikovsky et al.

MODELS OF SEIZURES AND EPILEPSY, 2ND EDITION (2017)

Article Medicine, Research & Experimental

Immunity and Inflammation in Epilepsy

Annamaria Vezzani et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

Review Cell Biology

Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development

Elzbieta Bronisz et al.

MEDIATORS OF INFLAMMATION (2016)

Review Hematology

Activated protein C: biased for translation

John H. Griffin et al.

Review Cell Biology

Blood-brain barrier dysfunction, seizures and epilepsy

E. A. van Vliet et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)

Article Multidisciplinary Sciences

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

Taito Matsuda et al.

NATURE COMMUNICATIONS (2015)

Article Clinical Neurology

Increased Expression of Matrix Metalloproteinase-9 in Patients with Temporal Lobe Epilepsy

Goksemin Acar et al.

TURKISH NEUROSURGERY (2015)

Article Multidisciplinary Sciences

Capillary pericytes regulate cerebral blood flow in health and disease

Catherine N. Hall et al.

NATURE (2014)

Review Pharmacology & Pharmacy

Functional role of protease activated receptors in vascular biology

Maria Adele Alberelli et al.

VASCULAR PHARMACOLOGY (2014)

Article Neurosciences

NG2 cells (polydendrocytes) in brain physiology and repair

Akiko Nishiyama et al.

FRONTIERS IN NEUROSCIENCE (2014)

Review Physiology

Inward rectifiers and their regulation by endogenous polyamines

Victoria A. Baronas et al.

FRONTIERS IN PHYSIOLOGY (2014)

Article Clinical Neurology

Fractalkine/CX3CLI modulates GABAA currents in human temporal lobe epilepsy

Cristina Roseti et al.

EPILEPSIA (2013)

Review Neurosciences

Endothelial calcium dynamics, connexin channels and blood-brain barrier function

Marijke De Bock et al.

PROGRESS IN NEUROBIOLOGY (2013)

Review Neurosciences

Glia and epilepsy: excitability and inflammation

Orrin Devinsky et al.

TRENDS IN NEUROSCIENCES (2013)

Article Multidisciplinary Sciences

Pericyte loss influences Alzheimer-like neurodegeneration in mice

Abhay P. Sagare et al.

NATURE COMMUNICATIONS (2013)

Article Biochemistry & Molecular Biology

Coagulation Factor Xa

Mark A. Brown et al.

HANDBOOK OF PROTEOLYTIC ENZYMES, VOLS 1 AND 2, 3RD EDITION (2013)

Article Pathology

Altered Expression of CX3CL1 in Patients with Epilepsy and in a Rat Model

Yali Xu et al.

AMERICAN JOURNAL OF PATHOLOGY (2012)

Review Endocrinology & Metabolism

Pathophysiology of the neurovascular unit: disease cause or consequence?

Danica B. Stanimirovic et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

Article Neurosciences

Seizure-Induced Neuronal Death Is Suppressed in the Absence of the Endogenous Lectin Galectin-1

Vincent Bischoff et al.

JOURNAL OF NEUROSCIENCE (2012)

Article Multidisciplinary Sciences

Responsive Electrical Stimulation Suppresses Epileptic Seizures in Rats

Lei Wang et al.

PLOS ONE (2012)

Review Pharmacology & Pharmacy

Structure, function and pathophysiology of protease activated receptors

Mark N. Adams et al.

PHARMACOLOGY & THERAPEUTICS (2011)

Article Clinical Neurology

The natural history of epilepsy in tuberous sclerosis complex

Catherine J. Chu-Shore et al.

EPILEPSIA (2010)

Article Multidisciplinary Sciences

Pericytes regulate the blood-brain barrier

Annika Armulik et al.

NATURE (2010)

Article Neurosciences

Transcriptome Profiling Reveals TGF-β Signaling Involvement in Epileptogenesis

Luisa P. Cacheaux et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Biochemistry & Molecular Biology

Nuclear factor-κB regulates seizure threshold and gene transcription following convulsant stimulation

Farah D. Lubin et al.

JOURNAL OF NEUROCHEMISTRY (2007)

Article Endocrinology & Metabolism

The NMDA and AMPA/KA receptors are involved in glutamate-induced alterations of occludin expression and phosphorylation in brain endothelial cells

Ibolya E. Andras et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2007)

Review Hematology

The cytoprotective protein C pathway

Laurent O. Mosnier et al.

Article Multidisciplinary Sciences

Bidirectional control of CNS capillary diameter by pericytes

Claire M. Peppiatt et al.

NATURE (2006)

Article Neurosciences

Blood-brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions

Yuri Persidsky et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2006)

Review Biochemistry & Molecular Biology

The anticoagulant protein C pathway

B Dahlbäck et al.

FEBS LETTERS (2005)

Review Cell Biology

Dynamics of CNS barriers: Evolution, differentiation, and modulation

NJ Abbott

CELLULAR AND MOLECULAR NEUROBIOLOGY (2005)

Article Neurosciences

Molecular and cellular mechanisms of neuroprotection by vascular endothelial growth factor

FY Sun et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2005)

Article Hematology

The blood coagulation cascade

M Schenone et al.

CURRENT OPINION IN HEMATOLOGY (2004)

Article Multidisciplinary Sciences

The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia

CE Junge et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Hematology

What is all that thrombin for?

KG Mann et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2003)

Article Cardiac & Cardiovascular Systems

Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor

CD Sharp et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)

Article Peripheral Vascular Disease

Early pericyte response to brain hypoxia in cats: An ultrastructural study

E Gonul et al.

MICROVASCULAR RESEARCH (2002)

Article Biochemistry & Molecular Biology

Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis

DE Joyce et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Peripheral Vascular Disease

Pericyte migration from the vascular wall in response to traumatic brain injury

P Dore-Duffy et al.

MICROVASCULAR RESEARCH (2000)

Article Neurosciences

Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus

MG De Simoni et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2000)