☆ 4.5 Review

Peripheral mechanisms of peripheral neuropathic pain

FRONTIERS IN MOLECULAR NEUROSCIENCE (2023)

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Human TrkAR649W mutation impairs nociception, sweating and cognitive abilities: a mouse model of HSAN IV

Paola Pacifico et al.

Summary: A mouse model carrying the HSAN IV TrkA(R649W) mutation was successfully generated, mimicking the clinical manifestations of HSAN IV patients. The pathological R649W mutation in TrkA led to kinase-inactive TrkA and affected its membrane dynamics and trafficking. TrkA(R649W/m) mice showed reduced response to thermal and chemical noxious stimuli, decreased skin innervation, and impaired sweating, resembling the HSAN IV phenotype.

HUMAN MOLECULAR GENETICS (2023)

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Article Multidisciplinary Sciences

Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function

Min Jung et al.

Summary: The authors generated a cross-species atlas of the dorsal root ganglia, uncovering conserved programs for sensory function that could be used for therapeutic development.

NATURE COMMUNICATIONS (2023)

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Review Chemistry, Medicinal

KIF1A-Associated Neurological Disorder: An Overview of a Rare Mutational Disease

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Summary: KIF1A-associated neurological diseases (KANDs) are a group of inherited diseases caused by mutations in the KIF1A gene, resulting in disrupted neuronal transport and various neurological pathologies. Currently, there is no permanent treatment, but gene therapy shows promise as a potential therapeutic approach.

PHARMACEUTICALS (2023)

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Article Medicine, General & Internal

Efficacy and safety of vixotrigine in idiopathic or diabetes-associated painful small fibre neuropathy (CONVEY): a phase 2 placebo-controlled enriched-enrolment randomised withdrawal study

Catharina G. Faber et al.

Summary: This clinical trial evaluated the efficacy and safety of vixotrigine in patients with painful small fibre neuropathy (SFN). The study found that vixotrigine can effectively reduce pain symptoms in SFN patients and is well tolerated.

ECLINICALMEDICINE (2023)

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Article Medicine, General & Internal

Selective Inhibition of NaV1.8 with VX-548 for Acute Pain

Jim Jones et al.

Summary: The oral Na(V)1.8 inhibitor VX-548 has been found to reduce acute pain after abdominoplasty or bunionectomy, with the highest dose showing the most significant reduction. However, lower doses of VX-548 were not significantly different from placebo in terms of pain relief. Adverse events associated with VX-548 were common but mild to moderate in severity.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

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Article Biochemistry & Molecular Biology

A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle

Manatsu Morikawa et al.

Summary: The mechanochemical coupling of ATPase hydrolysis and conformational dynamics in kinesin motors is crucial for the interaction between the motor and neck domains. We identified a charge-inverting KIF1A-E239K mutant in patients with Charcot-Marie-Tooth disease and other neuropathies. This mutation affects the motor-neck interaction and results in decreased ATPase activity and microtubule gliding velocity.

EMBO JOURNAL (2022)

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Review Dermatology

Single-cell transcriptomics in human skin research: available technologies, technical considerations and disease applications

Georgios Theocharidis et al.

Summary: Single-cell technologies, particularly single-cell RNA sequencing, have revolutionized research in skin biology by enabling the assessment of cell-to-cell variation and elucidation of cellular heterogeneity in human diseases. These technologies have found wide applications in inflammatory skin disorders, fibrotic skin diseases, wound healing complications, and cutaneous neoplasms.

EXPERIMENTAL DERMATOLOGY (2022)

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Article Cell Biology

Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors

Diana Tavares-Ferreira et al.

Summary: Nociceptors, specialized sensory neurons, play a crucial role in detecting and generating pain signals. This study used spatial transcriptomics to characterize the transcriptomes of human nociceptors, identifying different clusters and potential drug targets in the human dorsal root ganglia (DRG). Comparison with mouse sensory neuron transcriptomes and nonhuman primate DRG neuronal subtypes revealed conserved gene expression patterns but also species-specific differences. Sex differences in DRG subpopulation transcriptomes were also identified. This comprehensive spatial characterization of human nociceptors has significant implications for the development of improved treatments for pain disorders.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Article Anesthesiology

Mitochondrial calcium uniporter deletion prevents painful diabetic neuropathy by restoring mitochondrial morphology and dynamics

Dale George et al.

Summary: This research identified elevated mitochondrial fission proteins and increased calcium signaling in dorsal root ganglion (DRG) neurons in a mouse model of painful diabetic neuropathy (PDN). By selectively deleting the mitochondrial calcium uniporter, the study demonstrated the restoration of normal mitochondrial morphology, prevention of axonal degeneration, and reversal of mechanical allodynia in the PDN mouse model. These findings indicate the potential of targeting calcium entry into nociceptor mitochondria as an effective therapeutic approach for PDN.

PAIN (2022)

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Article Multidisciplinary Sciences

Transcriptomic analysis of human sensory neurons in painful diabetic neuropathy reveals inflammation and neuronal loss

Bradford E. Hall et al.

Summary: This study investigated the intraganglionic pathology and mechanisms causing neuropathic pain in patients with Type 2 diabetes mellitus. The transcriptome analysis revealed increased levels of inflammation-associated transcripts and frequent downregulation of neuronally-related genes in patients with painful diabetic peripheral neuropathy.

SCIENTIFIC REPORTS (2022)

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Review Medicine, Research & Experimental

The Use of Human Tissues for Research: What Investigators Need to Know

Marianna J. Bledsoe et al.

Summary: This article discusses the advantages of using human tissues in research, describes how human tissue is collected, and advises investigators on finding and using appropriate bioresources to support their research.

ATLA-ALTERNATIVES TO LABORATORY ANIMALS (2022)

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Article Multidisciplinary Sciences

PIEZO1 transduces mechanical itch in mice

Rose Z. Hill et al.

Summary: This study reveals that the transduction of mechanical itch is mainly mediated by the ion channel PIEZO1. Loss of PIEZO1 function greatly reduces mechanically evoked scratching behaviors and acute/chronic itch sensitization. In addition, mice expressing a gain-of-function Piezo1 allele exhibit enhanced mechanical itch behaviors.

NATURE (2022)

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Review Neurosciences

Mu-opioid receptor and receptor tyrosine kinase crosstalk: Implications in mechanisms of opioid tolerance, reduced analgesia to neuropathic pain, dependence, and reward

Mackenzie C. C. Gamble et al.

Summary: Despite the prevalence of opioid misuse, opioids remain the frontline treatment for severe pain. However, their side effects such as tolerance, reduced analgesia to neuropathic pain, physical dependence, and reward contribute to opioid use disorders. This review focuses on exploring how the transactivation of RTKs via MORs can modulate the undesirable effects of chronic opioid use and potentially serve as a therapeutic target for mitigating these side effects.

FRONTIERS IN SYSTEMS NEUROSCIENCE (2022)

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Article Biology

Keratinocyte PIEZO1 modulates cutaneous mechanosensation

Alexander R. Mikesell et al.

Summary: PIEZO1 is identified as a key mechanotransducer in epidermal keratinocytes, playing a crucial role in sensory neuron activity and behavioral responses to mechanical stimuli.

ELIFE (2022)

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Article Physiology

A High-Fat Diet Disrupts Nerve Lipids and Mitochondrial Function in Murine Models of Neuropathy

Amy E. Rumora et al.

Summary: As the prevalence of prediabetes and type 2 diabetes continues to increase, complications such as peripheral neuropathy are also on the rise. This study found that dyslipidemia, specifically certain lipid changes, may contribute to the development of peripheral neuropathy in prediabetes. High-fat diet was shown to trigger strain- and tissue-specific lipid changes in mice, with significant alterations in neutral lipids, phospholipids, lysophospholipids, and plasmalogens observed in the nerves. Sphingomyelin and lysophosphatidylethanolamine were identified as unique lipid species in the high-fat diet mice compared to other strains. These nerve-specific lipid changes were found to affect mitochondrial function and may contribute to the pathogenesis of peripheral neuropathy.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Anesthesiology

No pain, still gain (of function): the relation between sensory profiles and the presence or absence of self-reported pain in a large multicenter cohort of patients with neuropathy

Julia Forstenpointner et al.

Summary: The study revealed that hypersensitivity symptoms, including hyperalgesia and allodynia, are present in patients with central and peripheral lesions of the somatosensory system, even if they do not report spontaneous pain. There was a difference in pain sensitivity between painful and painless neuropathic conditions, with hyperalgesia more common in painful mononeuropathy and hypoalgesia more pronounced in painful polyneuropathy.

PAIN (2021)

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Editorial Material Anesthesiology

What can we learn from the failure of quantitative sensory testing?

Martin Schmelz

PAIN (2021)

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Review Rheumatology

The evolution of nerve growth factor inhibition in clinical medicine

Barton L. Wise et al.

Summary: NGF is an important neurotrophin involved in pain signal transmission, and inhibitors have shown efficacy in reducing joint pain in osteoarthritis patients, but higher doses may increase the risk of rapidly progressive osteoarthritis. Ongoing studies aim to better understand the mechanisms involved in this adverse event.

NATURE REVIEWS RHEUMATOLOGY (2021)

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Article Cell Biology

Small Molecule SARM1 Inhibitors Recapitulate the SARM1-/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

Robert O. Hughes et al.

Summary: Inhibiting SARM1 can protect axons from degeneration and promote functional recovery, offering a new potential treatment for axonopathies of the central and peripheral nervous systems.

CELL REPORTS (2021)

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Article Cell Biology

Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain

Kaikai Wang et al.

Summary: Researchers identified new neuronal clusters induced by spared nerve injury (SNI) through single-cell RNA sequencing on dissociated mouse DRG cells, revealing the transcriptomic changes during the process. Additionally, activation of specific transcription factors within 2 days after nerve injury might lead to changes in gene expression. This study provides a new molecular mechanism basis for understanding the development of neuropathic pain.

CELL RESEARCH (2021)

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Article Anesthesiology

Demise of nociceptive Schwann cells causes nerve retraction and pain hyperalgesia

Puneet Rinwa et al.

Summary: Recent findings suggest that nociceptive nerves terminate in a specialized end-organ in mice, consisting of nociceptive nerves and specialized Schwann cells. Similarly, human skin contains nociceptive Schwann cells that contribute to neuropathy and pain hypersensitivity. Ablation of nociceptive Schwann cells in mice results in nerve retraction and hypersensitivity to mechanical, cold, and heat stimuli, while ablating the nociceptive nerves leads to changes in Schwann cell morphology and hypersensitivity. These results highlight the interdependence between nerves and nociceptive Schwann cells.

PAIN (2021)

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Article Multidisciplinary Sciences

Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain

Jussi Kupari et al.

Summary: This study classified non-human primate dorsal root ganglion sensory neurons based on their transcriptome and mapped human pain heritability to neuronal types. The findings revealed the cellular origin of chronic pain by showing genome-wide associations converging on two different neuronal types with different genetic susceptibilities for chronic pain.

NATURE COMMUNICATIONS (2021)

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Article Biology

Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

Minh Q. Nguyen et al.

Summary: Through single nuclear transcriptomics of human DRG neurons, it was found that different types of neurons share similarities in their transcriptomic features, but there are species differences in the expression of genes related to sensory function. Surprisingly, several transcriptomic classes without clear equivalents in other species were identified.

ELIFE (2021)

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Article Clinical Neurology

Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy

Todd Bosanac et al.

Summary: SARM1 is a central driver of axonal degeneration in neurodegenerative disorders and a potential therapeutic target for treating axonopathies in peripheral and central nervous systems. Small molecule SARM1 inhibitors have the potential to prevent axonal degeneration and provide disease-modifying treatment for these disorders.

BRAIN (2021)

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Article Neurosciences

SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration

Yi-Hsien Chen et al.

Summary: Research has shown that SARM1 triggers axon degeneration in human neurons, and SARM1 inhibitors are proposed as a potential new therapy for the prevention and treatment of neurological diseases.

EXPERIMENTAL NEUROLOGY (2021)

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Article Medicine, General & Internal

Association of Genetic Variant at Chromosome 12q23.1 With Neuropathic Pain Susceptibility

Abirami Veluchamy et al.

Summary: This genetic association study conducted a meta-analysis of GWASs from three independent cohorts to identify genetic variants associated with NP susceptibility. The study discovered a significant locus on chromosome 12q23.1 and a suggestive variant near 13q14.2 that are related to NP susceptibility.

JAMA NETWORK OPEN (2021)

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Review Neurosciences

The physiological function of different voltage-gated sodium channels in pain

George Goodwin et al.

Summary: Evidence from human genetic pain disorders shows that voltage-gated sodium channel alpha-subtypes Nav1.7, Nav1.8 and Nav1.9 play important roles in peripheral pain signaling. Drug development targeting these channels requires a better understanding of their involvement in pain signal transmission.

NATURE REVIEWS NEUROSCIENCE (2021)

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Article Neurosciences

A central mechanism of analgesia in mice and humans lacking the sodium channel NaV1.7

Donald Iain MacDonald et al.

Summary: Deletion of SCN9A encoding Na(V)1.7 in humans leads to pain insensitivity and anosmia. Knockout mice show normal nociceptor activity, but synaptic transmission from nociceptor terminals in the spinal cord is reduced by an opioid-dependent mechanism, reversing analgesia. This mechanism is also responsible for anosmia.

NEURON (2021)

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Editorial Material Neurosciences

Human cells and networks of pain Transforming pain target identification and therapeutic development

William Renthal et al.

Summary: Chronic pain is a debilitating disease with limited treatment options. Understanding pain cells and networks in humans is crucial for translating knowledge from animal models to therapeutic applications. A multi-institutional collaboration is proposed to address this challenge rigorously and ethically.

NEURON (2021)

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Review Immunology

Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States

Daniel B. Lowy et al.

Summary: Bidirectional interaction between the peripheral immune and nervous systems plays a crucial role in maintaining homeostasis and responding to noxious stimuli. The skin is a highly complex biological structure where sensory nerve terminals and immune cells coexist. Sensory neurons regulate cutaneous immune responses through neuropeptides, while immune cells modulate sensory neurons through mediators.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Neurosciences

The mechanosensory neurons of touch and their mechanisms of activation

Annie Handler et al.

Summary: Our sense of touch is generated from mechanosensory structures within the skin, with low-threshold mechanoreceptors transmitting signals to the central nervous system, leading to a rich tactile discrimination. The diversity of LTMR subtypes and their associated end organ structures contribute to the specificity of tactile tuning, while the principal mechanosensitive channel PIEZO2 plays a crucial role in light touch sensation.

NATURE REVIEWS NEUROSCIENCE (2021)

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Review Clinical Neurology

Studying human nociceptors: from fundamentals to clinic

Steven J. Middleton et al.

Summary: Studying human nociceptors has led to significant advances in understanding chronic pain mechanisms and identifying potential new therapeutic targets. However, challenges remain in implementing these techniques at scale, generating a full diversity of nociceptor populations from induced pluripotent stem cells, and understanding inter-individual variation in nociceptors.

BRAIN (2021)

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Article Anesthesiology

Stratification of patients based on the Neuropathic Pain Symptom Inventory: development and validation of a new algorithm

Didier Bouhassira et al.

Summary: The study confirmed the effectiveness of an algorithm that stratifies patients into three clusters based on specific combinations of neuropathic symptoms for predicting treatment response. The algorithm accurately predicted treatment response to subcutaneous injections of botulinum toxin A in different patient clusters, demonstrating its relevance in clinical practice.

PAIN (2021)

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Article Clinical Neurology

Diagnosing small fiber neuropathy in clinical practice: a deep phenotyping study

Nadine Egenolf et al.

Summary: This case-control study suggests that the diagnosis of small fiber neuropathy (SFN) in patients with pain of uncertain origin can be primarily based on the results of neurological examination and distal intraepidermal nerve fiber density (IENFD), with further detailed phenotyping recommended in specialized centers. Abnormal distal IENFD and neurological examination were the most common indicators of small fiber disease, with additional tests like corneal confocal microscopy (CCM) and pain-related evoked potentials (PREP) increasing the number of patients with small fiber impairment. Genetic testing revealed potentially pathogenic gene variants in a subset of the index patients.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2021)

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Review Cell Biology

Ultrasonic vocalizations in mice: relevance for ethologic and neurodevelopmental disorders studies

Marika Premoli et al.

Summary: Mice use ultrasonic vocalizations (USVs) to communicate and communicate emotions, with different call categories defined but their meanings still unclear. USVs are also used to study pathologies such as neurodevelopmental disorders, especially in mouse models.

NEURAL REGENERATION RESEARCH (2021)

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Review Biochemistry & Molecular Biology

The changing opioid crisis: development, challenges and opportunities

Nora D. Volkow et al.

Summary: The current opioid epidemic in the US is one of the most severe public health crises in the country's history, and addressing it is challenging due to its rapidly changing nature and serious outcomes. Success in addressing the crisis will require advances in basic science, development of more acceptable and effective treatments, and implementation of public health approaches, including prevention. The progress made in addressing this crisis should also advance the science and treatment of other substance use disorders.

MOLECULAR PSYCHIATRY (2021)

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Mitochondrial Dynamics and Its Involvement in Disease

David C. Chan

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 15, 2020 (2020)

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Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis

Helen He et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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The emergence of transcriptional identity in somatosensory neurons

Nikhil Sharma et al.

NATURE (2020)

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Axons Matter: The Promise of Treating Neurodegenerative Disorders by Targeting SARM1-Mediated Axonal Degeneration

Raul Krauss et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

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Men Wu et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

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A machine-vision approach for automated pain measurement at millisecond timescales

Jessica M. Jones et al.

ELIFE (2020)

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Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization

Stephanie Shiers et al.

PAIN (2020)

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Single cell transcriptomics of human epidermis identifies basal stem cell transition states

Shuxiong Wang et al.

NATURE COMMUNICATIONS (2020)

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Cisplatin induced neurotoxicity is mediated by Sarm1 and calpain activation

Aysel Cetinkaya-Fisgin et al.

SCIENTIFIC REPORTS (2020)

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Molecular and Cellular Mechanisms of Itch in Psoriasis

Eriko Komiya et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration

Weili Tian et al.

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Sodium Channels in Human Pain Disorders: Genetics and Pharmacogenomics

Sulayman D. Dib-Hajj et al.

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Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons

Robert Y. North et al.

BRAIN (2019)

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Hui Xu et al.

CELL (2019)

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Composite Pain Biomarker Signatures for Objective Assessment and Effective Treatment

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Aaron DiAntonio

PAIN (2019)

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Tanezumab for Painful Osteoarthritis

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

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Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice

Yalan Cheng et al.

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MCU Up-regulation contributes to myocardial ischemia-reperfusion Injury through calpain/OPA-1-mediated mitochondrial fusion/mitophagy Inhibition

Lichun Guan et al.

INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY (2019)

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The translatability of pain across species

Jeffrey S. Mogil

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2019)

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Development of a Mouse Pain Scale Using Sub-second Behavioral Mapping and Statistical Modeling

Ishmail Abdus-Saboor et al.

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The Genetics of Neuropathic Pain from Model Organisms to Clinical Application

Margarita Calvo et al.

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Long noncoding RNA (lncRNA): a target in neuropathic pain

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A20 and ABIN1 Suppression of a Keratinocyte Inflammatory Program with a Shared Single-Cell Expression Signature in Diverse Human Rashes

Paymann Harirchian et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

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Review Anesthesiology

Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)

Rolf-Detlef Treede et al.

PAIN (2019)

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The IASP classification of chronic pain for ICD-11: chronic neuropathic pain

Joachim Scholz et al.

PAIN (2019)

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Article Medicine, Research & Experimental

Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program

Stefanie Geisler et al.

JCI INSIGHT (2019)

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Human vs. Mouse Nociceptors - Similarities and Differences

Charlotte Rostock et al.

NEUROSCIENCE (2018)

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Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy

Iulia Blesneac et al.

PAIN (2018)

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Review Anesthesiology

Stratification of neuropathic pain patients: the road to mechanism-based therapy?

Julia Forstenpointner et al.

CURRENT OPINION IN ANESTHESIOLOGY (2018)

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Article Medicine, Research & Experimental

Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy

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Article Dermatology

SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

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Optogenetic Inhibition of CGRP alpha Sensory Neurons Reveals Their Distinct Roles in Neuropathic and Incisional Pain

Ashley M. Cowie et al.

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Diagnosis and assessment of neuropathic pain through questionnaires

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TRPAI sensitization during diabetic vascular impairment contributes to cold hypersensitivity in a mouse model of painful diabetic peripheral neuropathy

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MOLECULAR PAIN (2018)

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Efficacy of the Na(v)1.7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy

Aoibhinn McDonnell et al.

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Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling

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Using stratified medicine to understand, diagnose, and treat neuropathic pain

Andreas C. Themistocleous et al.

PAIN (2018)

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Aaron D. Mickle et al.

PAIN (2018)

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Article Cell Biology

The Atypical Kinesin KIF26A Facilitates Termination of Nociceptive Responses by Sequestering Focal Adhesion Kinase

Li Wang et al.

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Article Cell Biology

Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain

Girish Bankar et al.

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Therapeutic opportunities and pitfalls in the treatment of axon degeneration

David J. Simon et al.

CURRENT OPINION IN NEUROLOGY (2018)

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Article Cell Biology

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice

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[Anonymous]

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Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice

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Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

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CaM kinase lα-induced phosphorylation of Drp1 regulates mitochondrial morphology

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Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable

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The Kyoto protocol of IASP Basic Pain Terminology

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Neuropathic pain - Redefinition and a grading system for clinical and research purposes

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4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

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Differential expression of cytokines in painful and painless neuropathies

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Modification of classical neurochemical markers in identified primary afferent neurons with Aβ-, Aδ-, and C-fibers after chronic constriction injury in mice

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Using screening tools to identify neuropathic pain

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Abnormal function of C-fibers in patients with diabetic neuropathy

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Novel class of pain drugs based on antagonism of NGF

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Ultrasound vocalisation by rodents does not correlate with behavioural measures of persistent pain

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Electrophysiological differences between nociceptive and non-nociceptive dorsal root ganglion neurones in the rat in vivo

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Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd

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NEURON (2005)

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The case for the inclusion of female subjects in basic science studies of pain

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Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Axonal swellings predict the degeneration of epidermal nerve fibers in painful neuropathies

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Diabetes-induced alterations in calcium homeostasis in sensory neurones of streptozotocin-diabetic rats are restricted to lumbar ganglia and are prevented by neurotrophin-3

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Effects of intrathecal administration of ziconotide, a selective neuronal N-type calcium channel blocker, on mechanical allodynia and heat hyperalgesia in a rat model of postoperative pain

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