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Rhea Sumpter et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2010)
HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction
Sanjeev Gupta et al.
PLOS BIOLOGY (2010)
Mendelian forms of Parkinson's disease
Thomas Gasser
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)
p62 at the Crossroads of Autophagy, Apoptosis, and Cancer
Jorge Moscat et al.
CELL (2009)
Role of BNIP3 and NIX in cell death, autophagy, and mitophagy
J. Zhang et al.
CELL DEATH AND DIFFERENTIATION (2009)
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
J. M. Vicencio et al.
CELL DEATH AND DIFFERENTIATION (2009)
Regulation of Autophagy by the p300 Acetyltransferase
In Hye Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Intranuclear Degradation of Polyglutamine Aggregates by the Ubiquitin-Proteasome System
Atsushi Iwata et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons IMPLICATIONS FOR THE PATHOGENESIS OF ALZHEIMER DISEASE
Rodrigo A. Quintanilla et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways
Jenelle M. Timmins et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
Xinglong Wang et al.
JOURNAL OF NEUROSCIENCE (2009)
A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates
Vladimir Kirkin et al.
MOLECULAR CELL (2009)
Induction of autophagy by spermidine promotes longevity
Tobias Eisenberg et al.
NATURE CELL BIOLOGY (2009)
Amyloid formation by globular proteins under native conditions
Fabrizio Chiti et al.
NATURE CHEMICAL BIOLOGY (2009)
Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses
Efrat Abramov et al.
NATURE NEUROSCIENCE (2009)
Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin
Gerardo A. Morfini et al.
NATURE NEUROSCIENCE (2009)
Amyloid precursor protein increases cortical neuron size in transgenic mice
Esther S. Oh et al.
NEUROBIOLOGY OF AGING (2009)
Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins
Sebastian Pechmann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Calcium dysregulation in Alzheimer's disease: From mechanisms to therapeutic opportunities
Jin-Tai Yu et al.
PROGRESS IN NEUROBIOLOGY (2009)
A Gene Network Regulating Lysosomal Biogenesis and Function
Marco Sardiello et al.
SCIENCE (2009)
Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning
Yann Senechal et al.
BEHAVIOURAL BRAIN RESEARCH (2008)
Mitochondrial association of alpha-synuclein causes oxidative stress
M. S. Parihar et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Gilad Twig et al.
EMBO JOURNAL (2008)
Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression
Tadanori Hamano et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2008)
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
Elizabeth L. Axe et al.
JOURNAL OF CELL BIOLOGY (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra et al.
JOURNAL OF CELL BIOLOGY (2008)
Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease
Jing-Ji Jin et al.
JOURNAL OF NEUROINFLAMMATION (2008)
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking
Adam L. Orr et al.
JOURNAL OF NEUROSCIENCE (2008)
Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease
Barry Boland et al.
JOURNAL OF NEUROSCIENCE (2008)
Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer's disease mice
Suzanne E. Hickman et al.
JOURNAL OF NEUROSCIENCE (2008)
Autophagy fights disease through cellular self-digestion
Noboru Mizushima et al.
NATURE (2008)
Regulation of TORC1 by Rag GTPases in nutrient response
Eunjung Kim et al.
NATURE CELL BIOLOGY (2008)
Endocytosis is required for synaptic activity-dependent release of amyloid-β in vivo
John R. Cirrito et al.
NEURON (2008)
Stress as a neuroinflammatory condition in brain:: Damaging and protective mechanisms
Borja Garcia-Bueno et al.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2008)
Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis
P. Pinton et al.
ONCOGENE (2008)
Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA
Philippe A. Parone et al.
PLOS ONE (2008)
Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes
Peter Kijun Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
Camilla A. Hansson Petersen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
Adapting proteostasis for disease intervention
William E. Balch et al.
SCIENCE (2008)
The itinerary of autophagosomes: From peripheral formation to kiss-and-run fusion with lysosomes
Luca Jahreiss et al.
TRAFFIC (2008)
Inhibition of vesicular monoamine transporter-2 activity in alpha-synuclein stably transfected SH-SY5Y cells
Jun Tang Guo et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2008)
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
Masaaki Komatsu et al.
CELL (2007)
Autophagy, amyloidogenesis and Alzheimer disease
Ralph A. Nixon
JOURNAL OF CELL SCIENCE (2007)
Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology
Michoel Forgac
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
Serhiy Pankiv et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
Udai Bhan Pandey et al.
NATURE (2007)
Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
Ganesh M. Shankar et al.
JOURNAL OF NEUROSCIENCE (2007)
Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide
Christian Haass et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Polymodal regulation of NMDA receptor channels
Anna Kloda et al.
CHANNELS (2007)
ROS, mitochondria and the regulation of autophagy
Ruth Scherz-Shouval et al.
TRENDS IN CELL BIOLOGY (2007)
Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
Yaping Chu et al.
NEUROBIOLOGY OF DISEASE (2007)
Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes
Ephraim Fass et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's disease
Soon-Tae Lee et al.
BRAIN RESEARCH (2006)
Relationship among α-synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigra
Fumiaki Mori et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2006)
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara et al.
NATURE (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu et al.
NATURE (2006)
Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons:: implications for free radical generation and oxidative damage in disease progression
M Manczak et al.
HUMAN MOLECULAR GENETICS (2006)
Consequences of the selective blockage of chaperone-mediated autophagy
AC Massey et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
Rapamycin alleviates toxicity of different aggregate-prone proteins
Z Berger et al.
HUMAN MOLECULAR GENETICS (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Progression patterns of neuronal loss and Lewy body pathology in the substantia nigra in Parkinson's disease
K. Wakabayashi et al.
PARKINSONISM & RELATED DISORDERS (2006)
Episodic memory impairment in Huntington's disease: A meta-analysis
Alonso Montoya et al.
NEUROPSYCHOLOGIA (2006)
The bipyridyl herbicide paraquat produces oxidative stress-mediated toxicity in human neuroblastoma SH-SY5Y cells: Relevance to the dopaminergic pathogenesis
WS Yang et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2005)
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
G Bjorkoy et al.
JOURNAL OF CELL BIOLOGY (2005)
Lithium induces autophagy by inhibiting inositol monophosphatase
S Sarkar et al.
JOURNAL OF CELL BIOLOGY (2005)
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
S Pattingre et al.
CELL (2005)
Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation
A Iwata et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Dynein mutations impair autophagic clearance of aggregate-prone proteins
B Ravikumar et al.
NATURE GENETICS (2005)
Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L Tau transgenic mice
DC David et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease
AJ Whitworth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Absence of inclusion body formation in the MPTP mouse model of Parkinson's disease
M Shimoji et al.
MOLECULAR BRAIN RESEARCH (2005)
Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease
K Takuma et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2005)
Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease
Nikunj S. Patel et al.
JOURNAL OF NEUROINFLAMMATION (2005)
Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
RA Nixon et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)
Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients
R Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Neurodegeneration or neuroprotection: The pivotal role of astrocytes
SJR Heales et al.
NEUROCHEMICAL RESEARCH (2004)
Mutant genes responsible for Parkinson's disease
W Le et al.
CURRENT OPINION IN PHARMACOLOGY (2004)
LC3 conjugation system in mammalian autophagy
I Tanida et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Involvement of macroautophagy in the dissolution of neuronal inclusions
HJ Rideout et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
M Arrasate et al.
NATURE (2004)
Stages in the development of Parkinson's disease-related pathology
H Braak et al.
CELL AND TISSUE RESEARCH (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
AR Tee et al.
CURRENT BIOLOGY (2003)
Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies
O Katsuse et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2003)
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
N Mizushima et al.
JOURNAL OF CELL SCIENCE (2003)
Paraquat and iron exposure as possible synergistic environmental risk factors in Parkinson's disease
JK Andersen
NEUROTOXICITY RESEARCH (2003)
Pathogenesis of Parkinson's disease:: Dopamine, vesicles and α-synuclein
J Lotharius et al.
NATURE REVIEWS NEUROSCIENCE (2002)
Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease
GE Meredith et al.
BRAIN RESEARCH (2002)
Effect of mutant α-synuclein on dopamine homeostasis in a new human mesencephalic cell line
J Lotharius et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Proteasome inhibition causes nigral degeneration with inclusion bodies in rats
KS McNaught et al.
NEUROREPORT (2002)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
J Hardy et al.
SCIENCE (2002)
A role for α-synuclein in the regulation of dopamine biosynthesis
RG Perez et al.
JOURNAL OF NEUROSCIENCE (2002)
Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice
H Li et al.
JOURNAL OF NEUROSCIENCE (2001)
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
YJ Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity
S Chen et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
Impairment of the ubiquitin-proteasome system by protein aggregation
NF Bence et al.
SCIENCE (2001)
Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network
A Kihara et al.
EMBO REPORTS (2001)
Aggresomes, inclusion bodies and protein aggregation
RR Kopito
TRENDS IN CELL BIOLOGY (2000)
Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice
I Dragatsis et al.
NATURE GENETICS (2000)
Maturation and endosomal targeting of β-site amyloid precursor protein-cleaving enzyme -: The Alzheimer's disease β-secretase
JT Huse et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Sequestration of iron by Lewy bodies in Parkinson's disease
RJ Castellani et al.
ACTA NEUROPATHOLOGICA (2000)
High-level neuronal expression of Aβ1-42 in wild-type human amyloid protein precursor transgenic mice:: Synaptotoxicity without plaque formation
L Mucke et al.
JOURNAL OF NEUROSCIENCE (2000)
Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline
J Näslund et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2000)
α-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the Parkinsonian toxin MPTP
M Vila et al.
JOURNAL OF NEUROCHEMISTRY (2000)
MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons
NW Kowall et al.
NEUROREPORT (2000)
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