期刊
CHEMELECTROCHEM
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/celc.202300301
关键词
Ferrocene peptide; bioorganometallic; ascorbic acid; sensor; voltammetry
In this study, a ferrocene-peptide conjugate was synthesized and used for the detection of ascorbic acid. The Cu(II) complex of this conjugate showed high sensitivity and selectivity for ascorbic acid detection, and it was successfully applied to quantify ascorbic acid in commercial beverages.
Ferrocene (Fc) is a widely used metallocene, with well-characterized redox behaviour that is vastly used in a variety of applications. Ferrocene-coupling to peptides renders the resulting bioorganometallic peptide conjugate redox active and sensitive to changes in the chemical environment. The disulfide-linked ferrocene peptide conjugate (FcCO-Phe-Cys-OH)(2) was synthesized and characterized by NMR, MS, and FT-IR spectroscopies and then exploited for the detection of ascorbic acid. Here we demonstrate that the Cu(II) complex of this peptide conjugate allows the detection of ascorbic acid with a limit of detection of 0.02 mu M with a linear range of 0.1-25 mu M. This is the first report of the use of a peptide metal complex for direct modification of a glass carbon electrode and its application for ascorbic acid detection and quantification, including in commercial beverages. The modified GCE exhibited excellent selectivity, stability, and sensitivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据