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Article
Chemistry, Physical
Achille Antenucci et al.
Summary: The E-G factor is a global green chemistry metric that evaluates the overall economy of the synthetic process of a given chiral molecule in optically pure form by considering the synthesis of the catalyst in the context of asymmetric organocatalysis. This study demonstrates its further usefulness in comparing diverse catalytic systems, even those different from organocatalysts, through analysis of four case studies.
Article
Chemistry, Physical
Caroline Gross Jacoby et al.
Summary: This study investigates the application of organocatalysts in polyesters, which are rarely used for this purpose. The proposal is to use the hydroxyl groups in chosen chiral compounds to promote the polymerization of epsilon-caprolactone, generating a support and anchoring the organocatalyst in a single step. A simple acid catalysis method was employed, which showed versatility in generating supported catalysts with different structures and functional groups. The materials were applied as organocatalysts in an aldol addition test reaction, yielding excellent product yields and good stereoselectivity. However, a recycling process seems to be necessary for their reuse.
Article
Chemistry, Physical
Alexey Nikiforov et al.
Summary: This study synthesized and studied carboxylate complexes of nickel(II) with different N-donor ligands for ring-opening polymerization (ROP) of lactide. Among the complexes, [Ni(DBED)(2)(O2CC(CH3)(3))(2)]center dot(CH3)(3)CCO2H showed the highest catalytic ability in the polymerization. A comprehensive density functional theory (DFT) study was conducted to understand the reaction mechanism and the role of carboxylate ligands in the process.
Article
Chemistry, Physical
Karolina Zalewska et al.
Summary: Different Chiral Ionic Liquids (CIL) based on L-proline have been developed using simple and efficient synthetic methodologies. These CILs, with L-proline as a cation or anion combined with suitable counter-ions, were characterized to evaluate the influence of counter-ions on their properties. The most promising CILs were tested as chiral catalysts in asymmetric Michael addition reactions, achieving similar or even better conversions and enantioselectivities compared to L-proline, and showed good product extraction performance using supercritical CO2 processes.
Review
Chemistry, Physical
Lorena S. R. Martelli et al.
Summary: Efficient synthetic methods that avoid the use of hazardous reagents and solvents have become crucial in organic synthesis. Organocatalysis is a powerful tool for building chemical bonds, but most examples still use toxic volatile organic solvents. This review discusses the use of bio-based solvents in asymmetric organocatalytic methods and their proposed mechanisms.
Article
Chemistry, Physical
Marcio Hayashi et al.
Article
Chemistry, Physical
Or Fleischer et al.
Summary: We have recently discovered that organocatalysts with a nucleophilic core and an extensive secondary-sphere envelope strongly influence the site selectivity in acylation and phosphorylation reactions. We have examined different catalysts of this design and found that the electron donation and intermediate stabilization effects of the core benzyl substituent increase catalyst activity and site selectivity in phosphorylation, while the lipophilicity of the secondary-sphere components improves site selectivity in both reactions but has an opposite effect on acylation. These findings provide valuable insights into the design of organocatalysts for selective transformations.
Editorial Material
Multidisciplinary Sciences
Jose M. Lassaletta
NATURE COMMUNICATIONS
(2020)
