ELOA promotes tumor growth and metastasis by activating RBP1 in gastric cancer

Article Oncology

Retinol binding protein 1-dependent activation of NF- κB signaling enhances the malignancy of non-glioblastomatous diffuse gliomas

Wei Wu et al.

Summary: Studies have shown that RBP1 is a significant potential therapeutic target that relies on the NF-kappa B signaling pathway, and its expression is closely associated with the malignancy of non-GDG neuroepithelial tumors.

CANCER SCIENCE (2022)

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Article Gastroenterology & Hepatology

STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis

Ruby E. Dawson et al.

Summary: The research found that AIM2 is upregulated in patients with gastric cancer due to the activation of the cancer-related transcription factor STAT3 in tumor epithelium. In mouse and cell line transplant models, genetic and therapeutic targeting of AIM2 suppressed tumorigenesis. AIM2 plays a key role in gastric tumorigenesis by promoting epithelial cell migration and tumor formation, independent of inflammasome activity.

GUT (2022)

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Article Biochemistry & Molecular Biology

Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer

Xue Wang et al.

Summary: DLGAP1-AS2 promotes tumorigenesis and metastasis in colorectal cancer by interacting with ELOA and degrading ELOA. It also decreases LHPP expression by inhibiting ELOA-mediated transcriptional activation, thus blocking LHPP-dependent suppression of the AKT signaling pathway. DLGAP1-AS2 is bound and stabilized by CPSF2 and CSTF3.

MOLECULAR CANCER (2022)

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Article Biochemistry & Molecular Biology

EXOSC8 promotes colorectal cancer tumorigenesis via regulating ribosome biogenesis-related processes

Kaisa Cui et al.

Summary: This study reveals that the RNA exosome gene (EXOSC8) promotes colorectal cancer (CRC) tumorigenesis by regulating cancer-related ribosome biogenesis in CRC. Silencing of EXOSC8 decreases levels of nucleolar proteins and proliferation markers, as well as rRNA/DNA and global protein syntheses. EXOSC8 knockdown triggers ribosomal stress, releasing nucleolar protein RPL5/11 into the nucleoplasm and hijacking Mdm2 to block its E3 ubiquitin ligase function, thereby releasing and activating p53. EXOSC8 may serve as a potential therapeutic target in CRC.

ONCOGENE (2022)

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Article Oncology

A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer

Kaisa Cui et al.

Summary: In this study, a new TME-based molecular subtype was developed using only two genes (CTSL and ZBTB7B) to identify a high-risk subgroup with unique tumor microenvironment features. This finding has potential implications for selecting treatment and management strategies for gastric cancer.

BRITISH JOURNAL OF CANCER (2022)

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Article Gastroenterology & Hepatology

E2F5 promotes proliferation and invasion of gastric cancer through directly upregulating UBE2T transcription

Lina Li et al.

Summary: This study confirmed for the first time the upregulation of E2F5 in gastric cancer and discovered that E2F5 can directly upregulate UBE2T transcription, thereby promoting malignant progression.

DIGESTIVE AND LIVER DISEASE (2022)

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Review Biochemistry & Molecular Biology

The application of CA72-4 in the diagnosis, prognosis, and treatment of gastric cancer

Yitian Xu et al.

Summary: CA72-4, as a tumor marker, plays an important role in the diagnosis, prognosis, and treatment of GC, especially in the Chinese population. By combining with other biomarkers and improving detection techniques, the sensitivity and specificity of CA72-4 can be enhanced. Furthermore, CA72-4 can evaluate therapeutic effectiveness and enhance drug efficacy.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Review Biochemistry & Molecular Biology

Advances in clinical immunotherapy for gastric cancer

Kexin Li et al.

Summary: Gastric cancer is a highly malignant cancer with increasing incidence worldwide, ranking among the top five malignant tumors in terms of incidence and mortality. Immunotherapy, as a breakthrough in cancer treatment, has shown to be effective in gastric cancer treatment, especially when used in combination with other modalities.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Article Oncology

SNHG17 promotes colorectal tumorigenesis and metastasis via regulating Trim23-PES1 axis and miR-339-5p-FOSL2-SNHG17 positive feedback loop

Zehua Bian et al.

Summary: In this study, SNHG17 was identified as an oncogenic lncRNA in colorectal cancer (CRC), with abnormal upregulation of SNHG17 serving as a prognostic risk factor for CRC. Mechanistic investigations revealed that SNHG17 promotes tumor growth and metastasis through two different regulatory mechanisms, the SNHG17-Trim23-PES1 axis and the SNHG17-miR-339-5p-FOSL2-SNHG17 positive feedback loop, which may present potential targets for CRC therapy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

Current treatment and recent progress in gastric cancer

Smita S. Joshi et al.

Summary: Gastric cancer is a common cause of cancer death worldwide, with treatment options including systemic chemotherapy, radiotherapy, surgery, immunotherapy, and targeted therapy. Classification and biomarkers for gastric cancer help in personalized therapy and identifying populations most likely to benefit from immunotherapy and targeted therapy.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Chemistry, Multidisciplinary

Nanobody-Engineered Natural Killer Cell Conjugates for Solid Tumor Adoptive Immunotherapy

Liang Gong et al.

Summary: The study proposes a glycoengineering approach to decorate NK cells with nanobodies such as 7D12, which enhances the affinity and specificity of NK cells to tumor cells overexpressing EGFR. The modified NK cells showed increased cytokine secretion and effective killing of EGFR-positive tumor cells, indicating a potential novel method for cancer-targeted immunotherapy.

SMALL (2021)

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Article Cell Biology

Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis

Shengbai Sun et al.

Summary: The circular RNA circ_0062682 promotes serine metabolism and tumor growth in colorectal cancer by regulating the miR-940/PHGDH axis, suggesting it as a potential novel therapeutic target for CRC.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

TCEB3 is Regulated by Circ-0000212/miR-140-3p Axis to Promote the Progression of Cervical Cancer

Yufeng Wang et al.

Summary: The study demonstrated that TCEB3 was up-regulated in cervical cancer tissues and cells, and silencing TCEB3 inhibited proliferation and invasion, promoted apoptosis of cervical cancer cells. Furthermore, the regulatory role of circ-0000212/miR-140-3p axis in TCEB3 expression and cervical cancer progression was identified, providing a potential therapeutic target for cervical cancer treatment.

ONCOTARGETS AND THERAPY (2021)

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Article Multidisciplinary Sciences

Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting

Wei Liu et al.

Summary: Proteomic analysis identified two molecular subtypes of esophageal cancer, with the S2 subtype being more aggressive and associated with a potential therapeutic outlook provided by a subtype diagnostic and prognostic model.

NATURE COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo

M. Behfar Ardehali et al.

Summary: EloA localizes to Pol II transcribed genes and active enhancers in mouse embryonic stem cells, regulating Pol II transcription levels through enhancer RNA synthesis and interacting with the machinery for ribosomal RNA production/processing in the nucleolus. It forms phase-separated condensates and truncation mutations in its intrinsically disordered regions interfere with its nucleolar localization.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology