期刊
CANCER MEDICINE
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/cam4.6395
关键词
health-related quality of life; prostate cancer; radiotherapy; surgery
类别
This study compared the health-related quality of life (HRQoL) of patients with localized prostate cancer (LPCa) after surgery and radiotherapy (RT). The results showed that surgery was associated with better bowel scores, while RT was associated with higher urinary and sexual scores. The difference between surgery and RT decreased over time.
BackgroundThe health-related quality of life (HRQoL) of patients with localized prostate cancer (LPCa) after treatment mainly surgery and radiotherapy (RT) has received increasing attention. The aim of this study is to compare the HRQoL of LPCa after surgery and RT. MethodsWeb of Science, Embase, PubMed and Cochrane databases were searched after January 2000 to observe the HRQoL scores after surgery and RT at different treatment time points. ResultsA total of 28 studies were included in this study, and the results showed that LPCa received surgery had better bowel scores than RT at & LE;3 (weighted mean differences [WMD] = 4.18; p = 0.03), 3-6 (WMD = 4.16; p < 0.001), 6-12 (WMD = 2.99; p = 0.004), 24-60 (WMD = 1.87; p = 0.06), and & GE;60 (WMD = 4.54; p = 0.02) months. However, LPCa received RT had higher urinary scores at & LE;3 (WMD = -7.39; p = 0.02), 3-6 (WMD = -6.03; p = 0.02), 6-12 (WMD = -4.90; p < 0.001), 24-60 (WMD = -3.96; p < 0.001), & GE;60 (WMD = -2.95; p < 0.001) months and had better sexual scores at & LE;3 (WMD = -13.58; p = 0.09), 3-6 (WMD = -12.32; p = 0.06), 6-12 (WMD = -12.03; p = 0.002), 24-60 (WMD = -11.29; p < 0.001), and & GE;60 (WMD = -3.10; p = 0.46) months than surgery. The scores difference between surgery and RT decreased over time. ConclusionOverall, for LPCa, surgery was associated with better HRQoL in the bowel domain, whereas RT was associated with better HRQoL in the urinary and sexual domains, with the difference between surgery and RT narrowing over time.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据