☆ 4.6 Article

Low-dose aspirin can inhibit exosomal release induced by radiotherapy in breast cancer and attenuate its inhibitory effect on NK cell proliferation

CANCER MEDICINE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Medicine, Research & Experimental

Tumor-derived extracellular vesicles: The metastatic organotropism drivers

Jafar Rezaie et al.

Summary: The communication between tumor cells and resident cells in the tissue environment is mediated through the secretion of particles called extracellular vesicles (EVs). These EVs play vital roles in tumorigenesis, including pre-metastatic niche formation and organotropic metastasis, by altering the tissue microenvironment and inducing phenotypic alterations in cells. EVs have potential therapeutic applications in cancer management as targeted therapy, cell-free therapy, drug delivery system, and diagnostic biomarker.

LIFE SCIENCES (2022)

添加到收藏夹

Article Medicine, General & Internal

Safety and effectiveness of low-dose aspirin for the prevention of gastrointestinal cancer in adults without atherosclerotic cardiovascular disease: a population-based cohort study

Jessica J. P. Shami et al.

Summary: This cohort study assessed the association between low-dose aspirin and the incidence of colorectal cancer, gastric cancer, esophageal cancer, and gastrointestinal bleeding. The results showed that low-dose aspirin reduced the risks of colorectal cancer and gastric cancer, but increased the risk of gastrointestinal bleeding. However, among patients prescribed gastroprotective agents at baseline, the association with gastrointestinal bleeding was attenuated.

BMJ OPEN (2022)

添加到收藏夹

Review Immunology

Feeder Cells at the Interface of Natural Killer Cell Activation, Expansion and Gene Editing

Mark Gurney et al.

Summary: Genome engineered natural killer (NK) cell therapies show promise in cancer immunotherapy. The use of feeder cells and genome editing technologies can enhance the anti-tumor activity of NK cells, but there are still uncertainties and complexities in the interactions between these components.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Tumor Cells-derived exosomal CircRNAs: Novel cancer drivers, molecular mechanisms, and clinical opportunities

Ali Vahabi et al.

Summary: Recently, circRNAs have gained increasing interest due to their abundant expression and potential functions in cancer development. They may act as sponge for miRNAs and proteins, promoting cancer progression. CircRNAs frequently show tumor-specific expression and can serve as diagnostic and prognostic biomarkers for cancers. They can also be potential targets for cancer treatment as they can sponge oncogenic miRNAs and proteins. Exosomes, containing circRNAs, deliver them to target cells and induce cancer development through different signaling pathways. Exosomal circRNAs may serve as diagnostic and prognostic biomarker for cancers. Targeting exosomes may represent novel therapeutic approaches for cancer treatment.

BIOCHEMICAL PHARMACOLOGY (2022)

添加到收藏夹

Review Oncology

Exosomes reveal the dual nature of radiotherapy in tumor immunology

Xinru Hu et al.

Summary: This review explores the dual effects of radiotherapy on the immune system and the role of exosomes in mediating these effects. It discusses how radiation-induced changes in exosomes can either inhibit or activate the immune system, leading to immunosuppression or immune clearance. By analyzing the relationship between exosome-derived molecules and immunity, this review sheds light on the potential of using exosomes to improve the treatment and prognosis of cancer patients.

CANCER SCIENCE (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Exosomes Derived from Senescent Endothelial Cells Contain Distinct Pro-angiogenic miRNAs and Proteins

Shadi Abdolrahman Shaban et al.

Summary: Exosomes from senescence cells have been found to play important roles in endothelium dysfunction. In this study, we investigated the cargo of exosomes released by endothelial cells undergoing senescence in vitro. We found that these exosomes have distinct miRNA and protein expression profiles, and can affect the migration rate of endothelial cells.

CARDIOVASCULAR TOXICOLOGY (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Mechanism and clinical value of exosomes and exosomal contents in regulating solid tumor radiosensitivity

Huihui Sun et al.

Summary: Radiotherapy is a common treatment for malignant tumors, and recent studies have shown the role of exosomes in tumor development and metastasis. The latest research suggests that radiation can affect the characteristics of exosomes and cell communication. The molecules carried by exosomes in cancer cells have differential expression and play a role in regulating biological processes such as oncogene expression.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Article Anatomy & Morphology

Crosstalk between exosomes signaling pathway and autophagy flux in senescent human endothelial cells

Shadi Mahbubfam et al.

Summary: This study investigated the dynamic of exosomal and autophagy pathways in human umbilical vein cells (HUVECs) in vitro. The results showed an increased secretion of exosomes and upregulation of genes involved in the exosomal secretory pathway, while autophagy process was inhibited.

TISSUE & CELL (2022)

添加到收藏夹

Review Cell Biology

A review on exosomes application in clinical trials: perspective, questions, and challenges

Jafar Rezaie et al.

Summary: Exosomes, as significant mediators of cell-to-cell communication, have promising applications in the treatment of various diseases. They can be used as biomarkers, cell-free therapeutic agents, and drug delivery carriers. However, there are challenges to overcome in the clinical application of exosomes, and further research and standardization are needed.

CELL COMMUNICATION AND SIGNALING (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

The distinct roles of exosomes in innate immune responses and therapeutic applications in cancer

Jafar Rezaie et al.

Summary: This article presents the current understanding of how exosomes regulate innate immune responses and discusses their potential applications in cancer therapy and immunotherapy.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

添加到收藏夹

Article Public, Environmental & Occupational Health

Low-dose aspirin use and cancer-specific mortality: a meta-analysis of cohort studies

Xianmin Wang et al.

Summary: The meta-analysis suggests that post-diagnosis, but not pre-diagnosis, low-dose aspirin use may reduce cancer-specific mortality, especially in the case of digestive tract cancers.

JOURNAL OF PUBLIC HEALTH (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Aspirin in the Prevention of Colorectal Neoplasia

David A. Drew et al.

Summary: High-quality evidence supports the use of aspirin for primary prevention of colorectal cancer. Key considerations include age-related effects, personalized prevention strategies, and the potential role of gut microbiota in aspirin-associated preventive measures against high-risk neoplasia.

ANNUAL REVIEW OF MEDICINE, VOL 72, 2021 (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Progress on the Mechanism for Aspirin's Anti-tumor Effects

Lin Zheng et al.

Summary: Aspirin, known for its antipyretic, analgesic, anti-inflammatory, and anti-rheumatic activities, has also shown great potential in the field of cancer with mechanisms including inhibiting mTOR pathways, acting as a calorie-restricted mimetic, and suppressing platelet function. More direct evidence and solutions for side effects are still needed for wider application in cancer treatment.

CURRENT DRUG TARGETS (2021)

添加到收藏夹

Correction Oncology

Aspirin Suppresses the Growth and Metastasis of Osteosarcoma through the NF-κB Pathway (vol 21, pg 5349, 2015)

Dan Liao et al.

CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Aspirin in the Prevention of Cardiovascular Disease and Cancer

Emanuela Ricciotti et al.

Summary: Aspirin is a milestone treatment for the secondary prevention of cardiovascular disease, but its role in primary prevention is still debated. While it may have some protective effects against colorectal cancer, further studies are needed to confirm its benefits for primary prevention of cardiovascular disease and cancer in apparently healthy individuals.

ANNUAL REVIEW OF MEDICINE, VOL 72, 2021 (2021)

添加到收藏夹

Review Oncology

Aspirin in Hepatocellular Carcinoma

Emanuela Ricciotti et al.

Summary: Aspirin shows promise as a preventative agent for cancer, particularly in individuals at high risk of colorectal cancer due to Lynch syndrome and in reducing the risk of sporadic colorectal cancer. Additionally, it has been shown to have a beneficial effect as a chemopreventive or adjuvant therapeutic agent in hepatocellular carcinoma (HCC).

CANCER RESEARCH (2021)

添加到收藏夹

Article Immunology

Asthmatic condition induced the activity of exosome secretory pathway in rat pulmonary tissues

Asheed Almohammai et al.

Summary: The study revealed that in asthmatic lung tissues, there was an increase in IL-4 expression and suppression of IL-10, along with an induction of TNF-alpha protein level, indicating a correlation between exosome biogenesis and inflammatory response.

JOURNAL OF INFLAMMATION-LONDON (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tumor-Derived Exosomes (TEX) and Their Role in Immuno-Oncology

Theresa L. Whiteside et al.

Summary: Extracellular vesicles, especially tumor-derived exosomes, play a crucial role in cancer by mediating interactions between tumor cells and immune cells. The molecular and functional profiles of these EVs vary in cancer patients, impacting immune cell functions and disease progression. Potential biomarkers and monitors of immune competence in cancer patients can be identified through the analysis of these EVs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Aspirin and its pleiotropic application

Jolanta Hybiak et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

Low-dose aspirin use and endometrial cancer mortality-a Danish nationwide cohort study

Cecilie D. Sperling et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Current Knowledge and Future Perspectives on Mesenchymal Stem Cell-Derived Exosomes as a New Therapeutic Agent

Hyeon Su Joo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Cell Biology

Exosome-mediated transfer of long noncoding RNA H19 induces doxorubicin resistance in breast cancer

Xinxing Wang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

添加到收藏夹

Review Cell Biology

Breast cancer-derived exosomes: Tumor progression and therapeutic agents

Nasrollah Jabbari et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

添加到收藏夹

Review Oncology

Recent advances in radiotherapy of breast cancer

Jan Haussmann et al.

RADIATION ONCOLOGY (2020)

添加到收藏夹

Review Immunology

Tumor-Derived Exosomes in Immunosuppression and Immunotherapy

Wioletta Olejarz et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2020)

添加到收藏夹

Review Oncology

Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer

James Meehan et al.

FRONTIERS IN ONCOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Aspirin Modifies Inflammatory Mediators and Metabolomic Profiles and Contributes to the Suppression of Obesity-Associated Breast Cancer Cell Growth

Chia-Chien Hsieh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Medicine, General & Internal

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial

John Burn et al.

LANCET (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Natural killer cells in cancer biology and therapy

Song-Yang Wu et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

High-metastatic cancer cells derived exosomal miR92a-3p promotes epithelial-mesenchymal transition and metastasis of low-metastatic cancer cells by regulating PTEN/Akt pathway in hepatocellular carcinoma

Beng Yang et al.

ONCOGENE (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine

Sepideh Nikfarjam et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Review Oncology

Radiotherapy side effects: integrating a survivorship clinical lens to better serve patients

V Dilalla et al.

CURRENT ONCOLOGY (2020)

添加到收藏夹

Review Oncology

Key steps for effective breast cancer prevention

Kara L. Britt et al.

NATURE REVIEWS CANCER (2020)

添加到收藏夹

Review Oncology

Inflammatory microenvironment remodelling by tumour cells after radiotherapy

Martin McLaughlin et al.

NATURE REVIEWS CANCER (2020)

添加到收藏夹

Article Oncology

SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination

Ce Li et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

添加到收藏夹

Article Cell Biology

Very-low-dose twice-daily aspirin maintains platelet inhibition and improves haemostasis during dual-antiplatelet therapy for acute coronary syndrome

William A. E. Parker et al.

PLATELETS (2019)

添加到收藏夹

Review Cell Biology

Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications

Reza Rahbarghazi et al.

CELL COMMUNICATION AND SIGNALING (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tumor Microenvironment as A Game Changer in Cancer Radiotherapy

Magdalena Jarosz-Biej et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Immunology

Role of exosomes in tumour and transplant immune regulation

Diego A. Lema et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Lin Song et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Oncology

Interleukin-15 Enhances Anti-GD2 Antibody-Mediated Cytotoxicity in an Orthotopic PDX Model of Neuroblastoma

Rosa Nguyen et al.

CLINICAL CANCER RESEARCH (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cisplatin-resistant MDA-MB-231 Cell-derived Exosomes Increase the Resistance of Recipient Cells in an Exosomal miR-423-5p-dependent Manner

Bing Wang et al.

CURRENT DRUG METABOLISM (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

Xianjie Jiang et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Article Oncology

Low-dose aspirin use and survival in colorectal cancer: results from a population-based cohort study

Ronan T. Gray et al.

BMC CANCER (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Effects of tumor metabolic microenvironment on regulatory T cells

Yi-an Wang et al.

MOLECULAR CANCER (2018)

添加到收藏夹

Article Oncology

Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1(+) regulatory B cell expansion

Linsen Ye et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Exosomes Derived From Natural Killer Cells Exert Therapeutic Effect in Melanoma

Liya Zhu et al.

THERANOSTICS (2017)

添加到收藏夹

Review Immunology

Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective

Wuzhen Chen et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2017)

添加到收藏夹

Article Public, Environmental & Occupational Health

Low-dose Aspirin, Nonsteroidal Anti-inflammatory Drugs, Selective COX-2 Inhibitors and Breast Cancer Recurrence

Deirdre P. Cronin-Fenton et al.

EPIDEMIOLOGY (2016)

添加到收藏夹

Article Oncology

Rapamycin-induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition

Yong Li et al.

THORACIC CANCER (2016)

添加到收藏夹

Review Biology

NK cell-based cancer immunotherapy: from basic biology to clinical application

Li Yang et al.

SCIENCE CHINA-LIFE SCIENCES (2015)

添加到收藏夹

Review Biochemical Research Methods

Human NK Cell Receptors/Markers: A Tool to Analyze NK Cell Development, Subsets and Function

Elisa Montaldo et al.

CYTOMETRY PART A (2013)

添加到收藏夹

Article Multidisciplinary Sciences

CD11b-CD27- NK Cells Are Associated with the Progression of Lung Carcinoma

Jing Jin et al.

PLOS ONE (2013)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.