Changes in spatial clusters of cancer incidence and mortality over 15 years in South Korea: Implication to cancer control

Background: The temporal investigation of high-risk areas of cancer incidence and mortality can provide practical implications in cancer control. We aimed to investigate the changes in spatial clusters of incidence and mortality from 1999 through 2013 by major cancer types in South Korea.Methods: We applied flexible scan statistics to identify spatial clusters of cancer incidence and mortality by three 5-year periods and seven major cancer types using the counts of new cases and deaths and population in 244 districts during 1999-2013. Then, we compared the changes across three periods in the locations of primary clusters of incidence and mortality by cancer types. To explore the determinants that possibly affect cancer cluster areas, we compared geographic characteristics between clustered and non-clustered areas.Results: While incidence clusters for lung, stomach, and liver cancer remained in the same areas over 15 years, mortality clusters were relocated to the areas similar to those of incidence clusters. In contrast, colorectal, breast, cervical, and prostate cancer displayed consistently different locations of clusters over time, indicating the disappearance of existing clusters and the appearance of new clusters. Cluster areas tended to show higher portions of older population, unemployment, smoking, and cancer screening compared to non-cluster areas particularly for mortality.Conclusions: Our findings of diverse patterns of changes in cancer incidence and mortality clusters over 15 years can indicate the degree of effectiveness in cancer prevention and treatment depending on the area and suggest the need for area-specific applications of different cancer control programs.

Automated summary

This study investigated the changes in spatial clusters of cancer incidence and mortality by major cancer types in South Korea from 1999 through 2013. The findings showed that the incidence clusters for lung, stomach, and liver cancer remained stable over 15 years, while mortality clusters were relocated to similar areas as the incidence clusters. On the other hand, colorectal, breast, cervical, and prostate cancer displayed consistently different cluster locations over time, indicating the disappearance of existing clusters and the appearance of new clusters. Cluster areas tended to have higher proportions of older population, unemployment, smoking, and cancer screening compared to non-cluster areas.