Cottonseed oil alleviates ischemic stroke injury by inhibiting ferroptosis

Article Biochemistry & Molecular Biology

Resveratrol pretreatment protects neurons from oxygen-glucose deprivation/reoxygenation and ischemic injury through inhibiting ferroptosis

Huimin Zhu et al.

Summary: Resveratrol pretreatment can inhibit ferroptosis and reduce neuronal damage and infarction volume in ischemia-reperfusion injury.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2022)

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Article Clinical Neurology

Electroacupuncture Ameliorates Cerebral Ischemic Injury by Inhibiting Ferroptosis

Guangda Li et al.

Summary: The study demonstrated that electroacupuncture intervention can reduce oxidative stress levels, inhibit ferroptosis, improve neurological function recovery, and protect brain tissue in rats with middle cerebral artery occlusion. Furthermore, electroacupuncture treatment regulates the expression of iron-related proteins, contributing to a reduction in ischemic damage.

FRONTIERS IN NEUROLOGY (2021)

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Article Neurosciences

Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis

Junmin Chen et al.

Summary: The study found that inhibiting ACSL4 can promote the recovery of neurological function after stroke by suppressing ferroptosis. Inhibiting ACSL4 significantly improves neurological function, reduces brain infarct volume, and decreases iron accumulation and lipid peroxidation.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Article Biochemistry & Molecular Biology

NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer?s diseases

Min Woo Park et al.

Summary: The study found elevated levels of NOX4 protein in impaired astrocytes of AD patients and mouse AD models, leading to oxidative stress and ferroptosis. Overexpression of NOX4 resulted in impaired mitochondrial metabolism and oxidative stress, increasing ferroptosis in astrocytes.

REDOX BIOLOGY (2021)

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Review Cell Biology

Insight into Crosstalk between Ferroptosis and Necroptosis: Novel Therapeutics in Ischemic Stroke

Yue Zhou et al.

Summary: Ferroptosis and necroptosis play crucial roles in ischemic stroke, with crosstalk between the two pathways. Iron overload and HSP90 are important factors associated with the occurrence of necroptosis and ferroptosis.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Medicine, Research & Experimental

Neuroprotective effects of minocycline and KML29, a potent inhibitor of monoacylglycerol lipase, in an experimental stroke model: a small-animal positron emission tomography study

Tomoteru Yamasaki et al.

Summary: Hypoxia-induced ischemia leads to neuronal death in the CNS through acidosis and neuroexcitotoxicity. This study used PET imaging to monitor MAGL-positive neurons and neuroinflammation in ischemic rats, finding that treatment with MAGL inhibitors had neuroprotective effects. PET imaging showed that minocycline and KML29 treatments had different effects on neuronal protection in the brain following ischemic injury.

THERANOSTICS (2021)

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Review Medicine, General & Internal