4.5 Article

Sex differences in obesity-induced renal lipid accumulation revealed by lipidomics: a role of adiponectin/AMPK axis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Urology & Nephrology

Dephosphorylation of AMP-activated protein kinase exacerbates ischemia/reperfusion-induced acute kidney injury via mitochondrial dysfunction

Haijian Ma et al.

Summary: This study reveals that AMP-activated protein kinase (AMPK) plays an important protective role in tubular epithelial cells during acute kidney injury. The deficiency of AMPK leads to lipid droplet accumulation and elevated levels of ceramides and free fatty acids in the kidney tubules, resulting in worsened kidney impairment.

KIDNEY INTERNATIONAL (2022)

Article Nutrition & Dietetics

Sex and Species Differences in the Development of Diet-Induced Obesity and Metabolic Disturbances in Rodents

Ivana Maric et al.

Summary: The prevalence and health consequences of obesity differ between men and women. Research shows that male and female rodents respond differently to high-fat diet (HFD) challenge, with female rodents displaying a higher preference for HFD but experiencing a delay in weight gain and fewer metabolic complications compared to males. These sex-based differences are divergent in rats and mice, with male SD rats being a better model for the lower prevalence of overweight in women, while C57BL/6 mice may better represent the increased prevalence of morbid obesity in women.

FRONTIERS IN NUTRITION (2022)

Article Biochemistry & Molecular Biology

Delayed Exercise Training Improves Obesity-Induced Chronic Kidney Disease by Activating AMPK Pathway in High-Fat Diet-Fed Mice

Florian Juszczak et al.

Summary: Exercise training is recognized as an effective therapeutic strategy in managing obesity and its related disorders. This study demonstrated the beneficial effects of delayed endurance exercise training (EET) in obese mice with chronic kidney disease, highlighting improvements in obesity-related disorders and kidney function through the AMPK pathway.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Immunology

Sex Differences in Macrophage Responses to Obesity-Mediated Changes Determine Migratory and Inflammatory Traits

Kuan-Hui Ethan Chen et al.

Summary: This study demonstrates that male mice are more prone to accumulating macrophages in adipose tissues in obesity-induced inflammation, with higher levels of leptin in serum and adipose tissue. Both hyperlipidemia and hyperleptinemia contribute to male macrophage-specific migration, with increased FFA inducing leptin receptors and higher leptin causing migration.

JOURNAL OF IMMUNOLOGY (2021)

Review Physiology

Ceramides in Metabolism: Key Lipotoxic Players

Bhagirath Chaurasia et al.

Summary: The review discusses the impact of lipid metabolites like ceramides on metabolic diseases and the potential therapeutic approaches to combat them.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 83 (2021)

Article Cell Biology

Sex differences in insulin resistance, but not peripheral neuropathy, in a diet-induced prediabetes mouse model

Sarah E. Elzinga et al.

Summary: Peripheral neuropathy (PN) is a common and increasing complication of prediabetes and diabetes worldwide. Treatment relies on glycemic control, but sex differences and obesity status can impact efficacy. In animal models, females retain early insulin sensitivity upon high-fat diet challenge, yet still develop the same degree of PN as males.

DISEASE MODELS & MECHANISMS (2021)

Article Endocrinology & Metabolism

Phenotypic sexual dimorphism in response to dietary fat manipulation in C57BL/6J mice

Isabel Casimiro et al.

Summary: The study revealed significant differences in responses to high-fat diet between male and female mice, particularly in body weight gain, food intake, energy expenditure, and insulin sensitivity. Male mice gained weight faster, had an increase in pancreatic beta cell area, and reduced insulin sensitivity after HFD feeding, while female mice did not exhibit these phenomena.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2021)

Review Cardiac & Cardiovascular Systems

Leptin in Leanness and Obesity JACC State-of-the-Art Review

Nikolaos Perakakis et al.

Summary: Leptin is a key hormone secreted by adipose tissue that conveys information about energy stores, playing a crucial role in neuroendocrine function and energy homeostasis. Studies have investigated leptin's mechanisms in both healthy states and various metabolic diseases, with similarities and differences between animal and human biology highlighted. Clinical applications, future research directions, and the development of next-generation leptin analogs are discussed in this review.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Review Endocrinology & Metabolism

Rotten to the Cortex: Ceramide-Mediated Lipotoxicity in Diabetic Kidney Disease

Rebekah J. Nicholson et al.

Summary: Diabetic kidney disease (DKD) is a prevalent and progressive comorbidity of diabetes mellitus that increases the risk of renal failure. Research suggests that bioactive ceramides may serve as a potential therapeutic target for DKD, as modulation of renal ceramide levels could improve kidney function and ameliorate DKD pathology. Studies have shown that circulating sphingolipid profiles can distinguish DKD patients from diabetic controls, highlighting the potential of ceramide as a central and therapeutically tractable lipid mediator of DKD.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Endocrinology & Metabolism

Diet-induced obesity in animal models: points to consider and influence on metabolic markers

Mariana de Moura e Dias et al.

Summary: Overweight and obesity are global public health problems that have increased considerably in prevalence. Diet-induced obesity animal models can replicate human overweight and obesity, with various protocols to lead to excess fat deposition. Key points for inducing obesity through diet include evaluating body weight, fat gain, inflammation, hormonal concentration, blood glycemia, lipid profile, liver health, and considering diet composition and calorie overconsumption for obesity development.

DIABETOLOGY & METABOLIC SYNDROME (2021)

Article Endocrinology & Metabolism

Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner

Maria M. Glavas et al.

Summary: Our study found that male Swiss Webster mice are susceptible to diabetes based on the timing of exposure to high-fat diet, while females are protected from hyperglycemia regardless of duration or timing of high-fat diet. The timing of exposure to high-fat diet during critical developmental periods significantly impacts metabolic outcomes, emphasizing the importance of careful consideration of dietary timing during these stages.

DIABETES (2021)

Article Endocrinology & Metabolism

Women Are at a Higher Risk of Chronic Metabolic Diseases Compared to Men With Increasing Body Mass Index in China

Xiao-He Wang et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Review Biochemistry & Molecular Biology

Adiponectin in Chronic Kidney Disease

Jaroslaw Przybycinski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease

Florian Juszczak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Endocrinology & Metabolism

Obesity: global epidemiology and pathogenesis

Matthias Blueher

NATURE REVIEWS ENDOCRINOLOGY (2019)

Article Pharmacology & Pharmacy

PAN-AMPK Activation Improves Renal Function in a Rat Model of Progressive Diabetic Nephropathy

Xiaoyan Zhou et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

Article Urology & Nephrology

Sex and the kidneys: current understanding and research opportunities

C. Noel Bairey Merz et al.

NATURE REVIEWS NEPHROLOGY (2019)

Review Cell Biology

AMPK: guardian of metabolism and mitochondrial homeostasis

Sebastien Herzig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Sphingolipids and Redox Signaling in Renal Regulation and Chronic Kidney Diseases

Owais M. Bhat et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Biochemistry & Molecular Biology

Sex differences in the development of hepatic steatosis in cafeteria diet-induced obesity in young mice

Fabiana Rodrigues Silva Gasparin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Urology & Nephrology

The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes

Yaeni Kim et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Article Endocrinology & Metabolism

Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy

Sun Ryoung Choi et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2018)

Review Urology & Nephrology

Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease

Juan Jesus Carrero et al.

NATURE REVIEWS NEPHROLOGY (2018)

Review Urology & Nephrology

The Warburg Effect in Diabetic Kidney Disease

Guanshi Zhang et al.

SEMINARS IN NEPHROLOGY (2018)

Review Endocrinology & Metabolism

Sex differences in lipid and lipoprotein metabolism

Brian T. Palmisano et al.

MOLECULAR METABOLISM (2018)

Article Physiology

Adiponectin Regulation and Function

Han Fang et al.

COMPREHENSIVE PHYSIOLOGY (2018)

Review Behavioral Sciences

Inclusion of females does not increase variability in rodent research studies

Annaliese K. Beery

CURRENT OPINION IN BEHAVIORAL SCIENCES (2018)

Article Physiology

Renoprotective impact of estrogen receptor-α and its splice variants in female mice with type 1 diabetes

Debra L. Irsik et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

Article Urology & Nephrology

High-Fat Diet-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney

Takeshi Yamamoto et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Article Biochemistry & Molecular Biology

Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids

Diego Scerbo et al.

JOURNAL OF LIPID RESEARCH (2017)

Article Agriculture, Dairy & Animal Science

Adiponectin induced AMP-activated protein kinase impairment mediates insulin resistance in Bama mini-pig fed high-fat and high-sucrose diet

Miaomiao Niu et al.

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES (2017)

Article Endocrinology & Metabolism

Hepatic FGF21 mediates sex differences in high-fat high-fructose diet-induced fatty liver

Natsasi Chukijrungroat et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2017)

Article Urology & Nephrology

Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism

Seung Hyeok Han et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Review Medicine, Research & Experimental

Sex and gender differences in chronic kidney disease: progression to end-stage renal disease and haemodialysis

Gabriela Cobo et al.

CLINICAL SCIENCE (2016)

Review Endocrinology & Metabolism

Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus

Alexandra Kautzky-Willer et al.

ENDOCRINE REVIEWS (2016)

Article Endocrinology & Metabolism

Higher Prevalence of Type 2 Diabetes in Men Than in Women Is Associated With Differences in Visceral Fat Mass

Anna Nordstrom et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

Article Medicine, Research & Experimental

Improved renal ischemia tolerance in females influences kidney transplantation outcomes

David D. Aufhauser et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Review Urology & Nephrology

Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis

Vivette D. D'Agati et al.

NATURE REVIEWS NEPHROLOGY (2016)

Review Nutrition & Dietetics

Animal models of metabolic syndrome: a review

Sok Kuan Wong et al.

NUTRITION & METABOLISM (2016)

Review Biochemistry & Molecular Biology

AMPK activators: mechanisms of action and physiological activities

Joungmok Kim et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2016)

Review Cell Biology

The sexual dimorphism of obesity

Biff F. Palmer et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2015)

Review Endocrinology & Metabolism

Sex differences in metabolic homeostasis, diabetes, and obesity

Franck Mauvais-Jarvis

BIOLOGY OF SEX DIFFERENCES (2015)

Article Biochemistry & Molecular Biology

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

Michal Herman-Edelstein et al.

JOURNAL OF LIPID RESEARCH (2014)

Article Urology & Nephrology

Regulation of lipid accumulation by AMK-activated kinase in high fat diet-induced kidney injury

Anne-Emilie Decleves et al.

KIDNEY INTERNATIONAL (2014)

Article Endocrinology & Metabolism

Decreased plasma levels of select very long chain ceramide species Are associated with the development of nephropathy in type 1 diabetes

Richard L. Klein et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2014)

Article Urology & Nephrology

The Modern Spectrum of Renal Biopsy Findings in Patients with Diabetes

Shree G. Sharma et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

Article Medicine, Research & Experimental

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

Laura L. Dugan et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Multidisciplinary Sciences

Angiotensin AT2 Receptor Contributes towards Gender Bias in Weight Gain

Preethi Samuel et al.

PLOS ONE (2013)

Review Cell Biology

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction

Frances M. Platt et al.

JOURNAL OF CELL BIOLOGY (2012)

Article Endocrinology & Metabolism

AICAR inhibits ceramide biosynthesis in skeletal muscle

Katherine A. Erickson et al.

DIABETOLOGY & METABOLIC SYNDROME (2012)

Article Urology & Nephrology

AMPK Mediates the Initiation of Kidney Disease Induced by a High-Fat Diet

Anne-Emilie Decleves et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

Article Biochemistry & Molecular Biology

AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes

Assaad A. Eid et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

Toshimasa Yamauchi et al.

NATURE MEDICINE (2007)

Article Physiology

A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy

Myung-Ja Lee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)

Article Endocrinology & Metabolism

Female rats do not exhibit free fatty acid-induced insulin resistance

A Hevener et al.

DIABETES (2002)

Article Biochemistry & Molecular Biology

The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes

C Blázquez et al.

FEBS LETTERS (2001)