Ellagic acid reduces hepatic lipid contents through regulation of SIRT1 and AMPK in old rats

Objective: Ellagic acid is used in traditional medicine for the treatment of lipid disorders. In this study, the effects of ellagic acid on key regulators of lipid metabolism, and histopathological alterations in aged liver were examined.Methods: A total of 21 male Wistar rats were divided into three groups, including young control, old control, and old ellagic acid. After one month of treatment with ellagic acid, the expression levels of hepatic SIRT1, AMPK, SREBP-1c, PPAR-alpha, and phosphorylated AMPK (p-AMPK) were evaluated. The levels of several serum biochemical factors, and hepatic triglyceride, and cholesterol contents were assessed.Results: Ellagic acid elevated the levels of SIRT1, p-AMPK, and PPAR-alpha and reduced SREBP-1c level in the liver of old rats. It decreased triglyceride and cholesterol contents in the aged liver and improved histopathological changes.Conclusions: The results demonstrated that ellagic acid can exert protective effects against hepatic lipid metabolism disorders induced by ageing.

Automated summary

The study demonstrated that ellagic acid has protective effects against hepatic lipid metabolism disorders induced by aging.