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Review
Cell Biology
Wangyu Bi et al.
Summary: The complex structure of the blood-brain barrier (BBB) poses challenges for modeling and treating brain diseases. Microfluidic BBB-on-a-chip platforms have been developed using microfluidic technology to replicate the intricate brain microenvironment and physiological responses. Compared to traditional trans-well technology, microfluidic BBB-on-a-chip offers technical advantages in terms of flexible control of fluid shear stress and efficient fabrication, which can be further enhanced by lithography and 3D printing. Integration of an automatic super-resolution imaging sensing platform enables accurate monitoring of dynamic changes in biochemical parameters of individual cells in the model. Biomaterials, especially hydrogels and conductive polymers, address the limitations of microfluidic BBB-on-a-chip by providing a 3D space and specific performance. Microfluidic BBB-on-a-chip has promoted advancements in basic research related to cell migration, neurodegenerative diseases, drug permeability, and SARS-CoV-2 pathology. This study summarizes recent advances, challenges, and future prospects of microfluidic BBB-on-a-chip, which can facilitate the development of personalized medicine and drug discovery.
AGEING RESEARCH REVIEWS
(2023)
Article
Chemistry, Applied
Qianqian Chen et al.
Summary: In this study, a coating-annealing approach was utilized to fabricate highly transparent, hydrophobic, and durable anisotropic cellulose films. Low surface energy chemicals poly(methyl methacrylate)-b-poly(trifluoroethyl methacrylate) (PMMA-b-PTFEMA) were coated onto regenerated cellulose films through physical and chemical interactions. The resulting films exhibited nano-protrusions, low surface roughness, high optical transparency, good hydrophobicity, and excellent stability and durability under various conditions. This work provides a promising large-scale production strategy for transparent and hydrophobic cellulose-based films for electronic device protection and other emerging flexible electronics.
CARBOHYDRATE POLYMERS
(2023)
Article
Optics
Ziming Zhao et al.
Summary: A fiber optic humidity sensor based on a PVA/Tween 20 film has been developed, which modulates the transmitted light intensity in the optical fiber. The sensor exhibits a linear response to humidity, with fast response and recovery times, and good repeatability.
Article
Chemistry, Multidisciplinary
Junyao Wang et al.
Summary: This paper presents a helical three-dimensional passive micromixer fabricated through 3D printing and polymer dissolution technology, which effectively improves the mixing efficiency according to experimental results.
Article
Chemistry, Physical
Nico Leister et al.
Summary: This study developed a new device to produce double emulsion droplets with several hundred monodispersed inner droplets using a two-step jet break-up within coaxial capillaries. Monodispersed multicompartment microcapsules were successfully obtained by adjusting the materials and process parameters.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Ali Roshanghias et al.
Summary: This study proposes and investigates a new method for using jet printing of glass frit materials at the wafer level. The jetting parameters were optimized and the effect of jetted pitch size on bond-line thickness was assessed. The results reveal that jet printing of glass frit is a straightforward, cost-effective, and flexible approach with significant implications for hermetic packaging.
Review
Cell Biology
Mufeeda C. Koyilot et al.
Summary: Organ-on-a-chip (OOAC) is an emerging technology that shows great potential in the healthcare industry. It combines microfluid platforms and in vitro cell culture, and offers numerous advantages over conventional systems. The integration of artificial intelligence in OOAC systems enhances their capabilities for accurate diagnosis and convenient data management. OOACs have a wide range of applications, including organ/disease modeling, pharmacology, personalized medicine, and dentistry.
Article
Engineering, Biomedical
Dingding Xiang et al.
Summary: In this study, PVA/PVP and PVA/Pectin composite hydrogels were prepared and tested, with the PVA/PVP CH showing the best performance, providing significant advantages for future clinical application in replacing nucleus pulposus.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Review
Chemistry, Analytical
Ghazaleh Gharib et al.
Summary: Both passive and active microfluidic devices are widely used in biomedical and chemical applications. Passive devices are limited by their geometry-dependence, while active devices include sensors and transducers for disease diagnosis and organ modeling. Microfluidic devices are fabricated using various techniques and have broad utility in detecting diagnostic biomarkers and organ-on-chip approaches.
Review
Chemistry, Analytical
Jihoon Ko et al.
Summary: This article provides guidance on the use of organ-on-chip technology in tissue engineering applications. Organ-on-chip technology is a microengineered cell culture platform that replicates in-vivo organ or tissue microenvironments. The platform consists of microfluidic channels, cell culture chambers, and stimulus sources that mimic the in-vivo microenvironment. The fabrication of these platforms involves the use of microfabrication strategies such as soft lithography, 3D printing, and injection molding. The article gives an overview of what organ-on-chip platforms are, their applications, composition, fabrication methods, and operation. It also introduces recent applications where different organs are modeled on a microscale using this technology.
Review
Chemistry, Analytical
Sagar Regmi et al.
Summary: Microfluidics and organ-on-a-chip technology have shown great potential in advancing oncology research. Microfluidics offers advantages such as low sample volume, minimal cost, and portability, making it valuable for cancer diagnostics and prognosis. Organ-on-a-chip technology, simulating human organ complexity, provides a dynamic platform to study tumor growth and progression. This paper provides an overview of the historical development, physics of fluid flow, and application of microfluidics and organ-on-a-chip technology in oncology. The current applications in cancer research, including CTC isolation, cancer cell phenotype study, organ replication, and drug development, are discussed. The significance and limitations of this technology are also addressed.
Article
Biophysics
Binfeng Yin et al.
Summary: This article introduces a Tape-based key valve microfluidic chip (KVMC) that utilizes commercially available 3M tapes to detect disease biomarkers in serum ranging from pg mL(-1) to mu g mL(-1). The system allows for automated, multiplexed, simultaneous bioassays of clinically relevant inflammatory biomarkers, offering a desirable strategy for early clinical diagnosis of sepsis.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Junyao Wang et al.
Summary: This study presents a Tesla valve micromixer with unidirectional flow characteristics and demonstrates its higher mixing efficiency compared to traditional T-shaped planar channels through experiments.
Article
Markus B. Blatz et al.
Dental Clinics of North America
(2022)
Article
Chemistry, Multidisciplinary
Jansen Zhou et al.
Summary: Direct glass-to-glass bonding is crucial for high-technology applications in optics, microfluidics, and micro-electromechanical systems. In this study, we investigated the bonding process of 1 mm thick soda-lime float glass substrates. By modifying the classic RCA-1 cleaning procedure and applying unidirectional pressure along with thermal treatment, we achieved strong bonds with an average shear strength of approximately 7.81 MPa. The bonded glass substrates exhibited robustness against high powered continuous wave fiber laser irradiation without delamination.
Article
Chemistry, Analytical
Shiyu Zeng et al.
Summary: The highly sensitive detection of cancer cells is crucial for improving the accuracy of early clinical diagnosis. In this study, a novel microfluidic mixer chip combined with fluorescence sensors was fabricated to detect and differentiate cancer cells from normal cells with excellent sensitivity and selectivity.
Review
Biochemistry & Molecular Biology
Nari Hong et al.
Summary: Neurons-on-a-Chip technology, enabled by soft lithography and microelectrode chip technology, provides diverse tools for studying neural behavior and network dynamics, opening a new era in neurobiology.
MOLECULES AND CELLS
(2022)
Article
Engineering, Electrical & Electronic
Brian Regan et al.
Summary: Centrifugal microfluidic devices combine low-cost instrumentation with highly integrated automation to provide a robust method for handling low-volume fluids. This paper presents the development of a low-cost centrifugal test-stand with an integrated imaging system using a generic wireless camera to record videos directly to a smartphone device. The imaging system allows high-fidelity imaging of the entire disc for flow visualization and real-time color intensity measurements.
Review
Materials Science, Multidisciplinary
Ali Ansari et al.
Summary: PDMS is widely used in microfluidic devices, and double-casting can prolong mold life and reduce costs.
Review
Biochemical Research Methods
Elain Fu et al.
Summary: Paper microfluidics is a rapidly growing subfield of microfluidics where paper-like porous materials are used to create analytical devices suitable for field applications, and 3D printing technology has the potential to positively impact the development of these devices. Current research focuses on solid support structures, channel barrier definition, and porous channels for capillary flow, highlighting the key areas for advancement in the next generation of paper microfluidic devices.
Article
Chemistry, Analytical
Binfeng Yin et al.
Summary: The study explores a method for rapid detection of Cu2+ in seawater using an enzyme-based microfluidic technology, which is efficient and shows a linear relationship with Cu2+ concentrations ranging from 3.91 nM to 256 mu M, with a detection limit of 0.87 nM. Successful detection in real seawater samples indicates practical applicability, and the chip also has the potential for practical implementations in biochemical detection and biological computing.
Article
Chemistry, Multidisciplinary
Binfeng Yin et al.
Summary: Three passive micromixers based on different mathematical spiral structures were studied for their mixing performance using numerical simulation and experiments. Among them, the Fermat spiral channel showed excellent fluid mixing performance and was successfully integrated into a microfluidic chip, reducing the detection time of acute myocardial infarction (AMI) markers and improving detection efficiency.
Review
Chemistry, Analytical
Simon Scott et al.
Summary: Microfluidic devices have the potential to automate a wide variety of chemical and biological operations with higher efficiency and repeatability. Polymer-based devices offer advantages in terms of cost and biocompatibility. Different manufacturing approaches, including direct and replication methods, are described in this study.
Article
Chemistry, Analytical
Chao Xiang et al.
Summary: This study introduces a resonant pressure microsensor with a wide range of pressure measurements, utilizing a silicon-on-insulator wafer and a silicon-on-glass cap for enhanced stiffness and stability of the pressure-sensitive diaphragm. By deploying silicon islands on the device layer and a vacuum cavity on the cap, the microsensor achieves high quality factors and pressure sensitivities, with temperature compensation ensuring high measurement accuracy.
Review
Polymer Science
Hyunhang Park et al.
Summary: This paper reviews recent atomistic simulation works on interfacial interactions at the nanoscale level, with a focus on understanding the bonding, adhesion strength, and failure behavior between polymer films and silicate glass. Non-bonded and bonded interactions are analyzed, revealing the dominance of hydrogen bonding in adhesion and the importance of external conditions on adhesion and failure behavior.
Article
Biochemical Research Methods
Livia Ribeiro de Souza et al.
Summary: The use of microfluidic technology allows precise control over the size and shell thickness of microcapsules for self-healing of cementitious materials. By utilizing parallel junctions in the microfluidic device, high throughput production of materials was achieved, demonstrating the potential for large-scale production. The production rate could be up to 1.5 kg per day with the unique features of the microfluidic device.
Article
Chemistry, Multidisciplinary
Pushparani Micheal Raj et al.
Summary: The article introduces a microfluidic device capable of analyzing liquid samples using synchrotron X-ray absorption spectroscopy under extreme conditions, showing good robustness and accuracy.
Article
Biochemical Research Methods
Andrew S. Clark et al.
Summary: We have developed two microfluidic lobe filters inspired by the filtration mechanism of manta rays to address clogging issues. These filters can efficiently filtrate particles around 10-30 μm with high throughput and precise control, showing increased filtration efficiency with fluid flow rate.
Article
Biochemical Research Methods
Shun-ichi Funano et al.
Summary: This study presents a simple glass-glass bonding method for microfluidic devices, which achieves stronger bonding through a higher density of SiOH on the glass surface cleaned by neutral detergent. The method can withstand pressure over 600 kPa and allows for cell recovery after cultivation in microchannels, significantly improving the productivity and usability of glass microfluidic devices for future applications.
Article
Dentistry, Oral Surgery & Medicine
Joanne Jung Eun Choi et al.
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
(2020)
Article
Environmental Sciences
Chandrasekaran Ebciba et al.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Yongquan Li et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Biochemical Research Methods
B. Camli et al.
Review
Chemistry, Multidisciplinary
Jing Nie et al.
Article
Chemistry, Analytical
Pin-Chuan Chen et al.
Review
Pharmacology & Pharmacy
Marie Weinhart et al.
PHARMACOLOGICAL RESEARCH
(2019)
Review
Chemistry, Analytical
Wenting Zhou et al.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Organic
Shinobu Miyagawa et al.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)
Article
Chemistry, Analytical
Pin-Chuan Chen et al.
Review
Chemistry, Multidisciplinary
Anthony K. Au et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2016)
