期刊
MICROMACHINES
卷 14, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/mi14071302
关键词
microfluidic; 3D printing; bonding method; HIPS; PDMS
This study proposes an integrated molding method for microfluidic chips that combines 3D printing and polymer dissolution technology. The channel mold of Poly(vinyl alcohol) (PVA) or high impact polystyrene (HIPS) is dissolved to complete the manufacturing of microfluidic chip channels. By comparing the microchannels made of PVA and HIPS, it is concluded that the quality of microchannels made of HIPS is significantly better than that made of PVA. This study provides a new idea for the fabrication of microfluidic chips and the application of HIPS.
Microfluidic chips have the advantages of miniaturization, integration, and portability, and are widely used in the early diagnosis of major diseases, personalized medical treatment, environmental detection, health quarantine, and other fields. The existing microfluidic chip manufacturing process is difficult to operate because of complex three-dimensional channels, complicated manufacturing steps, limited printing materials, the difficulty of operating the bonding process, and the need to purchase expensive new equipment. In this paper, an integrated molding method for microfluidic chips that integrates 3D printing and polymer dissolution technology is proposed. First, the channel mold of poly(vinyl alcohol) (PVA) or high impact polystyrene (HIPS) is dissolved to complete the manufacturing of the microfluidic chip channel. The integrated 3D-forming method of microfluidic chips proposed in this paper can manufacture microchannels inside the microfluidic chip, avoid the bonding process, and eliminate the need for rapid alignment of microchannels, material modification, and other operations, thus improving the stability of the process. Finally, by comparing the microchannels made by PVA and HIPS, it is concluded that the quality of the microchannels made by HIPS is obviously better than that made by PVA. This paper provides a new idea for the fabrication of microfluidic chips and the application of HIPS.
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