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Pharmacology & Pharmacy
Chengqi Yan et al.
Summary: The refractory diabetic wound has been a global challenge, and the impaired angiogenesis phase plays a role in its pathological process. This study found that miR-31-5p expression was significantly reduced in the wounds of diabetic mice. Further investigation showed that miR-31-5p promotes proliferation, migration, and angiogenesis of endothelial cells. By utilizing milk-derived exosomes as a delivery system, miR-31-5p mimics were successfully encapsulated and demonstrated improved therapeutic effects both in vitro and in vivo.
Review
Medicine, General & Internal
Steven A. Seifert et al.
Summary: Snakebites are a global health problem that can lead to thromboses and neuromuscular paralysis. Antivenoms made from horses and sheep are the preferred treatments, but accurate identification of the bite source is necessary and they can cause anaphylaxis and serum sickness.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Audrius Kilikevicius et al.
Summary: MicroRNAs (miRNAs) have the potential to regulate the expression of any RNA, but our understanding of their molecular mechanism is still limited. Insufficient focus on the mechanism of miRNAs and lack of evidence linking specific miRNA expression to biological phenotypes have hindered our accurate understanding of miRNA function.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Theo Tasoulis et al.
Summary: Understanding snake venom proteomes is crucial for comprehending snake venom biology, evolution, as well as the clinical effects of venoms and approaches to antivenom development. This study reviewed a range of research on snake venom proteomes and found that different methodological strategies can enhance protein identification, while combining methods can maximize proteome coverage. Variation in protein diversity and abundance was observed among different snake species, with viper venoms being compositionally more complex than elapid venoms. To ensure equivalent comparisons between studies, it is necessary to clarify methodological differences and establish standardized protein classification, nomenclature, and reporting procedures.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Food Science & Technology
Bhargab Kalita et al.
Summary: Cytotoxins are important toxins present in cobra venom that play a significant role in venom-induced toxicity, particularly in dermonecrosis. They mediate toxicity by affecting cell membrane structures, membrane-bound proteins, and activating apoptotic and necrotic cell death pathways. Some cytotoxins are also responsible for depolarizing neurons and heart muscle membranes, contributing to cardiac failure. They form complexes with other components in cobra venom, enhancing its toxic effects.
Review
Oncology
Mahshid Deldar Abad Paskeh et al.
Summary: This review discusses the role of exosomes in cancer progression, therapy, and regulation of the tumor microenvironment. The study found that exosomes can influence cancer cell proliferation and migration rates by modulating components of the tumor microenvironment. Depending on their cargo, exosomes can promote or suppress tumor cell progression and enhance or reduce the response to radiotherapy and chemotherapy. Additionally, exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by transferring RNA and modulating molecular signaling pathways. Moreover, exosomes can serve as carriers of anti-tumor agents and genetic tools to control cancer progression. Finally, exosomes are valuable diagnostic and prognostic tools in the treatment of cancer patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lidia Jorge Tasima et al.
Summary: Considerable heterogeneity and ontogenetic changes in venom composition have been observed in different species of snakes within the Viperidae family. The venom of young and adult snakes have distinct pathological effects and may require different treatment with antivenom. This study analyzed and compared the venom of Bothrops pauloensis snakes, revealing ontogenetic and sex-related variations in venom composition and biological activities. The findings underscore the importance of understanding intraspecific variations in snake venom for better treatment strategies.
Review
Chemistry, Multidisciplinary
Ana L. Oliveira et al.
Summary: This review discusses the chemistry of snake venom and its potential for medicinal purposes. It focuses on the molecular structure, chemical reactivity, and target recognition of bioactive toxins found in snake venom, and how they can be developed into bioactive drugs. The design and working mechanisms of snake-venom-derived drugs are illustrated, along with the strategies for transforming toxins into therapeutics. The challenges in realizing the curative potential of snake venom are also discussed, and chemical strategies for deriving new drugs from snake venom are proposed.
NATURE REVIEWS CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Zhengjun Lin et al.
Summary: This article systematically summarizes the roles and detailed molecular mechanisms of mesenchymal stem cell-derived exosomes (MSC-derived exosomes) in mediating cancer therapy resistance, providing novel insights into the clinical applications of MSC-derived exosomes in cancer management.
Review
Medicine, Research & Experimental
Jordan H. Driskill et al.
Summary: Research on the Hippo pathway has shown its significant role in liver size, regeneration, development, metabolism, and homeostasis, as well as its impact on common liver diseases. Targeting the Hippo pathway pharmacologically may help boost liver regeneration and prevent disease progression.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021
(2021)
Review
Biochemical Research Methods
Cassandra M. Modahl et al.
Summary: Snake venoms contain diverse protein and peptide isoforms, and integrating venom gland transcriptomics and proteomics can provide a comprehensive characterization of venom, especially for understudied species. Species-specific venom gland transcriptomes can correct the absence of unique peptide sequences in databases, improving the accuracy of venom profiling through the integration of transcriptomics and proteomics.
EXPERT REVIEW OF PROTEOMICS
(2021)
Review
Pharmacology & Pharmacy
Simin Zhao et al.
Summary: Research suggests that microRNAs play a crucial role in diabetes-related cardiovascular complication, with miRNAs in exosomes potentially both promoting and mitigating the development of complications. Targeting miRNAs may be an effective therapeutic approach for alleviating diabetes-related CVD.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Shuangshuang Du et al.
Summary: Exosomal miRNAs play a crucial role in regulating vascular aging by participating in the physiological functions of vascular cells and ECM remodeling, affecting the expression of senescence-related functions.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Roi Isaac et al.
Summary: Exosomes are nanoparticles secreted by all cell types, playing a role in intercellular and intraorgan communication by carrying biological signals such as proteins, lipids, and miRNAs. They have also been utilized as disease biomarkers.
Article
Cell Biology
Meng-Meng Shi et al.
Summary: MSC-EVs derived from mesenchymal stromal cells have shown promise as a cell-free therapy source. Nebulized haMSC-EVs improved survival rates and lung inflammation in a murine lung injury model, and were well tolerated in healthy volunteers. These findings suggest that nebulized haMSC-EVs could be a promising therapeutic strategy for lung injury diseases.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Review
Multidisciplinary Sciences
Raghu Kalluri et al.
Review
Food Science & Technology
Philip E. Bickler
Review
Pharmacology & Pharmacy
Nicholas R. Casewell et al.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2020)
Review
Food Science & Technology
Kun-Che Chang et al.
Review
Biochemistry & Molecular Biology
Ladan Mashouri et al.
Review
Biochemistry & Molecular Biology
D. Michiel Pegtel et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88
(2019)
Review
Cell Biology
Marcelo A. Mori et al.
Review
Pharmacology & Pharmacy
Pedro Henrique Souza Cesar et al.
CURRENT DRUG TARGETS
(2019)
Review
Gastroenterology & Hepatology
Elke A. Ober et al.
JOURNAL OF HEPATOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Zhenqiang Sun et al.
Article
Pharmacology & Pharmacy
Andreia Souza-Imberg et al.
Review
Food Science & Technology
Theo Tasoulis et al.
Review
Chemistry, Medicinal
Peter V. Dubovskii et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2015)
Article
Microbiology
Anja Honegger et al.
Review
Pharmacology & Pharmacy
Francis S. Markland et al.
Article
Biochemical Research Methods
Andre Zelanis et al.
Review
Veterinary Sciences
Amelia Goddard et al.
VETERINARY CLINICAL PATHOLOGY
(2011)
Article
Biology
Bashir M. Jarrar
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2011)
Article
Pharmacology & Pharmacy
Yuko Ogawa et al.
