☆ 4.7 Review

Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering

JOURNAL OF NANOBIOTECHNOLOGY (2023)

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Summary: This study developed electrospun nanofibrous films with improved antimicrobial and antioxidant activity as intelligent packaging for monitoring food freshness. The films demonstrated enhanced antibacterial effect, pH-responsive color changes, and spoilage indication.

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Silk Fibroin Combined with Electrospinning as a Promising Strategy for Tissue Regeneration

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Summary: Silk fibroin is an ideal material for tissue engineering scaffolds, and electrospinning can produce nanofibers with similar morphology to the extracellular matrix. This has significant implications for tissue regeneration.

MACROMOLECULAR BIOSCIENCE (2023)

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pH-Responsive nanofiber buttresses as local drug delivery devices

Ismail Altinbasak et al.

Summary: Electrospun nanofibers have numerous advantages as a scaffold for drug delivery devices. A new pH-responsive nanofiber buttress was synthesized via electrospinning. The buttress transforms from a hydrophobic to a hydrophilic state under relevant pH conditions and releases the encapsulated drug. It shows controlled drug release and cytotoxicity to cancer cells.

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Bin Kong et al.

Summary: Nano/micro fibers have attracted much attention in fiber science due to their special functions and properties, and they have a wide range of applications in fields such as environmental engineering, electronics, and biomedicine.

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Electrospun fibers as carriers for topical drug delivery and release in skin bandages and patches for atopic dermatitis treatment

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Summary: The skin is an important barrier between the environment and the body, but it can also develop various problems, with eczema being the most common. Treatment for atopic dermatitis focuses on increasing skin moisture and protection. Electrospun fibers have properties that meet the requirements for skin patches and show potential as a treatment for atopic dermatitis. The release of drugs from electrospun membranes is affected by various factors, and their use as a drug delivery system is extensively studied.

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Article Biotechnology & Applied Microbiology

Bio-functional hydrogel with antibacterial and anti-inflammatory dual properties to combat with burn wound infection

Yahui Xiong et al.

Summary: A new dressing with antibacterial and anti-inflammatory dual properties consisting of methacrylate gelatin hydrogel system with silver nanoparticles embedded in gamma-cyclodextrin metal-organic frameworks and hyaluronic acid-epigallocatechin gallate (HA-E) has been proposed for burn wound infection treatment. The hydrogel exhibits suitable physical properties, sustained release of Ag+, and excellent biocompatibility. In vivo evaluations demonstrate that the hydrogel reduces bacterial count, accelerates wound healing, promotes early angiogenesis, and regulates immune reaction. The noncanonical Wnt signal pathway is significantly activated in the hydrogel treated group. In conclusion, the GelMA/HA-E/Ag@MOF hydrogel shows great potential as a multifunctional dressing for burn wound healing.

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Multifunctional Electrospinning Polyhydroxyalkanoate Fibrous Scaffolds with Antibacterial and Angiogenesis Effects for Accelerating Wound Healing

Jian Li et al.

Summary: In order to treat large-scale wounds or chronic ulcers, a poly(3-hydroxybutyrate-co-4-hydroxybuty-rate) (P34HB) fibrous wound dressing that integrates an antibacterial ciprofloxacin (CIP) and pro-angiogenic dimethyloxalylglycine (DMOG) was successfully prepared. The resulting dressing showed excellent biocompatibility, increased cell proliferation, migration, and capillary-like tube formation. The dressings also exhibited broad-spectrum antimicrobial action and promoted wound closure, reepithelialization, collagen formation, angiogenesis, and hair follicle regeneration. This work provides a simple and efficient approach for the design of versatile wound dressings with antibacterial and angiogenic properties.

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Jialing Song et al.

Summary: This review outlines the progress of research on electrospinning nanofibers with different morphologies and functional characteristics in environmental sensors over the past decade. Electrospun nanofibers possess advantages such as porous structure and high specific surface area, and introducing functional nanomaterials can improve the performance of sensors.

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Article Chemistry, Multidisciplinary

pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

Yongping Liang et al.

Summary: A dual-responsive hydrogel dressing was constructed for the treatment of type II diabetic foot ulcers and shown to promote wound healing in a rat model. The addition of metformin and graphene oxide further enhanced wound repair.

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Recent Progress in Protective Membranes Fabricated via Electrospinning: Advanced Materials, Biomimetic Structures, and Functional Applications

Shuo Shi et al.

Summary: This research reviewed the progress and applications of multifunctional protective membranes fabricated via electrospinning. It identified gaps in current research and proposed solutions for technological development.

ADVANCED MATERIALS (2022)

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Development of fast-dissolving dosage forms of curcuminoids by electrospinning for potential tumor therapy application

Krisztina Kiss et al.

Summary: Special formulations were developed to enhance the water solubility of curcuminoids, leading to the preparation of fast-dissolving fibrous dosage forms for intravenous infusion. The antitumor activity of the curcuminoid complexes with HP-beta-CD was found to be similar or better compared to free APIs.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Wenju Wei et al.

Summary: Implantable thermo-responsive drug-loaded magnetic nanofibers show promising application prospects in melanoma chemotherapy, with the capability of heat generation and switchable release of curcumin. The combinatorial effect of hyperthermia and curcumin release significantly reduces the viability of melanoma cancer cells in experiments.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2022)

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Article Chemistry, Physical

Stimuli-responsive charge-reversal MOF@polymer hybrid nanocomposites for enhanced co-delivery of chemotherapeutics towards combination therapy of multidrug-resistant cancer

Liefeng Hu et al.

Summary: Combination chemotherapy using metal-organic framework (MOF)-based polymer-coated hybrid nanoparticles (NPs) holds promise for treating multidrug-resistant cancer by enhancing the delivery of multiple drugs into tumor cells.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing

Ye Wu et al.

Summary: The injectable glycopeptide hydrogel fabricated in this study possesses multifunctionality, including inherent antibacterial and antioxidant capabilities, as well as the ability to promote angiogenesis and accelerate wound healing. The spatiotemporal delivery of therapeutic agents within the hydrogel allows for effective anti-infection, anti-oxidation, and anti-inflammation effects, making it a promising strategy for treating chronic diabetic wounds.

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Coaxial structured drug loaded dressing combined with induced stem cell differentiation for enhanced wound healing

Chen Gao et al.

Summary: In this study, a directional core-shell drug-loaded magnetocaloric response dressing was developed to prevent drug-resistant infection and promote stem cell differentiation and wound healing. The functional fibers significantly accelerated the healing process.

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Multiple Stimuli-Responsive MXene-Based Hydrogel as Intelligent Drug Delivery Carriers for Deep Chronic Wound Healing

Xin Yang et al.

Summary: A novel MXene-based hydrogel drug delivery system for efficient treatment of deep chronic wounds is introduced in the study. This system demonstrates multiple response capability and controllable drug delivery ability, reducing toxic side effects of drugs and promoting wound healing process. The practical performance of the system in treating rat models indicates great prospect in clinical wound healing and related biomedical fields.

SMALL (2022)

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Stimuli-responsive nanoplatforms for antibacterial applications

Yue Huang et al.

Summary: This review provides an extensive overview of recent progress in endogenous and exogenous stimuli-responsive nanoplatforms for antibacterial applications. The mechanisms and strategies of designing endogenous stimuli-responsive nanoplatforms using specific infected microenvironments are discussed, with a focus on improving therapeutic efficacy and reducing side effects. Additionally, the use of exogenous stimuli-responsive nanoplatforms, particularly light-responsive nanoparticles, for controlled drug delivery is highlighted.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2022)

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Review Engineering, Biomedical

Expanding the Repertoire of Electrospinning: New and Emerging Biopolymers, Techniques, and Applications

Liszt Y. C. Madruga et al.

Summary: Electrospinning is a versatile technology for fabricating polymer fibers, especially for biological applications. Recent research has focused on using biopolymers such as sulfated polymers, tannin derivatives, and modified collagen to produce new fibers. The potential advantages of these biopolymer-based fibers for biomedical applications are also being explored to enhance or achieve new properties for electrospun materials.

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Review Chemistry, Multidisciplinary

Stimuli-Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

Jin Zhang et al.

Summary: This review discusses the use of stimuli-responsive nanoparticles (srNPs) in cancer immunotherapy, highlighting their potential to enhance anti-tumor immune responses by combining with tumor microenvironment and external stimuli. The goal is to achieve synergistic immunotherapy and long-term immune memory to prevent tumor recurrence.

ADVANCED SCIENCE (2022)

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Multiple stimuli-responsive nanosystem for potent, ROS-amplifying, chemo-sonodynamic antitumor therapy

JunJie Tang et al.

Summary: This study presents a novel oxygen-independent, ROS-amplifying chemo-sonodynamic antitumor therapy using pH/GSH/ROS triple-responsive PEG-PPMDT nanoparticles. The therapy effectively releases drugs and amplifies ROS levels in tumor cells, leading to significant tumor growth inhibition. The therapy also demonstrates minimal toxicity to main organs and can be guided by Fe(3)O(4) encapsulated in the nanoparticles.

BIOACTIVE MATERIALS (2022)

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Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

Hussein M. El-Husseiny et al.

Summary: Biomedicine and tissue regeneration have made significant advancements in recent years, opening up possibilities for improving the restoration of impaired tissues and their functions. Smart/stimuli-responsive hydrogels, as three-dimensional bioscaffolds, show great potential in tissue engineering and other biomedical applications. This review focuses on the synthesis schemes and responsiveness mechanisms of smart/stimuli-responsive hydrogels, as well as their potential in tissue engineering and other biomedical applications.

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Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment

Mi Zhang et al.

Summary: Inflammatory arthritis is a leading cause of disability in the elderly, and the available treatment options are limited. To address this issue, researchers propose using stimuli-responsive nanomaterials to manage inflammatory arthritis, releasing therapeutic medications by triggering pathological changes.

MATERIALS TODAY BIO (2022)

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Article Engineering, Biomedical

Metal-organic framework-based hydrogel with structurally dynamic properties as a stimuli-responsive localized drug delivery system for cancer therapy

Yuqin Zeng et al.

Summary: Metal-organic framework (MOF) is a porous biomaterial that can be used as a drug carrier. Researchers have designed an MOF-based hydrogel with self-healing and shear-thinning properties for localized drug delivery. The hydrogel exhibits pH and ATP-responsive drug release characteristics and efficiently kills cancer cells in vitro, showing enhanced tumor growth suppression compared to other drug delivery methods.

ACTA BIOMATERIALIA (2022)

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Targeted Drug/Gene/Photodynamic Therapy via a Stimuli-Responsive Dendritic-Polymer-Based Nanococktail for Treatment of EGFR-TKI-Resistant Non-Small-Cell Lung Cancer

Jinxing Huang et al.

Summary: This study proposes a nanococktail therapeutic strategy for treating EGFR-TKI resistant NSCLC by targeted co-delivery of drugs and genes, along with photodynamic therapy. The results show that this nanococktail therapy effectively releases drugs and genes at the tumor site, demonstrating potent antitumor efficacy.

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Article Chemistry, Applied

Multi-stimuli responsive hydrogels derived from hyaluronic acid for cancer therapy application

Yi-Jun Jo et al.

Summary: Researchers developed stimuli-responsive hydrogels based on hyaluronic acid and diselenide cross-linker for controlled drug release. These hydrogels exhibited rapid drug release under acidic, reducing, oxidizing, and NIR irradiation conditions, and showed good cytocompatibility and anti-tumor effect.

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Electrospinning porcine decellularized nerve matrix scaffold for peripheral nerve regeneration

Yan Kong et al.

Summary: In this study, a pure porcine decellularized nerve matrix conduit (xDNME) was successfully developed using an electrospinning technique without any additives. The xDNME conduit exhibited an obvious fiber structure and retained the natural components of the decellularized nerve tissue. In vivo experiments showed that xDNME significantly promoted the regeneration of rat sciatic nerve and exhibited comparable myelin sheath thickness and electrical signal transmission ability to the autologous nerve.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Antibacterial Vancomycin@ZIF-8 Loaded PVA Nanofiber Membrane for Infected Bone Repair

Yunbo Zhao et al.

Summary: By loading the antibacterial drug vancomycin into zeolitic imidazolate framework-8 (ZIF-8) and preparing it into polyvinyl alcohol (PVA) fiber membrane through electrospinning, a composite bone filler with antibacterial and bone cell-promoting effects can be obtained.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Polydopamine-coated nanocomposite theranostic implants for localized chemotherapy and MRI imaging

Ziwei Zhang et al.

Summary: In this study, a potential implant was developed to sustainably release the chemotherapeutic drug MTX and provide local contrast for MRI. The fibers showed sustained drug release and responsive behavior to conditions representative of the tumor microenvironment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Biochemistry & Molecular Biology

Light-Triggered Structural Modulation of Nanofibrous Meshes to Promote Deep Penetration of Cultured Cells

Oanh-Vu Pham-Nguyen et al.

Summary: Nanofibrous meshes are potential cultivation beds for cell differentiation, but their nanoporous structures hinder 3D cultivation. To overcome this, electrospun nanofibers with structures responsive to red laser light were used to facilitate cell migration. The study found that red laser light effectively promoted cell migration on nanofibrous meshes without affecting cell viability.

MACROMOLECULAR BIOSCIENCE (2022)

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Article Biotechnology & Applied Microbiology

Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells

Pritha Agarwalla et al.

Summary: This study introduces a novel implantable multifunctional scaffold (MASTER) that streamlines in vivo CAR-T cell manufacturing, resulting in the rapid generation and release of functional CAR-T cells in mice. MASTER shows improved therapeutic efficacy and persistence compared to conventional CAR-T cells, promising to transform CAR-T cell therapy.

NATURE BIOTECHNOLOGY (2022)

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Review Chemistry, Multidisciplinary

Progress in Stimuli-Responsive Biomaterials for Treating Cardiovascular and Cerebrovascular Diseases

Christos Tapeinos et al.

Summary: Cardiovascular and cerebrovascular diseases are major causes of death globally. Stimuli-responsive biomaterials have the potential to target diseased tissue by altering their properties and morphology.

SMALL (2022)

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Article Chemistry, Multidisciplinary

An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment

Tamas Veres et al.

Summary: The aim of this study was to synthesize an implantable, biodegradable membrane infused with magnetite nanoparticles for long-term treatment and MRI contrast. The results showed excellent MRI contrast, superparamagnetic properties, and biocompatibility of the membrane.

NANOMATERIALS (2022)

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Article Nanoscience & Nanotechnology

Biomimetic Asymmetric Composite Dressing by Electrospinning with Aligned Nanofibrous and Micropatterned Structures for Severe Burn Wound Healing

Chenhui He et al.

Summary: The surface structure and topography of biomaterials are crucial for cell behaviors and wound healing. Inspired by the skin structure and super-hydrophobicity of lotus leaf, an asymmetric composite dressing was developed. It effectively prevents bacterial colonization and infection, promotes cell adhesion and migration, reduces inflammation, and accelerates wound healing.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Review Chemistry, Multidisciplinary

Stimuli-Responsive Metal Complexes for Biomedical Applications

Ivanna Amarsy et al.

Summary: Metal-based prodrugs are developed to overcome the drawbacks of metal-based compounds for biomedical applications, by utilizing tumor-associated stimuli for selective delivery. This field has significant applications in oncology.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Review Biochemistry & Molecular Biology

Stimuli-responsive nanoassemblies for targeted delivery against tumor and its microenvironment

Chin Siew Sia et al.

Summary: This review discusses the application and design requirements of nanoassemblies in tumor-targeted diagnosis and therapy, describing the characteristics of the tumor microenvironment and multiple barriers that need to be overcome for successful drug delivery.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2022)

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Article Biochemistry & Molecular Biology

Near-Infrared Responsive Synergistic Chemo-Phototherapy from Surface-Functionalized Poly(ε-caprolactone)-Poly(D,L-lactic-co-glycolic acid) Composite Nanofibers for Postsurgical Cancer Treatment

Jakia Khanom et al.

Summary: This study combines hyperthermia and chemotherapy by attaching pyrrole to the surface of nanofibers, achieving localized cancer treatment. The increase in pyrrole concentration under NIR irradiation leads to a rise in local temperature, accelerating drug release and enhancing cytotoxicity.

BIOMACROMOLECULES (2022)

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Article Pharmacology & Pharmacy

Pharmacokinetic control on the release of antimicrobial drugs from pH-responsive electrospun wound dressings

Laura Miranda-Calderon et al.

Summary: The pH of healthy skin changes during wound healing, and chronic non-healing wounds commonly show an alkaline shift. In order to adjust drug release to the specific pH of wounds, drug-loaded wound dressings with pH-responsiveness were developed. These dressings contain antiseptics and antibiotics and exert different release kinetics depending on the pH conditions of each wound type.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Biochemistry & Molecular Biology

Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer

Xia Li et al.

Summary: This study developed a silk fibroin/polylactic-co-glycolic acid/black phosphorus (SF/PLGA/BP@SF) composite membrane with smooth and even fibers. The membrane exhibited excellent photothermal properties and effectively killed cancer cells in vitro.

MOLECULES (2022)

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Article Engineering, Biomedical

Coaxially Fabricated Dual-Drug Loading Electrospinning Fibrous Mat with Programmed Releasing Behavior to Boost Vascularized Bone Regeneration

Jinjie Cui et al.

Summary: This study successfully enhanced vascularized bone regeneration through the use of a dual-drug programmed releasing electrospinning fibrous mat. By adjusting the behavior of angiogenesis and osteogenesis, this approach has potential clinical application value in the treatment of critical-size defects.

ADVANCED HEALTHCARE MATERIALS (2022)

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Review Pharmacology & Pharmacy

Stimuli-Responsive Gold Nanocages for Cancer Diagnosis and Treatment

Chunming Li et al.

Summary: This review summarizes the recent advancements in gold nanocages (AuNCs) as drug delivery systems, including endogenous, exogenous, and dual/multi-stimuli responsive AuNCs, focusing on their properties, clinical translation potential, and limitations for cancer diagnosis and treatment.

PHARMACEUTICS (2022)

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Review Chemistry, Multidisciplinary

Emerging Strategies in Stimuli-Responsive Prodrug Nanosystems for Cancer Therapy

Chendi Ding et al.

Summary: Prodrugs are inactive drug molecules that are converted to active drugs after administration. They play a crucial role in drug treatment, especially in cancer therapy. Current research focuses on stimuli-responsive activation mechanisms, regulation of stimuli intensity in vivo, and the design of nanoscale prodrug formulations.

ACS NANO (2022)

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Article Medicine, Research & Experimental

Insights into stimuli-responsive diselenide bonds utilized in drug delivery systems for cancer therapy

Zhenfeng Shi et al.

Summary: This review summarizes the significance and application of diselenide bonds in redox responsive drug delivery systems (DDSs). It comprehensively reports the stimulation sensitivity of diselenide bonds and extensively discusses the potential and prospects for their application in next-generation anticancer drug treatment systems.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Polymer Science

Recent advances in electrospun nanofibers for wound dressing

Kai Chen et al.

Summary: Electrospun nanofibers have emerged as a promising option for wound dressings, with their high porosity, good mechanical properties, and excellent biocompatibility. They can promote wound healing by moisturizing the wound, facilitating cell respiration, and regenerating damaged skin. Furthermore, their ability to encapsulate active substances or incorporate them into their structural design allows them to meet the diverse requirements of wound therapy. This review article provides an overview of the recent developments in electrospun nanofibers as wound dressings, including the use of different polymer materials, their structural characteristics, and their role in promoting wound healing. The article also explores the future prospects of electrospinning in the development of wound dressings.

EUROPEAN POLYMER JOURNAL (2022)

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Review Nanoscience & Nanotechnology

Polysaccharide Electrospun Nanofibers for Wound Healing Applications

Guoxin Tan et al.

Summary: This paper reviews the preparation of natural polysaccharide nanofibers by electrospinning and their potential applications in wound healing. Various polysaccharide nanofibers, such as chitosan, starch, alginate, and hyaluronic acid, are introduced. The preparation strategy and functions of polysaccharide electrospun nanofibers in promoting wound healing are summarized. Additionally, the future prospects and challenges for the preparation of polysaccharide nanofibers by electrospinning are discussed.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Chemistry, Physical

Photothermal-responsive fiber dressing with enhanced antibacterial activity and cell manipulation towards promoting wound-healing

Lei Chen et al.

Summary: In this study, a composite fiber dressing with near-infrared laser-induced hyperthermia and transformable topographies was designed to protect chronic persistent skin injuries from bacterial infection and promote cell recruitment and tissue regeneration. The dressing demonstrated excellent photothermal performance and stagespecific transformable topographies, generating local heat and drug release for synergistic sterilization and tissue regeneration. In vivo testing showed that the dressing accelerated wound closure by improving antibacterial and cell manipulation. Overall, this composite fiber dressing offers a promising integrated wound healing strategy.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Review Chemistry, Multidisciplinary

Nanoparticles incorporated in nanofibers using electrospinning: A novel nano-in-nano delivery system

Karishma Shetty et al.

Summary: Nanofibers, as cutting-edge drug delivery systems, have great potential for treating various diseases. By incorporating nanoparticles into nanofibers, nano-in-nano delivery techniques offer advantages such as drug protection, extended release, increased drug loading capacity, etc. This review provides an insight into the applications and current state of nano-in-nano drug delivery systems.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Chemistry, Multidisciplinary

Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches

Milad Ashrafizadeh et al.

Summary: This review discusses the use of stimuli-responsive liposomes for targeted drug delivery in cancer therapy. These liposomes can be triggered by various stimuli such as pH, redox, enzymes, light, heat, and magnetic field to release drugs at tumor sites. The stimuli-responsive liposomes have shown great potential in improving the efficacy of anticancer drugs.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

Stable amorphous solid dispersion of flubendazole with high loading via electrospinning

Jana Becelaere et al.

Summary: This work demonstrates an important advancement in improving the bioavailability of poorly water-soluble drugs through solvent electrospinning. The resulting nanofibrous amorphous solid dispersions (ASDs) show high drug loadings and long-term stability. The formulation strategy involves strong hydrogen bonds between the drug and the polymer, leading to improved drug solubility and dissolution rates.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Materials Science, Biomaterials

Advances in electrospinning and 3D bioprinting strategies to enhance functional regeneration of skeletal muscle tissue

Madhumithra Thangadurai et al.

Summary: Skeletal muscles are crucial for body movement, but volumetric muscle loss leads to motor function impairment. Tissue engineering offers viable solutions for muscle regeneration using scaffolds. Electrospinning and 3D bioprinting are commonly used techniques to create muscle-like tissues. This review explores muscle defects, treatment options, and advancements in electrospinning and 3D bioprinting for skeletal muscle regeneration.

BIOMATERIALS ADVANCES (2022)

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Review Chemistry, Multidisciplinary

Stimuli-responsive therapeutic systems for the treatment of diabetic infected wounds

Yanling Hu et al.

Summary: Diabetic wound infection is a common disease that poses challenges due to the diabetic wound environment and bacterial resistance. Nanobiomaterial-based therapeutic systems with stimuli-responsive performance can address these challenges by delivering therapeutic agents on demand.

NANOSCALE (2022)

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Review Chemistry, Multidisciplinary

Recent update on electrospinning and electrospun nanofibers: current trends and their applications

Arif Nadaf et al.

Summary: Electrospinning is a versatile technique for generating ultrathin fibers, and this review provides a comprehensive overview of electrospinning and non-electrospinning processes, their setup, fabrication process, components, and applications. The review covers the characteristics of nanofibers, materials required for their production, and the diverse applications they have in various fields. It also discusses the challenges and future prospects of nanofiber development.

RSC ADVANCES (2022)

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Article Materials Science, Biomaterials

A fish-scale derived multifunctional nanofiber membrane for infected wound healing

Hailing Li et al.

Summary: The rapid development of modern medicine has brought about new requirements for wound infection healing methods. This study developed a multifunctional nanofibrous membrane combining nanoparticles and collagen to accelerate wound healing. The results showed that the composite material with near-infrared light exhibited excellent performance in promoting tissue regeneration and inhibiting inflammation.

BIOMATERIALS SCIENCE (2022)

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Article Materials Science, Biomaterials

Electroactive functional microenvironments from bioactive polymers: A new strategy to address cancer

S. Ribeiro et al.

Summary: The present work explores the use of electroactive microenvironments to mitigate skeletal muscle cancer. Mechanical stimuli were found to enhance the proliferation of rhabdomyosarcoma, while mechano-electrical stimuli decreased it. Additionally, it was observed that cell proliferation varied depending on the morphology of the fibers.

BIOMATERIALS ADVANCES (2022)

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Article Polymer Science

Stimuli-responsive and core cross-linked micelles developed by NiCCo-PISA of helical poly(aryl isocyanide)s

Setuhn Jimaja et al.

Summary: We report the synthesis of redox- and pH-sensitive block copolymer micelles that contain chiral cores composed of helical poly(aryl isocyanide)s. The introduction of cross-links and stimulus-sensitive nanostructures are achieved through post-polymerisation modification with various diamines. The stimuli-responsiveness of the nanoparticles towards a reducing agent and pH is evaluated by following the change in size using dynamic light scattering.

POLYMER CHEMISTRY (2022)

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Article Materials Science, Biomaterials

Development of stimulus-sensitive electrospun membranes based on novel biodegradable segmented polyurethane as triggered delivery system for doxorubicin

Salvatore Federico et al.

Summary: In this study, a pH-sensitive compound was chemically attached to an electrospun membrane, allowing for dual release under acidic and reducing conditions. The research showed that this dual release resulted in significant cytotoxic effects in human breast cancer cells, providing a promising approach for post-surgical treatment of solid tumors.

BIOMATERIALS ADVANCES (2022)

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Review Materials Science, Biomaterials

Stimuli-responsive cyclodextrin-based supramolecular assemblies as drug carriers

Ying Yuan et al.

Summary: This review summarizes the recent advances in stimuli-responsive supramolecular assemblies based on the host-guest chemistry of CDs. By integrating the host-guest chemistry of CDs with stimuli-responsive functions, various biomedical applications can be achieved in a spatiotemporally controlled manner.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Materials Science, Biomaterials

An implantable smart hyperthermia nanofiber with switchable, controlled and sustained drug release: Possible application in prevention of cancer local recurrence

Shadi Samadzadeh et al.

Summary: Smart hyperthermia nanofibers with temperature-responsive heat generation and dual-stage drug release capability have been developed, showing improved hyperthermic chemotherapy efficiency through 'ON-OFF' switching of an alternating magnetic field. These nanofibers exhibited reversible swelling ratio and controllable drug discharge properties in response to the magnetic field, leading to enhanced cytotoxicity compared to standard chemotherapy regimens.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Biophysics

Colon targeted delivery of niclosamide from β-cyclodextrin inclusion complex incorporated electrospun Eudragit® L100 nanofibers

Ozlem Coban et al.

Summary: By combining electrospun nanofibers with CD-IC, targeted delivery of hydrophobic drugs such as NIC to the colon can be achieved effectively, showing better controlled release compared to traditional drug delivery methods.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Chemistry, Applied

Magnetic bioactive glasses/Cisplatin loaded-chitosan (CS)-grafted- poly (ε-caprolactone) nanofibers against bone cancer treatment

Zahra Amini et al.

Summary: Bioactive glasses and magnetic bioactive glasses doped with Cisplatin were incorporated into chitosan-grafted-poly(epsilon-caprolactone) nanofibers for controlled drug release, resulting in accelerated release at lower pH and higher temperature conditions. The optimal concentration for killing MG-63 osteosarcoma cells was found to be 100 μg/mL of nanofibers. Future research may focus on the application of these nanofibers as implantable devices for bone cancer therapy.

CARBOHYDRATE POLYMERS (2021)

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Article Biochemistry & Molecular Biology

Alginate-magnetic short nanofibers 3D composite hydrogel enhances the encapsulated human olfactorymucosa stem cells bioactivity for potential nerve regeneration application

Sarah Karimi et al.

Summary: The study developed alginate hydrogels incorporating magnetic short nanofibers for encapsulation of OE-MSCs, which showed improved cell viability and enhanced proliferation rate.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Engineering, Biomedical

A core-shell structured alginate hydrogel beads with tunable thickness of carboxymethyl cellulose coating for pH responsive drug delivery

Mingzhu Yan et al.

Summary: pH-responsive core-shell structured composite hydrogel beads, composed of alginate core and carboxymethyl cellulose shell, were successfully prepared as a drug delivery system. These beads exhibited significant pH responsiveness and slower drug release rate compared to simple alginate beads. The mechanical stability of the beads was significantly improved by the carboxymethyl cellulose shell, making them potential candidates for in vivo pH-responsive drug delivery devices.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2021)

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Article Biochemistry & Molecular Biology

Self-coacervation of carboxymethyl chitosan as a pH-responsive encapsulation and delivery strategy

Huijuan Jing et al.

Summary: Carboxymethyl chitosan (CMCS)-based self-coacervates have shown great potential in drug oral delivery due to their pH-responsive properties and stability in a wide pH range. These self-coacervates also exhibit excellent encapsulation efficiency and loading capacity for lactoferrin (LF) encapsulation, protecting LF from hydrolysis during simulated gastric digestion. Overall, CMCS self-coacervation can be utilized as a pH-responsive encapsulation and delivery strategy.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Electrospun polyvinyl-alcohol/gum arabic nanofibers: Biomimetic platform for in vitro cell growth and cancer nanomedicine delivery

Francesca Serio et al.

Summary: The development of PVA/GA ECM-like electrospun nanofibers, with crosslinking and biocompatibility, creates a cell culture-friendly environment and efficiently delivers GA-AuNPs nanocomposites to metastatic melanoma cells. This biocompatible system shows promise as an in vitro tool for precision medicine.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Chemistry, Multidisciplinary

Electrospun PCL/MoS2 Nanofiber Membranes Combined with NIR-Triggered Photothermal Therapy to Accelerate Bone Regeneration

Ke Ma et al.

Summary: Innovative electrospun nanofiber membranes combined with photothermal therapy using MoS2 doping showed improved mechanical properties, enhanced cell growth, and osteogenic performance, accelerating bone regeneration and healing processes.

SMALL (2021)

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Article Engineering, Biomedical

The effect of hypoxia-mimicking responses on improving the regeneration of artificial vascular grafts

Muhammad Rafique et al.

Summary: Cellular transition to hypoxia following tissue injury can improve angiogenesis and regeneration in multiple tissues. Investigating the oxygen access state of implanted artificial small-diameter vascular grafts (SDVGs) is crucial for understanding vascular regeneration. Modification of SDVGs with HIF-1 stabilizer dimethyloxalylglycine (DMOG) has been shown to mimic hypoxia-mimicking responses and improve vascular regeneration. The use of DMOG-loaded PCL grafts supported the sustained release of DMOG, promoting endothelialization, contractile smooth muscle cells regeneration, vascularization and modulation of inflammatory reactions in abdominal artery replacement models.

BIOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Electrospinning for drug delivery applications: A review

Andrea Luraghi et al.

Summary: Drug delivery devices are promising in maximizing therapeutic effects and minimizing undesired side effects. Electrospun nanofibers have unique features like biocompatibility and flexibility, making them efficient in delivering active principles for a wide range of drugs. The technique of electrospinning allows for easy tuning and endless combinations, potentially leading to personalized medicine.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

An oxidative stress-responsive electrospun polyester membrane capable of releasing anti-bacterial and anti-inflammatory agents for postoperative anti-adhesion

Jin Zhang et al.

Summary: A smart oxidative stress-responsive membrane was fabricated as a physical barrier and drug reservoir to prevent peritendinous adhesion. Testing showed that membranes loaded with different drugs had good anti-adhesion capacity both in vitro and in vivo, with the best results seen in membranes loaded with both drugs simultaneously.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Chemistry, Multidisciplinary

Electromagnetically Stimuli-Responsive Nanoparticles-Based Systems for Biomedical Applications: Recent Advances and Future Perspectives

Raffaele Longo et al.

Summary: Nanoparticles have been used in the biomedical field for drug delivery by interacting with external stimuli, such as electromagnetic radiations, to enhance drug effects and reduce drug doses. Additionally, integrating these nanofillers into polymeric matrices can lead to promising applications for new transdermal drug delivery systems with controllable morphology and release kinetics.

NANOMATERIALS (2021)

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Article Multidisciplinary Sciences

A tumor microenvironment-induced absorption red-shifted polymer nanoparticle for simultaneously activated photoacoustic imaging and photothermal therapy

Shulong Wang et al.

Summary: The study found that the GSH level significantly increases in tumor tissues, thus it can be used as an endogenous molecule for diagnosing and treating tumors. The Fe-Cu@PANI nanoparticles prepared in the study utilize the tumor microenvironment-induced properties to activate tumor photoacoustic imaging and photothermal therapy in vivo, enhancing the efficiency of treatment.

SCIENCE ADVANCES (2021)

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Article Nanoscience & Nanotechnology

Fluorescent Magnesium Hydroxide Nanosheet Bandages with Tailored Properties for Biocompatible Antimicrobial Wound Dressings and pH Monitoring

Adam Truskewycz et al.

Summary: Fluorescent magnesium hydroxide nanosheets were synthesized and demonstrated to possess antimicrobial potential for medical applications. These nanosheets can be integrated into antimicrobial bandages and gels, showing good biocompatibility.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Pharmacology & Pharmacy

Electrospun gold nanorods/graphene oxide loaded-core-shell nanofibers for local delivery of paclitaxel against lung cancer during photo-chemotherapy method

Mohammadreza Hasani Azerbaijan et al.

Summary: The study successfully prepared a pH/temperature dual responsive carrier in the form of core-shell nanofibers for controlled release of paclitaxel against A549 lung cancer. Characterization of the synthesized nanofibers was conducted using SEM, TEM, and XRD analysis, with evaluation of drug encapsulation efficiency, drug release, kinetic studies, and compatibility of the nanofibers. In vitro cell viability studies showed promising results for the PTT/CHT combined method in treating lung cancer.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Review Biochemistry & Molecular Biology

A review on the applications of electrospun chitosan nanofibers for the cancer treatment

Parvaneh Ghaderi Shikhi-Abadi et al.

Summary: The study highlights that chitosan nanofibers prepared by electrospinning method have unique properties suitable for delivering anticancer drugs to treat cancer patients. Chitosan fibers have extensive application prospects in various cancer treatments.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

A novel alginate/gelatin sponge combined with curcumin-loaded electrospun fibers for postoperative rapid hemostasis and prevention of tumor recurrence

Kai Chen et al.

Summary: The novel alginate/gelatin sponge combined with curcumin-loaded electrospun fibers shows excellent hemostatic properties and effective prevention of tumor recurrence. This dual functional sponge was safe to implant in the body and did not cause toxicity to normal tissues and organs, representing a promising adjuvant strategy for cancer surgical treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Development of gold nanorods for cancer treatment

Qida Zong et al.

Summary: Gold nanorods (GNRs) have attracted increasing attention for tumor therapy due to their unique properties, although issues such as stability and toxicity have hindered their clinical application. Research is ongoing to investigate the toxic effects of GNRs, factors influencing toxicity, and methods to enhance biocompatibility for future development and safe utilization in tumor treatments.

JOURNAL OF INORGANIC BIOCHEMISTRY (2021)

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Article Materials Science, Biomaterials

Curcumin-loaded sandwich-like nanofibrous membrane prepared by electrospinning technology as wound dressing for accelerate wound healing

Kai Chen et al.

Summary: This study demonstrated that the prepared CSNM membrane has good hemostatic, antibacterial, and wound healing promoting effects. Through experiments and models, it showed its multifunctionality and promotion of various stages of wound healing.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Medicine, Research & Experimental

Advanced Delivery Systems Based on Lysine or Lysine Polymers

Saeed Manouchehri et al.

Summary: Polylysine and materials integrating lysine show promising prospects as drug delivery platforms, with smart, stimuli-responsive features that enhance the delivery of therapeutic agents. By conjugating with different functional groups, polylysine can improve cellular uptake and stability, making it a versatile tool for drug delivery systems.

MOLECULAR PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

pH-Responsive Chitosan/Alginate Polyelectrolyte Complexes on Electrospun PLGA Nanofibers for Controlled Drug Release

Jean Schoeller et al.

Summary: Surface functionalization of electrospun nanofibers allows for the introduction of additional functionalities while retaining high porosity and surface-to-volume ratio. In this study, chitosan and alginate were sequentially deposited on PLGA nanofibers to form a polyelectrolyte complex for controlled release of ibuprofen. Chitosan with a positive surface charge regulated the interactions between the drug and the coating, resulting in slower release at acidic pH compared to neutral pH.

NANOMATERIALS (2021)

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Article Oncology

Enhanced Paclitaxel Efficacy to Suppress Triple-Negative Breast Cancer Progression Using Metronomic Chemotherapy with a Controlled Release System of Electrospun Poly-d-l-Lactide-Co-Glycolide (PLGA) Nanofibers

Ming-Yi Hsu et al.

Summary: The study shows that using drug-loaded nanofibers for the treatment of TNBC holds potential, as it can provide sustained drug release to inhibit tumor growth without systemic toxicity.

CANCERS (2021)

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Article Pharmacology & Pharmacy

Electrically Triggered Drug Delivery from Novel Electrospun Poly(Lactic Acid)/Graphene Oxide/Quercetin Fibrous Scaffolds for Wound Dressing Applications

Alexa-Maria Croitoru et al.

Summary: This study developed a novel electro-responsive drug delivery system for controlled and localized drug release to target tissues with minimized side effects. The research focused on loading Quercetin (Q) into nanofiber scaffolds for wound dressing applications, demonstrating rapid drug release under electric field stimulation. The fabricated PLA/GO/Q scaffolds showed promising physico-chemical properties, electrical triggering capacity, antimicrobial efficacy, and biocompatibility, offering potential for applications in various therapeutic areas.

PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Stimuli-Responsive Nanofibers Containing Gold Nanorods for On-Demand Drug Delivery Platforms

Baljinder Singh et al.

Summary: This study focuses on the development of a on-demand drug delivery system using NIR-responsive nanofibers containing GNRs and PNIPAM. The system allows controlled drug release through thermal responses, with potential for combination chemotherapy and good biocompatibility. The versatility of the platform was confirmed in cell studies, demonstrating the advantages of the nanofibers' properties in drug delivery.

PHARMACEUTICS (2021)

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Article Engineering, Biomedical

Stimuli-responsive electrospun nanofibers based on PNVCL-PVAc copolymer in biomedical applications

Sogand Safari et al.

Summary: A high molecular weight PNVCL-PVAc thermo-responsive copolymer suitable for electrospun nanofiber fabrication was successfully synthesized and demonstrated to have biocompatibility and non-cytotoxicity. The synthesized copolymers showed promising characteristics for biomedical applications, as confirmed by contact angle test and cell proliferation results.

PROGRESS IN BIOMATERIALS (2021)

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Review Materials Science, Biomaterials

Electrospun nanofibers promote wound healing: theories, techniques, and perspectives†

Chen Gao et al.

Summary: The paper reviews recent research on how electrospun nanofiber scaffolds promote wound healing and the use of electrospinning technology for fabricating multi-functional scaffolds. Although there have been advancements, challenges remain in commercializing these materials to fully meet patient needs.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Applied

Honeycomb-like pH-responsive γ-cyclodextrin electrospun particles for highly efficient tumor therapy

Hyeong Sup Yu et al.

CARBOHYDRATE POLYMERS (2020)

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Review Nanoscience & Nanotechnology

Multifluid electrospinning for the generation of complex nanostructures

Deng-Guang Yu et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2020)

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Article Nanoscience & Nanotechnology

Photothermally Activated Electrospun Nanofiber Mats for High-Efficiency Surface-Mediated Gene Transfection

Yanjun Zheng et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

ROS-responsive polyurethane fibrous patches loaded with methylprednisolone (MP) for restoring structures and functions of infarcted myocardium in vivo

Yuejun Yao et al.

BIOMATERIALS (2020)

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Article Biochemistry & Molecular Biology

Tissue engineering with electrospun electro-responsive chitosan-aniline oligomer/polyvinyl alcohol

Babak Bagheri et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Materials Science, Biomaterials

Biologically responsive, long-term release nanocoating on an electrospun scaffold for vascular endothelialization and anticoagulation

Dongfang Wang et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Nanoscience & Nanotechnology

Tumor Responsive and Tunable Polymeric Platform for Optimized Delivery of Paclitaxel to Treat Glioblastoma

Elizabeth G. Graham-Gurysh et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Nanoscience & Nanotechnology

Advanced Black Phosphorus Nanomaterials for Bone Regeneration

Yun'an Qing et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Chemistry, Multidisciplinary

Functionalized silk fibroin nanofibers as drug carriers: Advantages and challenges

Mehdi Farokhi et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Biochemistry & Molecular Biology

Double stimuli-responsive cellulose nanocrystals reinforced electrospun PHBV composites membrane for intelligent drug release

Yuxiang Chen et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Chemistry, Multidisciplinary

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

Irene Bonadies et al.

NANOMATERIALS (2020)

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Review Chemistry, Multidisciplinary

Light-Responsive Inorganic Biomaterials for Biomedical Applications

Hung Pang Lee et al.

ADVANCED SCIENCE (2020)

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Review Pharmacology & Pharmacy

Electrospun nanofiber-based cancer sensors: A review

Prathamesh Parshuram Mane et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Agriculture, Multidisciplinary

Novel Controlled Release Microspheric Soil Conditioner Based on the Temperature and pH Dual-Stimuli Response

Fan Yang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Materials Science, Biomaterials

Fabrication of novel dual thermo- and pH-sensitive poly (N-isopropylacrylamide-N-methylolacrylamide-acrylic acid) electrospun ultrafine fibres for controlled drug release

Zhimei Wei et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Multidisciplinary Sciences

Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery

Kun Xi et al.

NATURE COMMUNICATIONS (2020)

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Article Nanoscience & Nanotechnology

Multifunctional Platform Based on Electrospun Nanofibers and Plasmonic Hydrogel: A Smart Nanostructured Pillow for Near-Infrared Light-Driven Biomedical Applications

Pawel Nakielski et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Polymer Science

In Vitro Hyperthermia Evaluation of Electrospun Polymer Composite Fibers Loaded with Reduced Graphene Oxide

Ignacio A. Zarate et al.

POLYMERS (2020)

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Article Polymer Science

Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers

Hoik Lee et al.

POLYMERS (2020)

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Article Chemistry, Multidisciplinary

Aqueous-based electrospun P(NIPAAm-co-AAc)/RSF medicated fibrous mats for dual temperature- and pH-responsive drug controlled release

Juan Li et al.

RSC ADVANCES (2020)

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Article Pharmacology & Pharmacy

pH-responsive delivery of Griffithsin from electrospun fibers

Kevin M. Tyo et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

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Review Chemistry, Multidisciplinary

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

Jiajia Xue et al.

CHEMICAL REVIEWS (2019)

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Article Chemistry, Analytical

Two-layer Electrospun System Enabling Wound Exudate Management and Visual Infection Response

Mohamed Basel Bazbouz et al.

SENSORS (2019)

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Article Multidisciplinary Sciences

Polydopamine-based Implantable Multifunctional Nanocarpet for Highly Efficient Photothermalchemo Therapy

Arjun Prasad Tiwari et al.

SCIENTIFIC REPORTS (2019)

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Article Pharmacology & Pharmacy

Gold Nanocage-Incorporated Poly(ε-Caprolactone) (PCL) Fibers for Chemophotothermal Synergistic Cancer Therapy

Ju Hyang Park et al.

PHARMACEUTICS (2019)

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Article Nanoscience & Nanotechnology

Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment

Jiulong Zhao et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Chemistry, Multidisciplinary

Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy

Rafael Contreras-Caceres et al.

NANOMATERIALS (2019)

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Article Nanoscience & Nanotechnology

Synergistic Photodynamic and Photothermal Antibacterial Nanocomposite Membrane Triggered by Single NIR Light Source

Jing Sun et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Materials Science, Biomaterials

Electrospun core-sheath poly(vinyl alcohol)/silk fibroin nanofibers with Rosuvastatin release functionality for enhancing osteogenesis of human adipose-derived stem cells

Mohammad Mehdi Kalani et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Nanoscience & Nanotechnology

Injectable, Magnetically Orienting Electrospun Fiber Conduits for Neuron Guidance

Christopher D. L. Johnson et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Physical

Cell Responses to Electrical Pulse Stimulation for Anticancer Drug Release

Anna Puiggali-Jou et al.

MATERIALS (2019)

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Review Chemistry, Multidisciplinary

Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy

Yaping Ding et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Biotechnology & Applied Microbiology

Electrospun Nanofibers With pH-Responsive Coatings for Control of Release Kinetics

Sezin Sayin et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

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Article Materials Science, Biomaterials

Synergistic antitumor efficacy of hybrid micelles with mitochondrial targeting and stimuli-responsive drug release behavior

Zhoujiang Chen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Article Materials Science, Biomaterials

Use of multifunctional composite nanofibers for photothermalchemotherapy to treat cervical cancer in mice

Xue Wang et al.

BIOMATERIALS SCIENCE (2019)

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Review Pharmacology & Pharmacy

Electrospinning: An enabling nanotechnology platform for drug delivery and regenerative medicine

Shixuan Chen et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Review Biophysics

Electrospun polymeric nanofibres as wound dressings: A review

Sonia P. Miguel et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Review Polymer Science

From nano to micro to macro: Electrospun hierarchically structured polymeric fibers for biomedical applications

Guang Yang et al.

PROGRESS IN POLYMER SCIENCE (2018)

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Article Chemistry, Multidisciplinary

Preparation of thermo-responsive drug-loaded nanofibrous films created by electrospinning

Jianbo Li et al.

RSC ADVANCES (2018)

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Review Chemistry, Multidisciplinary

Photo-Responsive Graphene and Carbon Nanotubes to Control and Tackle Biological Systems

Francesca Cardano et al.

FRONTIERS IN CHEMISTRY (2018)

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Article Chemistry, Applied

Magnetic nanofibrous materials based on CMC/PVA polymeric blends

J. G. Duran-Guerrero et al.

CARBOHYDRATE POLYMERS (2018)

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Article Nanoscience & Nanotechnology

Electric Field-Assisted In Situ Precise Deposition of Electrospun γ-Fe2O3/Polyurethane Nanofibers for Magnetic Hyperthermia

Chao Song et al.

NANOSCALE RESEARCH LETTERS (2018)

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Article Engineering, Biomedical

Design and development of pH-responsive polyurethane membranes for intravaginal release of nanomedicines

Seungil Kim et al.

ACTA BIOMATERIALIA (2018)

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Article Biophysics

In situ adjuvant therapy using a responsive doxorubicin-loaded fibrous scaffold after tumor resection

Ziming Yuan et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Review Chemistry, Applied

Alginate microparticles as oral colon drug delivery device: A review

Lissette Aguero et al.

CARBOHYDRATE POLYMERS (2017)

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Article Chemistry, Multidisciplinary

Designed Synthesis of Lipid-Coated Polyacrylic Acid/Calcium Phosphate Nanoparticles as Dual pH-Responsive Drug-Delivery Vehicles for Cancer Chemotherapy

Xin Wang et al.

CHEMISTRY-A EUROPEAN JOURNAL (2017)

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Article Engineering, Biomedical

Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning

Guang-Zhi Yang et al.

ACTA BIOMATERIALIA (2017)

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Article Nanoscience & Nanotechnology

Stimuli-Responsive Self-Immolative Polymer Nanofiber Membranes Formed by Coaxial Electrospinning

Daewoo Han et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Nanoscience & Nanotechnology

Sequence-Controlled Delivery of Peptides from Hierarchically Structured Nanomaterials

Carl Wei He et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Engineering, Biomedical

Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy

Z. Zhang et al.

ACTA BIOMATERIALIA (2015)

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Article Materials Science, Biomaterials

Ultrasound-triggered dual-drug release from poly(lactic-co-glycolic acid)/mesoporous silica nanoparticles electrospun composite fibers

Botao Song et al.

REGENERATIVE BIOMATERIALS (2015)

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Review Engineering, Biomedical

Electrospun Nanofibers-Mediated On-Demand Drug Release

Menglin Chen et al.

ADVANCED HEALTHCARE MATERIALS (2014)

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Article Biotechnology & Applied Microbiology

Fabrication and Characterization of Thermoresponsive Polystyrene Nanofibrous Mats for Cultured Cell Recovery

Hwan Hee Oh et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Article Engineering, Biomedical

Regulating drug release from pH- and temperature-responsive electrospun CTS-g-PNIPAAm/poly(ethylene oxide) hydrogel nanofibers

Huihua Yuan et al.

BIOMEDICAL MATERIALS (2014)

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Review Chemistry, Physical

Stimuli-responsive nanocarriers for drug delivery

Simona Mura et al.

NATURE MATERIALS (2013)

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Article Materials Science, Multidisciplinary

Temperature-responsive electrospun nanofibers for 'on-off' switchable release of dextran

Young-Jin Kim et al.

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS (2012)

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Review Chemistry, Multidisciplinary

Stimuli-responsive electrospun fibers and their applications

Chaobo Huang et al.

CHEMICAL SOCIETY REVIEWS (2011)

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