A Versatile PDA(DOX) Nanoplatform for Chemo-Photothermal Synergistic Therapy against Breast Cancer and Attenuated Doxorubicin-Induced Cardiotoxicity

Photothermal therapy (PTT) is a highly clinical application promising cancer treatment strategy with safe, convenient surgical procedures and excellent therapeutic efficacy on superficial tumors. However, a single PTT is difficult to eliminate tumor cells completely, and tumor recurrence and metastasis are prone to occur in the later stage. Chemo-photothermal synergistic therapy can conquer the shortcomings by further killing residual tumor cells after PTT through systemic chemotherapy. Nevertheless, chemotherapy drugs' extreme toxicity is also a problematic issue to be solved, such as anthracycline-induced cardiotoxicity. Herein, we selected polydopamine nanoparticles (PDA) as the carrier of the chemotherapeutic drug doxorubicin (DOX) to construct a versatile PDA(DOX) nanoplatform for chemo-photothermal synergistic therapy against breast cancer and simultaneously attenuated DOX-induced cardiotoxicity (DIC). The excellent photothermal properties of PDA were used to achieve the thermal ablation of tumors. DOX carried out chemotherapy to kill residual and occult distant tumors. Furthermore, the PDA(DOX) nanoparticles significantly alleviate DIC, which benefits from PDA's excellent antioxidant enzyme activity. The experimental data of the chemotherapy groups showed that the results of the PDA(DOX) group were much better than the DOX group. This study not only effectively inhibits cancer but tactfully attenuates DIC, bringing a new perspective into synergistic therapy against breast cancer.

Automated summary

Photothermal therapy (PTT) is a promising clinical application for cancer treatment, but it is difficult to eliminate tumor cells completely, leading to recurrence and metastasis. Chemo-photothermal synergistic therapy can overcome these limitations by killing residual tumor cells through chemotherapy. In this study, polydopamine nanoparticles (PDA) were used as a carrier for the chemotherapeutic drug doxorubicin (DOX) to construct a versatile nanoplatform for chemo-photothermal synergistic therapy against breast cancer and to attenuate DOX-induced cardiotoxicity (DIC). The PDA(DOX) nanoparticles showed excellent photothermal properties for tumor ablation and simultaneously alleviated DIC due to PDA's antioxidant enzyme activity.